• 제목/요약/키워드: 1-stage cycle

검색결과 943건 처리시간 0.039초

고리 1호기의 잔류방사능 유도농도(DCGL)를 적용한 회색영역 설정과 핵종농도평가 (Designation the Gray Region and Evaluating Concentration of Radionuclide in Kori-1 by Using Derived Concentration Guideline Level)

  • 전여령;박상준;안석영;김용민
    • 한국방사선학회논문지
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    • 제12권3호
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    • pp.297-304
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    • 2018
  • 미국의 원전해체 지침서인 MARSSIM과 MARLAP에서는 의사결정 전 부지조사를 계획하고, 계획한 조사를 시행하는데 Data Life Cycle의 사용을 권장하고 있다. 부지조사 계획단계에서 설정되는 데이터품질목표(DQO)는 부지조사 수행 및 설계의 모든 측면에서 얻을 수 있는 데이터를 최선으로 활용하는 방법을 제시하고, 부지조사 계획을 체계화하여 공식적으로 중요한 의사결정을 내리는데 필요한 정보를 얻을 수 있도록 한다. DQO의 일곱 과정 중 5~7단계에서는 앞선 단계에서 수집한 정보를 이용하여 합리적이고 신뢰성있는 의사결정을 내릴 수 있도록 부지조사를 설계하는 과정이다. 이 과정 중 설정되는 회색영역은 관심핵종에 대한 조사단위의 평균농도가 실제로 DCGL을 초과하지 않음에도 불구하고, 초과한다고 판단하여 제염활동과 같은 추가적인 활동을 하도록 결정내리는 Type II 의사결정 오류로 인한 결과가 미약할 것으로 생각되는 농도범위로 정의된다. 회색영역은 부지에서 수집한 Sample에 속한 특정 핵종의 평균농도와, 규제한도로서 설정될 수 있는 잔류방사능 유도농도(DCGL)를 이용하여 정할 수 있다. 회색영역을 설정함으로써 가장 자원효율적으로 부지조사계획을 설정할 수 있으며 의사결정 오류에 대한 영향을 최소화 할 수 있다. 선행연구로 도출된 고리 1호기의 DCGL을 이용하여 회색영역을 설정하고, 이를 이용해 올바른 의사결정을 내릴 수 있도록 하는 Sample의 농도평가 방법을 제시하였다.

주파수 배가 방법을 이용한 고속 전압 제어 링 발진기 (A High-Speed Voltage-Controlled Ring-Oscillator using a Frequency Doubling Technique)

  • 이석훈;황인석
    • 전자공학회논문지SC
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    • 제47권2호
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    • pp.25-34
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    • 2010
  • 본 논문에서는 주파수 배가 방법을 사용한 초고속 전압 제어 링 발진기를 제안하였다. 제안한 전압 제어 발진기는 TSMC 0.18um 1.8V CMOS 공정을 사용하여 설계하였다. 제안한 주파수 배가 방법은 한 주기 안에서 $90^{\circ}$의 위상차를 가지는 4개의 신호를 AND-OR 연산하여 기본 신호의 두 배 주파수를 가지는 신호를 얻어내는 방법이다. 제안한 발진기는 차동 4단 링 발진기와 NAND 게이트를 사용하여 구성하였다. 전압 제어 링 발진기는 완전 차동 형태로 설계하여 정확하게 $90^{\circ}$의 위상차를 가지는 4개의 신호를 얻을 수 있었으며 공통 모드 잡음에 대해 우수한 잡음 성능을 가지게 되었다. 주파수 배가회로는 AND나 OR 게이트에 비해 집적도가 뛰어난 NAND 게이트를 사용하여 AND-OR 연산을 구현하였다. 설계된 전압 제어 링 발진기는 컨트롤 전압에 따라 3.72GHz에서 8GHz의 출력 주파수를 가지며 4GHz에서 4.7mW의 소비 전력과 1MHz 오프셋 주파수에서 -86.79dBc/Hz의 위상잡음 성능을 가짐을 검증하였다. 기존의 고속 전압 제어 링 발진기와의 비교에서도 모든 면에서 가장 뛰어난 성능을 보였고 저렴한 고속 주파수 합성기와 위상 고정 루프 등에 응용될 수 있음을 보였다.

