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Quantitative Changes of Collagen and Malonedialdehyde as the Parameters of Skin Alteration  

김기영 (원광대학교 의과대학 병리학교실)
이재형 (원광보건대학 물리치료학)
진주영 (원광대학교 한의학전문대학)
양시용 (원광대학교 한의학전문대학원)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.30, no.1, 2004 , pp. 135-140 More about this Journal
Abstract
Anti-skin aging agent could be have an inhibition effect of ROS production as well as fragmentation and change of collagen cross linkage in collagen molecule. For the monitoring of lipid peroxidation and collagen degradation, the skin of young and old rats were incised and observed 7 days. In the result, the wound closure was observed in the skin from 10 of 11 young rats and in 8 of 11 old rats. And the longer wound length but shorter wound closure, weaker collagen density and thicker epidermis were observed in old rats than in young rats. The level of hydroxyproline as a parameter of collagen synthesis and MDA as a parameter of lipid peroxidation was lower in old group than in young group. The cyst and lacuna between collagen bundle and fibroblast were observed in old rats in contrast to young rats. So that we propose that MDA and hydroxyproline could be used for monitoring of anti-skin aging agent.
Keywords
alteration; antioxidant; malonedialdehyde; collagen; hydroxyproline;
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Times Cited By KSCI : 4  (Citation Analysis)
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