• 대한한의학방제학회지
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• 제11권2호
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• pp.125-134
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• 2003

We have examined the relaxational response to the water extract of Angelica gigas $N_{AKAI}$ (AG), Gingko biloba $L_{INNE}$ (GB), Acanthopanax senticosus $H_{ARMS}.$ (AP) and Augumented-Four-Substance Decoction (AG-FSD, GB-FSD, AP-FSD) in isolated thoracic aorta from sprague dawley(SD) rat. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at $10^{-4}M$ were inhibited by 26.3%, 75.8%, 87.5% and 6.9%, 22.6%, 30.8% after addition of the 0.1 g/mL water extract of AG, GB, AP and AG-FSD, GB-FSD, AP-FSD. In conclusion, AG, GB, AP and AG-FSD, GB-FSD, AP-FSD induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AP-FSD has very potent vasodilation.

• 대한한방부인과학회지
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• 제24권3호
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• pp.171-189
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• 2011

Objectives: Female Sexual Dysfuction(FSD) is a common gynecologic condition and its prevalence is more higher than men. Despite its high prevalence and clinical importance, research on FSD is not enough in both of oriental and western medicine. The purpose of this study is to review research tendency of recent oriental medicine studies on FSD and to suggest the following research on FSD. Methods: We searched oriental medicine papers related to FSD published in the last 10 years(2001-2011) through Korean Medicine Gynecology Society database, KISS, RISS, NDSL, CNKI(China National Knowledge Infrastructure), and Pubmed. Results: 26 papers were searched, then 18 papers of them were related to Traditional Chinese Medicine(TCM), 8 papers of them were related to Korean Medicine(KM). In classification according to paper type, 16 papers were clinical study, 1 paper was experimental study, 2 papers were bibliographic study, and 7 papers were the other study. Then 5 papers of clinical study was Randomized Controlled Trial(RCT). Conclusion: There was a lack of oriental medicine research on FSD. On the base of this study, so further research is needed. Especially, Clinical trials such as RCT have strong objective evidence power in the viewpoint of Evidence Based Medicine(EBM) are needed.

• Structural Engineering and Mechanics
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• 제68권1호
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• pp.121-130
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• 2018

This study deals with optimum geometry design of laterally loaded piles in a Winkler's medium through the Fully Stressed Design (FSD) method. A numerical algorithm distributing the mass by means of the FSD method and updating the moment by finite elements is implemented. The FSD method is implemented here using a simple procedure to optimise the beam length using an approach based on the calculus of variations. For this aim two conditions are imposed, one transversality condition at the bottom end, and a one sided constraint for moment and mass distribution in the lower part of the beam. With this approach we derive a simple condition to optimise the beam length. Some examples referred to different fields are reported. In particular, the case of laterally loaded piles in Geotechnics is faced.

• Bulletin of the Korean Chemical Society
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• 제35권6호
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• pp.1713-1719
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• 2014

1FSD is a 28-residue designed protein with a ${\beta}{\beta}{\alpha}$ motif. Since this protein displays most essential features of protein structures in such a small size, this model protein can be an outstanding system for evaluating the balance in the propensity of the secondary structures and the quality of all-atom protein force fields. Particularly, this protein would be difficult to fold to its correct native structure without establishing proper balances between the secondary structure elements in all-atom energy functions. In this work, a series of the recently optimized five amber protein force fields [$ff03^*$, $f99sb^*$-ildn, ff99sb-${\phi}^{\prime}$-ildn, ff99sb-nmr1-ildn, ff99sb-${\Phi}{\Psi}$(G24, CS)-ildn] were investigated for the simulations of 1FSD using a conventional molecular dynamics (MD) and a biased-exchange meta-dynamics (BEMD) methods. Among those tested force fields, we found that ff99sb-nmr1-ildn and ff99sb-${\Phi}{\Psi}$(G24, CS)-ildn are promising in that both force fields can locate the native state of 1FSD with a high accuracy (backbone rmsd ${\leq}1.7{\AA}$) in the global free energy minimum basin with a reasonable energetics conforming to a previous circular dichroism (CD) experiment. Furthermore, both force fields led to a common set of two distinct folding pathways with a heterogeneous nature of the transition state to the folding. We anticipate that these force fields are reasonably well balanced, thereby transferable to many other protein folds.

• 정신신체의학
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• 제27권1호
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• pp.1-12
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• 2019

한 종에 속하는 개체의 행동 양상은 다양한 변이를 가진다. 같은 종 내에서 다른 행동적 표현형이 유지되는 현상은 진화적으로 적소 특화나 빈도의존성 선택으로 설명할 수 있는데, 아직 명확하게 밝혀진 것은 아니다. 특히 극단적인 행동 양상으로서의 정신병리가 높은 비율로 관찰되는 현상은 진화심리학의 난제 중 하나다. 행동 양상의 다양한 변이 및 정신병리를 진화적인 견지에서 접근하기 위한 몇 가지 틀이 제안될 수 있을 것이다. 본 논문에서는 개체 간 행동 양상 변이에 관한 진화적 접근을 중심으로 동물 모델과 성격 요인모델, DSM-IV 다축 모델, FSD 모델, RDoC 모델 등을 간략하게 설명하고, 그 연구에 적용할 때 예상되는 장단점을 논의하고자 한다.

