• 한국가시화정보학회지
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• 제15권3호
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• pp.14-19
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• 2017

Increase of blood viscosity significantly changes the flow resistance and wall shear stress which are related with cardiovascular diseases. For measurement of blood viscosity, microfluidic method has proposed by monitoring pressure between sample and reference flows in the downstream of a microchannel with two inlets. However, it is difficult to apply this method to unknown flow conditions. To measure blood viscosity under unknown flow conditions, a microfluidic method based on micro particle image velocimetry(PIV) is proposed in this study. Flow rate in the microchannel was estimated by assuming velocity profiles represent mean value along channel depth. To demonstrate the measurement accuracy of flow rate, the flow rates measured at the upstream and downstream of a T-shaped microchannel were compared with injection flow rate. The present results indicate that blood viscosity could be reasonably estimated according to shear rate by measuring the interfacial width and flow rate of blood flow. This method would be useful for understanding the effects of hemorheological features on the cardiovascular diseases.

• 한국정보통신학회논문지
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• 제4권3호
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• pp.575-583
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• 2000

펄스 옥시메터는 수술실, 회복실, 집중 치료실 등에서 사용되는 산소포화도($SpO_2$)를 측정하는 방법 중 광흡수도를 이용하여 비관혈적인 방법으로 산소포화도륵 측정하는 장비이다. 펄스 옥시메터는 동맥혈의 광흡수도를 측정함으로써 혈액의 산소포화도를 나타낼 수 있다. 산소포화도를 측정하는 기존의 방법은 잡음을 제거하는 필터링 기술과 복잡한 처리 알고리즘, 그리고 많은 연산 수행 시간을 필요로 한다. 본 연구에서는 신호 검출 단계에서 적색광과 적외선광 각각의 AC 성분과 DC 성분을 분리하여 처리함으로써, 연산 알고리즘을 단순화 할 수 있었다. 그리고 시스템을 구현한 결과 기존의 방법(로그연산법, 미분법) 보다 속도향상과 0.3% 이상의 성능개선을 보였다.

• 한국가시화정보학회지
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• 제14권1호
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• pp.33-39
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• 2016

Radio-cephalic arteriovenous fistula(RC-AVF) is the most recommended operation of achieving access for hemodialysis. However, it has high rates of early failure depending on the many haemodynamic conditions. To increase RC-AVF patency rate, many researches were performed by in-vitro experiment via artificial vessel and blood analogue fluid, and there were conflicting opinions about whether the non-Newtonian properties of blood have an influence on the flow in large arteries. To investigate the influence of viscoelasticity of blood within the RC-AVF, we fabricated three dimensional artificial RC-AVF and two kinds of blood analogue fluid. The velocity field of two fluids within the vessel were measured by micro-particle velocimetry(m-PIV) and compared with each other. The velocity profiles of both fluids for systolic phase were matched well while those for diastolic phase did not correspond. Therefore, it is desired to use non-newtonian fluid for in-vitro experiment of RC-AVF.

• 한국가시화정보학회지
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• 제3권1호
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• pp.20-25
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• 2005

An x-ray PIV (Particle Image Velocimetry) technique was developed fur measuring quantitative information on flows inside opaque conduits and/or opaque-fluid flows. To check the performance of the x-ray PIV technique developed, it was applied to a liquid flow in an opaque Teflon tube. To acquire x-ray images suitable for PIV velocity field measurements, the refraction-based edge enhancement mechanism was employed with seeding detectable tracer particles. The amassed velocity field data obtained were in a reasonable agreement with the theoretical prediction. The x-ray PIV technique was also applied to get velocity fields of blood flow and to measure size and velocity of micro-bubbles simultaneously, and to visualize the water refilling process in bamboo leaves. The x-ray PIV was found to be a powerful transmission-type flow imaging technique fur measuring quantitative information of flows inside opaque objects and various opaque-fluid flows.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2007년도 추계학술대회
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• pp.105-108
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• 2007

To diagnose the vascular diseases from the viewpoint of hemodynamics, we need detailed quantitative hemodynamic information of related blood flows with a high spatial resolution of tens micrometer and a high temporal resolution in the order of millisecond. For investigating in-vivo hemodynamic phenomena of vascular circulatory diseases, a new diagnosing technique combining a medical radiography and PIV method was newly developed. This technique called 'Angiographic PIV system' consists of a medical X-ray tube, an X-ray CCD camera, a shutter module for generating double pulse-type X-ray, and a synchronizer. Through several preliminary tests, the feasibility of the Angiographic PIV technique was verified. For in-vivo applications to real blood flows, we developed tracer microcapsules, which were optimized to this system, made of a contrast material of iodine and a matrix material of PVA (polyvinylpyrrolidone). In near future, the Angiographic PIV technique will be used for understanding hemodynamic phenomena of vascular diseases and for their early detection.

