• The Journal of the Convergence on Culture Technology
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• v.3 no.1
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• pp.43-48
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• 2017

We are confirmed to the variation of the transfer condition and the functional penetration by the permitted conversion energy on the skin. The given conversion energy is consist of the flow level of penetration control and go to the processing transfer in the skin that is to create the modeling for algorithm. The energy level of control processing was achieved effectively modeling system that was the composition of auto and local control level in the epidermis-dermis layer. Their penetration pulse control system was consisted of conversion energy with reference of fixing situation and recreation of designed apparatus for the energy control function that was converted to capacity by the size, form and combination. Also, the system was shown accurately distribution of conversion at the depth of skin correction. Therefore, conversion modeling was established effectively to separate the division parts for conversion system. We will be possible to progress the improvement effectiveness of the skin and to consist of the continuous penetration control system for functional energy on the skin.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.3 s.52
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• pp.227-235
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• 2005

Skin aging is not a disease nor an abnormal phenomenon but a collection of degenerative changes with age, characterized by skin dryness, wrinkle formation, and loss of skin elasticity. The skin wrinkles are caused by either genetically predisposed factors or environmental factors such as UV irradiation or physical/chemical stimulus. The histological manifestations of wrinkles are changes in both amount and integrity of elastic and collagen fibers. Here we report the isolation and characterization of 3 active compounds, prangenidin, 8-hydroxybergapten, and xanthotoxol from Angelica dahurica root. The anti-wrinkle activities of these compounds were also investigated.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.141.2-141.2
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• 2016

디스플레이, 센서 등 전자소자는 소형화 단계를 지나 인체 부착형 소자로의 발전을 요구하고 있다. 인체 부착을 위해서는 민감한 피부에 장시간 부착시 무해성과 탈부착의 자유로움이 요구되기에 기존의 화학물질을 활용한 접착 방식에서 개코도마뱀 또는 딱정벌레 발바닥에서 영감을 얻은 자연모사형 건식 접착 방식에 대한 연구가 활발하게 진행되고 있다. 폴리머를 이용하여 자연모사형 마이크로/나노구조 형성은 기계적으로 가공된 금형 몰딩과 후처리를 통한 매우 복잡한 공정이 요구된다. 본 연구에서는 이러한 복잡한 공정을 단순화하기 위해서 폴리머 소재에 플라즈마를 활용한 나노구조를 형성하는 방법을 소개하고자 하며, 건식 접착용 폴리머 소재(PMMA, PDMS)에 따른 표면구조 변화와 표면에너지 변화에 대한 연구를 수행하였다. 플라즈마 표면처리를 위해서 본 연구실에서 자체 개발한 선형이온소스를 활용하였으며 입사에너지, 노출시간, 사용가스에 따른 표면형상 변화를 주사전자현미경을 활용하여 관찰하였다. 또한 처리조건에 따른 표면에너지 변화를 확인하기 위해 물접촉각 변화를 측정하였다. PMMA는 입사에너지, 노출시간이 증가함에 따라 쉽게 나노기둥구조가 형성되었으나, 과도한 입사에너지 또는 노출시간에서는 표면구조가 에칭되면서 무너지는 것이 관찰되었다. 또한 PDMS는 동일한 조건에서 주름구조 형태를 보였으며 노출시간이 증가할수록 주름구조의 간격이 늘어남을 확인하였다. 본 연구 결과를 통해 나노 구조를 쉽게 제어할 수 있는 PMMA가 피부 부착형 접착 패치에 응용이 가능할 것으로 기대된다.

