• 대한한방소아과학회지
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• 제26권4호
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• pp.51-60
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• 2012

Objectives: The purpose of this study is to evaluate the effect of Hwangryunhaedock-tang on Atopic Dermatitis Methods: This study population was 71 pediatric allergic rhinitis patients who had been treated in ${\bigcirc}{\bigcirc}$ hospital. All the patients were asked to answer the questionnaire consisting of 8 questions about symptoms of atopic dermatitis. Results: 1. The total scores from the same questionnaire about atopic dermatitis symptoms were significantly improved after the treatment compared to the scores before the treatment. 2. The score about papule/induration/edema, effusion/furuncle, and subjective symptoms at night were significantly improved in all groups after the treatment compared to the scores before the treatment. 3. The effect of Hwangryunhaedock-tang increase markedly with advancing age. The effect of Hwangryunhaedocktang increases markedly with advancing age. Conclusions Traditional Korean herbal medication; Hwangryunhaedock-tang is effective in treating pediatric atopic dermatitis.

• 대한한방내과학회지
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• 제22권1호
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• pp.5-11
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• 2001

Object : This study was carried out to examine the effect of Hwangryunhaedoktang on the liver and kidney of rats induced by carbon tetrachloride and ethanol. Methods : The histopathological changes were examined after preadministration of 100 and 200mg/100g Hwangryunhaedoktang. Results : The perivenular ballooning degeneration and infiltration of basophilic inflammatory cells were decreased in the experimental group when compared with the control group. No abnormalities were observed in the kidneys of both groups. But, interstitial nephritis was observed only in the experimental group. Conclusion : This study suggests that Hwangryunhaedoktang may be of benefit to the prevention of hepatotoxicity induced by carbon tetrachloride and ethanol, and it is more effective in high dosages.

• 대한한의학회지
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• 제39권3호
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• pp.81-88
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• 2018

Objectives : This study was performed1 to assess the effectiveness of HwangryunHaedokTang-gamibang on Obesity with atopic dermatitis. Methods : Patients were treated by HwangryunHaedokTang-gamibang. To measure treatment outcomes, BMI, weight, Fat mass, Fat %, VAS scale, SCORAD index were used. Results : After treatment, BMI, weight, Fat mass, Fat% were significantly decreased. Atopic dermatitis VAS and SCORAD index were also decreased at all cases. Conclusions: HwangryunHaedokTang-gamibang may be effective in the treatment of Obesity with atopic dermatitis patients.

• 대한한의학회지
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• 제27권2호
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• pp.182-195
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• 2006

Objectives : We examined the effect of Hwangryunhaedoktang(HH) on the experimental ulcerative colitis induced by dextran sulfate sodium (DSS). Methods : Experimental colitis was induced in rats by daily treatment with 5% DSS in the drinking water for 5 days. Afterward, the mts were divided into two groups: the control group was administered water and the sample group was administered HH for 7 days. Results : The sample group provided HH for 7 days demonstrated fast recovery of body weight compared with the control group. Histologic change showed fast regeneration of crypt and surface epithelial cells and decreased edema of the submucosa and decreased lymphatic follicle of mucosa compared with the control group. Immunohistochemical stain usingCOX-2 gene was decreased and there was localized Ki-67 positive reaction. Regeneration of surface epithelial cell and goblet cell in mucosa was observed by transmission electron microscope. These results indicate therapeutic effect of HH on DSS-induced colitis in rats.

• 대한한의학방제학회지
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• 제21권1호
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• pp.80-90
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• 2013

Objectives : The water extract of Hwangnyeonhaedok-tang (HHT), composed of the Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus has been traditionally used to treat fever, inflammation, gastritis and hypertension in east asia. However, little is known about the ameliorative effects of HHT on atopic dermatitis. Therefore, the purpose of this study was to investigate the therapeutic effect of HHT on atopic dermatitis Methods : We investigated the inhibitory effects of HHT on the production of proinflammatory cytokines in rat peritoneal mast cells (RPMCs), on the scratching behavior in ICR mice, and on atopic dermatitis symptoms in 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis-like model hairless mice. Results : Levels of TNF-${\alpha}$ and IL-$1{\beta}$ increased by PMA plus A23187 co-treatment were significantly inhibited by HHT in a dose-dependent manner. HHT also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. The oral administration of HHT reduced the scratching behavior induced by compound 48/80 and histamine in ICR mice. Furthermore, the intradermal treatment of HHT reduced the ear edema, skin lesions, and atopic molecular marker (IgE and IL-4) in DNFB-induced atopic dermatitis model mice. Conclusions : These results suggest that HHT may be used as a potential treatment for AD as a prescription for treatment of atopic dermatitis.

