• Proceedings of the Korea Contents Association Conference
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• 2012.05a
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• pp.169.2-169.2
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• 2012

암 관련 유전자를 후성유전학적으로 제어하는 방법에는 miRNA, DNA 메틸화, 그리고 히스톤 단백질의 변형에 의해서 가능하다. 그러나 후성유전학적 방법을 통해서 암 관련 유전자를 제어하기 위해서는 첫째, 한 유전자에 여러 miRNA들에 의해서 조절되기 때문에 선택의 문제가 있으며, 둘째, 암 관련 유전자를 제어하는 DNA 메틸화 패턴이 다양하며, 셋째, 히스톤 단백질의 변형 자체가 다양하며 각 유전자에 대한 히스톤 변형의 특이성이 있다. 따라서 후성유전학 기반 하에서 암 관련 유전자를 제어하기 위해서는 시스템 수준에서의 접근이 바람직하다. 본 연구에서는 암 관련 유전자의 네트워크를 구축하고, 이 네트워크를 기반으로 암 유전자를 제어하는 miRNA에 최우선 순위를 부여하는 방법, 암 유전자의 DNA 메틸화 모티프 패턴을 분석하는 방법, 히스톤 변형과 암 관련유전자의 상관관계를 분석하는 방법을 제시하고자 한다.

• The Journal of the Korea Contents Association
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• v.13 no.8
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• pp.466-473
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• 2013

Gene expression is regulated by a wide range of mechanisms at the DNA sequence level. In addition, gene expression is also regulated by epigenetic mechanisms through DNA methylation, histone modification, and ncRNA. To understand the regulation of gene expression at the epigenetic level, we constructed aging related gene database and analyzed epigenetic properties that are focused on DNA methylation. The DNA methylation of promoter or upstream region of the genes induces to repress the gene expression. We compared and analyzed distribution between whole human genes and aging related genes in the epigenetic properties such as CGI distribution, methylation motif pattern, and TFBS (transcription factor binding site) distribution. In contrast to methylation motif pattern, CGI and TFBS distributions are positively correlated with epigenetic regulation of aging related gene expression. In this study, the epigenetic data about DNA methylation of the aging genes will provide us to understand phenomena of the aging and epigenetic mechanism for regulation of aging related genes.

• Journal of Life Science
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• v.28 no.12
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• pp.1536-1544
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• 2018

Depression is a common, serious, and recurring mental disorder. The pathogenesis of depression involves many factors such as environmental factor, genetic factor and alteration of structure and function in neurobiological systems. Increasing evidence supports that epigenetic alteration may be associated with depression. The epigenetics is explained as the mechanisms by which environmental factor causes changes in chromatin structure and alters gene expression without changing DNA base sequence. DNA methylation and histone modification involving histone acetylation and methylation are the main epigenetic mechanisms. Animal studies have shown that stressful environment such as early life stress can leave persistent epigenetic marks in the genome, which alter gene expression and influence neural and behavioral function through adulthood. A potentially important gene in depression is brain-derived neurotrophic factor (BDNF). BDNF plays a central role in depression and antidepressant action. In studies of the rodent, exposure to stress at prenatal, postnatal, and adult stages alters BDNF expression through histone modification and DNA methylation of the BDNF gene which results in anxiety and depressive-like behavior. This review discusses recent advances in the study of the epigenetic mechanisms that contribute to depression, particularly histone modification and DNA methylation of the BDNF gene, that may help in the development of new targets for depression treatment.

• Journal of Veterinary Clinics
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• v.21 no.4
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• pp.398-401
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• 2004

A ten-year-old, female Yorkshire terrier dog with intermittent vomiting, weight loss, polydipsia and depression was referred to the Veterinary Medical Teaching Hospital of Konkuk University. On the radiological survey, gas and fluid-filled gastric distention was detected. No contrast medium entraneed to the small bowel, in 60 minutes after contrast medium administration. And marked fluid accumulation in gastric body and thickening of the pyloric mucosa were found with ultrasonograph. So gastric obstruction by reason of pyloric stenosis was strongly suspected. At the surgery, hypertrophied mucosa was resected adequately, and Heineke-Mikulicz pyloroplasty was applied. Microscopically the symptom was characterized by gastric mucosa hyperplasia and mild diffuse Iymphoplasmocytic gastritis. So this condition was diagnosed as chronic hypertrophic pyloric gastropathy. Intermittent vomiting and mild depression were shown for 9 days after the operation. After that, the patient was recovered gradually. One month later, the patient had normal appetite and activity without complications.

