• Maxillofacial Plastic and Reconstructive Surgery
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• v.38
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• pp.27.1-27.9
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• 2016

Background: The objective of this study was to place bone graft materials in cranial defects in a rabbit model and compare their bone regenerating ability according to the size and density of demineralized dentin matrix (DDM). Methods: We selected nine healthy male rabbits that were raised under the same conditions and that weighed about 3 kg. Two circular defects 8 mm in diameter were created in each side of the cranium. The defects were grafted with DDM using four different particle sizes and densities: 0.1 mL of 0.25- to 1.0-mm particles (group 1); 0. 2 mL of 0.25- to 1.0-mm particles (group 2); 0.1 mL of 1.0- to 2.0-mm particles (group 3); and 0.2 mL of 1.0- to 2. 0-mm particles (group 4). After 2, 4, and 8 weeks, the rabbits were sacrificed, and bone samples were evaluated by means of histologic, histomorphometric, and quantitative RT-PCR analysis. Results: In group 1, osteoblast activity and bone formation were greater than in the other three groups on histological examination. In groups 2, 3, and 4, dense connective tissue was seen around original bone even after 8 weeks. Histomorphometric analysis of representative sections in group 1 showed a higher rate of new bone formation, but the difference from the other groups was not statistically significant. RT-PCR analysis indicated a correlation between bone formation and protein (osteonectin and osteopontin) expression. Conclusions: DDM with a space between particles of $200{\mu}m$ was effective in bone formation, suggesting that materials with a small particle size could reasonably be used for bone grafting.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.2 no.2
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• pp.11-18
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• 1991

In this paper, the analysis of arbitrarily shaped microstrip antennas is described. The analysis method is based on the transmission - line matrix representation for the interior problem and the moment method for the problem along the peripheries of the patch. Using this method, the input impedance and other antenna parameters are calculated and compared with experimental results for a circular and an equilateral triangular microstrip antenna. For all of the results, theoretical and expreimental results are in good agreement and the validity of the method is confirmed. This analysis can also be used to analyze microstrip antennas with shorting pins.

• BMB Reports
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• v.34 no.1
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• pp.21-27
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• 2001

The structural stability of brain pyrydoxine-5'-phosphate (PNP) oxidase and the catalytic properties of the monomeric species were investigated. The unfolding of brain pyridoxine-5'-phosphate (PNP) oxidase by guanidine hydrochloride (GuHCl) was monitored by means of fluorescence and circular dichroism spectroscopy Reversible dissociation of the dimeric enzyme into subunits was attained by the addition of 2 M GuHCl. The perturbation of the secondary structure under the denaturation condition resulted in the release of the cofactor FMN. Separation of the processes of refolding and reassociation of the monomeric species was achieved by the immobilization method. Dimeric PNP oxidase was immobilized by the covalent attachment to Affi-gel 15 without any significant lass of its catalytic activity. Matrix-bound monomeric species were obtained from the reversible refolding processes. The matrix bound-monomer was found to be catalytically active, possessing only a slightly decreased specific activity when compared to the refolded dimeric enzyme. In addition, limited chymotrypsin digestion of the oxidase yields two fragments of 12 and 161 kDa with a concomitant increase of catalytic activity The catalytically active fragment was isolated by ion exchange chromatography and analyzed for association of two subunits using the FPLC gel filtration analysis. The retention time indicated that the catalytic fragment of 16 kDa behaves as a compact monomer. Taken together, these results are consistent with the hypothesis that the native quaternary structure of PNP oxidase is not a prerequisite for catalytic function, but it could play a role in the regulation.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.44 no.2
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• pp.79-85
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• 2018

Objectives: The aim of this study was to evaluate the effects of herbal extracts on bone regeneration. Two known samples were screened. Materials and Methods: We previously established a rat calvaria defect model using a combination of collagen scaffold and herbal extracts. An 8 mm diameter trephine bur with a low-speed dental hand piece was used to create a circular calvaria defect. The experimental group was divided into 4 classifications: control, collagen matrix, Danshen with collagen, and Ge Gan with collagen. Animals in each group were sacrificed at 4, 6, 8, and 10 weeks after surgery, and bone regeneration ability was evaluated by histological examination. Results: Results revealed that both Danshen and Ge Gan extracts increased bone formation activity when used with collagen matrix. All groups showed almost the same histological findings until 6 weeks. However, after 6 weeks, bone formation activity proceeded differently in each group. In the experimental groups, new bone formation activity was found continuously up to 10 weeks. In the Danshen and Ge Gan groups, grafted materials were still present until 10 weeks after treatment, as evidenced by foreign body reactions showing multinucleated giant cells in chronic inflammatory vascular connective tissue. Conclusion: Histological analyses showed that Danshen and Ge Gan extractions increased bone formation activity when used in conjunction with collagen matrix.

