Browse > Article

Evaluation of Phototoxicity for Cosmetics and Alternative Method  

Lee, Jong-Kwon (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration)
Sin, Ji-Soon (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration)
Kim, Jin-Ho (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration)
Eom, Jun-Ho (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration)
Kim, Hyung-Soo (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration)
Park, Kui-Lea (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.31, no.3, 2005 , pp. 245-251 More about this Journal
Abstract
Safety is one of the key issue in the regulation of cosmetics. Cosmetic Act deals with it in Korea. The guidance for the testing cosmetic ingredients and their safety evaluation are prepared by Korea Food and Drug Administration. Ultraviolet radiation could Induce skin damage, edema, erythema, photoaging, immune dysfunction and skin cancer. Ultraviolet radiation is classified as Group 2A(probably carcinogenic to humans) by International Agenry for Reaserch on Cancer(IARC). The in vitro methodologies for evaluating the toxic potential of ingredients reported in the literature have not yet been sufficiently validated for use in areas other than the study for mutagenicity/genotoxicity, for pre-screening for severe irritancy, for screening of phototoxicity and for evaluating the percutaneous absorption. The 3T3 neutral red uptake photoxicity test (3T3 NRU PT) was accepted as OECD toxicity guideline in 2002. The 3T3 NRU PT is an in vitro method based on a comparison of the cytotoxicitv of a chemical when tested in the presence and in the absence of exposure to a non-cytotoxic dose of UVA/visible light.
Keywords
ultraviolet irradiation; safety; 3T3 NRU PT;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 European Council Directive 76/778/EEC, Directive 2003/15/EC of European Parliament and the Council
2 기능성화장품안전성관리사업보고서, 3, 131 (2003)
3 J. K. Lee, E. H. Lee, and S. H. Lee, Comparison of sensitivity between Balb/c 3T3 cell and HaCaT cell by NRU assay to predict skin phototoxicity potential, J. Taxieal. Pub. Health, 18(3), 227 (2002)
4 OECD, OECD Guidelines for the testing of chemicals, In vitro corrosion: Human skin model test 431, OECD Publications service, Paris (2004)
5 OECD, OECD Guidelines for the testing of chemicals, In vitro corrosion: Transcutaneous electrical resistance test (TER) 430, OECD Publications service, Paris (2004)
6 식약청고시 2004-80호 기능성화장품등의 심사에 관한규정 (2004)
7 J. K Lee, J. H. Kim, K. T. Nam, and S. H. Lee, Molecular events associated with apoptosis and proliferation induced by ultraviolet-B radiation in the skin of hairless mice, J. Dermatoi. Sci., 32, 171 (2003)   DOI   ScienceOn
8 V. O. Melnikova and H. N. Ananthaswamy, Cellular and molecular events leading to the development of skin cancer, Mutation Res., 571, 91 (2005)   DOI
9 L. Daya-Grosjean and A. Saraisn, The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors, Mutation Res., 571, 43 (2005)   DOI   ScienceOn
10 S. E. Ullrich, Mechanism underlying UV-induced immune suppression, Mutation Res., 571, 185 (2005)   DOI   ScienceOn
11 화장품안전성관리사업보고서, 2, 135 (2002)
12 M. Ichihashi, M. Ueda, A. Budiyanto, T. Bito, M. Oka, M. Fukunaga, K. Tsuru, and T. Hotikawa, UV-induced skin damage, Toxicology, 189, 21 (2003)   DOI   ScienceOn
13 OECD, OECD Guidelines for the testing of chemicals, skin absorption : In vitro method 428, OECD Publications service, Paris (2004)
14 OECD, OECD Guidelines for the testing of chemicals, In vitro 3T3 NRU phototoxicity test 432, OECD Publications service, Paris (2004)
15 Y. Matsumaura and H. N. Ananthaswamy, Shortterm and long-term cellular and molecular events following UV irradiation of skin: implications for molecular medicine, Expert Rev. Mol. Med., 2, 1 (2002)   DOI   ScienceOn
16 OECD, OECD Guidelines for the testing of chemicals, skin sensitisation local lymph node assay 429, OECD Publications service, Paris (2004)