토끼 수정란의 체외발달에 미치는 배양액 및 소와 토끼의 난관상피세포들과의 공배양 효과 (Effect of Culture Media and Co-culture with Bovine and Rabbit Oviductal Epithelial Cells on In Vitro Development of Rabbit Embryos)

  • 노규진;이효종;송상현;윤희준;박충생
    • 한국가축번식학회지
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    • 제18권1호
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    • pp.39-46
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    • 1994
  • This experiment was carried out to develop an in vitro culture system for rabbit embryos. The zygotes or 2-cell embryos were collected from the oviducts of the superovulated and mated does with D-PBS/10% FCS at 24 hours after hCG injection. The in vitro developmental rate of blastocyst formation and the number of nuclei in the embryos were examined under the following treatments; 1) TCM-199 with 10% FCS, 2) EBSS with 10% FCS, 3) rabbit vitreous humor(VH), 4) TCM-199 with 10% FCS+BOEC, 5) TCM-199 with 10% FCS+ROEC, 6) EBSS with 10% FCS+BOEC and 7) EBSS with 10% FCS+ROEC. For a comparative study of in vivo and in vitro development, the fresh blastocysts, which were developed in vivo for 96 hours after hCG injection, were collected from the uterus and their numbers of nuclei were counted. 1. The zygotes or 2-cell embryos developed to the blastocyst stage in TCM-199, EBSS and VH at the rates of 93, 92 and 89%, respectively. 2. The higher developmental rates 95~98% of blastocyst formation was achieved when the embryos were co-cultured with a monolayer of bovine or rabbit oviductal epithelial cells in TCM-199 or EBSS. No significant difference in developmental rates was shown between bovine and rabbit oviductal epithelial cells. 3. In a comparative study of in vivo and in vitro development, the total numbers of nuclei were significantly less in the in vitro cultured embryos(104~224) than the in vivo developed embryos(1, 0090 at 96 hours after hCG injectin. 4. The mean cell cycle numbers in the embryos cultured for 72 hours in TCM-199 with 10% FCS, EBSS with 10% FCS, TCM-199 with 10% FCS+BOEC, TCM-199 with 10% FCS+ROEC, EBSS with 10% FCS+BOEC and in vivo was 7.38, 6.63, 7.76, 7.69, 7.01 and 9.92, respectively. From these results, it can be suggested the optimal culture system for in vitro culture of rabbit embryos is a co-culture system with bovine or rabbit oviductal epithelial cells in TCM-199 with 10% FCS. Considering the significant reduction in total numbers of nuclei in the in vitro cultured embryos, the advanced research on development of in vitro culture system for rabbit embryos is expected.

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유·가스정 최적 운영을 위한 ESP의 장기 성능 진단 및 고장 예측 실험 연구 (Experimental Study on the Diagnosis and Failure Prediction for Long-term Performance of ESP to Optimize Operation in Oil and Gas Wells)

