• Journal of the Korean Society of Food Science and Nutrition
• /
• v.24 no.1
• /
• pp.19-23
• /
• 1995

The purpose of this project was to investigate alcohol consumption, cigarette smoking and family disease history in the family members of normal and hypertension disease, excluding patients themselves. Mean daily alcohol consumption in family members of hypertension disease patients was significantly higher, especially in the male with thirties, forties, and fifties, than those of normal subjects. Mean daily cigarette smoking in family members of hypertension disease patients was also significantly higher, especially in the male with forties and sixties than those of normal subjects. Cases of hereditary family disease was significantly higher in the family members of hypertension disease patients than those of normal subjects. Especially, a degree to be attacked with cerebrovascular disease was very higher in the family members of hypertension disease patients than normal family.

• Tuberculosis and Respiratory Diseases
• /
• v.53 no.5
• /
• pp.550-560
• /
• 2002

Background : Lung cancer is the leading cause of cancer-related mortality in both men and women. Although most cases of lung cancer occur in the sixty to eight decades of life, 5 to 10% are diagnosed at a young age. There are characteristic features in young patients with lung cancer that differ from those in older patients with lung cancer. The purpose of this study was to determine if the basal characteristics and survival in young patients with lung cancer differed from those of old patients. Methods : We retrospectively reviewed the medical records of 94 young patients who were under 45 years of age and compared them with 1,728 old patients (= 46 years of age) in 4 medical schools at Daegu, between August 1986 and July 1995. Results : Significantly more female patients and adenocarcinomas were found in the young patients group. when compared to the old patients. Cough and sputum were the most frequent presenting symptom in both age groups. This was followed by chest discomfort, dyspnea and hemoptysis. The rates of smoking was significantly lower in the young patients. There was no statistical difference in the severity of the disease in terms of staging between the two age groups. Young patients received treatment more frequently than the older patients. The location of the primary tumors was equally frequent in both the upper and lower lobe. However, the survival was bettrer in the young patients(median survival time, 67.3 weeks), when compared to the old patients (median survival time, 26.8 weeks) (p<0.05). Conclusion : Females and adenocarcinoma patients were predominant in young patients with lung cancer. The young patients appeared to have significantly better prognosis.

• Tuberculosis and Respiratory Diseases
• /
• v.40 no.5
• /
• pp.540-547
• /
• 1993

Backgrounds: The measurement of volume of isoflow has been considered as a sensitive test for detecting small airway diseases showing normal pulmonary function in a routine pulmonary function test. To evaluate the functions of small airway among dust exposed workers, the changes of volume of isoflow were measured and its applicability of managing early stage pneumoconiosis patients was studied. Method: The subjects were 67 male, pneumoconiosis with small opacity and FEV1>80%, FEV1/FVC>75% in spirometry and the controls were 20 male, no dust-exposed office workers. The maximal epiratory volume curves after inhalation of indoor air and $He-O_2$ gas mixtures were measured and ${\Delta}V_{max50},\;{\Delta}V_{max75},\;V_{iso}V/VC$ between the dust exposed and control workers were compaired. Results: 1) There were no significant differences between two group in ${\Delta}V_{max50}$ and ${\Delta}V_{max75}$. But the ratio of $V_{iso}V/VC$ of the subjects was siginificantly higher than that of the control (p<0.01). This study confirms that $V_{iso}V/VC$ is a very useful index in early detection of small airway dysfunction. 2) The ratio of $V_{iso}V/VC$ of the subjects was signigicantly different between only smoker group and mixed group(smoker and nonsmoker). It suggestes that smoking is an important cousative factor of small airway dysfunction. 3) As the profusion of the chest X-ray increased, the rartio of $V_{iso}V/VC$ increased, but no significant difference of $V_{iso}V/VC$ was found between categories of pneumoconiosis. The categories of pneumoconiosis and small airway dysfunction may not be related. 4) No significant relationship was established between the duration of work and the ratio of $V_{iso}V/VC$. Conclusions : It is concluded that the measurement of $V_{iso}V/VC$ is useful to detect small airway dysfuction of early stage pnuemoconiosis patents with small opacities but showing normal pulmonary function in a routine pulmonary function test.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.38 no.7
• /
• pp.852-861
• /
• 2009

This study was performed to assess the risk factors associated with hypertension from Jan/2003 to Feb/2003. The subjects were 1,296 people (496 males, 800 females) aged 40 years and over living in Andong rural area. The hypertensive group was composed of 602 people (272 males, 330 females), who were diagnosed as hypertension ($SBP{\geq}140\;mmHg$ or $DBP{\geq}90\;mmHg$) for the first time at this health examination. The mean anthropometric values of body weight, body fat (%), body mass index (BMI) and waist circumference were significantly higher in hypertensive group than those in normal group. However, the biochemical measurements such as total-cholesterol (TC), triglyceride (TG), HDL-C, LDL-C and fasting blood glucose (FBG) levels did not show any difference between two groups except TG in female. The risk factors of interest in the development of hypertension were analyzed using the multiple logistic regression and expressed as odds ratio (OR) and 95% confidential interval (CI). The results showed that age, sex, obesity, waist circumference, alcohol drinking and meat intakes were risk factors for hypertension. In contrast, cigarette smoking, exercise and the increased fish, fruit and vegetable (except Kimchi) consumption, blood lipid levels and FBG were not linked with the development of hypertension. Nutrient intakes were not associated with hypertension, either. In conclusion, we cannot assert that this study established the existence of the cause-and-effect relationship between nutrient intakes and risk of hypertension in the subjects, but it does suggest that this is a question worth investigating further using a larger scale of case-control study to determine how the past exposure to some nutrient or dietary component relates to the development of the disease.