• 대한디지털의료영상학회논문지
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• 제11권2호
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• pp.101-107
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• 2009

With the recent development of diagnosis using radiation and increasing demand of the medical treatment, we need to minimize radiation exposure dose. So, This is the method which reduce patient dose by measuring surface dose of radiographic change factor and by comparing theoretical and actual dose, when we take an X-ray which is generally used. By changing the factor of kV, mAs, FSD, whose range is 60 to 120 kV, 20 to 100 mAs, 80 to 180 cm, we compared theoretical surface dose with actual surface dose calculated by the simple calculation program, Bit system, and NDD-M method As a result, when kV and mAs were higher, theoretical surface dose and actual surface dose were more increased. but the higher FSD was, the more decreased surface dose was. According to this, the error were measured about 0.1 to 0.2 mGy in low dose part and about 0.7 to 1.5 mGy in high dose part. Therefore, this shows that theoretical surface dose calculation method is more correct in low dose part than in high dose part. In conclusion, we will have to make constant efforts which can reduce patient and radiographer's exposure dose, studying methods which can predict patient's radiation exposure dose more exactly.

• Animal Bioscience
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• 제36권2호
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• pp.275-283
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• 2023

Objective: This study was to evaluate standardized ileal digestibility (SID) of amino acids (AA) in fermented soybean meal (FSBM) for nursery pigs using both direct procedure and difference procedure when FSBM was added at 20% in diets. Methods: Forty-eight pigs at 9.2±0.9 kg body weight (BW) were individually housed and allotted to 4 treatments. Treatments included NFD (a semi-purified N free diet), FSD (a diet with 20% FSBM), CBD (corn basal diet), and CFD (corn basal diet:FSBM at 80:20). The FSD was used to measure AA digestibility in FSBM using the direct procedure, whereas CBD and CFD were used in the difference procedure. Pigs were fed for 10 days (0.09×BW^0.75 kg per day) and euthanized to collect ileal digesta for TiO₂ and AA. Results: Total endogenous AA loss was 12.1 g/kg of dry matter intake. The apparent ileal digestibility (AID) Thr was greater (p<0.05) and AID His (p = 0.073) and Leu (p = 0.052) tended to be greater using the direct procedure compared with the difference procedure. The SID Thr were greater (p<0.05) in FSBM for nursery pigs calculated using a direct procedure compared with a difference procedure. In addition, SID Lys in FSBM was about 83% to 88% for nursery pigs higher than SID Lys described in National Research Council (2012). Conclusion: The SID of AA in FSBM when included at practical levels using the direct procedure were similar to those from the difference procedure. Considering the SID of AA obtained using both direct and difference procedures, FSBM is an effective protein supplement providing highly digestible AA to nursery pigs. The SID of AA from this study was considerably higher than those previous reported. This study also indicates the importance of including the test feedstuffs at practical levels when evaluating digestibility.

• 한국항공운항학회지
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• 제16권4호
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• pp.20-25
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• 2008

The purpose of this study is leading to reduce the setup time and cost of the ground telemetry system for FA-50 program. And using the accumulated experience during T-50 and TA-50 development period, remove the risk of development and construct the optimal ground telemetry system for FA-50. For this study, collect the ground telemetry data of the T-50/TA-50, analyze the data and problems and then suggest the optimal telemetry ground system for FA-50.

• 항공우주시스템공학회지
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• 제2권2호
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• pp.42-45
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• 2008

Under the non-operating exposure condition in the hot area, the T-50 cockpit temperature is expected over the requirement according to T-50 environmental criteria. So it is necessary to protect the cockpit from the high temperature condition during the non-operating exposure because the high temperature of the cockpit may result in the cockpit equipment malfunction. In this study, the transparency coating is selected as the method for protecting the cockpit from the high temperature exposure and analyzed the effect on the cockpit heat load attenuation. Some kinds of cockpit coating were reviewed and selected and the analysis was performed about the effect before and after coating application under 1% hot day condition based on the T-50 FSD hot soaking test data. The result of analysis show transparency coating is so effective to attenuate the heat load of T-50 cockpit.

• 항공우주시스템공학회지
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• 제1권4호
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• pp.22-27
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• 2007

The 150 gal Ion EFT(External Fuel Tank) used to enlarge the aircraft operation range was adopted an import equipment in T-50 FSD phase. But in Production phase the EFT was planed to develop for the stable ILS(Integrated Logistics Support) and technical ability improvement by using the composite materials. The design for configuration and fuel system is intended to maintain compatibility with aircraft systems and the development test is performed on component, assembly and aircraft. This study is conducted to provide the technology of design and test for the 150 gallon composite EFT in LRU level. The test results show that the composite EFT is satisfied with structural, functional and environment requirements which are described in specification.