• 건강소식
• /
• v.30 no.9 s.334
• /
• pp.6-11
• /
• 2006

건강하고 깨끗한 피부, 주름 없는 피부를 간직하고 살 수 있는 비결은 피부를 어떻게 고나리하느냐에 달려있다. 이제까지 우리는 피부 노화가 단지 나이라는 어쩔 수 없는 현상이라고만 생각한 채 체념해 왔지만 피부 노화의 주된 요인은 가는 세월이 아니라 햇빛(자외선)과 피부에 대한 무관심이라 할 수 있다. 건강도 건강할 때 지키라는 말이 있듯이 피부도 젊었을 때 더 늙지 않도록 관리하면 나이보다 훨씬 젊은 얼굴로 살아갈 수 있다. 이번 9월호 특집에서는 S&Y피부과 여운철 원장과 경희의료원 피부과 이무형 교수의 도움말로 '피부 노화'에 대해 자세히 알아 본다.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.31 no.2 s.51
• /
• pp.147-152
• /
• 2005

As a part of searching tot the natural components which inhibit the skin aging and wrinkle formation, the $80\%$ methanolie extracts of 121 species of traditional herbal medicines used to treat lung and skin disease were investigated for their in vitro anti-oxidative activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide radicals, and inhibitory activity against elastase. We selected 9 kinds of the traditional herbal medicines showing inhibitory activities of winkle formation. The effective concentrations of 9 candidates for anti-wrinke/skin firming activity was less than 0.1 mg/mL, and there is no toxicity to cell viability at these concentrations. Through analysis of human skin primary patch test data, the traditional herbal medicines represented non-irritant materials. We suggest that these 9 candidates with ability to help anti-wrinkle/skin firming may be useful for functional cosmetic materials.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.47 no.4
• /
• pp.341-352
• /
• 2021

Acerola is an excellent ingredient because of its high natural vitamin C content, but it is difficult to stabilize and has hardly been studied as a cosmetic material. Therefore, this study developed a mixed liposome preparation for stabilizing acerola extract. As a safety test, the skin irritation test was evaluated by BCOP assay and HET-CAM assay. We evaluated the inhibition of tyrosinase activity, the whitening effect of melanin production, and the wrinkle effect of prochloragentype-I C-peptide production, and confirmed the possibility of functional cosmetics. In addition, a cream of liposomes containing acerola extract mixture was developed to evaluate the clinical studies of skin wrinkles and whitening. BCOP assay, HET-CAM assay and human skin primary irritation test results of liposomes containing acerola extract mixture showed no irritation and were safe from skin and eye. The result of tyrosinase activity by 75.8% at 1,000 ㎍/mL. As a result of the melanogenesis inhibition test, liposome with acerola extract showed the melanin content by 46.2% at 1,000 ㎍/mL that does not effect the viability of the B16F10 cell line. The result of collagen production test using ELISA kit, liposomes containing acerola extract mixture showed collagen synthesis ability by 152.1% at 1,000 ㎍/mL that does not affect the viability of the HS68 cell line. But it did not showed any inhibition of collagenase (MMP-1) activity at all concentrations in the MMP-1 activity inhibition test in the HS68 cell line. We performed clinical studies for the whitening and skin-wrinkle activity of cream containing acerola extract mixes liposome, was showed that the melanin contents and wrinkle was statistically significant reduction. These results suggest that liposomes containing acerola extract mixture have safe natural material, and skin wrinkle, whitening effects allowing their application in cosmetics as a natural product.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.31 no.3 s.52
• /
• pp.227-235
• /
• 2005

Skin aging is not a disease nor an abnormal phenomenon but a collection of degenerative changes with age, characterized by skin dryness, wrinkle formation, and loss of skin elasticity. The skin wrinkles are caused by either genetically predisposed factors or environmental factors such as UV irradiation or physical/chemical stimulus. The histological manifestations of wrinkles are changes in both amount and integrity of elastic and collagen fibers. Here we report the isolation and characterization of 3 active compounds, prangenidin, 8-hydroxybergapten, and xanthotoxol from Angelica dahurica root. The anti-wrinkle activities of these compounds were also investigated.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.31 no.3 s.52
• /
• pp.213-218
• /
• 2005

Recently, with the remarkable increase in elderly persons and improvement of skin care technique, the requirements of customer for anti-aging care have become very important. Also, after cosmeceutical-product law was done in 2001, the major interesting field in cosmetic industry has been focused to developing anti-aging materials having safety and efficacy by basic science. In this review, we ill introduce the trend of anti-aging research and materials to prevent wrinkle or improve elasticity of skin.

