• Title/Summary/Keyword: -S9 Mix

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Genotoxicity Test of Bojungikkeehapdaechilki-tang water extract (보중익기합대칠기탕(補中益氣合大七氣湯) 추출물의 유전독성 평가)

  • Hwang, Hui-Jeung;Byun, Joon-Seok;Heo, Jin-Il
    • Herbal Formula Science
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    • v.14 no.1
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    • pp.141-167
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    • 2006
  • The genotoxicity of water extract of Bojungikkeehapdaechilki-tang was tested by In Vitro Chromosome Aberration Test. Bacterial Reverse Mutation Assay and Micronucleus test according to OECD Guidelines and KFDA Guidelines. The obtained results were as follows : 1. Chromosome Aberration Test: In Vitro Chromosome Aberration Test of Bojungikkeehapdaechilki-tang extracts was carried out using cultured Chinese hamster lung cells in the presence and absence of metabolic activation system(S-9 mix). No significant changes in the number of aberrant metaphases having structural and number of aberrations were detected in Bojungikkeehapdaechilki-tang extracts treated groups. 2. Bacterial Reveres Mutation Assay: Bojungikkeehapdaechilki-tang extracts was evaluated for its potential to induce reverse mutation in the histidine auxotroph strains of Salmonella typhimurium such as TA100, TA1535, TA98 and TAl537 and the tryptophan auxotroph strain of Escherichia coli WP2 uvrA. No significant changes in the number of revertant colonies compared to its negative control were detected in Bojungikkeehapdaechilki-tang extracts treated groups against all 5 strains. 3. Micronucleus test: Micronucleus test of Bojungikkeehapdaechilki-tang extracts were performed using specific pathogen free 7-week old male ICR mouse. No significant changes in the number of micronucleated polychromatic erythrocytes among 2000 polychromatic erythrocytes compared to negative control were detected in all Bojungikkeehapdaechilki-tang extracts treated groups. In summarized above-mentioned results, it is concluded that Bojungikkeehapdaechilki-tang extracts have not genotoxicity against In Vitro Chromosome Aberration Test, Bacterial Reverse Mutation Assay and Micronucleus test.

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Survivable Traffic Grooming in WDM Ring Networks

  • Sankaranarayanan, Srivatsan;Subramaniam, Suresh;Choi, Hong-Sik;Choi, Hyeong-Ah
    • Journal of Communications and Networks
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    • v.9 no.1
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    • pp.93-104
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    • 2007
  • Traffic grooming, in which low-rate circuits are multiplexed onto wavelengths, with the goal of minimizing the number of add-drop multiplexers (ADMs) and wavelengths has received much research attention from the optical networking community in recent years. While previous work has considered various traffic models and network architectures, protection requirements of the circuits have not been considered. In this paper, we consider survivable traffic grooming, or grooming traffic which contains a mix of circuits that need protection and that do not need protection. We assume a unidirectional ring network with all-to-all symmetric traffic with $t\geq1$ circuits between each node pair, of which s require protection. As it turns out, survivable traffic grooming presents a significant tradeoff between the number of wavelengths and the number of ADMs, which is almost non-existent in non-survivable traffic grooming for this type of traffic. We explore this tradeoff for some specific cases in this paper. We also present some new results and solution methods for solving certain non-survivable traffic grooming problems.

Antimutagenic Effect of Plant Flavonoids in the Salmonella Assay System

  • Choi, Jae-Sue;Park, Kun-Young;Moon, Suk-Hee;Rhee, Sook-Hee;Young, Han-Suk
    • Archives of Pharmacal Research
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    • v.17 no.2
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    • pp.71-75
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    • 1994
  • The antimutagenic effects of 27 kinds of plant flavonoids on the mutagenicity of aflatoxin $B_1(AFB_1)$ and N-methyl-N'-nitro-N-nitrosoguanidine(MANG) in Salmonella typhimurium TA 100 were investigated. In the mixed applications of $AFB_1\;(1\;\mu{g/plate)}$ with the flavonoids $(300\;\mu{g/plate)}$ in the presence of a mammalian metabolic activation system (S9 mix), chrysin, apigenin, luteolin and its glucoside, kaempferol, fisetin, morin, naringenin, hesperetin, persicogenin, (+)-catechin and (-)epicatechin showed the antimutagenic effect against $AFB_1$ with more than 70% inhibition rate. A little or no antimutagenicities except flavone against MNNG $(0.5\;\mu{g/plate)}$ were observed. For the antimutagencity of the flavonoids on $AFB_1$, the flavonoid structure that contains the free 5, 7-hydroxyl gorup seemed to be essential. However, saturation of the 2, 3-double bond of elimination of the 4-keto group did not affect the activity.

