• KSBB Journal
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• v.21 no.6 s.101
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• pp.444-450
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• 2006

Skin anti-aging effect of Forsythia viridissima L. extract was evaluated by using antioxidant assay, expression of type I procollagen, and UVA-induced matrix metalloproteinase-1 in human dermal fibroblasts. Matairesinol-rich Forsythia viridissima L. extract was showed the scavenging activity of radicals and reactive oxygen species with the $IC_{50}$ values of $4.50\;{\mu}m/ml$ against 1,1-diphenyl-2-picrylhydrazly radical and $542.43\;{mu}m/ml$ against superoxide radicals in the xanthine/xanthine oxidase system, respectively. The type I procollagen was increased 33.76% by treatment with matairesinol-rich Forsythia viridissima L. extract, and UVA-induced MMP-1 was reduced 35.78% in a dose dependent manner. In the human skin irritation test, 2% matairesinol-rich Forsythia viridissima L. extract did not show any adverse effect. Also, the clinical study indicated that a cream group treated with 0.2% matairesinol-rich Forsythia viridissima L. extract significantly reduced skin wrinkles, as compared with a non-treated cream group (p < 0.05). These results suggest that Forsythia viridissima L. extract may be useful as a potential source of functional anti-aging cosmetics.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.4 s.48
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• pp.463-470
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• 2004

Artificial skin culture broth (DA-3711) was developed by using Dong-A pharmaceutical's artificial skin culture technique, and it contains plenty of nutrients, natural extracellular matrix proteins and human growth factors, which may improve aged skin conditions. The anti-aging effect of DA-3711 was investigated both in vitro and in vivo. Furthermore the clinical studies showed that DA-3711 had been very effective in improving firmness and reducing wrinkles. The results suggest that the novel anti-wrinkle agent. DA-3711, may have anti-aging and anti-wrinkle effects by stimulating skin regeneration.

• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.2
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• pp.186-192
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• 2010

Skin wrinkles typically appear as a result of aging processes. One of causes may be the nonenzymatic glycation followed formation of browning products called advanced glycation endproducts (AGEs), an irreversible cross-linked protein. The accumulation of glycated collagen cross-linked in skin inhibits the formation and function of skin tightening agents such as collagen and elastin. To development for anti-wrinkle ingredients from edible plants, MeOH and hot-water extracts were prepared and evaluated for their inhibitory effects of AGEs formation. The activities of both extracts from bay laurel (Laurus nobilis), cinnamon (Cinnamomum loureirii), clove (Eugenia caryophyllate), oregano (Origanum vulgare), rosemary (Rosemarinus officinalis), savory (Satureja hortensis) and star anis (Illicium verum) of western spices, and blackberry (Rubus coreanus), dayflower (Commelina communis), Epimedium koreamun (whole), termunalia frutus (Terminalia chebula) and turkestan rose (Rosa rugosa) of medicinal plants were higher than the others. Of Korean vegetables, however, MeOH and hot-water extract from only Asters caber and green tea showed higher activities, and no activity in Korean marine plants (seaweeds).

• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.1
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• pp.42-46
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• 2010

This study was performed to investigate anti-wrinkle effects of Acanthopanax senticosus (AS) on ultraviolet B (UVB)-induced photoaging with wrinkle formation. AS extract showed higher DPPH radical scavenging activity (3 ${\mu}g/mL$ as $IC_{50}$) and collagenase inhibition (1.52 mg/mL as $IC_{50}$) than those of ascorbic acid (50 ${\mu}g/mL$ and 2.17 mg/mL, respectively). Cell proliferation and type I pN collagen synthesis were increased by 11.4% and 96.4%, respectively, compared with non treatment control. In vivo, SKH-1 hairless mice were administrated AS 400 mg/kg for 10 weeks with UVB irradiation three times a week. After 10 weeks, a visual assessment and replica assay were performed on each mouse. According to visual assessment of close-up photos and skin replica, oral administration of A. senticosus affected on inhibition of wrinkle formation caused by UVB irradiation on the skin of mice as compared to the vehicle treated control mice. These results indicated that A. senticosus could protect skin wrinkle formation caused by collagen synthesis of fibroblast cells and photo-irradiation of UVB in hairless mice.