• Tuberculosis and Respiratory Diseases
• /
• v.48 no.1
• /
• pp.24-32
• /
• 2000

Purpose: Microsatellite instability(MSI) is frequently used as an indicator of microsatellite mutator phenotype(MMP) tumors. MSI has been observed in a percentage of non-small cell lung cancer(NSCLC). However, its role in tumorigenesis of NSCLC remains unknown. The frequency and pattern of MSI in NSCLC were evaluated and clinical parameters of MSI-positive tumors with those of MSS(microsatellite stable) tumors were compared. Materials and Methods: Twenty surgically resected NSCLCs were analyzed for 15 microsatellite markers located at chromosomes 3p and 9p. The peripheral blood lymphocytes of patients were used as the source of the normal DNA. Results: 1) Of 20 cases, 8(40%) demonstrated MSI. 2) Instability was observed more frequently in tri- and tetra-nucleotide repeats than in dinucleotide repeats. In all cases, instability appeared as a shift of individual allelic bands. 3) LDH was observed in 10(50%) of 20 tumors analyzed. 4) Of 20 cases, MSI-H tumor(showing MSI in the majority of markers) was absent. There were 5 MSI-L tumors(showing MSI in a greater than 10% of markers). 5) No significant difference was observed between MSI-L tumors and MSI-negative tumors in terms of clinicopathologic features such as pack-year history of smoking, histologic subtype, and(delete) stage of disease. There was also no significant difference in the incidence of LDH in relation to the status of MSI. Conclusion: These data strongly suggest that MSI plays different roles in lung and colon cancer. MMP pathway appears to be far less important in the tumorigenesis of NSCLC, caused mainly by cigarette smoke, with little familial tendency.

• Journal of Digital Convergence
• /
• v.10 no.3
• /
• pp.207-218
• /
• 2012

The purpose of this study is to provide preliminary data for political measures to minimize the variations by understanding the regional variations and trends of hospital services for heart diseases, and analyzing the factors that could occur any variations. The various data collected from nation-wide inpatient services conducted separately by small region show that there have been some differences in income level, supply of medical resources, standardized rate of hospitalization by sex and age, health level in the residence, and the length of stay per head. Then it indicated that the number of special medical equipment per 10,000 people and the rate of vigorous physical activity have the highest influence over the regional variations in using hospital services. On the other hand, the number of sick-beds per 10,000 people, the number of special medical equipment, and the present smoking rate have significant degree of influence on the length of stay per head. Thus, it is imperative for the authorities to set aside health promoting policies and to distribute the medical resources equitably throughout the country and to enhance the accessibility of local residents to the health care services.

• Journal of Chest Surgery
• /
• v.30 no.2
• /
• pp.158-163
• /
• 1997

From July 1994 to August 1995, 32 patients underwent coronary artery bypass surgery. There were 14 men and 18 women. The mean age was 59 years (range from 37 to 81 years). Preoperatively 26 patients had unstable angina pectoris and 6 patients had stable angina pectoris. Nine patients had previous myocardial infarction hi tory. Five patients had preoperative left ventricular ejection fraction of 40% or less, The involved risk factors were as follows ; smoking 19 cases, hypertension 16 cases, hypercholesterolemia 14 cases, diabetes mellitus 6 cases, and obesity 3 cases.21 patients had three-vessel disease, 7 patients had two-vessel disease, 2 patients had one-vessel disease and 2 patients had left main coronary artery disease. We performed 103 distal bypasses out of 32 cases, and the mean number of grafts per patients is 3.22. We used arterial grafts (left internal mammary artery,)1, radial artery; 2) in 32% of total grafts. Postoperative complications were low cardiac output, perioperative myocardial infarction, respiratory failure and atrial fibrillation, etc. Early mortality was 6.25% (2/32). The causes of deaths were low cardiac output (1), and perioperative myocardial infarction(1).

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.7
• /
• pp.645-655
• /
• 2020

This is a descriptive study investigating the relationships between sexual function, depression, and sleep quality in male hemodialysis patients. The participants of this study consisted of 134 outpatients who were diagnosed with end stage chronic kidney disease and who had undergone hemodialysis. The data were collected from June 10, 2019, to October 30, 2019. The collected data were then analyzed using descriptive statistics, the mean from independent sample t-tests, one-way analysis of variance (ANOVA), the Scheffe test, and Pearson's correlation coefficient using SPSS version 21.0. The lower the overall satisfaction, the lower the sexual function and the higher the degree of depression (r=.-19, p=.028). The greater the depression, the lower the quality of sleep (r=.60, p<.001). This study shows it is necessary to develop a program including symptom management to reduce depression in male hemodialysis patients. When developing nursing interventions to improve sexual function and quality of sleep, it will be necessary to develop a program that includes people who help the subjects.