  • 이승재;최준호;이정환
    • 한국가스학회지
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    • 제27권2호
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    • pp.71-78
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    • 2023
  • 일반적으로 평균 수명이 1.0~1.5년인 전기식 액중형 펌프(electrical submersible pump, ESP)는 유·가스 및 저류층 특성, 운영 조건에 따라 성능 저하 및 수명 감소가 발생하며, 이에 따른 ESP의 고장은 회수 및 설치에 따른 높은 유정 개·보수(workover) 비용과 생산 중단에 따른 추가 비용이 발생한다. 이에 본 연구에서는 유·가스정에서 ESP 장기 운영에 따른 수명을 예측하고자 환형 유동 시스템(flow loop system)을 설계 및 구축하고, ESP 설치 초기 시점부터 고장 시점까지의 ESP 수명에 대한 전 주기 데이터를 취득 및 분석하였다. 구축한 시스템에서 산출되는 데이터 중 ESP의 유체유량, 흡입구 및 토출구의 온도, 압력 그리고 외측부에 설치된 진동 측정기의 데이터 분석을 통하여 ESP 장기 운영에 따른 성능 상태를 정상(normal), 권고 I (advise I), 권고 II (advise II), 유지관리(maintenance), 고장(failed)의 총 5단계로 분류하였다. 실험 결과를 통해 ESP 장기 운영시 단계별 데이터의 경향 차이를 확인하였으며, 이를 통해 운영 기간에 따른 ESP의 상태를 진단하고 펌프의 고장을 예측하였다. 본 연구를 통해 도출된 결과는 유·가스정에서 운영되는 ESP의 상태 모니터링(monitoring) 을 위한 고장 예측 프로그램 및 데이터 분석 알고리즘 개발에 활용될 수 있을 것으로 판단된다.

LCA기법을 이용한 랜탈 재제조품의 환경성 평가 (Environmental Evaluation for the Remanufacturing of Rental Product Using the LCA Methodology)

  • 곽인호;황용우;박광호;박지형;설소영;신화정;양은혁;민곤식
    • 대한환경공학회지
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    • 제38권11호
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    • pp.611-617
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    • 2016
  • 사용 후 제품을 회수하여 완전 해체하고 부품들을 세척, 수리, 또는 새로운 부품으로 교체하여 재조립함으로써 신품과 동일한 성능 수준으로 재 제품화 하는 재제조는 천연자원과 에너지 사용의 저감 등 자원순환 측면에서의 환경적 개선효과가 뛰어나 자원 측면에서 주목받고 있다. 재제조는 뛰어난 환경개선 효과 및 자원보존으로 인해 우리나라에서 많은 연구가 수행되어왔으며, 현재 자동차 부품, 프린터 토너 및 카트리지를 중심으로 재제조가 이루어지고 있다. 하지만 코어의 상태가 양호한 상태로 반환되어 재제조 공정을 거쳐 새 제품과 동일한 상태의 재제조품 생산이 가능한 렌탈 제품은 아직까지 활성화 되어있지 않다. 따라서, 본 연구에서는 LCA 기법을 이용해 렌탈 제품 중 하나인 공기청정기 신품과 재제조 제품의 환경성평가를 수행하였으며, 이를 통해 렌탈 제품 신품 대비 재제조품의 환경적 개선 효과를 정량적으로 분석하였다. 분석결과 공기청정기 1대 재제조 시 환경영향은 신품대비 약 20.7% 감소하는 것으로 나타났다. 환경과 관련된 영향범주 중 오존층 파괴(ODP)가 94% 감소하여 가장 큰 효과가 있는 것으로 나타났으며, 공기청정기의 수명주기에서 원료 추출 단계에서는 자원고갈(ADP) 및 지구온난화(GWP)에 대한 환경개선 효과가 가장 큰 것으로 나타났다.

자연산 바지락, Ruditapes philippinarum의 생식주기와 수온-먹이섭이 및 절식조건에 의한 생식소발달의 인위적 제어 (Reproductive Cycle of Natural Population and Artificial Control of Gonadal Development of Ruditapes philippinarum by the Conditions of Water Temperature-Feeding and Starvation)

