• The Monthly Diabetes
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• s.166
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• pp.64-67
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• 2003

인슐린 치료를 필요로 하는 당뇨병 환자에서는 당뇨병성 합병증의 발생을 예방하거나 합병증이 진행된 경우에는 기존의 고식적인 치료로 만족할 만한 효과를 거두기가 어려워 이상적인 치료 방법에 대한 기대가 높은 상태이다. 특히 췌도이식 대상자는 급증하고 있으나 공급 가능한 췌장은 한정되어 있어 이식에 필요한 췌도는 절대적인 부족 상태로 오직 일부 제 1형 당뇨병 환자에서만 제한적으로 췌도이식이 적용 가능하다. 따라서 충분한 췌도 이식원을 확보할 수 있는 췌도 이식원의 개발은 췌도이식의 가장 큰 목표라 할 수 있다. 본 난에서는 당뇨병 치료에서 시험관내 및 생체실험에서 줄기세포의 현황과 줄기세포를 이용하여 당뇨병을 극복하고자 하는 연구의 성과와 이에 따른 새로운 치료법에 대한 최근 내용을 고찰해 보고자 한다.

• Journal of Periodontal and Implant Science
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• v.35 no.3
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• pp.661-674
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• 2005

The purpose of this study was to quantify and compare the level of MMP-2, MMP-8 in the healthy, inflammed gingival tissue and inflammed gingival tissue associated with type 2 DM. We investigate whether expression of MMP-2, MMP-8 is increased by chronic periodontitis associated with type 2 DM. Gingival tissue samples were obtained during periodontal surgery or tooth extraction. Based on patient's systemic condition & clinical criteria of gingiva, each gingival samples were divided into three groups. Group l(n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from 8 systemically healthy patients. Group 2(n=8) is inflammed gingiva from patients with chronic periodontitis. Group 3(n=8) is inflammed gingiva from type 2 diabetic patients with chronic periodontitis. Tissue samples were prepared and analyzed by Western blotting. The quantification of MMP-2, MMP-8 was performed using a densitometer and statistically analyzed by ANOVA. MMP-2, MMP-8 was expressed in all samples including healthy gingiva and increased in group 3 compared to group 1 and 2, and showed that significant variation was observed between group 1 & 3 in MMP-8 results. In conclusion, this study demonstrated that human gingival tissue with chronic periodontitis associated to type 2 diabetes showed slightly elevated MMP-2, MMP-8 levels compared to healthy gingiva and non-diabetic inflamed gingiva.

• Journal of agricultural medicine and community health
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• v.47 no.2
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• pp.67-77
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• 2022

Objective: This study was to evaluate the effectiveness of an individually tailored program based on self-measurement of blood glucose on health behavior and HbA1c in diabetes and pre-diabetes patients. Methods: The program consisted of seven sessions for 12 weeks which were carried out every two weeks. Almost all sessions were progressed on untact method except for the first and last session. The 71 subjects were assessed for their knowledge of diabetes, health behavior, the experience of self-measurement of blood glucose, body mass Index (BMI) and hemoglobin A1c (HbA1c) at before and after the program. They were also evaluated on their degree of utilization of blood glucose measurements after the program. Results: Each mean score on their knowledge of diabetes, health behavior and the experience of self-measurement of blood glucose was significantly increased from 14.77, 25.50, and 2.70 to 15.41, 28.40, and 4.81, respectively. Each mean score on both BMI and HbA1c (n=53) was significantly decreased from 24.47kg/m² and 7.27% to 24.01kg/m² and 6.67%, respectively. The post-HbA1c had a significant negative correlation(r=-0.415) with the degree of utilization of blood glucose measurements. The degree of utilization of blood glucose measurements had a significant positive correlation(r=0.581) with post-health behavior. Conclusions: The program shows effectiveness in improving HbA1c in Type 2 diabetes and pre-diabetes patients. The post-HbA1c might be related to the degree of utilization of blood glucose measurements which might be related to the health behavior.