• Proceedings of the KAIS Fall Conference
• /
• 2011.05b
• /
• pp.1057-1060
• /
• 2011

본 연구는 건강신념모형의 주요 변수와 고지혈증 환자의 건강행태와의 관계를 파악하여 고지혈증 환자의 건강행태를 촉진하고 더 나아가 만성질환 보건사업 및 교육프로그램을 계획하는데 기초 자료를 제공하고자 시도되었다. 자료는 2009년 07월부터 2010년 9월까지 총콜레스테롤이 240mg/dl 이상이고, 중성지방이 200mg/dl 이상으로 고지혈증을 진단받은 20세 이상의 성인 남녀 146명을 대상으로 구조화된 설문지를 이용하여 조사하였으며, SPSS WIN(14.0 한글판) 프로그램을 이용하여 Chronbach's alpha의 신뢰성 분석, 요인분석, 단변량 및 다변량 분석을 시행하였다. 본 연구의 결과는 다음과 같다. 첫째, 본 연구에서는 LDL-cholesterol, HDL-cholesterol, TG에 대한 인지수준 중 TG에 대한 인지가 가장 높았고, 3가지 모두를 인지한 경우는 28.08%였다. 또한 9가지 항목에 대한 고지혈증 지식수준은 9점 만점에 평균 6.51이었으며, 지식수준이 높을수록 건강행태수준도 높았다. 둘째, 요인분석을 통하여 10개의 건강행태를 2개 요인으로 재분류 하였다. 그 결과, 건강행태 요인 1은 '식이, 운동 습관 및 고지혈증 검사 및 관련 검사요인', 건강행태 요인 2는 '흡연, 음주 습관 및 고지혈증 치료 관련 요인'이었다. 건강행태 요인1에 유의한 관련성이 있는 건강신념변수는 심각성, 이득, 장애로 나타났고, 취약성은 상관 관계가 없는 것으로 나타났다. 각 신념 요인들과 건강행태 간의 상관되는 순서는 이득(r =.455), 심각성 (r=.38), 장애(r=-.244) 순으로 나타나 고지혈증에 대한 이득 인식이 건강행태 요인1과 가장 관련성이 높은 것으로 파악되었다. 그러나, 건강행태 요인2는 건강신념변수와 관련성이 없는 것으로 나타났다. 셋째, 행동계기에 따른 건강행태의 관계를 살펴보면, 교육을 받았을 때 건강행태 요인1과 요인2에 모두 유의한 차이를 보이는 것으로 나타나, 교육이 고지혈증 환자의 건강행태에 중요한 영향을 미치는 것을 보여 주었다. 넷째, 다중회귀분석 결과 고지혈증 건강행태 요인1에 영향을 미치는 요인 중 유의한 요인으로 인지된 심각성 및 이점 신념요인, 교육여부, 보건소 교육정도 이었다. 건강행태 요인2에서는 성별, 연령, 교육여부가 유의한 영향을 미치는 요인으로 나타났다. 이상의 결과를 종합하면 건강신념모형이 고지혈증 건강행태를 예측하는데 적합한 모형이라고 판단 할 수 있으며, 건강행태 요인 특성에 따라 건강신념변수 중 고지혈증 예방에 대한 이득을 높이 인식할 수 있도록 프로그램과 교육목표를 설정하면 보다 효과적인 교육이 될 것이라 생각된다.

• Journal of agricultural medicine and community health
• /
• v.25 no.2
• /
• pp.293-302
• /
• 2000

The relationship between sodium intake and stomach cancer risk has been studied much in Japan but a great portions still remain controversial. There has been few studies on relationship between sodium intake and stomach cancer in Korea. The goal of this nested case-control study is to investigate the association between sodium intake and stomach cancer risk in a rural county of Korea We estimated sodium intake indirectly by the threshold of salt-water taste of patients. This study was based on both of the data from 'Kangwha Cohort Study' which had been conducted from March 1985 and 'Kangwha Community Cancer Registry' which had been launched on July in 1982 by the College of Medicine, Department of Preventive Medicine. Yonsei University. A total of 145 patients who developed stomach cancer in Kangwha County were initially recruited as the case group. We tried to get two community-controls per stomach cancer case by matching age and gender. Finally we got information from 90 cases and 146 controls about the threshold of the salt taste and preference of salty food and so on. Some 79% of the information about ease group came from proxy respondents and 56% among controls. Risk ratios of developing stomach cancer adjusted for smoking, body mass index and self-stated health level were estimated. No statistically significant association between the threshold of salt taste and stomach cancer risk found in this study. We recommend some further studies utilizing urinary salt excretion, diet record method for better estimating of salt intake with a paticular emphasis on interaction effect between salty and spicy food in hospital-based case-control study designs.