• Title/Summary/Keyword: 폐기포

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Immunohistochemical Analysis of the Bullae in Patients with Primary Spontaneous Pneumothorax (원발성 기흉환자 폐기포의 면역조직화학적 분석)

  • 김광호;윤용한;김정택;백완기;김현태;김영삼;손국희;한혜승;박광원
    • Journal of Chest Surgery
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    • v.36 no.2
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    • pp.86-90
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    • 2003
  • Bulla is an air-filled space within the lung parenchyma resulting from deterioration of the alveolar tissue. Molecular mechanism of the formation of the bulla is not well described. Fibroblast growth factor(FGF)-7, bone morphogenetic protein(BMP) receptor, and transforming growth factor(TGF)-$\beta$ receptor are known to have a stimulatory or inhibitory role in the lung formation. We investigated to see if these growth factor or cytokine receptors are involved in the bulla formation by immunohistochemical staining of bullous lung tissues from patients with primary spontaneous pneumothorax. Material and Method: Bullous lung tissues were obtained from 31 patients with primary spontaneous pneumothorax, including 30 males and 1 female from 15 to 39 years old. The bullous tissues were obtained by video-thoracoscopic surgery and/or mini-thoracotomy and fixed in formalin. Blocks of the specimens were embedded with paraffin and cut into 5-6 ${\mu}{\textrm}{m}$ thick slices. The sections were deparaffinized and hydrated and then incubated with primary antibodies against FGF-7, BMP-RII, or TGF-RII. Result: Of the 31 patients, 24 were TGF-RII positive including 18 strong and 6 weak positives. Observation with high magnification showed that strong immunostaining was detected in the boundary region between bullous and normal lung tissues. In contrast, all of the sections were negative with FGF-7 or BMP-RII antibodies. Conclusion: These results suggest that overexpression of TGF- P RII may be involved in the formation of bulla, although further molecular studies are needed to find out more detailed molecular mechanisms.

Thoracoscopic Bleb Ligation in Patients with Primary Spontaneous Pneumothorax (일차 자연 기흉의 치료를 위한 흉강경하 폐기포 결찰술)

  • Mun, Sung-Ho;Jang, In-Seok;Lee, Chung-Eun;Kim, Jong-Woo;Choi, Jun-Young;Rhie, Sang-Ho
    • Journal of Chest Surgery
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    • v.43 no.2
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    • pp.133-138
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    • 2010
  • Background: Video assisted thoracic surgery has been widely accepted for the treatment of primary spontaneous pneumothorax. Material and Method: We retrospectively reviewed the medical records of 89 primary pneumothorax patients who had undergone thoracoscopic bleb ligation from February 2002 to June 2006, and we assessed the patients for recurrence. The mean follow-up period was 65 months. Result: Pneumothorax recurred in 7 patients (8%) during the follow-up period. Conclusion: Thoracoscpic bleb ligation might be an acceptable alternative technique for treating primary spontaneous pneumothorax.

Malignant Gastrointestinal Stromal Tumor of Esophagus - A case report - (식도의 악성 위장관 간질종양 - 1례 보고 -)

  • Kang, Shin-Kwang;Won, Tae-Hee;Ku, Kwan-Woo;Yoon, Soo-Young;Yu, Jae-Hyun;Na, Myung-Hoon;Lim, Seung-Pyung;Lee, Young
    • Journal of Chest Surgery
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    • v.36 no.2
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    • pp.109-112
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    • 2003
  • Stromal tumors of the gastrointestinal tract, especially of the esophagus, are rare. We had a case of malignant gastrointestinal stromal tumor(GIST) of the esophagus. A 46 years old woman was admitted for abnormal mass shadow in the chest radiograph. The mass was originated from the lower thoracic esophagus, and compressed the right lower pulmonary vein and the inferior vena cava. We removed the tumor externally without injuring of the esophageal mucosa via right posterolateral thoracotomy. The tumor was positive for CD 34 and CD 117, and diagnosed malignant CIST of the esophagus.