• Composites Research
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• v.19 no.4
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• pp.7-14
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• 2006

Interfacial shear strength between epoxy and carbon fiber has been analyzed utilizing the microbond specimen with an epoxy micro-droplet adhered onto single carbon fiber. The interfacial shear stress distributions along the fiber/matrix interface were calculated by finite element analysis using three kinds of finite element models such as droplet model, circular-crosssection model and pull-out model. Conclusions were obtained as follows. (1) Interfacial shear stress distribution showed that larger stresses were concentrated in the fiber/matrix interface for microbond test than for pull-out test. Thus, debonding at the fiber/matrix interface during microbond test was liable to occur at low load level. (2) Microbond test showed higher interfacial strength which was caused by various effects of micro-droplet geometry and size as well as stress concentration in the region contacting with the micro-vise tip.

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.2
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• pp.488-496
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• 1991

Dynamic chanracterisitcs and control of a submerged working robot manipulator have been investigated for articulated type robot manipulator with three revoluted joints. A dynamic equation of the manipulator has been derived. The dynamic equation includes not only mass matrix, centrifugal and Coriolis terms and gravity terms but also added mass, buoyant force and drag force terms, which are important terms for underwater motion description. A series of simulations using computed torque method have been performed for the cases of straight and circular trajectory motion controls. The results of this study show that the dynamic characteristics of the submerged working robot manipulator are very different from that of the manipulator which works in air. The influences of added mass, buoyant force and drag force terms to the total required torques have been discussed as distribution ratios to the total required torques.

• Advances in nano research
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• v.16 no.2
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• pp.175-186
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• 2024

Dynamical behaviors of one-dimensional (1D) nano-sized structures are of great importance in nanotechnology applications. Therefore, the torsional dynamic response of functionally graded nanorods which could be used to model the nano electromechanical systems or micro electromechanical systems with torsional motion about the center of twist is examined based on the theory of strain gradient nonlocal elasticity in this work. The mathematical background is constructed based on both strain gradient theory and Eringen's nonlocal elasticity theory. The equation of motions and boundary conditions of radially functionally graded nanorods are derived using Hamilton's principle and then transformed into the eigenvalue analysis by using Fourier sine series. A general coefficient matrix is obtained to assemble the Stokes' transformation. The case of a restrained functionally graded nanorod embedded in two elastic springs against torsional rotation is then deeply investigated. The effect of changing the functionally graded index, the stiffness of elastic boundary conditions, the length scale parameter and nonlocal parameter are investigated in detail.

• Interaction and multiscale mechanics
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• v.2 no.3
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• pp.321-332
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• 2009

Recent development in composites containing phase-transforming particles, such as vanadium dioxide or barium titanate, reveals the overall stiffness and viscoelastic damping of the composites may be unbounded (Lakes et al. 2001, Jaglinski et al. 2007). Negative stiffness is induced from phase transformation predicted by the Landau phase transformation theory. Although this unbounded phenomenon is theoretically supported with the composite homogenization theory, detailed stress analyses of the composites are still lacking. In this work, we analyze the stress distribution of the Hashin-Shtrikman (HS) composite and its two-dimensional variant, namely a circular inclusion in a square plate, under the assumption that the Young's modulus of the inclusion is negative. Assumption of negative stiffness is a priori in the present analysis. For stress analysis, a closed form solution for the HS model and finite element solutions for the 2D composite are presented. A static loading condition is adopted to estimate the effective modulus of the composites by the ratio of stress to average strain on the loading edges. It is found that the interfacial stresses between the circular inclusion and matrix increase dramatically when the negative stiffness is so tuned that overall stiffness is unbounded. Furthermore, it is found that stress distributions in the inclusion are not uniform, contrary to Eshelby's theorem, which states, for two-phase, infinite composites, the inclusion's stress distribution is uniform when the shape of the inclusion has higher symmetry than an ellipse. The stability of the composites is discussed from the viewpoint of deterioration of perfect interface conditions due to excessive interfacial stresses.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.18 no.2
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• pp.133-140
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• 2005

A Plate on the elastic half-space may be generally be analyzed by the finite element method. However, there ate some difficulties to obtain the flexibility matrix of the foundation based on the Boussinesq's theory. In this study, an efficient numerical procedure which uses the analysis results of the vertical displacements due to the uniformly distributed loading in a circular area is presented. Some numerical examples represent better results than those of numerical integration technique or subsection method especially in the case of irregular mesh pattern.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.2 no.3
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• pp.134-142
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• 1990

A wide-angle approximation in the parabolic equation method is presented to calculate wave transformation in the shallow water. The parabolic approximation to the mild-slope equation is obtain-ed by the use of a splitting matrix, which leads to a generalized equation in form. A numerical model based on a finite difference scheme is presented and computational results are provided to test the model against the laboratory measurements of circular and elliptical shoals. The numerical results are in good agreement with most of experimental data. Therefore it can be concluded that the model shows greater capability to reproduce the characteristics of waves in the refractive focus.