  • 정의영;이정식;이창훈;허성범
    • 한국패류학회지
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    • 제18권2호
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    • pp.83-91
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    • 2002
  • 자연산 바지락 (Ruditapes philippinarum) 개체군의 생식 주기와 수온-먹이섭이 및 절식조건에 따른 생식소 발달의 인위적 제어 결과를 조직학적 관찰에 의해 조사하였다. 곰소만 자연산 바지락 개체군의 생식소 발달에 따른 암수 개체의 생식주기는 초기활성기 (4-5월), 완숙기 (4-8월), 부분산란기 (5-10월), 퇴화 및 비활성기 (8-3월)의 연속적인 5단계로 구분할 수 있었다. 수온에 따른 생식소 발달의 인위적 제어 실험에서, 바지락은 저수온 (10$^{\circ}C$) 에 의해 억제되었다. 19$^{\circ}C$ 및 22$^{\circ}C$의 고수온에 노출시킨 실험구에서 생식소 발달은 고수온에 의해 촉진되었는데, 자연산 개체군의 것보다 약 1달 빠르게 나타났다. 고수온-먹이섭이 실험구에서, 작은개체 실험구의 생식소 발달 단계가 큰개체구 실험보다 더 빠르게 나타났으며, 저수온 (10$^{\circ}C$)의 것보다 더 빠르게 나타났다 (p=0.01). 암, 수 모든 개체들에서 고수온 (22-28$^{\circ}C$)-절식구 실험구의 생식소 발달관계가 고수온-섭이 실험구의 것들보다 더 빠른 것으로 나타났다. (paired sample t-test, p=0.004). 42일 경과 후 암컷과 수컷의 먹이섭이-고수온 실험구에서, 고수온-작은개체 실험구 조건이 큰개체의 생식소 발달보다 더 민감하게 나타났다. 그러나 저수온-수컷개체 실험구는 암컷 개체들의 실험구보다 반응이 좀 더 민감하게 나타났다. 전반적으로 고수온 실험구의 성적성숙이 저수온구보다 빠르게 나타났으며, 암수 개체 간에 유의한 차이를 보였다 (paired sample t-test, p=0.001). 42일 경과 후 절식 실험구에서, 고수온-수컷 큰개체 실험구의 생식소 발달이 고수온-암컷 큰개체 실험구의 것들보다 빠르게 나타났다. 그러나 작은 개체들의 생식소 발달 단계는 먹이섭이 실험구와 절식 실험구사이에 동일한 양상을 보였다. 산란 성기중 암수 개체들의 경우는 고수온-절식 실험구의 생식소 발달이 암컷과 수컷의 성 및 개체의 크기에 관계없이 고수온-먹이섭이 실험구의 것들보다 더 빠르게 나타났으며, 암수간 유의한 차를 보였다(paired sample t-test, p=0.004).

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설비공학 분야의 최근 연구 동향 : 2013년 학회지 논문에 대한 종합적 고찰 (Recent Progress in Air-Conditioning and Refrigeration Research : A Review of Papers Published in the Korean Journal of Air-Conditioning and Refrigeration Engineering in 2013)