Facters Affecting Recurrence after Video-assisted Thoracic Surgery for the Treatment of Spontaneous Pneumothotax (자연기흉에 대한 비디오흉강경수술후 재발에 영향을 미치는 요인들)

  • 이송암;김광택;이일현;백만종;최영호;이인성;김형묵;김학제
    • Journal of Chest Surgery
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    • v.32 no.5
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    • pp.448-455
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    • 1999
  • Background: Recent developments in techniques of video-assisted thoracic surgery(VATS) and endoscopic equipment has expanded the application of video-assisted surgical procedures in the field of thoracic surgery. Especially, it will probably become the treatment of choice of spontaneous pneumothorax(SP). There is, however, a high recurrence rate, high cost, and paucity of long-term results. We report the results of postoperative follow-up and analyze perioperative parameters affected to recurrence, retrospectively. Material and Method: From march 1992 to march 1997, 276 patients with spontaneous pneumothorax underwent 292 VATS procedures. Conversion to open thoracotomy was necessitated in eight patients, and this patients excluded from the study. Result: The sex distribution was 249 males and 31 females. The mean age was 28.1 12.2 years(range, 15 to 69 years). Primary SP was 237cases(83.5%) and secondary SP was 47cases(16.5%). The major underlying lung diseases associated with secondary SP were tuberculosis 27cases(57.4%) and emphysema 8cases (38.3%). Operative indications included Ipsilateral recurrence 123(43.9%), persistent air-leak 53(18.9%), x-ray visible bleb 40(14.3%), tension 30(10.7%), contralateral recurrence 21(7.5%), uncomplicated first episode 8(2.9%), bilateral 3(1.1%), complicated episode 2(0.7%). Blebs were visualized in 247cases(87%) and 244cases(85.9%) performed stapled blebectomy. Early postoperative complications occurred in 33 cases(11.6%): 16 prolonged air-leak more than 5 days(four of them were required a second operation and found missed blebs); 5 bleeding; 5 empyema; 2 atelectasis; 1 wound infection. No deaths occured. The mean operative time was 52.8 23.1 minutes(range, 20 to 165 minutes). The mean d ration of chest tube drainage was 5.0 4.5 days(range, 2 to 37 days). The mean duration ofhospital stay was 8.2 5.5 days (range, 3 to 43days). At a mean follow-up 22.3 18.4 months(range, 1 to 65 months), 12 patients(4.2%) were lost to follow-up. There were 24 recurrences and seven patients underwent second operation and 6 patients(85.7%) were found the missed blebs. 12 perioperative parameters(age, sex, site, underlying disease, extent of collapse, operative indication, size of bleb, number of bleb, location of bleb, bleb management, pleural procedure, prolonged postoperative air-leak) were analyzed statistically to identify significant predictors of recurrence. The significant predictors of recurrence was the underlying disease[17.0%(8/47): 6.8%(16/237), p=0.038], prolonged postoperative air-leakage[37.5%(6/16): 6.7%(18/268), p=0.001], and pleural procedure [11.4%(19/167): 4.3%(5/117), p=0.034]. Blebectomy has less recurrence rate then non-blebectomy [8.2%(20/244) : 10.0%(4/40), p>0. 5]. However, this difference was not statistically significant(p=0.758). Conclusion: We conclude that it is important that we shoud careful finding of bleb during VATS due to reducing of recurrnece, and cases of no bleb identified and secondary spontaneous pneumothorax were indicated of pleurodectomy. VATS is a valid alternative to open procedure for the treatment of spontaneous pneumothorax with less pain, shorter hospital stay, more rapid return to work, high patient acceptance, less scar and exellent cosmetics. But, there is high recurrence rate and high cost, and than it is necessary to evaluate of long-term results for recurrence and to observate carefully during VATS.

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TGF-${\beta}1$ Protein Expression in Bullae of Patients with Spontaneous Pneumothorax (자연기흉환자의 폐기포에서 TGF-${\beta}1$ 단백질 발현에 대한 연구)