• 대한한방내과학회지
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• 제40권6호
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• pp.1288-1293
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• 2019

Objective: This study reports the effects of Huanglianjiedu-tang (黃連解毒湯) granules as a treatment for transient hypertension. Methods: Four patients experienced sudden blood pressure elevation without a history of hypertension treatment. There was no specific history of disease, as confirmed by laboratory examination and image diagnosis. The patients were treated with Huanglianjiedu-tang (黃連解毒湯) granules and their blood pressure analyzed over time. Results: After treatment with Huanglianjiedu-tang granules, the mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) of all patients decreased significantly. Conclusions: The study suggests that Huanglianjiedu-tang (黃連解毒湯) granules could be a primary treatment for hypertension. A well-designed study should be conducted for further evaluation of the effectiveness of the treatment.

• 동의신경정신과학회지
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• 제21권1호
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• pp.43-57
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• 2010

Objectives: This study was designed to assess neuroprotective effects of herb medicine against Alzhheimer's disease related brain damage in organotypic hippocampal slice culture. Methods: We induced dementia related brain damage in organotypic hippocampal slices by $\beta$-amyloid. Those slices were treated with herb medicines - Hwangryeonhaedoktang, Sopungsoongiwon. Using by PI staining, the extents of cell death were assessed. After that, we selected the best effective one among those herb medicines and the major components of that medicine were studied to reveal neuroprotective effects and related proteins by using PI stating. Results: In PI staining, Sopungsoongiwon is the best effective herb medicine between Hwangryeonhaedoktang and Sopungsoongiwon. Notopterygii Rhizoma, Corni Fructus, Areca Catechu, Aurantii Fructus Immaturus, Plantaginis Semen is the best effective one among the components of Sopungsoongiwon. Conclusions: We suggested that purgative effect would be the best effetive medicine on dementia related brain damage between clearing heat and toxic materials.

• Journal of Acupuncture Research
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• 제25권5호
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• pp.89-95
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• 2008

Objectives : This study was aimed at comparing clinical effectiveness among dry needle, Bee Venom Acupuncture, Hwangryunhaedoktang Herbal Acupuncture for treating acute ankle sprain. Methods : The subjects in this study were sixty patients with lateral ankle pain who came to Jaseng Hospital of Oriental medicine from Oct. 28. 2007 to Jul. 14. 2008. Among them, the number of patients after 3 session of each treatment was 17 with dry needle, 18 with Bee Venom Acupuncture, 17 with Hwangryunhaedoktang Herbal Acupuncture, and they were evaluated with Numerical Rating Scale(NRS), and Ankle-Hindfoot Scale(AHS) before and after every session of treatment. Results : 1. Each group had significant decrease in NRS(P<0.05) and increase in AHS score(P>0.05) after 3 session of each treatment. 2. There was no significant difference among 3 groups after 3 session of each treatment. Conclusions : When treating patients with acute ankle pain, Acupuncture, Bee Venom Acupuncture, Hwangryunhaedoktang Herbal Acupuncture each has clinical effect.

• Korean Journal of Acupuncture
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• 제31권4호
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• pp.229-233
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• 2014

Objectives : The purpose of this report is to show the effectiveness of traditional korean medical treatment with Hwangryunhaedok-tang pharmacopuncture. Methods : Twenty five patients were treated by korean medical treatment including Hwangryunhaedok-tang pharmacopuncture. We measured valuation standards such as House-Brackmann Grade(H-B Grade) and Numeric Rating Scale(NRS) to assess the effectiveness of treatments. These valuation standards were measured at admisson and discharge. Results : The results were obtained as below. 1. In House-Brackmann Grade, 60.0% of patients were improved and 36.0% were maintained at the same level. 4.0% of patients were worsen. 2. Average of Numeric Rating Scale was changed from 8.5 to 3.0 after whole treatment. Conclusions : Korean medical treatments including Hwangryunhaedok-tang pharmacopunture can be effective for improving symptoms of facial paralysis.

• 대한한방내과학회지
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• 제41권3호
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• pp.502-507
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• 2020

This study aimed to investigate the effect of Hwanglyeonhaedok-tang on the clearance of vancomycin-resistant Enterococcus (VRE) colonization in a patient with traumatic subarachnoid hemorrhage and subdural hematoma. A 73-year-old man who was diagnosed with traumatic subarachnoid hemorrhage and subdural hematoma with isolation of VRE colonization was administered Hwanglyeonhaedok-tang and followed up with a rectal swab VRE culture every week. After treatment with Hwanglyeonhaedok-tang, VRE colonization was no longer detected. This case report proved that Hwanglyeonhaedok-tang could be an effective treatment for clearance of VRE colonization in a patient with traumatic subarachnoid hemorrhage and subdural hematoma.