• 한국컴퓨터산업학회논문지
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• 제7권1호
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• pp.47-56
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• 2006

혈액에서 추출된 프로테옴 패턴(단백질 DNA 정보)는 인간 신체 기관의 병리학적 상태를 잠재적으로 반영하고 있다. 신체기관의 질병이나 이상은 이러한 프로테옴 패턴의 분석에 의해 식별될 수 있다고 알려져 있으며 프로테옴 패턴 정보를 분석하는 여러 가지 방법들이 현재 존재하고 있다. 본 논문에서는 SVM(Support Vector Machine)과 GA(Genetic Algoritm)의 융합에 근거하여 암 진단을 위한 디시전 모델의 효과적 학습(learning) 방법을 제안한다. <중략> 그 결과로서 개별적 kernel function 들보다 더 우수한 분류성능을 갖는 최적의 디시전 모델이 얻어졌다. 위암 데이터 셋 과 두 개의 일반 데이터 셋(대장암, 백혈병)을 사용한 컴퓨터 실험에서 제안된 방법이 다른 Kernel function 들에 비해 더 우수한 분류 성능을 보여주었다.

• 한국컴퓨터정보학회논문지
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• 제17권3호
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• pp.105-111
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• 2012

광용적맥파는 심박과 동맥 혈액의 산소포화도 등을 측정하기 위하여 널리 사용된다. 본 논문에서는 요골동맥에서 780nm와 940nm 적외선 LED를 사용하여 PPG 신호를 측정할 수 있는 모니터링 시스템을 구현하였다. 구현된 시스템은 여러 상황에서 특성이 서로 다른 8종의 LED와 2종의 광전 센서를 조합하여 요골동맥에서 광전용적맥파를 측정하였다. 요골동맥에서 측정된 파형들은 반전되어서 기록된다. 이렇게 반전된 파형은 수축기의 신호는 감소시키고, 확장기의 신호는 증가시킨다. 시스템을 통하여 투과형 방식과 반사형 방식에서 각각의 신호 검출이 적합한 환경과 최적의 센서 조합을 파악하여 모니터링 시스템을 구현하고, 각 조합별 그 결과 피검자의 요골동맥에서 안정적으로 사용할 수 있는 심박신호 측정 시스템을 개발하였다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2006년도 춘계종합학술대회
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• pp.1032-1036
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• 2006

In this study, we implement the potable blood gas analyzer measuring pH, $pCO_2\;and\;pO_2$ of the arterial blood. The implemented system by this study is divided into hardware and software part and also the hardware portion is parted by mechanism and electronic circuit mit. The system program is composed of operating, washing, correcting and measuring program. And to correct the system, two-point calibration method is used, one-point calibration method is also added for more accuracy, and system program is coded. For verifying the implemented system, We examine to response property of each electrode. And evaluate accuracy of the system using standard reagent and was construed as statistical.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2006년도 추계학술대회 논문집
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• pp.121-124
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• 2006

The arteries are very important in cardiovascular system and easily adapt to varying flow and pressure conditions by enlarging or shrinking to meet the given hemodynamic demands. The blood flow in arteries is dominated by unsteady flow phenomena due to heart beating. In certain circumstances, however, unusual hemodynamic conditions cause an abnormal biological response and often induce circulatory diseases such as atherosclerosis, thrombosis and inflammation. Therefore quantitative analysis of the unsteady pulsatile flow characteristics in the arterial blood vessels plays important roles in diagnosing these circulatory diseases. In order to verify the hemodynamic characteristics, in-vivo measurements of blood flow inside the extraembryonic arterial bifurcation cascade of chicken embryo were carried out using a micro-PIV technique. To analyze the unsteady pulsatile flow temporally, the (low images of RBCs were obtained using a high-speed CMOS camera at 250fps with a spatial resolution of $30{\mu}m\times30{\mu}m$ in the whole blood vessels. In this study, the unusual flow conditions such as flow separation or secondary flow were not observed in the arterial bifurcations. However, the vorticity has large values in the inner side of curvature of vessels. In addition, the mean velocity in the arterial blood vessel was decreased and pulsating frequency obtained by FFT analysis of velocity data extracted in front of the each bifurcation was also decreased as the bifurcation cascaded.

• 한국가시화정보학회지
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• 제17권2호
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• pp.10-16
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• 2019

Considering the role of viscosity in the hemorheology, the characteristics of non-Newtonian fluid are important in the pulsatile blood flows. Stenosis, with an abnormal narrowing of the vessel, contributes to block blood flows to downstream tissue and lead to plaque rupture. Therefore, systematic analysis of blood flow around stenosed vessels is crucial. In this study, non-Newtonian behaviors of blood analog fluids around the micro-stenosis with 60 % severity in diameter of $500{\mu}m$ was examined by using CFX under the pulsatile flow conditions with the period of 10 s. Viscosity information of two non-Newtonian fluids were obtained by fitting the value of normal blood and highly viscous blood. As the Newtonian fluid, the water at room temperature was used. During the pulsatile phase, wall shear stress (WSS) is highly oscillated. In addition, high viscous solution gives rise to increases the variation in the WSS around the micro-stenosis. Highly oscillating WSS enhance increasing tendency of plaque instability or rupture and damage of the tissue layer. These results, related to the influence on the damage to the endothelium or stenotic lesion, may help clinicians understand relevant mechanisms.