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Prediction of compressive strength of concrete modified with fly ash: Applications of neuro-swarm and neuro-imperialism models

  • Mohammed, Ahmed;Kurda, Rawaz;Armaghani, Danial Jahed;Hasanipanah, Mahdi
    • Computers and Concrete
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    • v.27 no.5
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    • pp.489-512
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    • 2021
  • In this study, two powerful techniques, namely particle swarm optimization (PSO) and imperialist competitive algorithm (ICA) were selected and combined with a pre-developed ANN model aiming at improving its performance prediction of the compressive strength of concrete modified with fly ash. To achieve this study's aims, a comprehensive database with 379 data samples was collected from the available literature. The output of the database is the compressive strength (CS) of concrete samples, which are influenced by 9 parameters as model inputs, namely those related to mix composition. The modeling steps related to ICA-ANN (or neuro-imperialism) and PSO-ANN (or neuro-swarm) were conducted through the use of several parametric studies to design the most influential parameters on these hybrid models. A comparison of the CS values predicted by hybrid intelligence techniques with the experimental CS values confirmed that the neuro-swarm model could provide a higher degree of accuracy than another proposed hybrid model (i.e., neuro-imperialism). The train and test correlation coefficient values of (0.9042 and 0.9137) and (0.8383 and 0.8777) for neuro-swarm and neuro-imperialism models, respectively revealed that although both techniques are capable enough in prediction tasks, the developed neuro-swarm model can be considered as a better alternative technique in mapping the concrete strength behavior.

Characteristics of Allergic Patients in Soonchunhyang University Cheonan Hospital (순천향대학교 천안병원에 내원한 알레르기 환자의 특성)

  • Park, Jae-Suk;Lee, Tae-Young;Choi, Seoung-Hey;Kim, Hwi-Jun;Choi, Young-Jin
    • Korean Journal of Clinical Laboratory Science
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    • v.39 no.2
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    • pp.104-112
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    • 2007
  • The purpose of this study was to evaluate the general features of allergic patients in northwestern Chungcheongnamdo who visited Soonchunhyang University Cheonan Hospital. The subjects in this study were 1692 suspected allergic patients. After their allergic symptoms were checked and a MAST-CLA test was conducted, the following results were obtained: 1. The mean age of the subjects was 23.1 years old. The male patients represented 56.2% and the female patients accounted for 43.8%. 1387 (82.0%) patients of those investigated suffered from allergic disease. 2. Among the 1387 patients, 1022 (73.7%) patients showed an increased total IgE level. The positive rate of those who were in their 40s (87.0%) was the highest, but their age made no difference to their positive rate of total IgE. 3. Concerning the positive rate for allergen specific antibody by age, those who were in their teens (73.5%) topped the list and similar in all age group except in their 40s. By gender, the positive rate of the male and female were 56.3% and 43.9% respectively. Regarding the positive rates by allergic disease, those who suffered from allergic rhinitis (60.4%) were most vulnerable, followed by the patients with allergic dermatitis (47.4%), with bronchial asthma (47.2%) and with urticaria (39.4%). 4. As for seasonal positive rates, they were most susceptible in April (77.2%) and May (71.1%). We discovered a significant difference according to seasons; Spring (60.1%), Winter (45.4%) and Summer (39.2%). 5. In case of Korean inhalent panel, the most dominant allergen-specific antibodies were "Cockroach mix" (31.1%), followed by "D. pteronyssius" (23.8%) and "Dog" (14.3%). In the event of food panel, the most popular allergen-specific antibodies were "D. farinae" (25.0%), followed by "D. pteronyssinus" (19.8%) and "Hose dust" (12.0%). 6. The residential type made no difference to the positive rates of "House dust", "Cockroach mix" and "Dog" as major antigen but compared with others, positive rates for "Tick" were somewhat higher in apartment buildings.