  • Kim, Kwang-Ho;Cho, Jung-Soo;Kim, Young-Sam;Yoon, Yong-Han;Kim, Joung-Taek;Baek, Wan-Ki;Kim, Lucia;Song, Sun-U.
    • Journal of Chest Surgery
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    • v.39 no.11 s.268
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    • pp.805-809
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    • 2006
  • Background: In our previous study, we demonstrated that transforming growth factor-beta 1 receptor II(TGF-${\beta}1RII$) may have a role in the formation of bullae. In this study, we investigated if expression of transforming growth factor-beta 1 (TGF-${\beta}1$) ligand was altered in a bullous lung tissue by immunohistochemical staining of bullous tissues from patients with primary spontaneous pneumothorax. Material and Method: Bullous lung tissues were obtained from 36 patients with primary spontaneous pneumothorax, including 34 males and 2 females aged 14 to 38 years old. Result: Of the 36 patients, 19 were TGF-${\beta}1$ positive and 24 were transforming growth factor-beta 1 receptor II(TGF-${\beta}1RII$) positive. Among the 19 TGF-${\beta}1$ positives, 15 were also TGF-${\beta}1RII$ positive, observation at high magnification showed that strong immunohistochemical stain was detected in the boundary region between the bullous and normal lung tissues. Conclusion: These results suggest that overexpression of TGF-${\beta}1$ may be involved in the formation of a bulla as well as the alteration of TGF-${\beta}1RII$ expression. Further molecular studies are needed to elucidate the more detailed molecular mechanisms of the bulla formation.

Diagnostic Value of Thoracography in Pneumothorax (기흉에서 흉강조영술(Thoracography)의 진단적 가치)

  • 박영식;한재열;장지원
    • Journal of Chest Surgery
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    • v.31 no.7
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    • pp.730-734
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    • 1998
  • Background: It is important to know the location, number, size and shape of bullae before thoracotomy or VATS bullectomy. Chest X-ray and chest CT may be used but with some limitation. The purpose of this study was to compare the diagnostic value of thoracography with that of chest X-ray in preoperative detection of bullae. Meterial and Method: Thoracography was performed by injection of non-ionic water-soluble dye into pleural space in 22 primary spontaneous pneumothoraces, which underwent thoracotomy or VATS bullectomy. Chest X-ray and thoracography were compared through operative finding. Results: Sensitivity and accuracy of thoracography(75% and 72.7%) were higher than those of chest X-ray(30% and 36.4%). However, specificity of thoracography(50%) was lower than that of chest X-ray (100%). There were no complications during or after thoracography. Conclusion: Thoracography is a safer and more useful method for preoperative detection of bullae when compared with chest X-ray.

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The Comparison of Transaxillary Minithoracotomy Versus VATS in the Operative Treatments of Spontaneous Pneumothorax (자연성 기흉에서 액와절개술과 비디오 흉강경을 이용한 수술의 비교)

  • 정경영;김길동
    • Journal of Chest Surgery
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    • v.29 no.8
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    • pp.910-915
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    • 1996
  • The bullectomy through transaxillary minithoracotomy and video assisted thoracic surgery(VATS) have been widely used in treatment of spontaneous pneumothorax. The study comprised a retrospective review of 1 13 consecutive cases of whom underwent bullectomy through transaxillary minithoracotomy at Shinchon Severance Hospital(group T) and 129 consecutive cases of whom underwent thoracoscopical bullectomy at Youngdong Severance(group V) between January 1992 to Jun 1994. This study compare the clinical and economic resuts of group T and group V There were no significant differences for operation time, indwelling periods of chest tube, hospital stay, complication rate and rate of recurrence in the two groups. The times of parenteral analgesics use and treatment cost were significant less in group T.

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Giant Bulla with Pulmonary Fibrosis Caused by Gramoxon Toxicity -A case report- (그라목손 중독에 의한 폐섬유화와 동반된 거대 폐기포 - 1례 보고 -)

  • 정진악;금동윤;이재원
    • Journal of Chest Surgery
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    • v.33 no.9
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    • pp.773-776
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    • 2000
  • Accidental or suicidal fatalities of paraquat(Gramoxon) poisong are occasionally seen in the emergency room or intensive care unit in this country. In most cases, respiratory symptoms and eventual death by respiratory distress occur within several days. The most striking pathologic change is fibrosis of the lung due to widespread proliferation of fibroblastic cell. We experience a 21-year-old woman with huge bulla on left lung and diffuse fibrosis in other site, who ingested paraquat 10 months ago. After thoracoscopic removal of bulla, the patient survive without progression of pulmonary complication till now.

