• Title/Summary/Keyword: 향사육군자탕

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Effects of Hyangsayukgunjatang and Hyangsayukgunjatang-ga-kyenegum, moryobun on experimental gastric ulcers in rats (향사육군자탕(香砂六君子湯) 및 향사육군자탕가계내김모려분(香砂六君子湯加鷄內金牡蠣粉)이 백서(白鼠)의 위궤양(胃潰瘍)에 미치는 영향(影響))

  • Han Hyun-Hee;Byun Joon-Seok
    • Herbal Formula Science
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    • v.6 no.1
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    • pp.157-173
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    • 1998
  • The following study looked at the effects of Hyangsayukgunjatang and Hyangsayukgunjatang-ga-kyenegum, moryobun on gastric ulcers in rats. In the 1st experiment, ulcers were induced by method of shay's pylorus-ligated in rats. Subjects were administered 2 kinds of medicine, Hyangsayukgunjatang and Hyangsayukgunjatang-ga-kyenegum, moryobun, which were taken orally. The quantity of gastric juice secretion, total acidity of gastric juice, HCI secretion and serumgastrin content were measured and tissues of gastric mucosa epithelium were observed. 1. The quantity of gastric juice secretion in Hyangsayukgunjatang-treated and Hyangsayukgunjatang-ga-kyenegum, moryobun-treated groups showed significant decrease incomparision with the control group. 2. In relation to total acidity of gastric juice, only Hyangsayukgunjatang -treated groupshowed significant decrease in comparison with the control group. 3. HCI secretion of Hyangsayukgunjatang-treated and Hyangsayukgunjatang-ga-kyenegum, moryobun-treated groups showed significant decrease in comparision with the control group. 4. Content of serum gastrin, which were present in Hyangsayukgunjatang -treated and Hyangsayukgunjatang-ga-kyenegum, moryobun- treated groups showed significant decrease in comparision with the control group. 5. The degree of ulcer occurrence & parietal cell numbers and chief cell numbers of Hyangsayukgunjatang-treated and Hyangsayukgunjatang-ga-kyenegum, moryobun-treatedgroups, which were observed by macrographic & histologic method showed signicant decreasein comparison with the control group. Hyangsayukguniatang-treated group prooved to be increasingly effective. From above the experiment results it can be concluded that Hyangsayukgunjatang will be more clinical effective on curing gastric ulcers induced by method of Shay's pylorus-ligated rather than that of Hyangsayukgunjatang-ga-kyenegum, moryobun.

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A Case Study of Parkinson's Disease Patient with Anorexia and Nausea Treated with Korean-medicine Treatment including Hyangsayukgunja-tang (향사육군자탕을 포함한 한방치료로 호전된 파킨슨병 환자의 식욕부진 및 오심 치험 1례)

  • Lee, Su-jung;Ha, Jeong-been;Lew, Jae-hwan
    • The Journal of Internal Korean Medicine
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    • v.41 no.5
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    • pp.717-723
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    • 2020
  • Objectives: The purpose of this study was to address a case of a Parkinson's disease with anorexia and nausea. Methods: A patient diagnosed with Parkinson's disease with anorexia and nausea was treated with Korean medicine therapies including herbal medication (Hyangsayukgunja-tang), acupuncture, electro-acupuncture, and moxibustion for 7days. To evaluate the therapeutic effect, we used a visual analogue scale(VAS). Results: After the treatment, the VAS score for anorexia and nausea had decreased. Conclusion: These results suggested that Korean medicine therapies with Hyangsayukgunja-tang have a beneficial effect on the gastrointestinal symptoms of Parkinson's disease.

