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http://dx.doi.org/10.5407/jksv.2017.15.3.014

Microfluidic Method for Measurement of Blood Viscosity based on Micro PIV  

Hong, Hyeonji (School of Mechanical Engineering, Pusan National University)
Jung, Mirim (Busan Dongrae Wooridul Spine Hospital)
Yeom, Eunseop (School of Mechanical Engineering, Pusan National University)
Publication Information
Journal of the Korean Society of Visualization / v.15, no.3, 2017 , pp. 14-19 More about this Journal
Abstract
Increase of blood viscosity significantly changes the flow resistance and wall shear stress which are related with cardiovascular diseases. For measurement of blood viscosity, microfluidic method has proposed by monitoring pressure between sample and reference flows in the downstream of a microchannel with two inlets. However, it is difficult to apply this method to unknown flow conditions. To measure blood viscosity under unknown flow conditions, a microfluidic method based on micro particle image velocimetry(PIV) is proposed in this study. Flow rate in the microchannel was estimated by assuming velocity profiles represent mean value along channel depth. To demonstrate the measurement accuracy of flow rate, the flow rates measured at the upstream and downstream of a T-shaped microchannel were compared with injection flow rate. The present results indicate that blood viscosity could be reasonably estimated according to shear rate by measuring the interfacial width and flow rate of blood flow. This method would be useful for understanding the effects of hemorheological features on the cardiovascular diseases.
Keywords
Micro PIV; Viscosity; Microfluidic Device;
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1 Allmendinger, A., Dieu, L. H., Fischer, S., Mueller, R., Mahler, H. C. and Huwyler, J., 2014, "High-Throughput Viscosity Measurement Using Capillary Electrophoresis Instrumentation and Its Application to Protein Formulation," Journal of Pharmaceutical & Biomedical Analysis, Vol. 99, No. 0, pp. 51-58.   DOI
2 Gupta, S., Wang, W. S. and Vanapalli, S. A., 2016, "Microfluidic Viscometers for Shear Rheology of Complex Fluids and Biofluids," Biomicrofluidics, Vol. 10, No. 4, pp. 043402.   DOI
3 Pipe, C. J., Majmudar, T. S. and McKinley, G. H., 2008, "High Shear Rate Viscometry," Rheologica Acta, Vol. 47, No. 5-6, pp. 621-642.   DOI
4 Solomon, D. E., Abdel-Raziq, A. and Vanapalli, S. A., 2016, "A Stress-Controlled Microfluidic Shear Viscometer Based on Smartphone Imaging," Rheologica Acta, Vol. 55, No. 9, pp. 727-738.   DOI
5 Srivastava, N., Davenport, R. D. and Burns, M. A., 2005, "Nanoliter Viscometer for Analyzing Blood Plasma and Other Liquid Samples," Anal Chem, Vol. 77, No. 2, pp. 383-392.   DOI
6 Yeom, E., Kim, H. M., Park, J. H., Choi, W., Doh, J. and Lee, S. J., 2017, "Microfluidic System for Monitoring Temporal Variations of Hemorheological Properties and Platelet Adhesion in Lps-Injected Rats," Sci Rep, Vol. 7, No. 1, pp. 1801.   DOI
7 Yeom, E., Park, J. H., Kang, Y. J. and Lee, S. J., 2016, "Microfluidics for Simultaneous Quantification of Platelet Adhesion and Blood Viscosity," Sci Rep, Vol. 6, No., pp. 24994.   DOI
8 Cornish, R. J., 1928, "Flow in a Pipe of Rectangular Cross-Section," Proceedings of the Royal Society of London Series A, Vol. 120, No. 786, pp. 691-700.
9 Chien, S., 1970, "Shear Dependence of Effective Cell Volume as a Determinant of Blood Viscosity," Science, Vol. 168, No. 3934, pp. 977-979.   DOI
10 Sherwood, J. M., Dusting, J., Kaliviotis, E. and Balabani, S., 2012, "The Effect of Red Blood Cell Aggregation on Velocity and Cell-Depleted Layer Characteristics of Blood in a Bifurcating Microchannel," Biomicrofluidics, Vol. 6, No. 2, pp. 24119.   DOI
11 Cowan, A. Q., Cho, D. J. and Rosenson, R. S., 2012, "Importance of Blood Rheology in the Pathophysiology of Atherothrombosis," Cardiovascular Drugs & Therapy, Vol. 26, No. 4, pp. 339-348.   DOI
12 Srivastava, N. and Burns, M. A., 2006, "Analysis of Non-Newtonian Liquids Using a Microfluidic Capillary Viscometer," Anal Chem, Vol. 78, No. 5, pp. 1690-1696.   DOI
13 Krieger, I. M., 1968, "Shear Rate in the Couette Viscometer," Transactions of the Society of Rheology, Vol. 12, No. 1, pp. 5-11.   DOI
14 Cho, Y. I., Hartnett, J. P. and Lee, W. Y., 1984, "Non-Newtonian Viscosity Measurements in the Intermediate Shear Rate Range with the Falling-Ball Viscometer," Journal of Non-Newtonian Fluid Mechanics, Vol. 15, No. 1, pp. 61-74.   DOI
15 Kim, H., Cho, Y. I., Lee, D. H., Park, C. M., Moon, H. W., Hur, M., Kim, J. Q. and Yun, Y. M., 2013, "Analytical Performance Evaluation of the Scanning Capillary Tube Viscometer for Measurement of Whole Blood Viscosity," Clin Biochem, Vol. 46, No. 1-2, pp. 139-142.   DOI