• Applied Microscopy
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• v.31 no.1
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• pp.37-47
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• 2001

In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total burn surface area $20\sim25\%$) except for inhalated injury. At 5 and 24 h after scald burn, biochemical assay and morphological changes in serum and liver tissue were examined. Skin burn increased liver weight (% of body weight, p<0.05) and the activity of serum aniline amino-transferase (ALT, p<0.05), in addition, the activity of xanthine oxidase (XO), an enzyme of oxygen free radical generating system, was elevated (p<0.01) in serum, but not in skin and in liver. Postburn treatment of allopurinol intraperitoneally decreased liver weight, serum ALT activity and serum XO activity. Scald burn induced ultrastructurally swelling of endoplasmic reticulum, ribosome detachment, accumulation of lipid, dilatation of bile canaliculi and intercellular space, neutrophil infiltration, activation of Kupffer's cells and degeneration of hepatocytic microvilli. Futhermore , thermal injury decreased not only the protein concentration in plasma but also the number of intravascular leukocytes, that indicates induction of edema formation with protein exudation and inflammation by neutrophil infiltration into the internal organs. However allopurinol injection after burn inhibited post burn ultrastructural changes. These data suggest that acute dermal scald burn injury leads to liver damage, that is related to elevation of xanthine oxidase activity in serum. Xanthine oxidase may be a key role in the pathogenesis of liver damage induced by skin burn.

• Korean Journal of Ichthyology
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• v.23 no.1
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• pp.70-74
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• 2011

During the winter, the rice field-dwelling muddy loach Misgurnus mizolepis is buried in burrows constructed of mud and are subjected to exposure to air at times of shortage of water. To investigate the environmental factors that lead to changes of the skin mucus cells of the muddy loach in rice fields, we carried out an experiment where we artificially exposure the fish to air, duplicating as close as possible winter conditions in nature. During the summer, a water tank containing M. mizolepis was filled with mud, and the water was allowed to evaporate. After a month of evaporation, the loach constructed burrows similar to those in a winter rice field. The epidermis in the experimental fish was mostly occupied by large elongated mucus cells, whose numbers drastically increased in all observed regions of the dorsum, lateral region, and the occiput. Such features are typically seen in fishes in wild habitats during the winter season.

• Korean Journal of Ichthyology
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• v.22 no.4
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• pp.230-237
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• 2010

Histological observation on the seasonal variation of mucus cells of the mud loach Misgurnus mizolepis inhabiting a natural stream was carried out on three skin regions (dorsal, lateral and occiput) from March 2008 to February 2009. Our results showed no differences in general morphology by season, but the mucus cells of the epidermis showed significant seasonal change in their size and number as the water temperature changed. The ratio of surface area of the mucus cell layer and mucus cells, and the number of mucus cells in surface area of the epidermis were the greatest in the cold winter and the least in the hot summer in all regions of the epidermis. In particular, the occiput seemed to be a very sensitive region in response to environmental change, showing wide fluctuations in the size of mucus cells throughout the year and a great change in between seasons, especially from late autumn to early winter when the temperature decreased. As the temperature became colder, a small and spherical-shaped mucus cell was transformed into a large and elongated columnar form with a lot of secreted mucus material in a superficial layer of the epidermis. From our results, we can safely surmise that cold temperature is an important environmental factor having a close relationship with the modification of mucus cells of M. mizolepis in winter.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.1
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• pp.135-140
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• 2004

Anti-skin aging agent could be have an inhibition effect of ROS production as well as fragmentation and change of collagen cross linkage in collagen molecule. For the monitoring of lipid peroxidation and collagen degradation, the skin of young and old rats were incised and observed 7 days. In the result, the wound closure was observed in the skin from 10 of 11 young rats and in 8 of 11 old rats. And the longer wound length but shorter wound closure, weaker collagen density and thicker epidermis were observed in old rats than in young rats. The level of hydroxyproline as a parameter of collagen synthesis and MDA as a parameter of lipid peroxidation was lower in old group than in young group. The cyst and lacuna between collagen bundle and fibroblast were observed in old rats in contrast to young rats. So that we propose that MDA and hydroxyproline could be used for monitoring of anti-skin aging agent.

