• Nuclear Medicine and Molecular Imaging
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• v.41 no.4
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• pp.299-308
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• 2007

Purpose: The aim of this study was to develop a bioinformatics software and to test it in serum samples of papillary thyroid cancer using mass spectrometry (SELDI-TOF-MS). Materials and Methods: Development of 'Protein analysis' software performing decision tree analysis was done by customizing C4.5. Sixty-one serum samples from 27 papillary thyroid cancer, 17 autoimmune thyroiditis, 17 controls were applied to 2 types of protein chips, CM10 (weak cation exchange) and IMAC3 (metal binding - Cu). Mass spectrometry was performed to reveal the protein expression profiles. Decision trees were generated using 'Protein analysis' software, and automatically detected biomarker candidates. Validation analysis was performed for CM10 chip by random sampling. Results: Decision tree software, which can perform training and validation from profiling data, was developed. For CM10 and IMAC3 chips, 23 of 113 and 8 of 41 protein peaks were significantly different among 3 groups (p<0.05), respectively. Decision tree correctly classified 3 groups with an error rate of 3.3% for CM10 and 2.0% for IMAC3, and 4 and 7 biomarker candidates were detected respectively. In 2 group comparisons, all cancer samples were correctly discriminated from non-cancer samples (error rate = 0%) for CM10 by single node and for IMAC3 by multiple nodes. Validation results from 5 test sets revealed SELDI-TOF-MS and decision tree correctly differentiated cancers from non-cancers (54/55, 98%), while predictability was moderate in 3 group classification (36/55, 65%). Conclusion: Our in-house software was able to successfully build decision trees and detect biomarker candidates, therefore it could be useful for biomarker discovery and clinical follow up of papillary thyroid cancer.

• Archives of design research
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• v.18 no.4 s.62
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• pp.95-104
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• 2005

The purpose of this study is to estimate the determinants of product design and analyze the impacts of product design on quality competitiveness, product reliability, and consumer satisfaction in an attempt to provide a foundation for the theory of design management. For this empirical analysis, this study has derived the relevant measurement variables from a survey on 400 Korean manufacturing firms during the period of $August{\sim}October$ 2003. The empirical findings are summarized as follows: First, the determinants of product design are very significantly (at p<0.001) estimated to be the R&D capability, the level of R&D expenditure, the level of innovative activities(5S, TQM, 6Sigma, QC, etc.). This empirical result can support Pawar and Driva(1999)'s two principles by which the performance of product design and product development can be simultaneously evaluated in the context of CE(concurrent engineering) of NPD(newly product development) activities. Second, the hypothesis on the causality: product design${\rightarrow}$quality competitiveness${\rightarrow}$customer satisfaction${\rightarrow}$customer loyalty is very significantly (at p<0.001) accepted. This implies that product design positively affects consumer satisfaction, not directly but indirectly, by influencing quality competitiveness. This empirical result of this study can also support the studies of for example Flynn et al.(1994), Ahire et at.(1996), Afire and Dreyfus(2000) which conclude that design management is a significant determinant of product quality. The aforementioned empirical results are important in the following sense: the empirical result that quality competitiveness plays a bridging role between product design and consumer satisfaction can reconcile the traditional debate between QFD(quality function development) approach asserted by product developers and conjoint analysis maintained by marketers. The first empirical result is related to QFD approach whereas the second empirical result is related to conjoint analysis. At the same time, the empirical results of this study can support the rationale of design integration(DI) of Ettlie(1997), i.e., the coordination of the timing and substance of product development activities performed by the various disciplines and organizational functions of a product's life cycle. Finally, the policy implication (at the corporate level) from the empirical results is that successful design management(DM) requires not only the support of top management but also the removal of communication barriers, (i.e. the adoption of cross-functional teams) so that concurrent engineering(CE), the simultaneous development of product and process designs can assure product development speed, design quality, and market success.

• Journal of Korean Society of Forest Science
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• v.98 no.3
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• pp.215-224
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• 2009

A review was given of the role of traditional morphometrics in plant morphological studies using 54 published studies in three major journals and others in Korea, such as Journal of Korean Forestry Society, Korean Journal of Plant Taxonomy, Korean Journal of Breeding, Korean Journal of Apiculture, Journal of Life Science, and Korean Journal of Plant Resources from 1997 to 2008. The two most commonly used techniques of data analysis, cluster analysis (CA) and principal components analysis (PCA) with other statistical tests were discussed. The common problem of PCA is the underlying assumptions of methods, like random sampling and multivariate normal distribution of data. The procedure was intended mainly for continuous data and was not efficient for data which were not well summarized by variances or covariances. Likewise CA was most appropriate for categorical rather than continuous data. Also, the CA produced clusters whether or not natural groupings existed, and the results depended on both the similarity measure chosen and the algorithm used for clustering. An additional problems of the PCA and the CA arised with both qualitative and quantitative data with a limited number of variables and/or too few numbers of samples. Some of these problems may be avoided if a certain number of variables (more than 20 at least) and sufficient samples (40-50 at least) are considered for morphometric analyses, but we do not think that the methods are all mighty tools for data analysts. Instead, we do believe that reasonable applications combined with focus on objectives and limitations of each procedure would be a step forward.