  • 이대영;김사량;김현정;김동선;박준석;임병찬
    • 설비공학논문집
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    • 제26권12호
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    • pp.605-619
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    • 2014
  • This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2013. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. Conclusions are as follows. (1) The research works on the thermal and fluid engineering have been reviewed as groups of fluid machinery, pipes and relative parts including orifices, dampers and ducts, fuel cells and power plants, cooling and air-conditioning, heat and mass transfer, two phase flow, and the flow around buildings and structures. Research issues dealing with home appliances, flows around buildings, nuclear power plant, and manufacturing processes are newly added in thermal and fluid engineering research area. (2) Research works on heat transfer area have been reviewed in the categories of heat transfer characteristics, pool boiling and condensing heat transfer and industrial heat exchangers. Researches on heat transfer characteristics included the results for general analytical model for desiccant wheels, the effects of water absorption on the thermal conductivity of insulation materials, thermal properties of Octadecane/xGnP shape-stabilized phase change materials and $CO_2$ and $CO_2$-Hydrate mixture, effect of ground source heat pump system, the heat flux meter location for the performance test of a refrigerator vacuum insulation panel, a parallel flow evaporator for a heat pump dryer, the condensation risk assessment of vacuum multi-layer glass and triple glass, optimization of a forced convection type PCM refrigeration module, surface temperature sensor using fluorescent nanoporous thin film. In the area of pool boiling and condensing heat transfer, researches on ammonia inside horizontal smooth small tube, R1234yf on various enhanced surfaces, HFC32/HFC152a on a plain surface, spray cooling up to critical heat flux on a low-fin enhanced surface were actively carried out. In the area of industrial heat exchangers, researches on a fin tube type adsorber, the mass-transfer kinetics of a fin-tube-type adsorption bed, fin-and-tube heat exchangers having sine wave fins and oval tubes, louvered fin heat exchanger were performed. (3) In the field of refrigeration, studies are categorized into three groups namely refrigeration cycle, refrigerant and modeling and control. In the category of refrigeration cycle, studies were focused on the enhancement or optimization of experimental or commercial systems including a R410a VRF(Various Refrigerant Flow) heat pump, a R134a 2-stage screw heat pump and a R134a double-heat source automotive air-conditioner system. In the category of refrigerant, studies were carried out for the application of alternative refrigerants or refrigeration technologies including $CO_2$ water heaters, a R1234yf automotive air-conditioner, a R436b water cooler and a thermoelectric refrigerator. In the category of modeling and control, theoretical and experimental studies were carried out to predict the performance of various thermal and control systems including the long-term energy analysis of a geo-thermal heat pump system coupled to cast-in-place energy piles, the dynamic simulation of a water heater-coupled hybrid heat pump and the numerical simulation of an integral optimum regulating controller for a system heat pump. (4) In building mechanical system research fields, twenty one studies were conducted to achieve effective design of the mechanical systems, and also to maximize the energy efficiency of buildings. The topics of the studies included heating and cooling, HVAC system, ventilation, and renewable energies in the buildings. Proposed designs, performance tests using numerical methods and experiments provide useful information and key data which can improve the energy efficiency of the buildings. (5) The field of architectural environment is mostly focused on indoor environment and building energy. The main researches of indoor environment are related to infiltration, ventilation, leak flow and airtightness performance in residential building. The subjects of building energy are worked on energy saving, operation method and optimum operation of building energy systems. The remained studies are related to the special facility such as cleanroom, internet data center and biosafety laboratory. water supply and drain system, defining standard input variables of BIM (Building Information Modeling) for facility management system, estimating capability and providing operation guidelines of subway station as shelter for refuge and evaluation of pollutant emissions from furniture-like products.

