• Journal of Ginseng Research
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• v.24 no.1
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• pp.8-17
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• 2000

Estrogen can influence on the expression of behaviors not associated directly with reproduction, including learning and memory. Recently estrogen has received considerable attention for its effects on neuroprotection and neural circuits in brain areas associated with cognition. Although estrogen replacement therapy may be helpful to postmenopausal women, it also results in a number of harmful side effects. Ginseng also has steroidal qualities and contains several ginsenoside components which have similar backbone structure to estrogen. The objectives of this experiment were 1) to examine the effects of estrogen and 2) to investigate the effects of ginsenosides as estrogenic agent on learning and memory using the Morris water maze, a traditional experimental task for spatial memory. In the experiments designed here, ovariectomized mice were implanted subcutaneously with Sila, itic capsules containing 17${\beta}$-estradiol (100∼250 $\mu\textrm{g}$/$m\ell$), panaxadiol (PD) and panaxatriol (PT) saponins (15∼100 $\mu\textrm{g}$/$m\ell$) diluted with sesame oil. In the first set of experiment, the effects of estradiol on learning and memory during the Morris water maze was examined. When estradiol was delivered via Silastic capsules following training improved spatial memory performance in ovariectomized female mice. In the second set of experiment, three different PD and PT saponin concentrations were delivered via Silastic implants to ovariectomized female mice and their effects were compared with estrogenic effects. Results of three separate experiments demonstrated that estradiol, PD and PT administrated by Silastic implants for 2 weeks prior to water maze training significantly improved spatial memory performance compared to ovariectomized (OVX) mice, as indicated by lower escape latency over trial. The positive effect of estradiol suggests that estrogen can affect performance on learning and memory. In addition, the positive effect of PD and PT saponins suggest that ginsenosides have an estrogen-like effects in mediating learning and memory related behavior action.

• Proceedings of the Korean Society of Computer Information Conference
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• 2011.06a
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• pp.179-182
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• 2011

본 논문의 정보소외계층 위한 웹 접근성 기법에 관한 연구에서는 웹 접근성(web accessibility)의 세부항목을 준수하는 웹사이트를 구축하여 신체적 장애를 가진 사람이 일반 사람과 동일하게 웹사이트를 편리하고 쉽게 이용할 수 있게 구현하고 운영하였다. 웹 사이트가 웹 접근성 규칙을 준수하여 올바르게 설계되어 개발되고 편집되어 있을 때 모든 사용자들은 정보와 기능에 동등하게 접근할 수 있다. 본 논문에서 실험 사이트로 구축하며 준수한 웹 접근성은 시각에 대하여 실명, 색각 이상, 다양한 형태의 저 시력을 포함한 시각 장애와 이동성에 대하여는 파킨슨병, 근육병, 뇌성마비, 뇌졸중과 같은 조건으로 인한 근육 속도 저하, 근육 제어 손실로 말미암아 손을 쓰기 어렵거나 쓸 수 없는 상태와 청각에 대하여는 귀머거리, 청각 장애와 발작에 대하여는 깜박이는 효과나 시각적인 스트로보스코프를 통해 일어나는 간질성 발작과 인지능력에 대하여는 문제 해결과 논리 능력, 집중력, 기억력에 문제가 있는 정신 지체 및 발달 장애, 학습 장애 (난독증, 난산증 등)에 대한 지침 규정이다.

• The Journal of the Korea Contents Association
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• v.14 no.12
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• pp.854-862
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• 2014

Attention deficit hyperactivity disorder (ADHD) students' intellctual defects, learning problems, and poor academic achievements seem to be due to significantly lower intelligence compared to the normal students, but rather the characteristic of inability to pay attention at a given time can be seen as the more attributing reason. In this study, a comparison between the ADHD students and the normal students will be performed using a fMRI analysis in order to differentiate the brain function between the two groups during a working memory task performance and to assess the difference in the activated regions of the brain. Clinical survey examinations and fMRI measurements were performed for a group of 26 elementary students from the Incheon area. The stimulus of fMRI was a working memory. Cartography statistically analyzed parameters and the Statistical Package of Social Sciences using single-sample t-test, two-sample t-test, were analyzed by multiple regression analysis, the statistical significance level was p<0.05 in, respectively. The disproportionate developments could be seen in the ADHD students group such as the frontal cortex, parietal cortex, thalamus, and caudate nucleus, among others. In addition, as some students felt the increase in the difficulty of working memory task performance, the orbitofrontal cortex and the hippocampus were activated, which seems to be the result of an effort for looking for an answer. More types of ADHD students needs to be secured as research subjects, and more stimulations for fMRI experiments should be considered as it would be useful in the overall evaluation of brain function.