• Korean journal of communication and information
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• v.76
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• pp.61-91
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• 2016

This research is designed to evaluate perception of "the role of broadcasting in the process of unification" among South Korean propaganda broadcasting experts. This research used Q-methodology for in-depth evaluation of the experts' perception towards propaganda broadcasts. Total sixteen experts who work at the propaganda broadcasting company domestically or internationally as well as conduct related researches were selected as P-samples. This research listed sixty Q statements covering issues such as Perception of Unification, General Propaganda Broadcasts, Private Propaganda Broadcasts, Communication between North and South Korea. According to traditional way of Q-analysis, it drew two types of perception; Type 1: North Korean Liberal Broadcasts, Type2: Inter-Korean Exchange and Cooperation Broadcasts. For in-depth analysis, positive and negative statements were analyzed based on its tendency. As a result, positive statements tend to follow 'the Role of Unification Broadcasts' and negative statements followed 'the regulation of Private Broadcasts' When further researches were conducted on positive statements based on its axis of tendencies, Type 1 and Type 2 were categorized as follows; the Role of Unification Broadcasts- North Korean Liberal Broadcasts and Inter-Korean Exchange and Cooperation Broadcasts. On the other hand, when negative statements were analyzed based on its tendencies, the result of Type 1 and Type 2 were as follows; the Improvement of Private Broadcasts- Redeeming the Private Propaganda Broadcasts and Criticizing Private Propaganda Broadcasts. Regardless such differences, experts do agree on the idea which emphasize the role of broadcasts in the process of unification and also they share the same thought on the need to improve the private propaganda broadcasts. This research expected to contribute to society by making differences in analyzing propaganda broadcasting experts' perception in an objective and positive way compare to other existing researches. Therefore, it proposes several suggestions to consider when producing propaganda broadcasts.

• Journal of Hospice and Palliative Care
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• v.15 no.1
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• pp.18-29
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• 2012

Purpose: We analyzed how clinical nurses in Korea perceive terminally ill patients' medical decision-making. Methods: The Q-methodology which analyzes the subjectivity of each item was used. We selected 34 Q-statements among those provided by each of 37 subjects and grouped them into a shape of normal distribution using a 9 point scale. The collected data were analyzed using a QUANL PC program. Results: Four types of perception toward medical decision-making were identified. Type I focuses on patient participation, and Type II emphasizes the role of health professionals. Type III is characterized by an open-minded culture toward death, and Type IV values the role of family members. Conclusion: The results of this study indicate the need for development of a multi-disciplinary curriculum medical decision-making and death for medical and nursing students.

• Proceedings of the Korea Contents Association Conference
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• 2006.11a
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• pp.145-148
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• 2006

This study aimed at preventing women from suffering from health problems and stress due to excessive lookism and encouraging them to participate in sports activities to form desirable body image and eventually to live a healthy and sound life. To achieve this goal, this study formed a population with members of sports centers located in Seoul and Daejeon areas as of 2006 and made a sample of 450 participants in physical exercise at a sports center through stratified cluster random sampling and that of 450 non-participants through a survey with mothers and sisters of those students from elementary and secondary schools within the areas for sampling the participants' group, thereby analyzing the data on a total of 900 persons. A questionnaire was used as a tool to collect data; a reliability test presented weight-, health-, and figure-related factors as a=.807, a=.819, and a=.784, respectively. This study used such statistical analysis methods as t-test, One-way ANOVA, and the Analysis of Covariance to analyze data. This study produced the following conclusions through these research methods and procedure. Pticipation in physical exercise has a positive effect on body image. Pticipation in physical exercise at a sports center show higher satisfaction with body image than non-participats.

• Pediatric Infection and Vaccine
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• v.21 no.2
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• pp.96-103
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• 2014

Purpose: The aim of this study is that the prevalence of rotavirus infection was evaluated by each group and clinical features of group A, B and C rotaviruses infections were described respectively to compare one with another. Methods: Between January 2010 and December 2010, we enrolled a group of children below 10 years of age admitted for management of acute diarrhea at the Catholic University of Korea Bucheon St. Mary's Hospital. A total of 310 stool samples documented to be free of common bacterial pathogens were collected from children with diarrhea. The presence of group A, B or C rotavirus is indicated by amplification of DNA segments of the expected lengths after the first and second PCRs Results: In a total of 310 stool specimens, 40 (12.9%) specimens were positive for rotaviruses. These included 23 (7.4%) positive for group A, 5 (1.6%) for group B and 12 (3.9%) for group C rotaviruses. Group B rotavirus infected patients had significantly less diarrheas per day (group A: P =0.01, group C: P =0.01) and shorter duration of vomiting days (group A: P =0.03, group C: P =0.03) than those with group A and C rotaviruses infection respectively. All the group B rotaviruses had been isolated in March and October. Group C rotavirus infections were prevalent during late summer and early winter and peaked in October. Conclusion: These findings indicate that group B and C rotaviruses are notable causes or the contributing causes of diarrhea among infants and children in Korea.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.1
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• pp.10-16
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• 2011