• Journal of the Korean Applied Science and Technology
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• v.29 no.2
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• pp.286-294
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• 2012

This study is a review paper on powders for makeup cosmetics. They play the roles of the camouflage of skin defect, UV screening, skin adhesion, makeup sustainability, and skin protection. This function is endowed on the powders by shape control, surface treatment, and encapsulation. The future powders are expected to be evolved into the smart model responding to the environmental change.

• Korean Journal of Food Science and Technology
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• v.40 no.4
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• pp.436-442
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• 2008

Hydroxyproline and Pro-Hyp dipeptide are the digestive products of collagen hydrolysate called collagen peptide. Some suggested that collagen peptides could improve aged or damaged skins, however, the effects of collagen peptides on the skin have not been known. In this study, we investigated the effects of digestive products of collagen peptides, hydroxyproline and Pro-Hyp dipeptide on skin quality using the UV-damaged dorsal skin of hairless mouse as a model system. Female SKH hairless mice were pre-irradiated with UV for 7 weeks, and then hydroxyproline, Pro-Hyp dipeptide were orally administered for 7 weeks with UV irradiation. Wrinkle formation (by replica image), skin elasticity, barrier status (by TEWL, transepidermal water loss), epidermis thickness, and biophysical changes in the stratum comeum (by hematoxylin & eosin staining) were examined. With the oral peptide treatment, effects such as skin barrier maintenance, anti-skin thickening, and recovery of the stratum corneum were observed. These results indicate that oral intake of collagen peptides may have beneficial effects on damaged skin cells.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2009.11a
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• pp.236-238
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• 2009

에너지 절약차원에서 냉방을 줄여 지구온난화 방지에 일조하고자 여름철에 가벼운 차림의 의복을 권장하는 쿨비즈 캠페인이 시작되었으나 이의 정량적인 효과를 분석하는 연구가 미흡하였다. 본 연구에서는 여름철 온실가스 줄이기 및 직장인 등의 건강증진 등을 위하여 기후복장 적응형에 대한 범국민 인식 및 실천 필요를 바탕으로, 실험을 통해 쿨비즈에 의한 생리적 반응 측정 및 주관적 감각평가를 실시하였다. 1 차실험은 두 복장(전통의복,기후의복)의 피부온 측정실험으로, 환경온 25, $27^{\circ}C$, 상대습도 50% RH 에서 20 대 성인남성 4 명을 대상으로 실험을 하였다. 피험자는 심신을 안정할 수 있도록 30 분간의 안정기를 가진 후에 60 분 동안 실험을 하였으며, 사무실 내 작업환경과 같은 분위기 조성을 위해 편안하게 의자에 앉아 가벼운 대화나 컴퓨터 워드작업 및 설문을 응할 수 있도록 피험자 앞 책상 위에는 노트북을 설치해 두었고, 실험 진행기간 동안 피부온, 직장온, 습도, 발한량, 열화상 카메라, 온열감, 습윤감, 쾌적감 등과 같은 주관적 감각을 측정하였다. 2 차 실험은 동일 피부온 발현하는 환경온 찾기로 기준온도($27^{\circ}C$)에서 전통복장을 입고 온도를 점진적으로 하강시키면서 $27^{\circ}C$ 기후 복장을 입은 상태의 피부온도와 동일해지는 실내온도를 측정한다. 착의 형태에 따른 피부온도 변화에서 환경온도 $25^{\circ}C$ 전통의복 기후의복에 의한 피부온도의 차이는 전통의복이 최소 0.3~최대 $1.6^{\circ}C$ 더 높게 나타났으며, 환경온도 $27^{\circ}C$에서 전통의복 기후의복에 의한 피부온도의 차이는 대체적으로 전통의복이 최소 0.4~최대 $1.0^{\circ}C$ 더 높게 나타났다. 주관적 감각평가에서도 기후의복보다 전통의복에서 온열감 습윤감 불쾌감이 더 높은 경향을 보였다. 주관적 감각으로는 $25^{\circ}C$ 전통의복과 $27^{\circ}C$ 기후의복에서 중립적인 느낌을 나타냈다.