• Korean Journal of Food Science and Technology
• /
• v.40 no.4
• /
• pp.436-442
• /
• 2008

Hydroxyproline and Pro-Hyp dipeptide are the digestive products of collagen hydrolysate called collagen peptide. Some suggested that collagen peptides could improve aged or damaged skins, however, the effects of collagen peptides on the skin have not been known. In this study, we investigated the effects of digestive products of collagen peptides, hydroxyproline and Pro-Hyp dipeptide on skin quality using the UV-damaged dorsal skin of hairless mouse as a model system. Female SKH hairless mice were pre-irradiated with UV for 7 weeks, and then hydroxyproline, Pro-Hyp dipeptide were orally administered for 7 weeks with UV irradiation. Wrinkle formation (by replica image), skin elasticity, barrier status (by TEWL, transepidermal water loss), epidermis thickness, and biophysical changes in the stratum comeum (by hematoxylin & eosin staining) were examined. With the oral peptide treatment, effects such as skin barrier maintenance, anti-skin thickening, and recovery of the stratum corneum were observed. These results indicate that oral intake of collagen peptides may have beneficial effects on damaged skin cells.

• The Journal of the Convergence on Culture Technology
• /
• v.4 no.3
• /
• pp.197-207
• /
• 2018

The radish skin and radish greens (mucheong) are an edible part of the radish. But they are removed before eating the radish and used as a byproduct or an animal feed material because of their tough and rough texture. This study was conducted to investigate the effect of supercritical heat-treated radish-extract on UV-induced Hos: HRM-2 wrinkled mouse animal model on anti-aging wrinkles. Supercritical heat-treated radish-extract was applied on the back of seven-weeks old HRM-2 mice. The effect of HRE on skin thickness, elasticity and wrinkle formation of the mice was observed by using UVB lamp to induce melanogenesis and wrinkle formation. As the result, increased depth of wrinkles was observed in the negative control group in comparison to the normal group. In contrast, decreased depth of wrinkles was observed in the radish-extract-free group compared to the negative control group. In the study of the effect of radish-extract on wrinkle-formation related gene expression and protein what protein expression, MMP-2 and MMP-2 gene expression significantly increased in the negative control group compared to the normal group. The gene expression reduced independence to the mass of radish-extract treated. Similar to quantitative results of mRNA expression, the expression of MMP-2 protein increased as a result of UVB-irradiation. The MMP-2 expression was inhibited in dependence to the mass of radish-extract treated. In conclusion, the supercritical heat-treated radish-extract has an effect on improving skin wrinkles not only when it is applied to the skin but also when orally ingested. Thus, it can be effectively used as a composition to health functional products. Thereafter, we can also conclude that radish, a food that does not show any side-effects even upon long-term intake, can reduce wrinkle formation as well as improve skin elasticity when taken regularly for a long period.

• Journal of the Korean Applied Science and Technology
• /
• v.31 no.1
• /
• pp.120-129
• /
• 2014

The structure and physiological function of human skin continuously weaken due to growing older. The reasons of aging from external conditions are long term exposure to sun, wind, heat, cigarette smoke, and etc. This also palmitoyl oligopeptide or ceramide oligopeptide are known asc ingredient stimulating collagens and have the effect of reproducing the upper level of skin. Acetyl hexapeptide is an ingredient that makes the skin and muscle suppler and reduces wrinkles. It is a major high function beauty ingredient that substitutes botox. After dividing 7%, 14%, and 20% Acetyl hexapeptide experimental groups as groups A, B, and C the control group and experiment groups' change of wrinkles, hair follicles, moisture content, and dead skin cells was analyzed. According to the results, Acetyl hexapeptide seems to affect wrinkles, hair follicles and moisture content contrasting to the control group. Experimental groups and control group showed similar change in dead skin cells. In contrast to the control group satisfaction of examines was affected in wrinkles, hair follicles and moisture but removing dead skin cells had similar result in experimental groups and control group.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.42 no.4
• /
• pp.550-555
• /
• 2013

Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.

• Applied Microscopy
• /
• v.42 no.1
• /
• pp.35-42
• /
• 2012

The skin is the largest organ of the integument system whose surface is closely related to many physiological and pathological conditions. The skin surface is closely related to functional status of the epidermis and dermis. The outermost surface of the skin shows characteristic pattern defined by small furrows are called micro-relief. The micro-relief change is according to physiological and pathological conditions of the skin. But, there is no data on health Korean skin micro-relief yet. This study presents some aspect of health Korean skin micro-relief from the twenties. The silicon replicas obtained from forearm, dorsum hand and finger were analyzed by profiles were accessed by stereoscopy. We measured density of furrow, width of furrow, and depth of furrow in micro-relief with sectioned silicon replica sample using stereoscope. Stereoscopic analysis showed that male group has a larger density of furrow and depth furrow in finger significantly. The densities of furrow were shown different not only between forearm and finger but also between finger and hand in male with female group. In conclusion, there were differences results between sex different and regional difference in skin replica profile. These quantitative data can be used for basis of further skin research for Korean.