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Comparative Study of 2 mm Video-thoracoscopic Examination and High-resolution Computed Tomography for Spontaneous Pneumothoarx Patients (자연기흉에서 고해상 전산화단층촬영술과 2 mm 비디오 흉강경검사의 비교 연구)

  • Lee, Song-Am;Chee, Hyun-Keun;Hwang, Jae-Joon;Cho, Seong-Joon;Lee, Sung-Ho;Kim, Kwang-Taik
    • Journal of Chest Surgery
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    • v.40 no.5 s.274
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    • pp.362-368
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    • 2007
  • Background: Spontaneous pneumothorax patients with blebs or bullae are considered to be good candidates for operation, and various objective diagnostic modalities have been performed for detection of blebs and bullae. This study was performed to compare the efficacy of thoracoscopic examination with using a minimally invasive 2 mm thoracoscope with high-resolution computed tomography (HRCT) for treating primary spontaneous pneumothorax. Material and Method: From June 2001 to March 2002, 34 patients with spontaneous pneumothorax undewent study with 2 mm video-thoracoscopic examination and HRCT. We regarded a blob larger than 5 mm in diameter as significant. Standard thoracoscopic wedge resection was performed in 18 patients with significant blob via a 2 mm video-thoracoscopic examination. 1 patient incurred bleeding, and the remaining 15 patients were treated with pleural drainage. Result: Multiple or single blob lesions were detected by 2 mm video-thoracoscope in 52.9% (18/34) of the patients with primary pneumothorax. For a total of 19 patients who were operated on, the diagnostic accuracy of the 2 mm video-thoracoscopic examination for bullae and blob was 94.7% (18/19), which was superior to that of HRCT (73.7%, 14/19). At a mean follow-up of $30{\pm}3$ months, no recurrence occurred in both the operative group and the non-operative group. Conclusion: 2 mm video-thoracoscopic examination under local anesthesia has higher diagnostic accuracy than HRCT, and it is a useful alternative for determining the operative indications for spontaneous pneumothorax.

시멘트 산업에서의 자원재활용

  • O, Jae-Hyeon
    • Ceramist
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    • v.20 no.1
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    • pp.103-118
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    • 2017
  • 1. 2014년도 우리나라 전체 폐기물 발생량은 146,607천 톤이며, 건설폐기물이 46.2%(67,644천 톤), 사업장 일반폐기물이 38.1%(55,914천 톤), 생활폐기물이 12.4%(18,219천 톤), 사업장 지정페기물이 3.3%(48,810천 톤)을 나타내고 있다. 2. 건설폐기물의 97.9%, 배출시설계 폐기물의 77.3%, 생활폐기물의 67.0%, 지정폐기물의 57.3%가 재활용되고 있다. 3. 2015년도 우리나라 시멘트산업에서 18,801천 톤의 순환자원을 재활용하였다. 폐기물이 6,136천 톤이고, 부산물이 12,665천 톤이다. 부산물은 11,000천톤이 제철슬래그이고, 1,600천 톤이 폐석고(탈황석고 중화석고)로 추정된다. 그리고 폐기물 6,136천 톤은 사업장 일반폐기물의 약 11.0%에 해당된다. 4. 시멘트 톤당 순환자원 사용량(재활용 원단위)은 일본이 400kg/톤 이상이고 우리나라는 300kg/톤 대를 나타내고 있다. 일본이 우리나라보다 재활용량/톤이 많은 이유를 다음에서 찾을 수 있다. (1) 고품위 석회석 원료 (2) 법 제도(지원금 포함) 5. 원료 대체율의 산출은 다음 두 산출방법으로 나타낼수 있다. (1) 이론적인 원료 상한 대체량에 대한 실제 원료 대체량 (2) 이론적인 원료 조합량에 대한 실제 원료 대체량 2015년도 우리날 전체 원료 대체량(17,770천 톤)은 (1)에 의한 대체율 : 71% (2)에 의한 대체율 : 27% 6. 자동차 슈레더 더스트(ASR)를 시멘트산업에서 자원화 하게끔 ASR처리의 보완 및 법적지원(지원금 포함)이 요망된다. 7. 부산물 및 폐기물의 자원화는 시멘트산업에서의 이용이 가장 우수한 장점을 갖추고 있다. 그러므로 시멘트산업에서 폐기물의 자원화를 적극 추진하게끔 제도의 보완 및 시설지원 등 정부의 대책수립이 간절하다.