• Fire Science and Engineering
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• v.26 no.3
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• pp.40-48
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• 2012

Fire patterns have been used to determine the origin and cause of fires in every setting imaginable. However, it is very difficult to identify fire patterns and causes from the fire-damaged remains of a devastated structure. If someone was killed by the fire, it is possible to identify fire patterns by analyzing the Hb-CO concentration in charred bodies of deceased as well as the pace of the fire. For example, a low level of Hb-CO concentration in the charred bodies indicate a rapid fire with accelerants and the death was caused by severe heat and thick toxic fumes. However, a high level of Hb-CO concentration in the charred bodies demonstrates that the fire was slow and/or there was a flameless form of combustion. Thus, it is possible to identify fire patterns through analyzing the level of Hb-CO concentration on the dead from the fire. In this study, the Hb-CO concentration in the charred bodies was from 3 % at the case of gas burning oneself to death to 93 % at the death caused by smoldering fire.

• Korean Journal of Clinical Laboratory Science
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• v.54 no.1
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• pp.73-77
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• 2022

Blood products (BPs) can only be obtained through blood donation and hence represent a finite resource. BPs should therefore be used conservatively. However, BPs are being used indiscriminately without evidence. The purpose of this study was to evaluate the reasons for the use of BPs and their appropriateness. The investigation was carried out based on hemoglobin levels. Data were obtained from Nov 1, 2020, to Oct 31, 2021, from a hospital's OCS/EMR systems. The BPs were dispensed in 21,303 cases, and the number of hemoglobin levels >7.0 g/dL or higher among red blood cell drugs used by each treatment department was 1,173 (>7.0 g/dL). The misuse of blood transfusions is increasing social costs, with the adequacy of transfusion becoming increasingly important. Hence, each medical institution should review the transfusion guideline evaluation index, check the status of the release of BPs, and institute educational programs covering transfusion guidelines and continually evaluate their adequacy.

• Korean Journal of Food Science and Technology
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• v.48 no.2
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• pp.178-186
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• 2016

The present study was conducted to investigate the effect of whole wheat bread with added Lindera obtusiloba (LO) and Capsosiphon fulvescens (CF) ethanol extracts on serum glucose and lipid levels in Sprague Dawley rats. Rats were divided into five groups depending on the diet administered: normal bread (NC), whole wheat bread (W), whole wheat bread with LO leaves extract (WL), whole wheat bread with CF extract (WC), and whole wheat bread with freeze-drying CF (WDC). After 4 weeks of consuming the experimental diet, the blood glucose level and hemoglobin A1c contents were found to be significantly lower in the W, WL, WC, and WDC groups than in the NC group. The high-density lipoprotein-cholesterol levels increased in the WL group when compared to those in the NC group and triglycerides levels decreased in all wheat groups compared to those in the NC group. These results suggest that wheat breads containing LO and CF extracts are effective for preventing hypercholesterolemia and obesity.

• Proceedings of the Korean Environmental Health Society Conference
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• 2005.11a
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• pp.150-153
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• 2005

A gas chromatography/electron impact mass spectrometric assay method was developed for the determination of Hb-adduct, 2-(hydroxyethyl)valine (HEVal), of ethylene oxide(EO). Globin was separated from hemoglobin by acid iso-propanol and ethyl acetate, then HEVal was isolated as PFPITH-HEVal by Edman degradation. PFPITH-HEVal was silylated with N-methyl-N-(tert-butyl-dimethylsilyl)trifluoroacetamide(MTBDMSTFA)-NH4I (1000:4) under catalysis of dithioerythritol. The detection limit of the assay was 5.8 pmol/g based upon assayed hemoglobin of 0.1g. Two groups of mice were exposed to EO for 0.5 and 1.0 hr/day, respectively at 400ppm during 4 weeks. As the result, the adduct levels increased according to the exposure time with the linearity of 0.7011 and 0.8914, respectively, HEVal was very valuable as biomarker for the exposure of EO. In human, HEVal was analyzed until 8.33 pmol/mg.

• Biomolecules & Therapeutics
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• v.10 no.2
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• pp.114-116
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• 2002

This study was performed to investigate the acute toxicity of PEG-hemoglobin SB1, a blood substitute, in beagle dogs. The male and female dogs were administered intravenously at the doses of 0.4375, 0.875 and 1.75 g/kg body weight, respectively. After a single intravenous administration of SB1 to dogs, we observed them daily for 2 weeks. SB1 did not induce any toxic signs in the mortalities, clinical signs, body weight changes, and gross necropsy findings of dogs. Based on these results, acute toxicity, dogs SB1 may have no side effect and its $LD_{50}$ value may be over 1.75 g/kg (25 ml/kg) of body weight in dogs.

