대한소아치과학회지 (Journal of the korean academy of Pediatric Dentistry)

  • 제50권1호
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  • Pages.1-12
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  • 2023
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  • 1226-8496(pISSN)
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  • 2288-3819(eISSN)
대한소아치과학회 (Korean Academy of Pediatric Dentistry)
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타액 연구의 최신 지견과 임상 응용

Trends in Saliva Research and Biomedical Clinical Applications

  • 박소영 (부산대학교치과병원 소아치과) ;
  • 이은경 (부산대학교치과병원 소아치과) ;
  • 신종현 (부산대학교치과병원 소아치과) ;
  • 정태성 (부산대학교치과병원 소아치과)
  • Soyoung Park (Department of Pediatric Dentistry and Dental Research Institute, Pusan National University Dental Hospital) ;
  • Eungyung Lee (Department of Pediatric Dentistry and Dental Research Institute, Pusan National University Dental Hospital) ;
  • Jonghyun Shin (Department of Pediatric Dentistry and Dental Research Institute, Pusan National University Dental Hospital) ;
  • Taesung Jeong (Department of Pediatric Dentistry and Dental Research Institute, Pusan National University Dental Hospital)
  • 투고 : 2022.12.27
  • 심사 : 2023.01.20
  • 발행 : 2023.02.28
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초록

타액선의 기능과 타액의 구성성분은 개체의 건강 상태를 반영하는 지표가 될 수 있다. 타액에서 바이러스와 미생물, 호르몬, 면역 및 대사산물 등을 검출하는 미량원소 분석기술이 발달함에 따라, 전신건강의 진단, 평가, 예방 분야에서 타액의 활용가능성이 높아지고 있다. 진단 검체로써 타액은 혈액에 비해 채취 방법이 비 침습적이어서 환자의 불편감이 적고 비 전문가에 의한 검체 수집이 가능할 뿐 아니라 채취과정 중 감염 위험성이 낮다는 점에서 장점이 있다. 이러한 이유로 스트레스, 마이크로바이옴, 유전학 및 후생유전학 분야의 연구에 있어 타액 내 단백질, 유전물질이나 각종 생체표지자 등을 활용하는 방법이 주목받고 있다. 또한 전신 건강에 대한 빅데이터 수집 연구와 관련하여 타액을 효율적으로 활용, 보관하기 위한 인체 자원 은행의 필요성이 강조되고 있으며, 조직공학과 접목하여 타액선 재생연구도 활발히 진행되고 있다. 검체 채취법이나 보관, 활용 방법의 표준화를 비롯하여 해결해야 할 과제가 남아있으므로, 본 리뷰에서 타액 및 타액선에 관한 최근의 연구 동향을 알아보고 미래 발전 방향에 대하여 검토해 보고자 하였다.

Function of salivary gland and saliva composition can be an indicator of individual's health status. Recently, saliva has been thought to have a high potential for usage in the biomedical field to diagnose, evaluate, and prevent systemic health due to the technological advances in analyzing and detecting small elements such as immunological and metabolic products, viruses, microorganisms, hormones in saliva. As a diagnostic specimen, saliva has some useful advantages compared to serum. Because of simple non-invasive method, saliva sampling is quite comfort for the patient, and it doesn't require specialists to collect samples. The possibility of infection during the collection process is also low. For this reason, proteins, genetic materials, and various biomarkers in saliva are actively being utilized on studying stress, microbiomics, genetics, and epigenetics. For the research on collecting big data related to systemic health, the needs on biobank has been focused. Regeneration of salivary gland based on tissue engineering has been also on advancement. However, there are still many issues to be solved, such as the standardization of sample collection, storage, and usage. This review focuses on the recent trends in the field of saliva research and highlight the future perspectives in biomedical and other applications.

키워드

과제정보

We would like to thank Prof. Hyungsik Kim at Department of Life Science in Dentistry (School of Dentistry in Pusan National University) for commenting and informing on organoid of salivary gland. This work was supported by a 2-Year Research Grant of Pusan National University.

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