The Effects of Hyang-Sa-Yuk-Gun-Ja-Tang and Oh-Pe-San on The Gastric Mucosal Repair (위장관(胃腸管) 점막층(粘膜層)의 회복(恢復)에 향사육군자탕(香砂六君子湯)과 오패산(烏貝散)이 미치는 영향(影響))

  • Chang, Hen-Yel;Kang, Yoon-Ho
    • The Journal of Dong Guk Oriental Medicine
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    • v.2 no.1
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    • pp.127-137
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    • 1993
  • In order to investigate the clinical efficiency based on Oriental Medical References of Hyang-Sa-Yuk-Gun-Ja-Tang and Oh-Pe-San, histological studies have been done by using the experimental animal. The following results were obtained. 1. The Hyang-Sa-Yuk-Gun-Ja-Tang showed a significant promoting effect of repair on the epithelial layer from the basement membrane of duodenal ulcer in rats. 2. The Oh-Pe-San showed efficiencies about repair of the necrosis in epithelial layer on the acute gastritis in rats. According to above results, it is concluded that Oh-Pe-San and Hyang-Sa-Yuk-Gun-Ja-Tang were recognized to be effective on the acute gastritis and the duodenal ulcer in rats, and this study may suggest a clinical guidance to the prescriptions for the treatment of gastritis end gastric ulcer.

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Case Report of a Type 3 Spinocerebellar Ataxia Patient Treated with Traditional Korean Medicine (제 3형 척수소뇌실조 환자의 한방 치험 1례)

  • Hur, Hee-soo;Lee, Myeong-hwa;Kim, Kyoung-min;Kim, Young-kyun
    • The Journal of Internal Korean Medicine
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    • v.37 no.2
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    • pp.322-329
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    • 2016
  • Objective: This study reports on one clinical case of type 3 spinocerebellar ataxia (SCA) to examine the effectiveness of herbal medicine and traditional Korean treatments.Methods: A patient with type 3 spinocerebellar ataxia was treated using traditional Korean medicine options such as acupuncture and Hyangsayukgunja-tang. The effects on type 3 spinocerebellar ataxia were measured using the numeric rating scale (NRS) and ambulatory status.Results: Improvements in NRS and ambulatory status were observed after treatment.Conclusion: According to this study, traditional Korean medicine may be effective in the treatment of type 3 spinocerebellar ataxia.

Quantitative Analysis of Hyangsayukgunja-Tang Using an Ultra-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry (LC-MS/MS를 이용한 향사육군자탕의 주요성분의 함량분석)

  • Seo, Chang-Seob;Shin, Hyeun-Kyoo
    • Korean Journal of Pharmacognosy
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    • v.46 no.4
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    • pp.352-364
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    • 2015
  • The aim of this study was to quantitatively analyze for quality assessment of eighteen marker compounds, including homogentisic acid, 3,4-dihydroxybenzaldehyde, spinosin, liquiritin, hesperidin, ginsenoside Rg1, liquiritigenin, ginsenoside Rb1, glycyrrhizin, 6-gingerol, atractylenolide III, honokiol, costunolide, dehydrocostuslactone, atractylenolide II, nootkatone, magnolol, and atractylenolide I, in Hyangsayukgunja-tang using an ultra-performance liquid chromatography-electrospray ionization-mass spectrometer. The column for separation of eighteen marker components were used a UPLC BEH $C_{18}$ analytical column ($2.1{\times}100mm$, $1.7{\mu}$) and kept at $45^{\circ}C$ by gradient elution with 0.1% (v/v) formic acid in water and acetonitrile as mobile phase. The flow rate and injection volume were 0.3 mL/min and $2.0{\mu}l$, respectively. The correlation coefficient of all marker compounds was ${\geq}0.9914$, which means good linearity, within the test ranges. The limits of detection and quantification values of the all analytes were in the ranges 0.04-1.11 and 0.13-3.33 ng/mL, respectively. As a result, five compounds, homogentisic acid, 3,4-dihydroxybenzaldehyde, spinosin, liquiritigenin, and atractylenolide I, in this sample were not detected and the amounts of the 13 compounds except for the 5 compounds were $8.10-6736.37{\mu}g/g$ in Hyangsayukgunja-tang extract.

