Browse > Article

Prevention of Photoaging and Wrinkle Formation in Hairless Mice Dorsal Skin by APB-03  

Lee, Ji-Hae (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center)
Lee, Byoung-Seok (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center)
Yang, Mi-Suk (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center)
Byun, Bum-Sun (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center)
Kim, Wan-Gi (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center)
Kim, Bae-Hwan (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center)
Lee, Sang-Jun (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center)
Publication Information
Korean Journal of Food Science and Technology / v.37, no.6, 2005 , pp. 989-996 More about this Journal
Abstract
Ultraviolet (UV) induces photo aging, erythema, sunburn, photo-toxicity, photo-allergy, and skin tumor, To investigate photo-protective effects of AmorePacific Beauty-03 (APB-03; mixture of red ginseng extract powder and soybean extract powder) on UV-induced damaged skins, 40 SKH hairless female mice were orally administered APB-03 or saline five times a week and irradiated with UV three times per week far up to 12 weeks. Visible skin changes and skin damage in dermis and epidermis by replica image analysis and histological analysis. In APB-03-treated group, better skin, negative replica appearance and less wrinkle formation were observed compared to the UV control group. These results demonstrate oral administration of APB-03 have photo-protective effects on UV-damaged hairless mouse skin.
Keywords
soy and red ginseng extract mixture (APB-03); photo aging; wrinkle; hairless mouse; UV;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Im SJ, Kim KN, Yun YG, Lee JC, Mun YJ, Kim JH, Woo WH. Effect of Radix Ginseng and Radix Trichosanthis on the melanogenesis. Biol. Pharm. Bull. 26: 849-853 (2003)   DOI   ScienceOn
2 Record IR, Dreosti IE, Konstantinopoulos M, Buckley RA. The influence of topical and systemic vitamin E on ultraviolet light-induced skin damage in hairless mice. Nutr. Cancer. 16: 219-225 (1991)   DOI   ScienceOn
3 Hiroaki M, Ichiro K, Tomomi S, Toshio I. Prevention of the photodamage in the hairless mouse dorsal skin by kojic acid as an iron chelator. Eur. J. Pharmacol. 411: 169-174 (2001)   DOI   PUBMED   ScienceOn
4 Kenarova B, Neychev H, Hadjiivanova C, Petkov VD. Immuno-modulating activity of ginsenoside Rgl from Panax ginseng. Jpn. J. Pharmacol. 54: 447-454 (1990)   DOI
5 Miyazaki K, Hanamizu T, Iizuka R, Chiba K. Genistein and daidzein stimulate hyaluronic acid production in transformed human keratinocyte culture and hairless mouse skin. Skin Pharmacol. Appl. Skin Physiol. 15: 175-183 (2002)   DOI   PUBMED
6 Cai Q, Wei H. Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice. Nutr. Cancer. 25: 1-7 (1996)   DOI   PUBMED   ScienceOn
7 Nishimori Y, Edwards C, Pearse A, Matsumoto K, Kawai M, Marks R. Degenerative alterations of dermal collagen fiber bundles in photodamaged human skin and UV-irradiated hairless mouse skin: possible effect on decreasing skin mechanical properties and appearance of wrinkles. J. Invest. Dermatol. 117: 1458-1463 (2001)   DOI
8 Bisset DL, Hannon DP, Orr TV. An animal model of solar-aged skin: histological, physical, and visible changes in UV-irradiated hairless mouse skin. Photochem. Photobiol. 46: 367-378 (1987)   DOI   ScienceOn
9 Choi S. Epidermis proliferative effect of the Panax ginseng ginsenoside Rb2. Arch. Pharm. Res. 25: 71-76 (2002)   DOI   PUBMED   ScienceOn
10 Kim S, Kang BY, Cho SY, Sung DS, Chang HK, Yeom MH, Kim DH, Sim YC, Lee YS. Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin. Biochem. Biophys. Res. Commun. 316: 348-355 (2004)   DOI   ScienceOn
11 Kambayashi H, Yamashita M, Odake Y, Takada K, Funasaka Y, Ichihashi M. Epidermal changes caused by chronic low-dose UV irradiation induce wrinkle formation in hairless mouse. J. Dermatol. Sci. 27: S19-25 (2001)   DOI   ScienceOn
12 Laure R, Gary FS. Uv-light-induced signal cascades and skin aging. Aging Res. Rev. 1: 705-720 (2002)   DOI   ScienceOn
13 Kligman LH, Akin FH, Kligman AM. Prevention of ultraviolet damage to the dermis of hairless mice by sunscreens. J. Invest. Dermatol. 78: 181-189 (1982)   DOI   ScienceOn
14 Lee EH, Cho SY, Kim SJ, Shin ES, Chang HK, Kim OH, Yeom MH, Woe KS, Lee J, Sim YC, Lee TR. Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolet-B-induced apoptosis by maintaining constant levels of Bcl-2. J. Invest. Dermatol. 121: 607-613 (2003)   DOI   ScienceOn