Browse > Article
http://dx.doi.org/10.9721/KJFST.2015.47.3.380

Anti-amnesic and Neuroprotective Effects of Artemisia argyi H. (Seomae mugwort) Extracts  

Ha, Gi-Jeong (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Lee, Doo Sang (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Seung, Tae Wan (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Park, Chang Hyeon (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Park, Seon Kyeong (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Jin, Dong Eun (Gyeongsangnamdo Agricultural Research and Extension Service)
Kim, Nak-Ku (Gyeongsangnamdo Agricultural Research and Extension Service)
Shin, Hyun-Yul (Gyeongsangnamdo Agricultural Research and Extension Service)
Heo, Ho Jin (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Publication Information
Korean Journal of Food Science and Technology / v.47, no.3, 2015 , pp. 380-387 More about this Journal
Abstract
The anti-amnesic effect of Artemisia argyi H against trimethyltin (TMT)-induced learning and memory impairment and its neuroprotective effect against $H_2O_2$-inducedoxidative stress were investigated. Cognitive behavior was examined by Y-maze and passive avoidance test for 4 weeks, which showed improved cognitive functions in mice treated with the extract. In vitro neuroprotective effects against $H_2O_2$-induced oxidative stress were examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium-bromide and lactate dehydrogenase (LDH) assays. A. argyi H. extract showed protective effects against $H_2O_2$-induced neurotoxicity; moreover, LDH release into the medium was inhibited. Finally, high-performance liquid chromatography (HPLC) analysis showed that eupatilin and jaceosidin were the major phenolic compounds in A. argyi H. extract. These results suggest that A. argyi H. could be a good source of functional substances to prevent neurodegenerative diseases.
Keywords
Artemisia argyi H; Seomae mugwort; trimethyltin; neurodegeneration;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Fridovich I. Biological effects of the superoxide radical. Arch. Biochem. Biophys. 247: 1-11 (1986)   DOI
2 Jeong EJ, Sung SH, Kim JW, Kim SH, Kim YC. Rhus verniciflua stokes attenuates glutamate-induced neurotoxicity in primary cultures of rat cortical cells. Nat. Prod. Sci. 14: 156-160 (2008)
3 Parfenova H, Basuroy S, Bhattacharya S, Techranova D, Qu Y, Regan RF, Leffler CW. Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of $HO-_1$ and $HO-_2$ to cytoprotection. Am. J. Physiol.-Cell. Ph. 290: C1399-C1410 (2006)   DOI
4 Papandreou MA, Dimakopoulou A, Linardaki ZI, Cordopatis P, Klimis-Zacas D, Margarity M, Lamari FN. Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity. Behav. Brain Res. 198: 352-358 (2009)   DOI
5 Lee JS, Jeong BC, Ahn YS, Chung MN, Kim HS. Color stability according to storage period of purple sweetpotato products. Korean J. Crop Sci. 51: 204-208 (2006)
6 Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, Delon MR. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 215: 1237-1239 (1982)   DOI
7 Chung YK, Heo HJ, Kim EK, Kim HK, Huh TL, Lim YH, Kim SK, Shin DH. Inhibitory effect of ursolic acid purified from Origanum majorana L. on the acetylcholinesterase. Mol. Cells 11: 137-143 (2001)
8 Murray IVJ, Sindoni ME, Axelsen PH. Promotion of oxidative lipid membrane damage by amyloid ${\beta}$ proteins. Biochemistry-US. 44: 12606-12613 (2005)   DOI
9 Iciek M, KwiecieI, Wlodek L. Biological properties of garlic and garlic-derived organosulfur compounds. Environ. Mol. Mutagen. 50: 247-265 (2009)   DOI
10 Deng YM, Xie QM, Zhang SJ, Yao HY, Zhang H. Anti-asthmatic effects of perilla seed oil in the guinea pig in vitro and in vivo. Planta Med. 73: 53-58 (2007)   DOI
11 Kim RJ, Kang MJ, Hwang CR, Jung WJ, Shin JH. Antioxidant and cancer cell growth inhibition activity of five different varieties of Artemisia cultivars in Korea. J. Life Sci. 22: 844-851 (2012)   DOI
12 Hwang YK, Kim DC, Hwang WI, Han YB. Inhibitory effect of Artemisia princeps Pampan. Extract on growth of cancer cell lines. J. Nutr. Health 31: 799-808 (1998)
13 Rho TH, Seo GS. Growth characteristics and chemical components in local collections of Artemisia sp. Korean J. Medicinal Crop Sci. 1: 171-177 (1993)
14 Choi SJ, Kim MJ, Heo HJ, Kim JK, Jun WJ, Kim HK, Kim EK, Kim MO, Cho HY, Hwang HJ, Kim YJ, Shin DH. Ameliorative effect of 1,2-benzenedicarboxylic acid dinonyl ester against amyloid ${\beta}$ peptide-induced neurotoxicity. Amyloid 16: 15-24 (2009)   DOI
15 Cho YH, Chiang MH. Essential oil composition and antibacterial activity of Artemisia capillaris, Artemisia argyi, and Artemisia princeps. Korean J. Int. Agric. 13: 313-320 (2001)
16 Kim MJ, Choi SJ, Lim ST, Kim HK, Heo HJ, Kim EK, Jun WJ, Cho HY, Kim YJ, Shin DH. Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice. Biosci. Biotech. Bioch. 71: 1063-1068 (2007)   DOI
17 Ellman GL, Courtney KD, Andres jr V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7: 88-90 (1961)   DOI
18 Kim JK, Choi SJ, Cho HY, Hwang HJ, Kim YJ, Lim ST, Kim CJ, Kim HK, Peterson S, Shin DH. Protective effects of kaempferol (3,4',5,7-tetrahydroxyflavone) against amyloid beta peptide ($A{\beta}$)-induced neurotoxicity in ICR mice. Biosci. Biotech. Bioch. 74: 397-401 (2010)   DOI
19 Heo HJ, Lee CY. Strawberry and its anthocyanins reduce oxidative stress-induced apoptosis in PC12 cells. J. Agr. Food Chem. 53: 1984-1989 (2005)   DOI
20 Heo HJ, Lee CY. Phenolic phytochemicals in cabbage inhibit amyloid ${\beta}$ protein-induced neurotoxicity. LWT-Food Sci. Technol. 39: 331-337 (2006)   DOI
21 Zhao B. Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochem. Res. 34: 630-638 (2009)   DOI
22 Cai M, Phan PTT, Hong JG, Kim DH, Kim JM, Park SJ, Liu X, Han JE, Park H, Choi JW, Ryu JH. The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. Eur. J. Pharmacol. 689: 104-110 (2012)   DOI
23 Wang Q, Lee AY, Choi JM, Lee DG, Kim HY, Lee SH, Cho EJ. In vitro radical scavenging effect and neuroprotective activity from oxidative stress of Petasites japonicus. Kor. J. Pharmacogn. 45: 147-153 (2014)
24 Kim MJ, Han JM, Jin YY, Back MI, Bang MH, Chung HG, Choi MS, Lee KT, Sok DE, Jeong TS. In vitro antioxidant and antiinflammatory activities of jaceosidin from Artemisia princeps Pampanini cv. Sajabal. Arch. Pharm. Res. 31: 429-437 (2008)   DOI