• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.4
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• pp.535-543
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• 2019

This study examined the empirical meaning of skylight in underground space, and for this purpose, 29 questions were drawn, consisting of technical performance, functional performance, and behavioral performance. In addition, under the assumption that the meaning of the skylight will be clearly revealed through the comparison between the underground streets with and without the skylight, three underground streets with the skylight and three underground streets without the skylight of Japan were selected as the subjects of the study. Based on the results of the survey, descriptive statistical analysis and frequency analysis were conducted, and an independent sample T-test was conducted for each analysis, and correlation analysis was conducted to derive improvement priority. As a result of the analysis, it was found that skylight had a certain effect on the sense of time and imageability inside the underground commercial space. In addition, it was analyzed that skylight exerted important function in the qualitative aspect of underground commercial space. Lastly, the improvement rankings for three underground streets without skylight were derived in the order of sign/guide map, space diversity, maintenance, rest space, and floor design.The improvement rankings for three underground streets with skylight were drawn in order of resting space, diversity of space, temperature and humidity, air, and maintenance.

• (The)Study of the Eastern Classic
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• no.68
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• pp.99-144
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• 2017

This paper focused on the narrative and theme of which is one of the different versions of when published in 1910's as a modern printing. Generally researchers regarded different version as a means of research for finding best version. But this paper aimed at the characteristics of different version . This version kept in mind for play(drama), so we could easily find the purpose of change for scenario. 'Yeon-jeong' in is 연정(演訂) in Korean words in Chinese characters. It is sure that this word means that the text considered play(drama). The narrative of also told us that this old novel aimed at the stage. Tendencies are classified four features, first, abundant situation description, second, frequent direct conversation, third, concrete description about direct conversation, fourth, showing poem and appeal for audience. The theme of has an interesting differences in comparison to the group of best version. When main character awakened, this novel showed the most important message. In the group of best version, he awakened to the cloud that he couldn't distinguish anything. But in this novel, cloud didn't appear, in other words, didn't change the scene. Instead, main character realize himself that he changed from Yang-so-yoo to Seong-jin. It is probable that change of process to conclusion aroused reader and audience's sympathy. To sum up, we could know that this novel kept in mind for play(drama).

• Journal of the Korean Society of Marine Environment & Safety
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• v.28 no.7
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• pp.1169-1178
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• 2022

This study examines an effective operational plan of a maritime safety enforcement task that is distributed in the Ministry of Oceans and Fisheries and the Korea Coast Guard for maritime safety. Considering the sinking of the MV Sewol and Seohae vessels and the MV Hebei Spirit oil spill, normally marine safety accidents tend to not only damage human life, property, and marine environment but can also expand to disasters; therefore, precautionary measures are required. However, the Korean government takes superficial efforts in case of large-scale accidents. In case of the MV Sewol ferry, the government only focused on punishing the officials involved as a follow up and never mentioned any effective plan, such as "unification of maritime safety enforcement," in contrast to an advanced country. As a result, there are endless major and minor backward accidents. The probability of large-scale maritime accidents and backwardness accidents is increasing owing to vessels becoming large sized, high speed, and aged; sailors being unqualified; port traffic increase, development of marine leisure; and inefficiency dual marine safety systems. Therefore, based on the review of previous studies related to maritime safety, major advanced country's cases, and unified case of the vessel traffic service, this study suggests effective methods such as coastal vessel safety management, port state control and aid to navigation management, which are directly connected with maritime safety.

