• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.4-4
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• 2021

전 세계는 covid 19의 pandemic 상황이 장기화되면서 화장품 분야의 trend 변화가 일어나고 있다. covid 19의 예방으로 마스크는 생활필수품이 되었고, 행정적으로도 사무공간에서도 마스크를 착용하지 않으면 과태료를 부과하는 상황에 이르렀다. 이로 인하여 장시간 마스크 착용은 필수 불가결한 상황이며, 이로 인하여 얼굴 피부의 장벽기능(barrier function)의 와해로 인하여 피부가 예민해지고 크고 작은 피부의 trouble이 많이 발생하고 있다. 이에 따라 소비자들은 화장품의 선택에 있어 피부 진정과 피부에 자극완화(anti-irritation) 및 안전성(safety)에 대한 것으로 점차적으로 변화하고 있다. Covid 19 이전의 화장품 소재 및 제품 개발의 트렌드는 국내의 기능성화장품 범주에 있는 미백 관련, 주름관련, 자외선 차단관련, 염모관련, 육모 탈모 관련, 여드름관련, 피부장벽관련, 튼살 관련 기능성 소재 및 제품 개발과 화장품 용도외의 고기능성 부여를 위한 코스메슈티컬(cosmeceutical)용 제품의 개발이 중요한 시기였다. 코스메슈티컬(cosmeceutical)은 화장품(cosmetic)과 의약품(pharmaceutical)의 합성어이다. 그러나 최근 Covid 19의 상황에 따라 화장품 업계는 포스트 코로나의 트렌드로 피부 장벽기능 강화, 피부노화 억제, 식물성, 자극완화, 비건, 안전성 확보에 대한 다양한 천연 소재의 연구와 제품을 개발 출시하고 있다. 따라서, 2020년 Covid 19의 상황에 따른 화장품 분야의 천연 신소재 및 화장품 개발 방향에 대하여 자원 식물의 활용성 및 개발 동향에 대하여 논의 하고자한다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.1
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• pp.78-95
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• 2023

목적 : 마이크로니들 패치는 피부장벽의 주요 구성성분인 각질층을 관통할 수 있어 일반적인 경피를 통한 약물 전달 수단보다 더 효율적으로 약물을 전달할 수 있다는 장점이 있어 다양한 분야에서 응용되고 있다. 본 임상연구는 아토피피부염 환자의 피부 건조 증상에 대하여 용해성 히알루론산 마이크로니들 패치와 외용제를 병행하여 용해성 마이크로니들 패치의 유효성과 안전성을 평가하였다. 방법 : 본 연구는 단일 기관, 연구자 주도, 평가자 눈가림, 인체 분할 연구로 설계된 무작위 배정 임상시험으로, 피부건조 증상이 있는 아토피피부염 환자 20명을 대상으로 임상연구를 수행하였다. 한 명의 피험자에서 2곳의 시험 병변을 선택한 후, 무작위 배정으로 각각 시험 병변과 대조 병변을 결정하여 2주 동안 매일 양측 병변에 모두 아로마 크림을 도포한 다음, 시험 병변에만 용해성 히알루론산 마이크로니들 패치를 추가로 부착하였다. 결과 : 1차 유효성 평가지표인 local scoring atopic dermatitis(L-SCORAD) index는 치료 후에 시험 병변이 대조 병변보다 유의성 있게 호전되었다. 2차 유효성 평가지표 중 피부 건조감 VAS와 피부 수분 함유량도 시험 병변이 대조 병변보다 유의성 있는 개선을 보였다. Investigator's Global Assessment scale, 소양감 VAS, 경피수분손실량에 있어서는 시험 병변과 대조 병변 모두 치료 후에 유의성 있게 호전되었으나, 두 병변 간의 차이에는 유의성이 없었다. 이상 반응은 나타나지 않았으므로 안전성도 확인되었다. 결론 : 용해성 히알루론산 마이크로니들 패치와 외용제 병행치료는 외용제만 사용하였을 때보다 L-SCORAD index 및 피부 건조감 VAS, 피부 수분 함유량에 있어서 아토피피부염의 증상을 유의성 있게 개선시켰다.

