• The KIPS Transactions:PartC
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• v.12C no.1 s.97
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• pp.53-62
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• 2005

The NG-SDH system requires signal synchronization to synchronize incoming ethernet signal with GFP frame. The foreign nation research completes a chipset development until now and it secures a relation technique, but it does not secure a relation technique from domestic. Therefore, in this paper, we presented with signal synchronization method of Ethernet signal through GFP frame. We knew that the synchronized method of Ethernet signal through GFP-F must apply ingress & egress buffer and GFP Idle. We understood that the synchronized method of Ethernet signal through GFP-T must apply GFP Idle and $65B{\_}PAD$, and require maximum 3-bit addition & deletion of idle. Also we showed signal synchronization realization through simulation and obtained MTIE/TDEV characteristics and peak to peak jitter in egress output.

• Bulletin of the Korean Space Science Society
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• 2009.10a
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• pp.25.2-25.2
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• 2009

한국천문연구원 한국우주전파관측망(Korean VLBI Network, KVN)에서 도입하여 시험운용중인 VLBI 상관서브시스템(VLBI Correlation Subsystem, VCS)은 한일공동 VLBI 상관기(Korea-Japan Joint VLBI Correlator, KJJVC)의 핵심 장비로서, 최대 16 관측국의 관측국 당 최대 8Gbps의 데이터를 처리할 수 있는 상관처리장치이다. VCS의 상관처리 결과는 총 4회선의 10GbE 광케이블을 통하여 UDP 프로토콜로 출력된다. 이 상관처리 결과는 광케이블 하나당 8개씩 총 32개의 상관 처리 블록(correlation block)으로 구성되며, 최대 출력속도는 1.4 GBytes/sec이다. 이 출력은 초고속 대용량 자료저장 시스템(Peta-scale Epoch Data Archive, PEDA)을 이용하여 저장하고 후속 자료처리를 위해 가공된다. PEDA는 총 4대의 고성능 자료 전송 및 저장 서버(writing server) 및 대용량 하드디스크 어레이로 구성된다. 상관처리 과정에 맞추어 PEDA의 writing 서버를 연계하여 제어하는 자료 전송 및 저장 제어 소프트웨어를 개발하였다. 이 소프트웨어는 핵심이 되는 전송 및 저장 프로세서와 이를 제어하는 제어프로세서로 구성된다. 전송 및 저장 프로세서는 개개의 상관 처리 블록에 대한 전송과 저장을 전담한다. 제어 프로세서는 총 32개의 상관 처리 블록을 처리하기 위하여 전송 및 저장 프로세스를 32개를 실행하고 각각의 상관 처리 블록에 해당하는 개별파라미터를 전달하는 전체적인 제어를 담당한다. 이 연구에서는 이 자료전송 및 저장 제어 소프트웨어의 설계 구성과 테스트 내용을 소개한다.

• Publications of The Korean Astronomical Society
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• v.28 no.1
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• pp.1-6
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• 2013

Real-time data reduction pipeline for the Korea Microlensing Telescope Network (KMTNet) was developed by Korea Astronomy and Space Science Institute (KASI). The main goal of the data reduction pipeline is to find variable objects and to record their light variation from the large amount of observation data of about 200 GB per night per site. To achieve the goal we adopt three strategic implementations: precision pointing of telescope using the cross correlation correction for target fields, realtime data transferring using kernel-level file handling and high speed network, and segment data processing architecture using the Sun-Grid engine. We tested performance of the pipeline using simulated data which represent the similar circumstance to CTIO (Cerro Tololo Inter-American Observatory), and we have found that it takes about eight hours for whole processing of one-night data. Therefore we conclude that the pipeline works without problem in real-time if the network speed is high enough, e.g., as high as in CTIO.

