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http://dx.doi.org/10.5392/JKCA.2013.13.08.466

Epigenetic Characterization of Aging Related Genes  

Ryu, Jea Woon (충북대학교 생화학과)
Lee, Sang Cheol (충북대학교 생화학과)
Yoo, Jaesoo (충북대학교 정보통신학과)
Kim, Hak Yong (충북대학교 생화학과)
Publication Information
The Journal of the Korea Contents Association / v.13, no.8, 2013 , pp. 466-473 More about this Journal
Abstract
Gene expression is regulated by a wide range of mechanisms at the DNA sequence level. In addition, gene expression is also regulated by epigenetic mechanisms through DNA methylation, histone modification, and ncRNA. To understand the regulation of gene expression at the epigenetic level, we constructed aging related gene database and analyzed epigenetic properties that are focused on DNA methylation. The DNA methylation of promoter or upstream region of the genes induces to repress the gene expression. We compared and analyzed distribution between whole human genes and aging related genes in the epigenetic properties such as CGI distribution, methylation motif pattern, and TFBS (transcription factor binding site) distribution. In contrast to methylation motif pattern, CGI and TFBS distributions are positively correlated with epigenetic regulation of aging related gene expression. In this study, the epigenetic data about DNA methylation of the aging genes will provide us to understand phenomena of the aging and epigenetic mechanism for regulation of aging related genes.
Keywords
Aging; Epigenomics; DNA mehtylation; CpG island; TFBS;
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