• Journal of Convergence for Information Technology
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• v.11 no.8
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• pp.212-223
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• 2021

This study has purposes : evaluating how safe the skin is when applied with the Spicules-containing cosmetic, and whether Diamond-spicules is permeated into the skin and showed the efficacy of the active ingredients well. For these aims, women in their 30s and 60s were surveyed for skin irritation and changes after applying cosmetics to their skin for four weeks. As a result, Spicules-containing cosmetics were safer on the skin than general functional cosmetics, and in particular, in the case of cosmetics containing Diamond-spicules, statistically significant results (p<.001) were obtained in improvement of anti-wrinkle, firmness, moisturizing, whitening, alleviation of inflammation, and sensitivity. Thus, It has been proved Diamond-spicules containing functional active ingredients, not only as transdermal delivery system, but also can be used as multifunctional cosmetic material.

• Journal of the Korean Applied Science and Technology
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• v.40 no.3
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• pp.453-461
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• 2023

This study was to verify the skin safety of Coptis Japonica extract(CJE) -containing cosmetics by patching them on sensitive skin and checking its stimulating level. 32 subjects diagnosed with sensitive skin by the result of the lactic acid injury test, were subjected to 20 ㎕ of solubilized essence mixed with 2% CJE on the test subjects' back and closed patched for 24 hours. No stimulus reactions were found by bare eyes and scored 0 stimulus figure points after they were taken off in 30 minutes, 24 hours, and 48 hours. Coptis japonica's medical efficacies such as antioxidant, and anti-inflammatory are expectable to be used as functional cosmetics, and this research would be the foundation of further research into its cosmetical usage.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.29 no.1
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• pp.169-184
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• 2003

비타민 C(L-ascorbic acid)는 강한 항산화성, 피부에 대한 높은 안전성으로 인해 피부의 노화방지, 미백, 주름 개선 등의 기능성 화장품 원료로써 많은 관심이 있는 물질이지만, 화학적으로 매우 불안정하여 쉽게 산화, 분해되므로 화장품 제형으로 포함시키는데 곤란한 문제가 있다. 본 연구에서는 비타민 C 의 안정성에 대한 단점을 보완하기 위하여 생체 및 피부 친화성이 우수한 무기물을 사용하여 비타민 C 를 캡슐화(encapsulation)한 분말상의 유-무기 복합물질 Vitabrid-C 를 합성하고, 이를 함유하는 피부 미백용 트윈케익 파우더를 개발하였다. 우선 Vitabrid-C 는 수용액상에서 비타민 C 를 수화된 산화아연(ZnO)으로 1 차 캡슐화하여 나노입자를 형성시키고, 그 표면을 실리카(silica)나노 입자로 한번 더 코팅하여 표면의 껍질이 다공특성을 갖는 분말을 제조함으로써 완성하였다. 이렇게 제조된 Vitabrid-C는 순수 비타민 C 에 비해 우수한 안정성을 보였으며, 캡슐 내 비타민 C 가 서서히 방출되는 서방특성을 발휘하였다. 또한 Vitabrid-C는 입자의 크기가 미세하고 균일하여 트윈케익 처방에 용이하게 적용할 수 있었다. Vitabrid-C와 순수 비타민 C의 생화학적 동등성에 대한 평가는 tyrosinase 억제능(L-DOPA oxidase 억제) 및 DPPH항산화 실험을 통하여 비교하였다. 트윈 케익 처방에 적용된 Vitabrid-C 에서 비타민 C 의 피부 투과경향을 Franz diffusion cell 법을 이용하여 확인하였다 또한 Vitabrid-C가 포함된 트윈케익을 건강한 피부를 가진 25 세 이상되는 여성의 전박에 색소 침착을 유도한 후 피부색 개선 효과 평가를 통해 임상적 효능을 평가하였다.