• Proceedings of the Optical Society of Korea Conference
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• 2006.07a
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• pp.227-228
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• 2006

• Korean Journal of Food Science and Technology
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• v.37 no.6
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• pp.989-996
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• 2005

Ultraviolet (UV) induces photo aging, erythema, sunburn, photo-toxicity, photo-allergy, and skin tumor, To investigate photo-protective effects of AmorePacific Beauty-03 (APB-03; mixture of red ginseng extract powder and soybean extract powder) on UV-induced damaged skins, 40 SKH hairless female mice were orally administered APB-03 or saline five times a week and irradiated with UV three times per week far up to 12 weeks. Visible skin changes and skin damage in dermis and epidermis by replica image analysis and histological analysis. In APB-03-treated group, better skin, negative replica appearance and less wrinkle formation were observed compared to the UV control group. These results demonstrate oral administration of APB-03 have photo-protective effects on UV-damaged hairless mouse skin.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.3 s.52
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• pp.253-257
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• 2005

Assurance of the objectivity and reproducibility is a major key point in wrinkle measurement used for evaluating the degree of skin aging. The measurement of relief is quickly converted to a non-contact method, of which tools or instruments do not come in contact with skin directly, to minimize the artificial effects which influence the shape or depth of the relief. Here, we showed how wrinkle measurement techniques have been changed briefly and compared PRIMOS and replica method in the point of view of measurement principle and features, the former is non-contact fringe projection tool and the latter is contact type of the method.

• 건강소식
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• v.30 no.7 s.332
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• pp.24-25
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• 2006

노인의 피부는 노화로 말미암아 여러 가지 문제가 생길 수 있따. 그러나 적절하게 관리하지 못하여 여러 가지 피부 질환으로 고생하게 되는 경우가 많다. 노인에게 올 수 있는 피부 문제를 알고 대처하는 것이 중요하다. 흔히 노인들은 외모의 변화를 심각하게 고민하지만, 생명과 관련이 없는 현상이기 때문에 무관심하게 되고, 적절한 관리를 받을 기회를 놓쳐 심각한 피부 질환으로 진행되기도 한다. 노인들은 피부의 변화와 주름을 창피하거나 부끄럽게 생각하지 말고, 자신의 삶의 일부를 나타내는 행복의 선으로 받아들여야 한다. 또한 이를 성형수술이나 화장으로 감추려 하지 말고 적절한 관리를 통해 가능하다면 피부 노화가 느리게 올 수 있도록 관리하는 것이 중요하다. 노인에게서 흔한 피부 질환은 피부 소양증, 대상포진, 피부 건조증, 피부암 등이 있다.

• Proceedings of the Korea Contents Association Conference
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• 2006.11a
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• pp.47-51
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• 2006

As the recent announcement of the functional cosmetics law, the need of studies on efficacy evaluation of skin related cosmetics and medical supplies has grown. Especially to identify skin improvement, we have to compare the exact parts of the skin, however up to now it is compared only by image matching that is appeared to the human eye. This study proposes the automatical image matching system for improving the accuracy of evaluation a skin improvement. Firstly we define the feature of the skin pores and wrinkles, and extract anticipation region from skin images. And then, we calculate moments for each extracted regions and classify them as pores and wrinkles. After that, we calculate the vector by computing centroids between each regions. Through this process, we compare the vector similarities and perform the matching between existing image and reference image. To verify the efficiency of the algorithm several experiments are conducted.

• Journal of Internet Computing and Services
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• v.10 no.4
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• pp.25-33
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• 2009

In the paper, we proposed a new system to retrieve 3D wrinkle data based on stereo images. Usually, 3D reconstruction based on stereo images or video is very popular and it is the research focus, which has been applied for culture heritage, building and other scene. The target is object measurement, the scene depth calculation and 3D data obtained. There are several challenges in our research. First, it is hard to take the full information wrinkle images by cameras because of light influence, skin with non-rigid object and camera performance. We design a particular computer vision system to take winkle images with a long length camera lens. Second, it is difficult to get the dense stereo data because of the hard skin texture image segmentation and corner detection. We focus on semi-dense stereo matching algorithm for the wrinkle depth. Compared with the 3D scanner, our system is much cheaper and compared with the physical modeling based method, our system is more flexible with high performance.