• Journal of the Society of Cosmetic Scientists of Korea
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• v.45 no.1
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• pp.37-47
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• 2019

Recently, due to the increase in skin diseases caused by particulate matter, endocrine disruptor and environmental changes, the trend of development of cosmetic materials has been shifting to the more safe and effective ingredients based on natural materials rather than existing synthetic compounds like steroids and antihistamines. This study aimed to develop a new natural cosmetic materials using oriental herbs such as Eucommiae cortex, Alpinia oxyphylla Miquel and Bombyx batryticatus. First, DPPH assay was performed to examine the antioxidative activity of the herbal extract (Mix) and 98.8% DPPH radical scavenging activity was confirmed at $400{\mu}g/mL$ concentration of it. In order to confirm the whitening efficacy of oriental herbal extracts(mix), the amount of melanin synthesized after stimulation of ${\alpha}-MSH$ with B16F10 cells was measured. Results showed that it was decreased to 27.1% comparing with the only ${\alpha}-MSH$ treated group, which confirmed the whitening efficacy. Also, both nitric oxide(NO) production and iNOS and COX-2 expression were significantly reduced in RAW264.7 macrophages activated by LPS in the presence of the extracts(Mix). The mRNA expression of the inflammatory cytokines such as $IL-1{\alpha}$, $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ was also analyzed to confirm the inhibition effect of the extracts on inflammation. Finally, to confirm the enhancement of skin barrier function, the expression of claudin 1 gene, a tight junction protein, was observed using human keratinocyte HaCaT cells and increased as concentration dependent manner. From these results, it is concluded that the oriental herbal extracts(Mix) containing Eucommiae cortex, Alpinia oxyphylla Miquel and Bombyx batryticatus is effective for antioxidant, anti-inflammation, skin whitening, and skin barrier and thus could be applied as a new natural cosmetic material.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.27 no.2
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• pp.45-56
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• 2001

Korea mountain ginseng known as oriental miracle drug is an important medicinal plant. The effect of mountain ginseng adventitious roots extract has been described. The valuable root of mountain ginseng contained several kinds of ginsenosides that have been confirmed to have many active functions for the human body. However, the study of mountain ginseng has a limit because the price of wild ginseng is very expensive and rare. The mountain ginseng adventitious roots were derived from mountain ginseng callus that were induced from mountain ginseng roots. Adventitious roots were separated from callus and grown in solid media(Murachige and stoog media). It was cultured in a 20L bioreactor. After culturing for 40days, adventitious roots were harvested. Afterwards the harvested mountain ginseng adventitious roots were dryed and extracted. We examined the effect on melanogenesis of mountain ginseng adventitious roots extract. Here, we report the inhibitory effect of melanin biosynthesis on the adventitious roots extract of In vitro test. Also, we assessed the safety of adventitious roots extract. In vitro, cytotoxicity of adventitious roots extract was assessed in mouse fibroblast using two method: The neutral red uptake assay and the MTT assay. In vivo, the allergic and irritant were Patch teated in 30 patients. Consequently, extract of mountain ginseng adventitious roots have inhibitory effect on melanin biosynthesis in B-16 melanoma cell test, tyrosinase inhibitory test and DOPA auto-oxidation test. There were decreased 86%(0.5% concentration), 45%(1% concentration) and 61%(1% concentration), respectively.

• 한국방재학회:학술대회논문집
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• 2011.02a
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• pp.189-189
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• 2011

