Toxicity Study of a New PEG-hemoglobin SB1, a Red Blood Cell Substitute: Single Intravenous Administration in Beagle dogs |
한정희
(한국화학연구원 부설 안전성평가연구소)
차신우 (한국화학연구원 부설 안전성평가연구소) 김종춘 (한국화학연구원 부설 안전성평가연구소) 기충용 (한국화학연구원 부설 안전성평가연구소) 이미가엘 (한국화학연구원 부설 안전성평가연구소) 노광 (선바이오(주)) |
1 | Usuba, A., Motoki, R., Sakaguchi, K., Suzuki, K. and Kami-tani, T. (1994). Effect of neo red ceIIs on the hemodynam-ics and blood gas transport in canine hemorrhagic shock and its safety for vital organs. Artif. Cells Blood Substit. ImmobiI. BiotechnoI., 22, 503-506 DOI |
2 | Baldwin, A. L., Wilson, L. M. and Valeski, J. E. (1998). Ultra-strucural effects of intravascularly injected polyethylene glycol-hemoglobin in mtestinal mucosa. Am. J. Physiot., 275,H615-625 |
3 | Phillips, W. T., Klipper, R. W., Awasthi, V. D., Rudolph, A. S., Cliff, R., Kwasiborski, V. and Goins, B. A. (1999). Polyelh-ylene glycol-modified liposome-encapsulated hemoglobin:a long circulating red cell substitute. J. Pharmacol. Exp. Ther., 288, 665-670 |
4 | Sakaguchi, K., Miyauchi, Y., Suzuki, K. and Takahashi, A. (1991). A effects on the Neo Red Cell on the blood coagu-lation system and the complement system. Jpn. J. Artif. Oreans, 20, 620-625 |
5 | Sweeney, M. I., Yager, J. Y, Walz, W. and Juurlink, B. H (1995). Cellular mechanisms involved in brain ischemia. Can. J. Physiol. Pharmacol., 73, 1523-1535 |
6 | Shin, H., Shim, H., Yu, S., Kim J., Yang, S. and Chung, M. (2000). Pharmacokinetics of a New PEG-hemoglobin SBl for single intravenous administration to rats. Yakhak Hoeji, 44, 232-236 |
7 | Takahashi, A. (1995). Characterization of Neo Red CeIIs (NRCs), their function and safety in vivo tests. Artif. CeIIs Blood Substit. Immobil. Biotechnol., 23, 247-254 |
8 | Usuba, A., Motoki, R., Ogata, Y., Suzuki, K. and Kamitani, T. (1995). Effect and safety of liposome-encapsulated hemo-globin Neo Red CeIIs (NCRs) as a perfusate for total car-diovascular bypass. Artif. Cells BIood Substit. Immobil. Bio-technol., 23, 337-346 DOI |
9 | 식품의약품안전청고시 제1999-61호 의약품등의 독성시험기준, 식품의약품안전청 (1999. 12. 22.제정) |
10 | Yager, J. Y. and Thornhill, J. A. (1997). The effect of age on susceptibility to hypoxic-ischemic brain damage. Neurosci. Biobehav. Rev., 21, 167-174 DOI ScienceOn |