A Case Study of a Serious Antibiotics-associated diarrhea Patient Treated with Modified Hyangsayukgunja-tang (중증 항생제 유발 설사 환자에 대한 향사육군자탕(香砂六君子湯) 가감방(加減方) 투여 1예)

  • Park, Soim;Kang, Da-Hyun;Seo, Ho-Seok;Kim, Jin-Won
    • Herbal Formula Science
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    • v.22 no.2
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    • pp.121-131
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    • 2014
  • Objectives : The purpose of this study is to report a therapeutic effects of a Korean herbal prescription for antibiotics-associated diarrhea. Methods : Modified Hyangsayukgunja-tang was prescribed once or twice a day to a antibiotics-associated diarrhea patient. To observe the therapeutic effects, the frequency of defecation was counted and Bristol Stool Form Index was used. Laboratory tests were conducted periodically. Results : The frequency of defecation was decreased from 9 times a day to once a day. According to Bristol Stool Form Index, stool form was improved from Type 7 to Type 5. The level of red blood cell, hemoglobin and albumin increased slightly from the day of admission to discharge. Conclusions : Hyangsayukgunja-tang can be a choosable treatment option for a serious antibiotics-associated diarrhea.

Effects of the HyangsayukgunjatangGamibang on Children with Abdominal Pain (소아복통 환아에 대한 향사육군자탕 가미방의 임상적 효능에 관한 연구)

  • Jeong, Min-Jeong;Lyu, Sun-Ae;Lee, Seung-Yeon
    • The Journal of Pediatrics of Korean Medicine
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    • v.21 no.3
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    • pp.57-69
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    • 2007
  • Objectives This study for evaluating the effects of HyangsayukgunjatangGamibang on childhood with abdominal pain. Methods This clinical study has been carried out with 38 children, who visited to the Department of Pediatrics, $\bigcirc\;\bigcirc$oriental medical center from January 2005 to August 2007, who had been treated for abdominal pain with herbal medicine (HyangsayukgunjatangGamibang). This study had done by chart-review or by telephone research. Results 1. After treating with HyangsayukgunjatangGamibang, 34 children's abdominal pain was improved. (63.2%) 2. After treating with HyangsayukgunjatangGamibang, 13 children eat more than before. 3. After treatment with HyangsayukgunjatangGamibang, children's symptoms-constipation, nausea, headache, anorexia were improved. Conclusions HyangsayukgunjatangGamibang is effective in childhood abdominal pain.

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The Effects of Hyangsayukgunja-tang Extract on Indomethacin-Induced Gatric Mucosal Lesions (향사육군자탕(香砂六君子湯)의 Indomethacin 유발 위점막 손상에 대한 효과)

  • Baik, Tae-Hyun;Kong, Kyung-Hwan
    • The Journal of Internal Korean Medicine
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    • v.22 no.4
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    • pp.589-599
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    • 2001
  • Objective: This study was carried out to investigate the effects of Hyangsayukgunja-tang extract on indomethacin-induced gastric mucosal lesions of mice. Methods: To evaluate the effects of Hyangsayukgunja-tang extract and Misoprostol, the morphology of gastric mucosa, and the distribution of mucose cells, PNA(Peanut Agglutinin), ICAM(intercellular adhesion molecule), and apoptotic cells were observed. Hyangsayukgunja-tang extract and Misoprostol were intragastric injected to the test groups at hour 72 before and just before indomethacin treatment(HYT-J, HYT-72, M-J, M-72), while the INDO group was injected only with indomethacin and the control group was subcutaneously injected only with saline. Results: The gastric mucosal lesions incresed in the fundus and body of INDO group, but softened in HYT group and M group, the effects were more excellent in the HYT-72, M-72 groups than the HYT-J, M-J groups and in the HYT group than M group. The disappearance of surface and neck mucose cells were shown in INDO group, but softened in HYT group and M group. The mucosal configuration of HYT-72 group was the same as control group. The numerical increase of PNA positive reaction in cytoplasm of perietal cells were appeared in INDO group. The PNA positive reaction in HYT group and Miso-group were shown in surface mucous cells and microvilli of apical surface in chief cells as control group, and were the same as control group in all mucosa of HYT-72 group. The distribution of ICAM positive cells, increased in INDO group, but decreased in M-72 group, and were the same as control group in HYT-72 group. The apoptotic cells, increased noticeably in gastric mucosa of INDO group, decreased in HYT group and M group, and decreased noticeably in HYT-72 group. Conclusions: Hyangsayukgunja-tang extract had excellent effects on indomethacin-induced gastric mucosal lesions.