최근 공동주택은 보편적인 도시주거 유형으로 자리매김 하고 있지만, 성장 위주의 경제 산업 정책에 따른 안전의식미약, 사회구조개편에 따른 급격한 증가, 생활환경 변화와 에너지 사용 증가 등 화재 유발인자의 다양화로 인해 인적 물적 피해가 증가하고 있는 실정이다. 특히 다른 건물들과는 달리 공동주택의 거주자가 유아, 노인, 신체장애자 등 다양한 인적 구성의 형태로 이루어져 있어서 화재 발생 건수에 비해 인명피해가 월등히 높은 편이다. 공동주택에서의 화재에 대한 위험성을 인식하고, 그에 대한 인적 물적 피해를 최소화하기 위한 대책 마련이 시급하다. 본 논문은 CFAST(Consolidated Model of Fire Growth and Smoke Transport)를 사용하여 공동주택을 대상으로 실물 화재 실험을 실시하고 공간화재에서의 화재 성상을 파악하여 화재 시 개구부의 개폐 여부에 따라 발생되는 산소와 이산화탄소의 농도와 온도가 인체에 미치는 영향에 대해 알아본다. 개구부를 개방 했을 경우에 외부창문의 개폐 여부에 상관없이 모든 방의 온도 분포가 뚜렷하게 나타났지만 개구부를 폐쇄 할 경우에는 발화지점인 거실의 온도 분포만 나타났다. Flashover현상과 Back Draft현상은 개구부의 개폐여부에 상관없이 외부 창문을 폐쇄 했을 경우에 나타났지만 특히 모든 개구부와 외부창문을 폐쇄 했을 경우에 더욱 뚜렷하게 나타났다. 각 실은 점화 후 4분경에 최고 온도를 보였으며 다른 방에 비해 발화지점인 거실의 온도가 가장 높게 나타났다. 온도에 의해서는 두 가지 영향이 일어날 수 있는데, 하나는 비교적 장시간에 걸쳐 발생하는 열응력이고, 다른 하나는 짧은 시간에 발생할 수 있는 화상이다. 만약 피부온도가 $45^{\circ}C$에 이르면 인체는 고통을 느끼게 되며, 이보다 더 높은 온도에서는 깊은 피부조직까지 손상을 줄 수 있다. 움직이지 않는 사람에 대한 고통 유발 임계온도는 약 $200^{\circ}C$이며, 인체는 땀의 발산으로 온도에 대한 내성이 증가하지만 이체가 장시간 열을 받으면 사망에 이를 수 있다. 결론적으로 공동 주택을 대상으로 CFAST를 이용해 분석한 결과 플래쉬오버 현상으로 인해 화재가 성장하여 급격히 온도가 상승하다가, 산소 부족으로 인해 화재가 성장하지 않고 온도가 떨어지는 것을 알 수 있다. 화재 시 온도, 산소, 이산화탄소를 고려하였을 때 약 3분 이내에 대피해야 온도 및 가스로 인한 피해를 줄일 수 있을 것으로 판단된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.7 no.1
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• pp.83-86
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• 2004

Food allergy is not uncommon among small children. Cow milk and eggs are most frequently incriminated as the major cause of food allergy. A 4-month-old female infant who did not have a previous history of contact with the egg developed anaphylactic shock when an emulsion of raw egg white was rubbed on the buttock by her mother to relieve erosive diaper dermatitis. She had been fed on breast milk. She had no past medical history of any other allergy and no family history of atopy, asthma or allergic rhinitis. Her IgE PRIST was 29.46 IU/ml and multiple antigen simultaneous testing chemiluminescent assay for food specific IgE antibody showed a level 4 positive value only to egg white.

• Journal of the Society of Disaster Information
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• v.10 no.3
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• pp.374-387
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• 2014

Since the sexual violence crime has a high probability of repeated crime, the electronic monitoring system has been introduced as a measure to it. And this system allows the police to know the location of former criminal around the clock through the electronic device, the former criminal has the psychological/mental oppression which can restrain the intention of crime to a degree. However, there is a limit in blocking criminals with strong will from repeated crime. The next-generation intelligent electronic anklet currently under study collects and analyzes the change bio-data in real time through the location information of electronic monitoring target and attached sensor. This study is aimed to predict the symptom of crime occurrence in advance based on this and block the crime intention in advance or stop the ongoing crime before it is expanded.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.2
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• pp.135-145
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• 2017

Objectives : The study is to investigate clinical trial for efficacy and safety with acupuncture & suction in nasal cavity on snoring patients. Methods : 24 subjects were recruited from the patients received a hospital visit to the Semyung University Chungju oriental medical center and Jaechon oriental medical center from 1 October 2014 to 31 December 2014. According to the clinical protocol, we treated the patients with acupuncture and suction in the nasal cavity 8 times for 4 weeks. We compared their symptoms between before and after treatment. Results and Conclusions : 1. There was no significant decrease in the mechanical measurement of the reduction of snoring in the effectiveness of snoring patients, but there was a significant effect on the improvement of sleep quality and it was effective in improving the symptoms such as eye fatigue. 2. The safety of nasal treatment for snoring patients was normal in pre- and post-treatment Lab tests, and there was no adverse reaction before and after treatment. Acupuncture & suction in nasal cavity on snoring patients is efficient and safe.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.3 s.52
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• pp.237-244
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• 2005