• Clinical and Experimental Pediatrics
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• v.45 no.5
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• pp.646-653
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• 2002

Purpose : The incidence of type 2 diabetes mellitus in children has been increasing worldwide recently, which is thought to be related to the increasing prevalence of obesity. We investigated to evaluate the incidence and the characteristics of type 2 diabetes mellitus in children and also analysed the relationship between intrauterine growth retardation and type 2 diabetes mellitus. Methods : We investigated 25 children diagnosed as type 2 diabetes mellitus between March 1990 and December 2000. The analysis was performed retrospectively with medical records based on the clinical characteristics and laborotory findings. Results : Incidence of type 1 and type 2 diabetes mellitus in children has been increasing since 1990. We demonstrated an increase in the percentage of type 2 diabetes mellitus children from 5.3% in 1990 to 21.0% in 2000. Sixty eight percent of patients(17/25) were classified as obese group. Initial symptoms at first visit were polyuria, polydipsia and polyphagia 48%(12/25), asymptomatic glycosuria 40% (10/25), weight loss 8%(2/25) and obesity 4%(1/25). The mean age at diagnosis was $12.9{\pm}1.8$ years. 64%(16/25) of patients had positive family history of type 2 diabetes mellitus. Autoanti-bodies were positive in 18.1%(4/22) of patients. Twenty eight percent (7/25) of patients had an associated disease and two patients had fatty liver in association with obesity. Treatment consisted of diet, exercise, education and oral hypoglycemic agents. Three patients were treated with insulin as well as oral hypoglycemic agents because of poor blood glucose control. Long-term diabetic complications occurred in 4 patients. Intrauterine growth retardtion was found in 34.6%(9/25); 88.9% (8/9) of these patients were non-obese group. Conclusion : The increase in the incidence of type 2 diabetes mellitus in children is thought to be related to the increasing prevalence of obesity. The non-obese group of patients might be associated with intrauterine growth retardation.

• Journal of Nutrition and Health
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• v.47 no.5
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• pp.313-320
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• 2014

Purpose: In this study, we investigated the effects of jaceosidin on blood glucose regulation in type 1 diabetic mice. Methods: C57BL/6 mice were divided into four groups; normal control (Normal), diabetes control (D-Control), diabetes low-jaceosidin (D-0.005%), and diabetes high-jaceosidin (D-0.02%). Type 1 diabetes was induced by streptozotocin and mice were then fed a diet containing jaceosidin for eight weeks. Fasting blood glucose, oral glucose tolerance test, insulin tolerance test, lipid peroxidation, and antioxidant enzyme activities were assessed. Results: Jaceosidin supplementation for eight weeks had no effect on body weight, organ weight, and blood lipid profiles. However, jaceosidin supplementation significantly lowered fasting blood glucose level and reduced insulin resistance. We also found that jaceosidin supplementation increased antioxidant capacity by enhancement of catalase and GSH-px activities. Conclusion: These results suggest that jaceosidin could be a therapeutic candidate to ameliorate hyperglycemia through increase of antioxidant enzyme activity.

• Journal of Korean Public Health Nursing
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• v.31 no.1
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• pp.71-83
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• 2017

Purpose: It is thought to be crucial to guide diabetic children and adolescents through their adolescent period psychologically and emotionally. Therefore, we investigated what positive roles a type 1 diabetic camp program would play on subjects in terms of depression, anxiety, self-esteem and self-efficacy. Methods: This study evaluated 38 diabetic children and adolescents with type 1 diabetes who attended summer camp. Subjects were analyzed using a one-group pretest-posttest quasi-experimental research design. Results: There was a significant decrease in depression (t=3.55, p=.001) and anxiety (t=3.09, p=.004) after attending camp, as well as a significant improvement in self-efficacy (t=-3.64, p=.001). However, there was no significant change in self-esteem (t=0.14, p=.891). Conclusion: The results of this study indicate that type 1 diabetic camps are an effective intervention program to promote psychological and emotional stability among diabetic children; therefore, it is recommended that various diabetes programs related to camps be developed.

• Journal of Convergence for Information Technology
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• v.8 no.6
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• pp.75-84
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• 2018

Objects: This study is a descriptive study to identify the factors influencing the glycated hemoglobin control in type 2 diabetes patients. Methods: This study used raw data from the third year of the National Health and Nutrition Examination Survey performed from 2015. The subjects were 285 people who were classified as type 2 diabetes patients among the 7,380 participants of the National Health and Nutrition Examination Survey. Findings: The factors influencing the glycated hemoglobin control in type 2 diabetes patients were found to be age, education level, prevalence period and sleeping time. Improvements: In type 2 diabetes patients, it is very important to have appropriate education on diabetes when they discovered the disease morbidity in the middle age rather than in the aged period and to have enough sleeping time. A practical program to help this education and training should be developed.