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Antioxidant Effects of GaMiHyangSaYukGunJaTang against Gastric Mucosal Lesions induced by Indomethacin (가미향사육군자탕(加味香砂六君子湯)의 Indomethacin 유도 위점막손상 에 미치는 항산화효과(抗酸化效果))

  • Kim, Kyung-Sun;Shin, Heung-Mook
    • The Journal of Korean Medicine
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    • v.19 no.1
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    • pp.165-178
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    • 1998
  • This study was carried out to investigate the protective effects of GaMiHyangSaYukGunJaTang on gastric mucosal lesions caused by indomethacin in rats.The test group was injected with indomethacin after the oral administration of GaMiHyangSaYukGunJaTang, while the control group was injected only with indomethacin. The lipid peroxidation level increased considerably in the control group, but superoxide disnurtase(SOD), catalase and glutathione(GSH) levels remarkably decreased. The following effects induced by indomethacin were observed in the stomach of the control group; mucosa hemoIThagic infarct, mucosa cell necrosis, leukocyte appearance, mucosa hemorrhagic erosion and gastric pit disawearance. In the test group, lipid peroxides level was significantly reduced compared with the control group While SOD, catalase and GSH levels considerably increased. The following effects were also observed in the stomach of the test group; mucosa hemorrhagic infarct, mucosa cell necrosis, leukocyte appearance and mucosa hemorrhagic erosion occured far less and gastric pit disappearance was not observed at all. This results suggest that GaMiHyangSaYukGunJaTang is effective in the remedy of gastric mucosal lesions as GaMiHyangSaYukGunJaTang suppresses the production of the lipid peroxides and free radicals induced by indomethacin and activates SOD, catalase and GSH.

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Effects of the Gamihyangsayukgunjatang on Radioprotection and Apoptosis in Small Intestines of Mice (가미향사육군자탕(加味香砂六君子湯)이 생쥐 소장(小腸)에서 방사선조사(放射線照射) 후(後) 보호효과(保護效果)와 Apoptosis에 미치는 영향(影響))

  • Lee, Tae-Eob;Kim, Jin-Sung;Yoon, Sang-Heup;Ryu, Bong-Ha;Park, Dong-Won;Ryu, Ki-Won
    • THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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    • v.6 no.1
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    • pp.1-18
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    • 2000
  • The present study was performed in order to evaluate the effects of the gamihyangsayukgunjatang on radioprotection and apoptosis in small intestines of mice after whole body irradiation. Two hundred forty mice were divided into 40 groups according to the radiation dose and the gamihyangsayukgunjatang treatment. The extracts of the herbal medicines were orally administered to each group differently before and/or after irradiation. The gamihyangsayukgunjatang treated groups were divided into 3 groups. Sample Ⅰ was the group treated with the gamihyangsayukgunjatang for 3 days before the radiation, sample Ⅱ was the group treated with the gamihyangsayukgunjatang for 3 days after the radiation. Sample Ⅲ was the group treated with the gamihyangsayukgunjatang for both 3 days before and after the radiation. To analyze the crypt survival, the micradony survival assay was used according to the Withers and Elind's method. To analyze the apptosis, the TUNEL assay was done. The results obtained are a follows : 1. From the microcolony survival assay, the gamihyangsayukgunjatang treated groups showed the radioprotective effect with a statistical significance(p<0.05), as compared to the control group. Comparing the radioprotective effect among the 3 groups, sample III was statistically more significant than sample I and II (p<0.05). Sample I showed no effect. In accordance with the research mentioned above, it is suggested that the radioprotective effect of the gamihyangsayukgunjatang is more useful for the treatment of the radiation injury rather that the prevention. 2. The results of the TUNEL assay showed that the apoptotic index in the gamihyangsayukgunjatang treated group was slightly decreased with no effectiveness, as compared to the control group. According to the above results, it could be suggested that the gamihyangsayukgujatang has a prominent protective effect in mice intestines against the radiation damage. However, the radioprotective effect does not seem to be related to inhibition of the apoptosis.

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