Hardware Approach to Fuzzy Inference―ASIC and RISC―

  • Watanabe, Hiroyuki
    • 한국지능시스템학회:학술대회논문집
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    • 한국퍼지및지능시스템학회 1993년도 Fifth International Fuzzy Systems Association World Congress 93
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    • pp.975-976
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    • 1993
  • This talk presents the overview of the author's research and development activities on fuzzy inference hardware. We involved it with two distinct approaches. The first approach is to use application specific integrated circuits (ASIC) technology. The fuzzy inference method is directly implemented in silicon. The second approach, which is in its preliminary stage, is to use more conventional microprocessor architecture. Here, we use a quantitative technique used by designer of reduced instruction set computer (RISC) to modify an architecture of a microprocessor. In the ASIC approach, we implemented the most widely used fuzzy inference mechanism directly on silicon. The mechanism is beaded on a max-min compositional rule of inference, and Mandami's method of fuzzy implication. The two VLSI fuzzy inference chips are designed, fabricated, and fully tested. Both used a full-custom CMOS technology. The second and more claborate chip was designed at the University of North Carolina(U C) in cooperation with MCNC. Both VLSI chips had muliple datapaths for rule digital fuzzy inference chips had multiple datapaths for rule evaluation, and they executed multiple fuzzy if-then rules in parallel. The AT & T chip is the first digital fuzzy inference chip in the world. It ran with a 20 MHz clock cycle and achieved an approximately 80.000 Fuzzy Logical inferences Per Second (FLIPS). It stored and executed 16 fuzzy if-then rules. Since it was designed as a proof of concept prototype chip, it had minimal amount of peripheral logic for system integration. UNC/MCNC chip consists of 688,131 transistors of which 476,160 are used for RAM memory. It ran with a 10 MHz clock cycle. The chip has a 3-staged pipeline and initiates a computation of new inference every 64 cycle. This chip achieved an approximately 160,000 FLIPS. The new architecture have the following important improvements from the AT & T chip: Programmable rule set memory (RAM). On-chip fuzzification operation by a table lookup method. On-chip defuzzification operation by a centroid method. Reconfigurable architecture for processing two rule formats. RAM/datapath redundancy for higher yield It can store and execute 51 if-then rule of the following format: IF A and B and C and D Then Do E, and Then Do F. With this format, the chip takes four inputs and produces two outputs. By software reconfiguration, it can store and execute 102 if-then rules of the following simpler format using the same datapath: IF A and B Then Do E. With this format the chip takes two inputs and produces one outputs. We have built two VME-bus board systems based on this chip for Oak Ridge National Laboratory (ORNL). The board is now installed in a robot at ORNL. Researchers uses this board for experiment in autonomous robot navigation. The Fuzzy Logic system board places the Fuzzy chip into a VMEbus environment. High level C language functions hide the operational details of the board from the applications programme . The programmer treats rule memories and fuzzification function memories as local structures passed as parameters to the C functions. ASIC fuzzy inference hardware is extremely fast, but they are limited in generality. Many aspects of the design are limited or fixed. We have proposed to designing a are limited or fixed. We have proposed to designing a fuzzy information processor as an application specific processor using a quantitative approach. The quantitative approach was developed by RISC designers. In effect, we are interested in evaluating the effectiveness of a specialized RISC processor for fuzzy information processing. As the first step, we measured the possible speed-up of a fuzzy inference program based on if-then rules by an introduction of specialized instructions, i.e., min and max instructions. The minimum and maximum operations are heavily used in fuzzy logic applications as fuzzy intersection and union. We performed measurements using a MIPS R3000 as a base micropro essor. The initial result is encouraging. We can achieve as high as a 2.5 increase in inference speed if the R3000 had min and max instructions. Also, they are useful for speeding up other fuzzy operations such as bounded product and bounded sum. The embedded processor's main task is to control some device or process. It usually runs a single or a embedded processer to create an embedded processor for fuzzy control is very effective. Table I shows the measured speed of the inference by a MIPS R3000 microprocessor, a fictitious MIPS R3000 microprocessor with min and max instructions, and a UNC/MCNC ASIC fuzzy inference chip. The software that used on microprocessors is a simulator of the ASIC chip. The first row is the computation time in seconds of 6000 inferences using 51 rules where each fuzzy set is represented by an array of 64 elements. The second row is the time required to perform a single inference. The last row is the fuzzy logical inferences per second (FLIPS) measured for ach device. There is a large gap in run time between the ASIC and software approaches even if we resort to a specialized fuzzy microprocessor. As for design time and cost, these two approaches represent two extremes. An ASIC approach is extremely expensive. It is, therefore, an important research topic to design a specialized computing architecture for fuzzy applications that falls between these two extremes both in run time and design time/cost. TABLEI INFERENCE TIME BY 51 RULES {{{{Time }}{{MIPS R3000 }}{{ASIC }}{{Regular }}{{With min/mix }}{{6000 inference 1 inference FLIPS }}{{125s 20.8ms 48 }}{{49s 8.2ms 122 }}{{0.0038s 6.4㎲ 156,250 }} }}

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Efficacy and Toxicity of Gemcitabine Plus Docetaxel Combination as a Second Line Therapy for Patients with Advanced Stage Soft Tissue Sarcoma