• Journal of the korean academy of Pediatric Dentistry
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• v.50 no.1
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• pp.1-12
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• 2023

Function of salivary gland and saliva composition can be an indicator of individual's health status. Recently, saliva has been thought to have a high potential for usage in the biomedical field to diagnose, evaluate, and prevent systemic health due to the technological advances in analyzing and detecting small elements such as immunological and metabolic products, viruses, microorganisms, hormones in saliva. As a diagnostic specimen, saliva has some useful advantages compared to serum. Because of simple non-invasive method, saliva sampling is quite comfort for the patient, and it doesn't require specialists to collect samples. The possibility of infection during the collection process is also low. For this reason, proteins, genetic materials, and various biomarkers in saliva are actively being utilized on studying stress, microbiomics, genetics, and epigenetics. For the research on collecting big data related to systemic health, the needs on biobank has been focused. Regeneration of salivary gland based on tissue engineering has been also on advancement. However, there are still many issues to be solved, such as the standardization of sample collection, storage, and usage. This review focuses on the recent trends in the field of saliva research and highlight the future perspectives in biomedical and other applications.

• Korean Journal of Clinical Laboratory Science
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• v.54 no.1
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• pp.38-48
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• 2022

Carcinoembryonic antigen (CEA) is an oncofetal antigen primarily detected in the peripheral blood of cancer patients, particularly in those with colorectal cancer. CEA is considered a valuable target for antigen-specific immunotherapy. In this study, we induced the anti-tumor immunity for CEA through the administration of a dendritic cell (DC) vaccine. However, there was a limitation in inducing tumor regression in the DC vaccinated mice. To enhance the efficacy of anti-tumor immunity in MC38/CEA2 tumor-bearing mice, we evaluated the effects of DC vaccine in combination with cyclophosphamide (CYP). Administration of CYP 100 mg/kg in mice resulted in significant inhibition of tumor growth in the 2-day tumor model, whereas a lower inhibition of tumor growth was seen in the 10-day tumor model. Therefore, the 10-day tumor model was selected for testing chemo-immunotherapy. The combined CYP and DC vaccine not only increased tumor antigen-specific immune responses but also induced synergistic anti-tumor immunity. Furthermore, the adverse effects of CYP such as weight loss and immunosuppression by regulatory T cells and myeloid-derived suppressor cells showed a significant reduction in the combined chemo-immunotherapy treatment compared with CYP alone. Our data suggest that chemoimmunotherapy with the DC vaccine may offer a new therapeutic strategy to induce a potent anti-tumor effect and reduce the adverse effects of chemotherapy.

• Journal of the Korean Society of Marine Environment & Safety
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• v.29 no.7
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• pp.893-901
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• 2023

The International Association Marine Aids to Navigation and Lighthouse Authorities (IALA) proposed guidelines for VTS manual operation in 2016 for safe and efficient operation of ship. The Korea Coast Guard (KCG) established and operated 19 VTS centers in ports and coastal waters across the country by 2022 based on the IALA VTS manual and VTS operator's education and training guidelines. In addition, IALA proposed the Inter-VTS Exchange Format (IVEF) Service recommendation (V-145), a standard for data exchange between VTS, in 2011 for efficient e-Navigation system services and safe and efficient VTS service support by VTS authorities. The IVEF service in a common framework for ship information exchange, and it presents seven basic IVEF service (BISs) models. VTS service providers can provide safer and more efficient VTS services by sharing VTS information on joint area using IVEF standards. Based on the BIS data, interaction, and interfacing models, this paper introduced the development of the cloud-based VTS integration services performed by the KCG and the results of the VTS integration platform test-bed for IVEF service implementation. In addition, the results of establishing a cloud VTS integrated platform test-bed for the implementation of IVEF service and implementing the main functions of IVEF service were presented.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.6
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• pp.793-799
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• 2023

This study classifies the types of urban railway stations that reflect the location characteristics of urban railway stations, the structure and form of station taxes, and the number of users, and the level of inconvenience in the transfer movement line for users by station type, the number and connectivity of transfer information, and the level of transfer convenience facilities. The number of installations, conflicts between users, and transfer information signs were analyzed. As a result of data analysis, it was found that the factors that cause the most inconvenience to urban rail users when transferring are the length and curvature of the transfer line, pedestrian density and number of passengers in the transfer passage, presence or absence of transportation convenience facilities, and the size and height of transfer information letters. These transfer inconveniences were objectified, quantified, and presented as evaluation indicators that can measure the transfer convenience of urban railway stations. Additionally, an evaluation scale was developed to measure the service level for each evaluation indicator. The evaluation scale for each indicator presented six levels by applying linear interpolation based on the maximum and minimum values of data derived through field surveys. However, it is judged that a comprehensive evaluation of transfer convenience that combines the importance and weight of each convenience evaluation indicator should be established through future research.