• Journal of Veterinary Clinics
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• v.16 no.2
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• pp.289-292
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• 1999

마늘은 백합과 식물로서 인류의 식생활에서 중요한 역할을 할 뿐 아니라 최근에는 항암작용을 가진 것으로도 알려져 세계적으로 많은 연구가 수행되고 있다. 그러나 같은 백합과 식물인 양파의 경우 과량 섭취시 개에서 용혈성 빈혈이 유발된다는 것은 잘 알려진 사실이지만 마늘의 경우 이러한 부작용에 관한 보고는 전혀 없는 실정이다. 따라서 본 연구에서는 체중 25 kg 이상의 성견을 대상으로 마늘 추출액을 투여한 결과 다음과 같은 성적을 얻었다. 총적혈구수(RBC), 헤모글로빈(Hb)함량, 혈구용적(PCV), 평균적혈구용적(MCV), 평균적혈구혈색소농도(MCHC)는 실험기간 중 유의한(P＜0.05) 감소경향을 나타내었다. GSH 함량은 6일째 유의한(P<0.01)증가를 나타내었다. 본 실험 성적의 결과 과량의 마늘 투여시에도 양파에서와 동일한 용혈성 빈혈이 발생되는 것으로 생각된다.

• Journal of The Korean Society of Clinical Toxicology
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• v.4 no.2
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• pp.158-160
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• 2006

Acute methemoglobinemia is induced by various causes, especially ingestion of oxidizing agents such as phenazopyridine, dapsone, and nitrite. Indoxacarb is an oxadiazine insecticide with high insecticidal activity and low mammalian toxicity. It is known to block voltage-gated Na+ channels in insects and mammals, but the mechanism is not yet well understood. We describe a case of a 41-year-old woman with methemoglobinemia that developed following Indoxacarb ingestion, which improved after intravenous injection of methylene blue. This is the first known such case. If signs and symptoms of methemoglobinemia occur after Indoxacarb ingestion, antidotal therapy with methylene blue should be considered as a necessary treatment.

• Proceedings of the Korean Society of Computer Information Conference
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• 2011.01a
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• pp.111-112
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• 2011

본 연구에서는 광전 용적맥파(photoelectric plethysmography, PPG)를 기반으로 이를 이용하여 혈관 탄성도를 측정 할 수 있는 시스템에 관하여 연구하였다. 광전 용적맥파는 광을 이용한 비 침습적 맥파 측정 방식으로 손가락 끝 부분에서 측정하고 혈액 내에 헤모글로빈의 빛에 대한 광 흡수도의 차이로 인해 나타나게 된다. 얻어진 신호를 2차 미분 하게 되면 가속도 맥파 (acceleration photoplethymogram, APG)를 얻을 수 있고 이는 혈관 탄성도의 추정에 응용가능하다. 본 연구에서는 혈관 탄성도를 측정하기 위한 방법으로 광전 용적맥파를 적용하여 가속도 맥파 측정기기를 설계하고, 이를 바탕으로 혈관 탄성도 추정에 적용 가능 여부를 연구하였다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.05a
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• pp.1009-1011
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• 2013

최근 U-헬스케어 서비스가 증가함에 따라 예방과 건강증진 등에 관심과 연구가 활발히 이루어지고 있다. 이러한 U-헬스케어에 사용되는 ECG, EMG, PPG EEG등이 스마트폰 기반의 휴대용 장비와 연동된 센서들의 연구 역시 활발히 진행 중이다. 일반적으로 PPG신호는 적외선센서를 이용하여 모세혈관의 혈중 헤모글로빈 농도 변화에 의한 맥파를 측정한다. PPG신호의 잡음을 제거하기 위해 필터를 사용하였다. 필터된 정보를 ADC하여 스마트폰으로 BlueTooth통신을 이용하여 전송한다. 최종적으로 스마트 디바이스에 PPG신호를 그린다. 제작결과 PPG아날로그 신호를 보는 것과 동일하게 스마트 디바이스에 그릴 수 있음을 보였다. 이후 PPG신호를 이용하여 혈관건강도 및 건강예방의 측정의 연구를 계속해서 한다.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2000.11a
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• pp.315-319
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• 2000

400ppm의 pentachlorophenol(PCP) 오염토양을 5$m\ell$ scintillation vial의 multi reactor와 1L 크기의 one reactor를 써서 Hydrogen peroxide와 Hemoglobin 촉매반응에 의해 PCP 분해정도를 조사하였다. 대부분 초기에 반응이 빠르게 진행되므로 time scale을 8시간 이내와 한달여기간동안 살펴보았다. 8시간동안의 PCP 분해정도는 일차함수로 동력학 계수가 -0.0233으로 나타났고, 이때 제거효율은 60.8%이고 one reactor의 경우 30일동안 80%의 제거효율을 보였다. PCP 회수율은 multi reactor의 경우 96.5($\pm$6.7)이고 one reactor(fan scale)의 경우 90.1%였다.