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TGF-${\beta}1$ Protein Expression in Bullae of Patients with Spontaneous Pneumothorax  

Kim, Kwang-Ho (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Inha University)
Cho, Jung-Soo (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Inha University)
Kim, Young-Sam (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Inha University)
Yoon, Yong-Han (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Inha University)
Kim, Joung-Taek (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Inha University)
Baek, Wan-Ki (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Inha University)
Kim, Lucia (Department of Pathology, College of Medicine, Inha University)
Song, Sun-U. (Clinical Research Center, College of Medicine, Inha University)
Publication Information
Journal of Chest Surgery / v.39, no.11, 2006 , pp. 805-809 More about this Journal
Abstract
Background: In our previous study, we demonstrated that transforming growth factor-beta 1 receptor II(TGF-${\beta}1RII$) may have a role in the formation of bullae. In this study, we investigated if expression of transforming growth factor-beta 1 (TGF-${\beta}1$) ligand was altered in a bullous lung tissue by immunohistochemical staining of bullous tissues from patients with primary spontaneous pneumothorax. Material and Method: Bullous lung tissues were obtained from 36 patients with primary spontaneous pneumothorax, including 34 males and 2 females aged 14 to 38 years old. Result: Of the 36 patients, 19 were TGF-${\beta}1$ positive and 24 were transforming growth factor-beta 1 receptor II(TGF-${\beta}1RII$) positive. Among the 19 TGF-${\beta}1$ positives, 15 were also TGF-${\beta}1RII$ positive, observation at high magnification showed that strong immunohistochemical stain was detected in the boundary region between the bullous and normal lung tissues. Conclusion: These results suggest that overexpression of TGF-${\beta}1$ may be involved in the formation of a bulla as well as the alteration of TGF-${\beta}1RII$ expression. Further molecular studies are needed to elucidate the more detailed molecular mechanisms of the bulla formation.
Keywords
Bullae; Proteins;
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