• IMMUNE NETWORK
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• v.22 no.1
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• pp.4.1-4.22
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• 2022

In the era of immunotherapeutic control of cancers, many advances in biotechnology, especially in Ab engineering, have provided multiple new candidates as therapeutic immuno-oncology modalities. Bispecific Abs (BsAbs) that recognize 2 different antigens in one molecule are promising drug candidates and have inspired an upsurge in research in both academia and the pharmaceutical industry. Among several BsAbs, T cell engaging BsAb (TCEB), a new class of therapeutic agents designed to simultaneously bind to T cells and tumor cells via tumor cell specific antigens in immunotherapy, is the most promising BsAb. Herein, we are providing an overview of the current status of the development of TCEBs. The diverse formats and characteristics of TCEBs, in addition to the functional mechanisms of BsAbs are discussed. Several aspects of a new TCEB-Blinatumomab-are reviewed, including the current clinical data, challenges of patient treatment, drawbacks regarding toxicities, and resistance of TCEB therapy. Development of the next generation of TCEBs is also discussed in addition to the comparison of TCEB with current chimeric antigen receptor-T therapy.

• Journal of Ginseng Research
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• v.43 no.2
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• pp.196-208
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• 2019

Background: Nonalcoholic steatohepatitis (NASH) is one of the chronic inflammatory liver diseases and a leading cause of advanced liver fibrosis, cirrhosis, and hepatocellular carcinoma. The main purpose of this study was to clarify the effects of GBCK25 fermented by Saccharomyces servazzii GB-07 and pectinase, on NASH severity in mice. Methods: Six-wk-old male mice were fed either a normal diet (ND) or a Western diet (WD) for 12 wks to induce NASH. Each group was orally administered with vehicle or GBCK25 once daily at a dose of 10 mg/kg, 20 mg/kg, 100 mg/kg, 200 mg/kg, or 400 mg/kg during that time. The effects of GBCK25 on cellular damage and inflammation were determined by in vitro experiments. Results: Histopathologic analysis and hepatic/serum biochemical levels revealed that WD-fed mice showed severe steatosis and liver injury compared to ND-fed mice. Such lesions were significantly decreased in the livers of WD-fed mice with GBCK25 administration. Consistently, mRNA expression levels of NASH-related inflammatory-, fibrogenic-, and lipid metabolism-related genes were decreased in the livers of WD-fed mice administered with GBCK25 compared to WD-fed mice. Western blot analysis revealed decreased protein levels of cytochrome P450 2E1 (CYP2E1) with concomitantly reduced activation of c-Jun N-terminal kinase (JNK) in the livers of WD-fed mice administered with GBCK25. Also, decreased cellular damage and inflammation were observed in alpha mouse liver 12 (AML12) cells and RAW264.7 cells, respectively. Conclusion: Administration of GBCK25 ameliorates NASH severity through the modulation of CYP2E1 and its associated JNK-mediated cellular damage. GBCK25 could be a potentially effective prophylactic strategy to prevent metabolic diseases including NASH.

• Korean Journal of Construction Engineering and Management
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• v.17 no.2
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• pp.99-109
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• 2016

The utilization of Building Information Modeling (BIM) has increased in order to enhance the integration of information for management and resources throughout the construction projects. Therefore, various BIM softwares have been used under open BIM environments in the building and plant construction industry. However, it has obstructive factors due to the lack of interoperability. In order to address this problem, this study conducted an interoperability analysis of BIM software focused on user-defined properties for enhanced function and efficiency. Result of the analysis shows that authoring tools have more interoperability problems than viewer tools and simulation tools have. In terms of interoperability, user-defined properties outperforms than those of system basic properties and logic data. Therefore, it was found that functional improvement and workload minimization in BIM can be attained by applying the GBS (an user-defined property for automatic manipulation of BIM proposed by Jung et al. 2013) that enables automatic link between geometric data and non-geometric data. In this respect, this study concludes that the application of user-defined property (e.g. GBS) can be an effective method for information integration throughout construction projects.