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Yield Response of Chinese Cabbage to Compost, Gypsum, and Phosphate Treatments under the Saline-sodic Soil Conditions of Reclaimed Tidal Land (퇴비, 석고, 인산으로 개량한 염류-나트륨성 간척지 토양에서 배추의 생육)

  • Lee, Jeong-Eun;Seo, Dong-Hyuk;Ro, Hee-Myong;Yun, Seok-In
    • Horticultural Science & Technology
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    • v.34 no.4
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    • pp.587-595
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    • 2016
  • Salt stress in crops in reclaimed tidal lands can be reduced by applying soil amendments. To evaluate the effects of compost, gypsum, and phosphate on the growth of Chinese cabbage in saline-sodic soil conditions, we conducted a pot experiment in 2013 and 2014. The treatments consisted of a standard fertilizer application of a mix of compost and N-P-K fertilizer (S) and standard fertilizer applications with additional compost (S + C), gypsum (S + G), phosphate (S+P), and gypsum and phosphate (S + GP). The mean dry matter yield of cabbage in 2014 was three times as great as that in 2013, although soil EC (Electrical conductivity) in 2014 was not decreased. However, the mean ratio of sodium ion in soil solution ($SAR_{1:5}$) significantly decreased from $17.3{\pm}1.1$ in 2013 to $11.2{\pm}2.7$ in 2014. Application of gypsum had the greatest positive impact on the growth of Chinese cabbage. The S + G treatment increased dry matter yield by 7.0 (48.2) and 7.9 g/plant (16.6%) in 2013 and 2014, respectively, compared to the S treatment. Applying gypsum increased soil EC, but decreased $SAR_{1:5}$ by 14 and 38% in 2013 and 2014, respectively. The application of compost and phosphate had a small effect on the growth of Chinese cabbage. These results suggest that applying gypsum in reclaimed tidal lands can reduce the sodicity of the soil and improve crop growth.

Evaluation of Antimicrobial Activity and Mutagenicity of Ozonized Olive Oil (오존화 올리브유의 항균성 및 변이원성 평가)

  • Jang, Il-Woong;Lee, Seung-Jae;Ahn, Jeung-Youb;Miura, Toshiaki;Jung, Mun-Yhung;Choi, Dong-Seong
    • Korean Journal of Food Science and Technology
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    • v.38 no.6
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    • pp.805-809
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    • 2006
  • Ozonized olive oil was tested for its mutagenic potential in a Salmonella/microsome assay. Additionally, antimicrobial activity was tested against Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa, pathogenic strains related to acne, using the paper disk and agar dilution method. Ozonized olive oil showed antimicrobial activities against all the strains tested, with minimal inhibitory concentrations (MICs) values in a range of 2${\sim}$10 mg/mL. Mutagenicity of ozonized olive oil was evaluated with Salmonells typhimurium TA98, TA100 and Ta1535, with and without addition of S9 mixture. No increase in the number of $his^{+}$ revertants over the negative control (solvent and non-ozonized olive oil) values was observed with TA98 (1,000 ${\mu}g/plate$), TA100 (1,500 ${\mu}g/plate$) and TA1535 (1,500 ${\mu}g/plate$) strains. The results from this study suggested that ozonized olive oil does not show any mutagenic potential.

Desmutagenic Action of Sugar Degradation Products (당(糖) 분해생성물의 돌연변이원성 억제작용)