Sunscreens have been in use for about 70years and 'tanning without burning' was propagated as their major advantage. The objective changed from 'getting a tanned skin' to 'getting skin protection' since UV have been proposed to a major risk of skin cancer and the risk of developing skin cancer related also to non-burning UVA. The new expectation from consumers has triggered the development of new UV absorbers and led to the approval of 7 new, organic UV absorbers in Europe over the last few years. The significant progress due to these new UV absorbers will be discussed in this report. These UV absorbers provide an efficient absorption of UV radiation (UVB and/or UVA) and easily incorporate in any kind of formulation. These are also safe, i.e. devoid of adverse effects. These new filters give the formulators new possibilities to cover the whole UV range iron 290 to 400 nm, and also to use less filter due to the boosting effect of the new UVA and broadband fitters.

• Journal of the Korean Institute of Gas
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• v.22 no.6
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• pp.1-7
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• 2018

Currently chemical plant risk have been issued by occurring frequent accidents. Accidents can be generally composed of fire, explosion, release in chemical plant. In case of fire and explosion, accident victims are occurred immediately after accident but release accident, late emergency response cause damage to worker. Especially, there are many victims by late emergency response against chemical exposure to skin. In case of chemical exposure to skin, irreversible damage like death, blindness, burn can be prevented by washing immediately. Safety shower can provide the cleaning for chemical exposure to eye, skin. Most of chemical plants are built in 1980s so equipment become superannuated. In this reason, safety shower also cannot operate normally in emergency situation. Therefor safety shower should be managed by installation and management guideline. This study perform the establishment guideline for safety shower installation and inspection to increase the reliability.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.41 no.6
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• pp.51-60
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• 2004

In this paper, we optimized the PDT laser system to improve the therapy effects of malignancies. In order to optimize, the variation of laser output and specific wavelength shift have to reduced. To improve the PDT therapy clinician require the diverse radiation mode which irradiate the tumor surface. Continuous wave mode that general application may causes tissue thermal damage not only to tumor tissue, but also to normal tissue. In this paper, therefore, we suggested new technique for radiation method to improved PDT effects and prevented to the thermal effects for the tissue. In the experimental we verified the stability of wavelength, laser output stability and proved the reduced thermal effects to the tissue using the pulse & burst radiation modes in vitro.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.1 s.49
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• pp.51-58
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• 2005

Alkyl ethoxy sulfate type surfactants, widely used in commercial cleansers, are easily adsorbed to skin to often cause skin irritation and inflammation if not thoroughly rinsed nut. In order to replace or complement existing surfactants, we screened the existing surfactants through protein denaturation method, cell cytotoxicity assay and human IL-1$\alpha$ assay, etc. Fourteen surfactants have been chosen from among too irritant anionic, cationic and/or zwitter-ionic ones and investigated for cell cytotoxicity in human fibroblast cell lines using monolayer culture with the thirteen commercially available cleansers for sensitive skin. From these results, we selected 5 surfactants and 2 commercial cleansers (names not shown), such as sodium laureth sulfate (anionic), sodium cocoyl isethionate (anionic), sodium lauroamphoacetate (zwitter-ionic), and cocamidopropyl betaine (zwitter-ionic), alkyl polyglycoside (non-ionic). 20 formulations were made out of 5 surfactants and five of them were chosen through a protein denaturation method (lower than 3 M sodium dodecyl sulfate solution ($13.2\%$)), cell cytotoxicity and human patch test. These five selected formulations containing preservatives were compared to two selected commercial cleansers by cell cytotoxicity and human IL-1$\alpha$ ELISA assay using dermal equivalent. Finally, we selected the best formulation. To this formulation, fructan ($3\%$ or $5\%$) or/and portulaca extract ($3\%$ or $5\%$) well known for its anti-inflammatory and moisturizing effects were added and investigated for cell cytotoxicity using dermal equivalent. In cytotoxicity assay using dermal equivalent, two formulations containing $5\%$ fructan and $3\%$ or $5\%$ portulaca extract were less toxic than the others. In cytotoxicity assay and human IL-1$\alpha$ ELISA using 3D culture, the selected formulation containing $5\%$ fructan and $5\%$ portulaca extract showed better efficiency than those of the others and 2 commercial cleansers. As a result, we could develop a low irritant and safe liquid cleanser.