  • Ali Osman, Kaya;Suleyman, Buyukberber;Metin, Ozkan;Necati, Alkis;Alper, Sevinc;Nuriye Yildirim, Ozdemir;Suleyman, Alici;Onur, Esbah;Veli, Berk;Celalettin, Camci;Arife, Ulas;Ugur, Coskun;Mustafa, Benekli
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권2호
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    • pp.463-467
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    • 2012
  • Purpose: To assess the safety and efficacy of a gemcitabine plus docetaxel regimen as a second line therapy for patients with advanced soft tissue sarcoma (STS) resistant to doxorubicin and ifosfamide-based therapy. Patients and Methods: Medical records of 64 patients with advanced STS who received gemcitabine plus docetaxel regimen as a second line treatment between May 2006 and June 2011 were examined. All patients had been previously treated with doxorubicin plus ifosfamide-based regimen at first line setting. Patients received gemcitabine 900 $mg/m^2$ on days one and eight intravenously over 90 minutes, followed by docetaxel 75 $mg/m^2$ on day eight intravenously over one hour. Cycles were repeated every 3 weeks. Results: The male-to-female ratio was 37/27 and the median age was 44 years (range; 19-67 years). Objective responses were observed in 13 (20.3 %) patients (2 CR, 11 PR) and stable disease in 21 (32.8 %). Total clinical benefit (CR+PR+SD) was observed in 34 (53.1 %). Median overall survival (OS) was 18 months (95% confidence interval (CI):12.1-23.9) and Median time to progression (TTP) was 4.8 months (95% CI: 3.6-6). A total of 243 cycles of chemotherapy were administered. The median number of cycle was 3 (range;1-11). The most common grade 3-4 hematologic toxicity was neutropenia (35.9 %). The most common nonhematologic toxicities consisted of nausea/vomiting (37.5 %), mucositis (32.8 %), peripheral neuropathy (29.7%), and fatigue (26 %). There was no toxicity-related death. Conclusion: The combination of gemcitabine plus docetaxel is an active and tolerable regimen as a second line therapy for patients with advanced soft tissue sarcoma who have failed doxorubicin and ifosfamide-based therapy.

보중익기탕가미방의 면역기능 증진 효과 (Immune Function-enhancing Effects of Bojungikkitanggami-bang)

  • 이상훈;이승언;이시형;신조영
    • 동의생리병리학회지
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    • 제18권2호
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    • pp.528-533
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    • 2004
  • The immune system acts to protect the host from infectious agents that exist in the environment and from other noxious insults. The immune system has two functional divisions: the innate and the acquired. Both components involve various factors such as cytokines. A number of methodologies exist to assess aspects of immune function. There are large inter-individual variations in many immune functions even among the healthy. Genetics, age, gender, smoking habits, habitual levels of exercise, alcohol consumption, diet, stage in the female menstrual cycle, stress, history of infections and vaccinations, and early life experiences are likely to be important contributors to the observed variation. While it is clear that individuals with immune responses significantly below 'normal' are more susceptible to infectious agents and exhibit increased infectious morbidity and mortality, it is not clear how the variation in immune function among healthy individuals relates to variation in susceptibility to infection. Oriental medicine is an important factor contributing to immune competence. The author investigated the immune enhancement effects of Bojungikkitanggami-bang (BITB). The forced swimming test (FST) has been used as a screening model for new immune enhancement agents. In the present study, the author investigated the effects of BITB on FST and blood biochemical parameters related to fatigue, glucose (Glc); blood urea nitrogen (BUN); lactate dehydrogenase (LDH); creatinine; and total protein (TP). The author found that BITB (1 g/kg) significantly reduced the immobility time in the FST compared to the control. In addition, the contents of Glc, LDH, BUN, TP in the blood serum were increased in BITB (1g/kg)-fed group. Also, the author investigated the effects of BITB on the production of cytokines in human T-cell line, MOLT-4 cells. BITB (1 mg/ml) significantly increased the interferon (IFN)-vproduction compared with media control (about 2.2-fold for IFN-γ) at 24 h. However, BITB has not affect the production of IL-2 and IL-4. In addition, BITB increased the protein expression level of IFN-γ in MOLT-4 cells. Thus, BITB may have therapeutic value in generating or enhancing immune function in a clinical setting.