• Journal of Acupuncture Research
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• v.23 no.5
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• pp.177-185
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• 2006

Objectives : To observe the effect of acupuncture treatment and western medical treatment on frozen shoulder patients. Methods : 39 voluntary patients were randomly assigned to the Eastern treatment group(E group, n=22) and the Western treatment group(W group, n=17). The E group received acupuncture treatment on LI15, TE14, GB21 and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for 4 weeks. The W group received suprascapular nerve block, subacromial injection and trigger point injection, twice a week for 4 weeks. Both groups were instructed to practice self exercise during their daily lives. Evaluations were made before treatment and after treatment using Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's satisfaction concerning the treatment was measured by Visual Analogue Scale(VAS). The obtained data were analyzed and compared. Results : The E group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 5.67 on a scale of 10. The W group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 7.73. But the difference between the two groups were insignificant according to CSA and SPADI. Conclusion : Both acupuncture and nerve block treatment significantly improved frozen shoulder. But the difference of the two treatments was insignificant.

• Journal of Korean Medicine Rehabilitation
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• v.27 no.1
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• pp.27-35
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• 2017

Objectives This study aimed to review case studies on interventions of Korean medicine for hip pain. Methods We searched seven electronic databases for relevant studies up to Oct 2016. Case studies of Korean medicine interventions for hip pain were included and analysed. Results 15 case studies were included (Korean databases; n=15) and Total number of patients was 17 cases. A total of 13 types of interventions were reported, of which acupuncture (93.3%), herbal medicine (80.0%) and pharmacopuncture (40.0%) were the most frequently used. GB30 (66.7%), LR3 (41.7%), BL36 (33.3%) and ST31 (33.3%) were used in at least 4 papers. Cheongpa-jeon (25.0%) and symptom change (46.7%) were most frequently used in herbal medicine and outcome measure respectively. Conclusions Clinical studies, especially double-blinded randomized controlled trials, of Korean medicine interventions for hip pain must be conducted to obtain definite conclusions.

• Molecules and Cells
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• v.39 no.2
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• pp.141-148
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• 2016

Oriental melon (Cucumis melo L. var. makuwa) is one of six subspecies of melon and is cultivated widely in East Asia, including China, Japan, and Korea. Although oriental melon is economically valuable in Asia and is genetically distinct from other subspecies, few reports of genome-scale research on oriental melon have been published. We generated 30.5 and 36.8 Gb of raw RNA sequence data from the female and male flowers, leaves, roots, and fruit of two oriental melon varieties, Korean landrace (KM) and Breeding line of NongWoo Bio Co. (NW), respectively. From the raw reads, 64,998 transcripts from KM and 100,234 transcripts from NW were de novo assembled. The assembled transcripts were used to identify molecular markers (e.g., single-nucleotide polymorphisms and simple sequence repeats), detect tissue-specific expressed genes, and construct a genetic linkage map. In total, 234 single-nucleotide polymorphisms and 25 simple sequence repeats were screened from 7,871 and 8,052 candidates, respectively, between the KM and NW varieties and used for construction of a genetic map with 94 F2 population specimens. The genetic linkage map consisted of 12 linkage groups, and 248 markers were assigned. These transcriptome and molecular marker data provide information useful for molecular breeding of oriental melon and further comparative studies of the Cucurbitaceae family.

• International Journal of Industrial Entomology and Biomaterials
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• v.27 no.2
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• pp.271-276
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• 2013

The Asian honeybee, Apis cerana, is a native honeybee species in Korea which is important in agriculture for pollination and honey production. For better understanding of the physiology of A. cerana, high-throughput Illumina transcriptome sequencing was performed to analyze the gene expression profiles of queen, worker, and larva. A total of 219,799,682 clean reads corresponding to 22.2 Gb of nucleotide sequences was obtained from the whole body total RNA samples. The Apis mellifera reference mRNA sequence database was used to measure the gene expression level with Bowtie2 and eXpress software, and the Illumina short reads were then mapped to 11,459 out of 11,736 A. mellifera reference genes. Total of 9,221 genes with FPKM value greater than 5 of each sample group were subjected to eggNOG with BLASTX for gene ontology analysis. The differential gene expression between queen and worker, and worker and larva were analyzed to screen the overexpressed genes in each sample group. In the queen and worker sample group, total of 1,766 genes were differentially expressed with 887 and 879 genes overexpressed over two folds in queen and worker, respectively. In the worker and larva sample group, total of 1,410 genes were differentially expressed with 1,009 and 401 genes overexpressed over two folds in worker and larva, respectively.