• Journal of the Korean Orthopaedic Association
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• v.53 no.6
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• pp.530-539
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• 2018

Purpose: We aimed to evaluate the magnetic resonance imaging (MRI) findings of congenital postaxial polydactyly of the foot. Materials and Methods: Three-hundred and forty-seven feet of 288 patients who underwent congenital postaxial polydactyly or polysyndactyly correction were divided into five subtypes according to the radiographic shapes of deformity origins (widened metatarsal head, bifid, fused duplicated, incompletely duplicated, or completely duplicated). MRIs were assessed to determine whether they unrevealed areas were fused or separated. MRI was also used to assess cases with radiographic phalangeal aplasia. Results: Huge variations were noted in MRIs. Fusion or separation at the base or head between original and extra digits were observed, and MRI effectively depicted phalangeal aplastic areas. Conclusion: MRI evaluations of congenital postaxial polydactyly of the foot are useful for determining the anatomical statuses which were not visualized by plain radiography (level of evidence: 3).

• Proceedings of the KSLP Conference
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• 1997.11a
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• pp.258-258
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• 1997

전체 성대 마비 환자의 약 10%에서 발생하는 것으로 알려진 양측 성대 마비는 안정 혹은 경미한 운동시에도 호흡 장애를 초래하는 경우라면 이에 대한 치료가 요구되는 질환이다. 이에 대한 치료 방법으로는 성문 기도를 넓히면서 흡인이 되지 않고 음성장애를 일으키지 않는데 목적을 두고 피열연골 고정술, 피열연골 절제술, CO2, 레저 피열연골 절제술, 성대 측방 고정술, 후성대 절제술, 점막하 성대 절제술, 근-신경식술 등 다양한 방법이 사용되어져 왔다. (중략)

• Horticultural Science & Technology
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• v.32 no.3
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• pp.366-374
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• 2014

The study was conducted to investigate the possibility that epigenetic DNA methylation causes tree phenotypic variation in autotetraploids through evaluating the phenotypic variation and DNA methylation in autotetraploids occurred spontaneously from diploid trifoliate orange. Chromosome analysis confirmed that fourteen trifoliate orange trees of selected by flow cytometry were tetraploids (2n = 4X = 36) without any aneuploids. Chromomycin A3 staining determined that these trees were all autotetraploid with doubled chromosome set. Tree phenotypes, such as tree height and width, branching number, length, and angle, internode length, and leaf characteristics, varied in the autotetraploids. Chlorophyll indices were diverse in the autotetraploids, but photosynthetic rates were not significantly different. In addition, a wide range of variation was observed in stomatal density and guard cell length. Analysis of global cytosine DNA methylation showed that there was a variation of the methylation level in autotetraploids. More than half of 14 autotetraploids had at least 2 times higher methylation level than diploid trifoliate orange. The results indicate that tree phenotypic variation in autotetraploids might be related to global DNA methylation for reducing gene redundancy.

• The Journal of Internal Korean Medicine
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• v.29 no.2
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• pp.522-528
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• 2008

A 64 year-old male patient with acute postrenal failure from obstructive uropathy was treated. His symptoms were difficulty voiding, general weakness, fever, chills and dyspepsia. We diagnosed his symptoms as acute postrenal failure from obstructive uropathy and administered Hwajung-tang(和中湯), Jasin-hwan(滋腎丸) and nelaton catheterization. After 30 days, these clinical symptoms had improved and results of BUN:creatinine also showed improvement, so I report this case, but more clinical case reports are needed.

• Proceedings of the Korean Information Science Society Conference
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• 2012.06b
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• pp.420-422
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• 2012

DNA 메틸화는 후성유전학의 한 유형으로 유전자 발현을 조절하여 질병을 비롯한 다양한 생물학적 프로세스에 영향을 준다고 알려져 있다. 따라서 DNA 메틸화 정도와 인간 질병과의 연관성에 관한 연구는 질병의 원인 및 기전을 밝히고 메틸화 프로세스 조절을 통한 질병 치료 방법 개발을 위한 기반이 될 수 있다. 유전자 발현 조절 및 질병 발생은 많은 인자들의 복합적인 상호작용에 영향을 받으므로, 여러 위치에서의 메틸화 정도들의 고차원 조합을 이용한 질병과의 연관 관계 분석이 필수적이다. 본 연구에서는 진화 연산과 가중치 학습에 기반하여 유방암 발생과 연관되어 있는 메틸화 위치의 고차 상호작용을 탐색할 수 있는 방법을 제안한다.

• Journal of Korean Medicine Rehabilitation
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• v.30 no.1
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• pp.63-78
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• 2020

Objectives To review the epigenetic modifications involved in chronic pain and to improve individualized intervention for the chronic pain. Methods Focused literature review. Results Significant laboratory and clinical data support that epigenetic modifications have a potential role for development of chronic pain. Conclusions Epigenetic approach may identify mechanisms critical to the development of chronic pain after injury, and may provide new pathways and target mechanisms for future treatment and individualized medicine.