• Journal of Naturopathy
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• v.11 no.1
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• pp.31-38
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• 2022

Background: New beauty soaps are always subject to evaluation. Purposes: This study performed a human application test and safety evaluation on the cleaning effect of the fine dust mimic of the test product, Daziwar soap bar, on 52 women. Methods: The quantitative change measured the cleaning effect of fine dust before and after washing immediately after spraying the fine mimetic dust on the forearm of 22 women. In addition, the safety was evaluated at 30 minutes, 24 hours, and 48 hours after 24 hours after applying the patch to the woman's back. Results: After one time washing with the soap immediately after spraying dust on the inside of the arm, the amount of the remaining mimetic was statistically significantly decreased in both the test group and the control group (p < .001). However, the washing rate was 99.96% in the experimental group and 75.58% in the control group. The questionnaire was evaluated as 'Good' or higher in terms of efficacy. In the evaluating of adverse reactions after washing fine dust by a dermatologist, there were no reports or observations of specific skin adverse reactions or abnormal findings in the subjects. The safety evaluation was judged as non-irritating in the skin reaction evaluation at 30 minutes, 24 hours, and 48 hours after instillation on the back for 24 hours. Conclusions: The test product, Daziwar soap, was found to be very helpful in cleaning fine dust on the human body and was found to be safe for the human body.

• Journal of Food Hygiene and Safety
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• v.27 no.2
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• pp.188-193
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• 2012

This study was designed to evaluate to acute oral toxicity and skin irritation of Chrysanthemum dye in Sprague-Dawley (SD) rats. SD rats were orally treated with Chrysanthemum dye at a dose of 0, 1 and 2 ml/kg body weight. After oral administration, the rats were observed for 14days. In primary skin irritation test, SD rats were dermally treated with Chrysanthemum dye and observed for 3 days. To ensure the safety of Chrysanthemum dye such as the following were observed and tested. We examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the histopathological test, the mortality and skin irritation. As a result, no significant differences were found in body weight, feed intake and histopathological test between control and Chrysanthemum dye treated group. In the result of skin irritation test, Chrysanthemum dye did not induce erythema and edema after topical application. Primary irritation index was "0" in the test. Therefore, it is suggested that Chrysanthemum dye has no effect on acute toxicity and side effect in SD rats and is non-irritant material based on the score "0" of primary irritation index.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.1
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• pp.421-424
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• 2016

This study evaluated the efficacy and the skin safety and stability of a cosmetic that is an applied water extract and fermented hydrolysate of abalone (Haliotis discus hannai Ino), which was produced at the south coast of Korea. In the patch test, purified water, 1,3-butylene glycol and liquid crystal lotion were used as the reference group, and water extract and fermented hydrolysate of abalone and lotion formulation of water extract and fermented hydrolysate of abalone were used as the sample group. The results of patch test showed no irritation on skin among in any of the test groups. Therefore, the water extract and fermented hydrolysate of abalone (Haliotis discus hannai Ino) are safe for human skin.

• Journal of the Korea Convergence Society
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• v.13 no.3
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• pp.105-111
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• 2022

It was to test the stimulability of cosmetic which contains scalp extracted Leuconostoc mesenteroides when it's patched to skin and to investigate safety when it's used as skincare products. Scalp toner that contains L. mesenteroides extracts 1%, and PEG-60 Hydrogenated Castor Oil 0.6% was made and also scalp lotion containing L. mesenteroides extract 3%, Glyceryl Stearate 0.7%. Through the stimulant test of each toner and lotion by patch-testing 32 and 33 participants' backs, safety was verified by the result. Considering the result of antioxidant, anti-allergic, and anti-inflammatory properties of L. mesenteroids reported in previous studies, cosmetics containing these are safe for skin at low concentrations and worth for furthur research as non-stimmulative when used at other cosmetics.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.3 s.52
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• pp.245-251
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• 2005

Safety is one of the key issue in the regulation of cosmetics. Cosmetic Act deals with it in Korea. The guidance for the testing cosmetic ingredients and their safety evaluation are prepared by Korea Food and Drug Administration. Ultraviolet radiation could Induce skin damage, edema, erythema, photoaging, immune dysfunction and skin cancer. Ultraviolet radiation is classified as Group 2A(probably carcinogenic to humans) by International Agenry for Reaserch on Cancer(IARC). The in vitro methodologies for evaluating the toxic potential of ingredients reported in the literature have not yet been sufficiently validated for use in areas other than the study for mutagenicity/genotoxicity, for pre-screening for severe irritancy, for screening of phototoxicity and for evaluating the percutaneous absorption. The 3T3 neutral red uptake photoxicity test (3T3 NRU PT) was accepted as OECD toxicity guideline in 2002. The 3T3 NRU PT is an in vitro method based on a comparison of the cytotoxicitv of a chemical when tested in the presence and in the absence of exposure to a non-cytotoxic dose of UVA/visible light.