  • Kim, Seon-Bong;Kim, In-Soo;Yeum, Dong-Min;Park, Yeung-Ho
    • Korean Journal of Food Science and Technology
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    • v.20 no.1
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    • pp.119-124
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    • 1988
  • The desmutagenic effects of ${\alpha}$-hydroxycarbonyl compounds, such as glyceraldehyde, glycolaldehyde, dihydroxyacetone, furfural, 5-hydroxymethylfurfural, maltol, acetol and acetoin and ${\alpha}$-dicarbonyls, such as diacetyl, glyoxal, methyl glyoxal and 2, 3-pentanedione were investigated against the mutagenic heterocyclic amines, such as Trp-P-1, Trp-P-2, Glu-P-1, Glu-P-2 and IQ. Most of the carbonyl compounds suppressed the mutagenicity of heterocyclic amines for S. typhimurium TA98, ${\alpha}$-dicarbonyl compounds showing a higher desmutagenic effect than ${\alpha}$-hydroxycarbonyl compounds. Among the ${\alpha}$-hydroxycarbonyl compounds, glyceraldehyde, glycolaldehyde and dihy-droxyacetone showed more effective desmutagenicity, and diacetyl among the ${\alpha}$-dicabonyl compounds had the highest desmutagenic effect. These carbonyl compounds alone also showed mutagenicity to S. typhimurium TA100 without S-9 mix. The reaction of carbonyl compounds with mutagenic heterocyclic amines also eliminated the mutagenicity of the former for S. typhimurium TA100.

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An Analysis of A Circularly Polarized Conformal Microstrip Parch Antenna Using The Unsplit Anisotropic Perfectly Matched Layer(UAPML) (비분리형 비등방성 완전 정합층(UAPML)을 이용한 원형편파 등각 마이크로스트립 패치 안테나의 해석)

  • 박동희;김정기
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.9 no.6
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    • pp.813-823
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    • 1998
  • This paper analyzed the circularly polarized conformal microstrip patch antennal using the unsplit anisotropic perfectly matched layer(UAPML) method. Also, this paper are treated effectively the edge and corner parts on the 3 dimensional UAPML. Especially, to analyze microstrip patch antennas with the coaxial feeder line, it was applied to mixed the UAPML with Mur's first order absorbing boundary condition. Therefore this paper suggest the new the method to mix the UAPML with Mur's first order absorbing boundary condition. The results show the time responses of electromagnetics $E_z$ and $H\chi'$, input impedances of coaxial cable and radiation patterns of strip parchs on the single and the array patchs with central frequencies 1.575 GHz, 1.778 GHz and 4.8 GHz in L-band and C-band for mobile communication. The results of this paper shows that its results was compared the Mur's first order abc and mixed the second order dispersion boundary condition(SDBC) with the Mur's first order absorbing boundary condition. In accordance with, the validity of the method is confirmed.

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District 9 : Science Fiction as Social Critique (<디스트릭트 9> 사회비평으로서의 공상과학)

  • Cho, Peggy C.
    • Cross-Cultural Studies
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    • v.42
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    • pp.505-524
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    • 2016
  • This study examines the ways District 9, a film released in 2009, reworks the sci-fi genre to explore the human encounter with "other" alien populations. Like Avatar, released in the same year, District 9 addresses the tropes of conflict over land and human-alien hybridity and introduces non-humans and aliens, not as invaders, but as objects of human oppression and cruelty. Unlike many other science fiction films where the encounter between humans and non-humans occurs in an unidentifiable future time and location, District 9 crosses genre barriers to engage with urban realism, producing a social critique of contemporary urban population problems. The arrival of aliens in District 9 occurs as part of the recorded human past and the film's action is carried out in the present time in the specifically identified city of Johannesburg. A distinctly anti-Hollywood film that locates the action at the street level, District 9 plays out human anxieties about contact with others by referencing the divisions and conflicts historically attached to South Africa's sprawling metropolis and its current problems of urban poverty and illegal immigrants. Focusing on how this particular urban setting frames the film, the study investigates the ways Blomkamp's sci-fi film about extra-terrestrials presents a curious postcolonial mix of aliens and immigrants surviving in abject conditions in an urban slum and forces a realistic examination of the contemporary social problems faced by South Africa's largest city and by extension other major global cities. The paper also examines the film's representation of the human-alien hybrid and its potential as a force to resist human exploitation of the other. It also claims that though the setting is highly local, District 9 speaks to a wider global audience by making obvious the exploitative practices of profit-seeking multinationals. A sci-fi film that is keen on making a social commentary on urban population conflicts, District 9 resonates with the wider sense of insecurity and fear of others that form the horizon of the uncertain and potentially violent contemporary human world.