The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

A Histological Study of the effects of $CCL_4$ and Ethanol on the Liver and Kidneys of Rats after Preadministration of Hwangryunhaedoktang

황련해독탕(黃連解毒湯)의 전투여(前投與)가 $CCL_4$와 ethanol 중독(中毒) 흰쥐의 간장(肝臟) 및 신장(腎臟)에 미치는 조직병리학적(組織病理學的) 연구(硏究)

  • Yoon, Ju-Hyun (Department of internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Kim, Seong-Mo (Department of internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Leem, Myung-Hyun (Department of internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Park, Jae-Hyun (Department of internal Medicine, College of Oriental Medicine, Kyungsan University)
  • 윤주현 (경산대학교 한의학과 간계 내과학 교실) ;
  • 김승모 (경산대학교 한의학과 간계 내과학 교실) ;
  • 임명현 (경산대학교 한의학과 간계 내과학 교실) ;
  • 박재현 (경산대학교 한의학과 간계 내과학 교실)
  • Published : 2001.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Object : This study was carried out to examine the effect of Hwangryunhaedoktang on the liver and kidney of rats induced by carbon tetrachloride and ethanol. Methods : The histopathological changes were examined after preadministration of 100 and 200mg/100g Hwangryunhaedoktang. Results : The perivenular ballooning degeneration and infiltration of basophilic inflammatory cells were decreased in the experimental group when compared with the control group. No abnormalities were observed in the kidneys of both groups. But, interstitial nephritis was observed only in the experimental group. Conclusion : This study suggests that Hwangryunhaedoktang may be of benefit to the prevention of hepatotoxicity induced by carbon tetrachloride and ethanol, and it is more effective in high dosages.

Keywords

References

  1. 毒性學-原理와 試驗 方法 金良垣
  2. 肝系內科學 全國韓醫科大學肝系內科學敎授
  3. 주後備急方 葛洪
  4. 外臺秘要 王燾
  5. 中華名醫方劑大全 彭懷仁(主編)
  6. 中國歷代名醫名方大全書 任健主(編)
  7. 中國常用方劑手冊 劉東亮
  8. 中國方劑現代硏究大全 黃泰康(施誠)
  9. 中醫急症方精選 黃榮宗
  10. 黃連解毒湯의 藥理學的 硏究 杜鎬京
  11. 黃連解毒湯煎液이 thioac etamides 毒性으로 인한 代謝 障碍에 미치는 效果에 대한 實驗的 硏究 崔大善
  12. 黃連解毒湯煎液이 肝 및 腎毒性에 미치는 影響 韓永善
  13. 우석의대잡지 v.5 Carbon Tetrachloride 毒性에 미치는 人蔘의 效果 尹恒斌
  14. 우석의대잡지 v.6 Chloroform 毒性에 미치는 人蔘 및 alcohol의 效果 李熙溶
  15. Principles and Methods of Toxicology Hayes, A.Wallace
  16. 黃連解毒湯 엑기스가 家兎의 體溫 및 血壓에 미치는 影響 鄭遇悅
  17. 黃連解毒湯이 緬羊赤血球에 대한 免疫反應에 미치는 影響
  18. 黃連解毒湯加味方에 의한 免疫글로불린 E 媒介性 아나필락시의 抑制 尹星燦
  19. 黃連解毒湯과 溫淸飮이 高血壓 및 高脂血症에 미치는 影響 金恩善
  20. 대한한의학회지 paraquat 치험 3례 朴宰賢
  21. Indian J Exp Biol v.35 Effect of carbon tetrachloride on rat liver, following parathyroidectomy: histopathological observation Rasgoti, S.
  22. Pharmacol Toxicol v.77 The effect of nicotine and its interaction with carbon tetrachloride in the rat liver Yuen, S.T.;Gogo, A.R.Jr.;Luk, I.S.;Cho, C.H.;Ho, J.C.;Loh, T.T.
  23. Gasteroenterology v.108 Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor Czaja, J.J.;Xu, J.;Alt, E.
  24. Pharmacology v.48 Protective effect of ternatin, a flavonoid isolated from Egletes viscosa less., in experimental liver injury Rao, V.S.;Figueiredo, E.G.;Melo, C.L.;Vaina, G.S.;Menezes, D.B.;Matos, M.S.;Silveira, E.R.
  25. Indian J Gaseroenterol v.17 Prevention of carbon tetrachloride-induced hepatic injury in mice by Picrohiza kurrooa Santra, A.;Das, S.;Maity, A.;Rao, S.B.;Mazumder, D.N.
  26. Alcohol Alcohol v.31 Relative and combined effects of propylthiouracil, ethanol and protein deficiency on liver histology and hepatic iron, zinc, magnese and copper contents Gonzalez-Reimers, E.;Santolaria-Fernandez, F.;Perez-Labajos, J.;Rodriguez-Moreno, F.;Martinez-Riera, A.;Hernandez-Torres, O.;Valladares-Parrilla, F.;Molina-Perez, M.
  27. J Pharmacol Exp Ther v.277 Medium chain triglycerides and vitamin E reduce the severity of established experimental alcholic liver disease Nanjii, A.A.;Yang, E.K.;Fogt, F.;Sadrzadeh, S.M.;Dannenberg, A.J.
  28. J Clin Invest v.96 Experimental liver cirrhosis induced by alcohol and iron Tsukamoto, H.;Horne, W.;Kamimura, S.;Niemela, O.;Parkkila, S.;Yla-Herttuala, S.;Brittenham, G.M.
  29. J Pharmacol Exp Ther v.286 Glycine accelerates recovery from alcohol-induced liver injury Yin, M.;Ikejima, K.;Arteel, G.E.;Seabra, V.;Bradford, B.U.;Kono, H.;Rusyn, I.;Thurman, R.G.