• Journal of Life Science
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• v.34 no.5
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• pp.320-332
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• 2024

The aims of this study were to compare the differences in hemodynamics between cigarette smoking and using heated tobacco products (HTPs) and to determine the acute effects of using HTPs on cardiac autonomic regulation. Another goal was to examine the acute cardiac autonomic responses when using different tobacco sticks in HTPs. Sixteen healthy male smokers completed an open-label, randomized, crossover trial consisting of non-smoking (NS), cigarette smoking, and the use of two different HTPs (IQOS with HEETS; lil SOLID with Fiit). Sub-trials, which included NS, lil SOLID with Fiit, and lil SOLID with HEET, were performed on eight smokers among the total subjects. Hemodynamic variables, such as systolic blood pressure (SBP) and diastolic blood pressure (DBP), and heart rate variability were measured before, during, and 30 minutes after using each tobacco product. Using HTPs resulted in a significant increase in both SBP and DBP, comparable to smoking cigarettes. Cardiac sympathetic activity significantly increased, and cardiac vagal tone (CVT) significantly decreased after acute exposure to HTP aerosol, similar to the effects of cigarette smoke exposure. Furthermore, differences in the withdrawal of CVT were observed when using different tobacco sticks in the same HTPs. The findings of this study indicate that acute exposure to HTP aerosol increases the hemodynamic burden and disrupts cardiac autonomic balance, similar to exposure to cigarette smoke. Moreover, depending on the type of tobacco stick inserted into the HTP device, acute withdrawal of CVT may have been enhanced.

• Journal of the Korean Society of Radiology
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• v.83 no.3
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• pp.473-485
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• 2022

The incidence of neurodegenerative diseases in the older population has increased in recent years. A considerable number of studies have been performed to characterize these diseases. Imaging analysis is an important biomarker for the diagnosis of neurodegenerative disease. Objective and reliable assessment and precise detection are important for the early diagnosis of neurodegenerative diseases. Artificial intelligence (AI) using brain MRI applied to the study of neurodegenerative diseases could promote early diagnosis and optimal decisions for treatment plans. MRI-based AI software have been developed and studied worldwide. Representatively, there are MRI-based volumetry and segmentation software. In this review, we present the development process of brain volumetry analysis software in neurodegenerative diseases, currently used and developed AI software for neurodegenerative disease in the Republic of Korea, probable uses of AI in the future, and AI software limitations.

• Journal of Life Science
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• v.34 no.8
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• pp.594-607
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• 2024

Plastic products have long been widely used in both industrial and household applications. However, tiny plastic particles derived from plastic products, such as microplastics (MPs) and nanoplastics (NPs), can infiltrate the human body through inhalation, ingestion, or skin contact. Once inside cells via endocytosis, MPs and NPs (MNPs) can trigger autophagy, but lysosomal dysfunction can block autophagic flux. Accumulating in the cytoplasm, these particles induce cellular stress, including oxidative stress from free radicals, mitochondrial dysfunction, and increased inflammatory response. Meanwhile, cellular senescence is a hallmark of aging and is defined as the stable termination of the cell cycle in response to cell damage and stress. In particular, the accumulation of oxidative stress, a key factor in inducing cellular senescence, induces the expression of major senescence markers. Senescent cells increase the secretion of senescence-associated secretory phenotype, including inflammatory cytokines and chemokines. Despite growing interest in how MNPs induce cellular senescence, there remains a gap regarding their onset and therapeutic targets. Therefore, this review focuses on identifying recent research trends on how MNPs induce cellular aging in key human cell types and proposes future research directions to overcome these challenges.