• Journal of Digital Convergence
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• v.13 no.10
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• pp.587-595
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• 2015

The purpose of this study was to demonstrate exploring the field application of combined cognitive-motor learning program based on proprioceptive neuromuscular facilitation and Bartenieff Fundamental program. The combined cognitive-motor learning program(CC) was applied to the 10 MCI elder while 10 elder in occupational therapy(OT) took cognitive learning class. MMSE-K, Time up & go test(TUG), Tandem gait test(TA), GQOL-D were measured and analyzed. The collected data were analyzed by Independent & Paired T-test. The results were as follows: Both groups showed similar learning effect in MMSE-K test. However, in TA & GQOL-D test, CC group showed significant learning effect than OT group. From these result, we conclude that combined cognitive-motor learning program is valuable as alternative program for cognitive development and social development as well as physical development of MCI elder.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.13-17
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• 2009

In this thesis, we made a sheet to improve the concentration of study. To demonstrate the improvement in the concentration of study, we obtained functional magnetic resonance imaging (fMRI), which has superior time resolution and measures brain noninvasively by using intrinsic contrast agent. As a result of Brainwave measurement, we could verify the blood flow's activate in the nearby frontal lobe related to memory process and noticeable ratio change in absolute alpha wave and beta wave after the analysis of Brainwave measurement. fMRI ascertains the physiological function of the brain and is being used to prevent the trouble medically that can be caused before and after the operation. For the visibility of cranial nerve network, many researches will be carried out to develope the product which is related to brain like concentration of study.

• Journal of Music and Human Behavior
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• v.7 no.1
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• pp.1-15
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• 2010

The purpose of this study is to inquire into the theoretical background of music therapy interventions for the improvement of mathematical concepts among young children with special needs. The researcher provides a basis of theoretical background about musical activities as an effective tool for young children to understand and promote their mathematical concepts, and the necessity of practical application in the field of mathematics education is suggested. Music, as a multi-sensory modality, has an ability to hold and maintain one's attention, and can be used as a memory aid and a powerful and effective motivator and reinforcer for young children. Therefore, musical activities can be used to facilitate mathematical concepts in the field of education for young children. Possible musical activities for promoting mathematical development are suggested, and the necessity for developing various musical activities is discussed.

• Korean Journal of Food Science and Technology
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• v.47 no.3
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• pp.380-387
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• 2015

The anti-amnesic effect of Artemisia argyi H against trimethyltin (TMT)-induced learning and memory impairment and its neuroprotective effect against $H_2O_2$-inducedoxidative stress were investigated. Cognitive behavior was examined by Y-maze and passive avoidance test for 4 weeks, which showed improved cognitive functions in mice treated with the extract. In vitro neuroprotective effects against $H_2O_2$-induced oxidative stress were examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium-bromide and lactate dehydrogenase (LDH) assays. A. argyi H. extract showed protective effects against $H_2O_2$-induced neurotoxicity; moreover, LDH release into the medium was inhibited. Finally, high-performance liquid chromatography (HPLC) analysis showed that eupatilin and jaceosidin were the major phenolic compounds in A. argyi H. extract. These results suggest that A. argyi H. could be a good source of functional substances to prevent neurodegenerative diseases.

• Journal of Life Science
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• v.19 no.3
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• pp.317-321
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• 2009

Down syndrome (DS) results from overexpressed genes on an extra copy of human chromosome 21. Among various phenotypes seen in DS patients, mental retardation, such as learning and memory deficits, is a major factor that prevents DS individuals from leading fully independent lives. The Dyrk1A gene that plays a critical role in neurodevelopment has been isolated from chromosome 21, and transgenic mice with over-expression of Dyrk1A show severe hippocampal dependent learning and memory defects. In the present study, as an initial step to test the treatment of Dyrk1A dependent mental retardation phenotypes in model animals, we isolated human Dyrk1A specific lentiviral short hairpin RNA (shRNA) that inhibits the exogenous human Dyrk1A expression, but not the endogenous mouse expression in transgenic mice with human Dyrk1A overexpression. This limited and specific repression of exogenous human Dyrk1A will prove to be valuable information, if Dyrk1A dependent learning and memory defects in DS patients could be treated or at least ameliorated in vivo.

• Journal of Oriental Neuropsychiatry
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• v.10 no.2
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• pp.105-113
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• 1999

The purpose of this study was to investigate the effect of Sunhyangjungkisan on the learning and memory ability in rats. For this purpose we have evoked cerebral dysfunction in rats with NOS inhibitor and then performed the Morris water maze task for each rat. We have found that Sunghyangjungkisan have some improving effedts on impaired learning and memort ability in the NOS inhibitor treated rat. In these improving effects, memory effect was more evident then learning effect. This result implies that Sunghyangjungkisan may be one of useful prescriptions for treatment of vascular dementia after cerebral ischemia.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.10
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• pp.2985-2989
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• 2009

An experiment was conducted to examine the effects of ceramic sheet on concentration of students studies. To demonstrate the improvement in the concentration of study, we obtained functional magnetic resonance imaging (fMRI), which has superior time resolution and measures brain noninvasively by using intrinsic contrast agent. As a result of Brainwave measurement, we could verify the blood flow's activate in the nearby frontal lobe related to memory process and noticeable ratio change in absolute alpha wave and beta wave after the analysis of Brainwave measurement. fMRI ascertains the physiological function of the brain and is being used to prevent the trouble medically that can be caused before and after the operation. For the visibility of cranial nerve network, many researches will be carried out to develope the product which is related to brain like concentration of study.