Purpose: The partial volume effect occurs because of limit of the spatial resolution. It makes partial loss of intensity and causes SUV to be lower than it should actually be. So the purpose of this study is to calculate recovery coefficient for correcting PVE from phantom study and to compare before and after SUV correction applying to PET/CT examination. Materials and Methods: The flangeless Esser PET phantom consisting of four hot cylinders was used for this study. All of the hot cylinders were filled with FDG solution of 20.72 MBq per 1000 ml, and the phantom background was filled with FDG solution of different concentrations (33.30, 22.20, 16.65 MBq per 6440 ml) to yield H/B ratios of around 4:1, 6:1 and 8:1. Using the Biograph Truepoint 40(SIEMENS, Germany), we applied recovery coefficient method to 30 patients who were diagnosed with lung cancer after PET/CT exam. And then we analyzed and compared SUV before and after correcting partial volume effect. Results: The smaller the diameter of hot cylinder becomes, the more recovery coefficient decreased. When we applied recovery coefficient to clinical patients and compared SUV before and after correcting PVE, before the correction all lesions gave an average max SUV of 7.83. And after the correction, the average max SUV increases to 10.31. The differences in the max SUV between before and after correction were analyzed by paired t test. As a result, there were statistically significant differences (t=7.21, p=0.000). Conclusion: The SUV for quantification should be measured precisely to give consistent information of tumor uptake. But PVE is one of factors that causes SUV to be lower and to be underestimated. We can correct this PVE and calculate corrected SUV using the recovery coefficient from phantom study. And if we apply this correction method to clinical patients, we can finally assess and provide quantitative analysis more accurately.

• Korean Journal of Environment and Ecology
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• v.32 no.2
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• pp.203-214
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• 2018

This study was conducted to investigate the types, socio-demographic characteristics, use patterns, and visit motivations of visitors to "Jangseong Pyunbaek Healing Forest (JPHF)." Data were collected from 216 samples selected by convenient sampling method using questionnaire survey between October and November 2016. Data obtained from 476 respondents of the same type of survey during the same period were partly used to examine the types of activities of visitors to the study site. The results showed that 77.0 percent of respondents were categorized as "visitor for recreation" (VR: Those who visit JPHF for the purpose of general recreational experiences such as appreciating landscapes, tourism, social interactions rather than better health or healing). On the other hand, only 10.3 percent of respondents were "visitor for healing" (VH: Those who visit JPHF for the purpose of better health or physical and mental healing). VH showed a higher level of visit experiences to JPHF than VR and tended to expect JPHF as "the place to enjoy calm and natural experiences" more than VR did. VH tended to visit JPHF "alone" more, and their group size was also smaller than VR. About 26.8 percent of all respondents were not aware that JPHF was the "healing forest," and VH showed higher awareness of it than VR. About 66.8% of respondents assessed the managerial and operating states of JPHF positively while only 6.2% assessed them negatively. There was no difference in the assessment of managerial and operating states between VR and VH. The visitors of JPHF showed the markedly high use in main forest roads (use rate: 47.4%) and "Healing Field" (use rate: 59.2%) of JPHF. Regarding the visit motivations to JPHF, VH showed higher importance on "quietude," "health," and "tension release" than VR while VR rated higher importance on "social interaction." The paper discussed the managerial implications, findings, limitations and further studies.

• Korean Journal of Environment and Ecology
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• v.32 no.2
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• pp.231-243
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• 2018

This study was conducted to determine and compare the perceived number of users (PNU) and evaluative standards for each type of visitors to "Healing Field" of Jangseong Pyunbaek Healing Forest (JPHF). Data were collected from 158 samples selected by convenient sampling method from the users of "Healing Field" in JPHF during September 2017. Visitors to "Healing Field" consisted of 49.3% for recreation (VR), 15.3% for healing (VH), and 35.3% for both recreation and healing (VRH). Respondents' average PNU was 23.8 (median: 20.0), and the range of average PNU by visitor type was 21.1-27.8 (median: 20.0). Respondents' PNU showed low correlations with perceived crowding (PC) (r=0.23) and perceived interference of healing experience (PIHE) (r=0.20). There were no differences in the optimal number of users (ONU) of "Healing Field" among the types of visitors. The overall average ONU was 28.9(median: 25.0), and the range of average ONU by types of visitors was 25.4-31.4 (median: 25.0-27.5). The overall maximum acceptable number of users (MANU) was 38.1, and MANU for VR, VH, and VRH was 36.9, 32.0, and 38.0, respectively. Respondents' mean PC was 2.73 (SD: 3.26, 9-point scale) while mean PIHE was 3.26 (SD: 1.77, 9-point scale). The VRH group showed a higher PC and PIHE than the VR group. The group with greater PNU than ONU showed higher PC and PIHE than the other groups. Based on the results, this paper presented some managerial implications, discussed the limitations of the study, and suggested the further studies.