• The Monthly Diabetes
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• s.217
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• pp.21-23
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• 2007

당뇨병환자에서 혈당조절의 중요성은 '앙꼬 없는 찐빵' 또는 '김 없는 김밥'과의 관계와 같다. 당뇨병이 우리가 먹은 음식이 우리 몸에서 잘 활용되지 못하고, 소변으로 당이 넘쳐흘러서 나오는 현상을 보고 붙여진 이름인 것을 생각하면 둘 간의 관계는 땔래야 땔 수 없는 관계라 할 수 있습니다. 우리가 무서워하는 당뇨병의 합병증은 혈당조절을 잘 하게 되면 많은 부분 예방이 가능하다는 것을 알 수 있습니다. 제 1형 당뇨병의 대표적 연구인 DCCT 연구 결과를 보면 당화혈색소를 8.0%에서 7.2%로 낮추면 망막증의 진행을 40$\sim$50%를 줄일 수 있었습니다. 제 2형 당뇨병의 대표적 연구인 UKPDS연구는 당화혈색소 1%를 줄이면 미세혈관합병증은 37%, 심근경색은 14% 감소된다는 것을 확인해 주었습니다. 그 이외에도 많은 연구들에서 결과의 차이는 있지만 적극적이고 엄격한 혈당조절은 합병증의 발생을 예방하며, 발생된 합병증의 진행 속도를 늦출 수 있는 가장 효과적인 방법으로 증명하고 있습니다. 그런데 여러분들께서는 위에 언급한 '당화혈색소'를 알고 계십니까? 공복 혈당조절 목표를 알고 계십니까? 식후 혈당조절 목표를 알고 계십니까? 혹시 모르고 계시다면 100미터 출발 선상에서 출발 신호가 났지만 어디로 달려갈지 모르고 있는 것과 같습니다. 아무리 잘 달리고 훌륭한 선수라도 뛰어갈 방향을 모르고 있다면 좋은 성적을 낼 수 없는 것과 같습니다. 혈당조절의 중요성을 알고 관리 목표를 알고 현재 나의 수치를 그 목표를 행해 열심히 실행한다면 건강한 삶을 영위할 수 있습니다.

• The Monthly Diabetes
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• s.222
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• pp.13-14
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• 2008

제 2형 당뇨병환자에서 식이요법 및 운동요법으로 목표 혈당에 도달하지 못하면 경구혈당강하제를 사용해야한다. 목표 혈당은 물론 개인마다 차이는 있을 수 있지만, 일반적으로 식전혈당 90$\sim$130mg/dl, 식후 2시간 혈당 180mg/dl 미만, 당화혈색소 7% 미만이다. 제 2형 당뇨병의 원인은 인슐린 분비결함과 인슐린 저항성으로 알려져 있으며, 이 중 췌장에서의 인슐린 분비를 촉진시켜 혈당을 조절하는 약물로 설폰요소제와 메글리티나이드 약물이 있다. 최근에 개발되어 국내에서 사용되기 시작한 약물로 글루카곤유사펩티드-1 작용제가 있는데, 이는 인슐린 분비를 촉진시켜 식후 혈당을 조절하는데 도움이 된다.

• Journal of Life Science
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• v.18 no.6
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• pp.852-857
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• 2008

The effects of Bulnesia sarmienti water extract on lipid metabolism were investigated in type-1 diabetes rats. The rats were fed a basal diet and B. sarmienti water extract for 8 weeks. The rats were randomly assigned to each treatment group: normal, control, three kinds of treatment group (BWO: 0.45 mg/ml, BW1: 0.9 mg/ml, BW2: 1.8 mg/ml). After 8 weeks of experimental diets consumption, the body weights and food efficiency ratio of B. sarmienti water extract fed groups were not change with those in the control group. The concentration in plasma total-cholesterol, LDL-cholesterol, triglyceride were significantly decrease in the B. sarmienti water extract groups compared with those in the control group. Although it was not possible to observe blood glucose control effects of eight weeks of B. sarmienti water extract feeds in type-1 diabetes model, it was discovered that the feeds are highly effective in lowering the levels of blood lipid substances triglycerides, total-cholesterol, and LDL-cholesterol.