• Title/Summary/Keyword: 카페인

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Formulation of Caffeine Nasal Sprays and Its Enhanced Permeation through Rabbit Nasal Mucosa (카페인의 비강 분무액의 제제설계 및 점막 투과 증진)

  • Noh, Eun-Sun;Chun, In-Koo
    • Journal of Pharmaceutical Investigation
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    • v.34 no.2
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    • pp.131-138
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    • 2004
  • This study was aimed to investigate the feasibility of nasal delivery of caffeine for the elimination of sleepiness. The effects of various vehicles, solubilizers, and enhancers on the permeation of caffeine through rabbit nasal mucosa was observed. The permeation study was carried out using a Franz-type permeation system at $37^{\circ}C$, and the amount of caffeine permeated though the rabbit nasal mucosa was determined by a validated HPLC. The apparent solubility and phys iochemical stability of caffeine in various nasal formulations were was determined. The effect of hydrotropes and modified cyclodextrins on the solubility of caffeine in water was determined by equilibrium solubility method. The solubility of caffeine in water was 29 mg/mL at $30^{\circ}C$. The addition of sodium benzoate and nicotinamide at 10% improved the solubility of caffeine (115 and 132 mg/mL, respectively) in aqueous solution. The flux of caffeine though the nasal mucosa from aqueous solution was $2.1{\pm}0.26\;mg/cm^2/hr$. The addition of sodium benzoate reduced its permeation $(1.4{\pm}0.01\;mg/cm^2/hr)$, but sodium benzoate with 5% $2HP{\beta}CD$ and 0.03% monoterpenes increased its permeation $(2.4{\pm}0.04\;mg/cm^2/hr)$ markedly. The addition of nicotinamide also increased also increased its permeation $(2.5{\pm}0.36\;mg/cm^2/hr)$. markedly. As the concentration of caffeine in nasal formulation increased, the permeation flux increased linearly. Caffeine was stable physicochemically and enzymatically in the nasal mucosa extract at $37^{\circ}C$. These results suggest that caffeine can be efficiently delivered nasally and the development of nasal formulation will be feasible.

The Design and Implementation of EL/LX level3 C Standard Library for RTOS Qplus-P (EL/IX 단계 3을 적용한 실시간 운영체제 Qplus-P용 C 표준 라이브러리의 설계 및 구현)

  • Kim, Do-Hyung;Shin, Chang-Min;Park, Sung-Min
    • The KIPS Transactions:PartA
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    • v.9A no.4
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    • pp.485-490
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    • 2002
  • As the products of internet appliance, such as digital TV, internet set-top box, and internet phone, are continually produced, the market of real time operating system which controls those products is being highly increased. ETRI developed the extensible real time operating system, Qplus-P, which can be used from PDA to internet set-top box and home server. This paper describes the design and implementation of C standard library for real-time operating system Qplus-P. The Qplus-P C standard library follows EL/IX API level, which is proposed to the real-time operating system international standard by the RedHat. And, the C standard library functions, which are needed to support the Tiny-X and Kaffe, are also implemented. The implemented C standard library can reduce the size of library about 30% compare to the C library that does not follow EL/IX API level.

Design and Implementation of a Web-Based Toy Trading System (웹 기반 장난감 거래 시스템 설계 및 구현)

  • Lim, Jongtae;Lim, Yunsoo;Lee, Dong-Geun;Yoo, Jaesoo
    • The Journal of the Korea Contents Association
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    • v.19 no.10
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    • pp.45-58
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    • 2019
  • As modern people's daily lives are becoming more harsh in Korea, the so-called Kidults generation has appeared since a few years ago as adults have come back to their childhood sensibility and are exposed to various cultures online, and there are many people who have a hobby for collecting toys. However, as there is currently no formalized system for individual toy trade online, it is difficult to acquire expertise and share information with each other through a major portal site's $caf{\acute{e}}$, and is exposed to security or fraud while trading toys. In this paper, we design and implementation of a web-based toy trading system. Analyzing the advantages and disadvantages of the various trading and relay systems currently in use, it will provide opportunities for professional toy knowledge and information exchange to many users who have a hobby of collecting toys, and will greatly help vitalize the toy market through a secure and convenient trading environment between individuals.

Associated Factors on Energy Drink Consumption among Korean High School Students (고등학생의 고카페인 에너지 음료 섭취에 대한 관련 요인)

  • Ra, Jin Suk;Yun, Hee Kyung;Kim, Hye Sun;Ryu, Jeong Lim
    • Journal of the Korean Society of School Health
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    • v.30 no.1
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    • pp.48-58
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    • 2017
  • Purpose: The purpose of this study was to identify the factors associated with energy drink consumption in Korean high school students. Methods: This cross sectional study used the secondary data from the 2015 Adolescent Health Behavior Online Survey. A total of 33,744 high school students were included in the study. Energy drink consumption was measured by asking how often they consumed energy drink during the previous week. Associated factors were categorized into socio-demographic characteristics, psychological characteristics, and health related behavioral characteristics. Complex samples logistic regression was used to analyze the influence of associated factors on energy drink consumption. Results: For socio-demographic characteristics, adolescent boys were likely to consume more energy drink than adolescent girls (Adjusted Odds Ratio [AOR]: 1.351, 95% Confidence Interval [CI]: 1.209~1.510). For psychological characteristics, depressed adolescents were likely to consume more energy drink than their counterparts (AOR: 1.697, 95% CI: 1.537~1.874). For health related behavioral characteristics, cigarette smoking (AOR: 1.336, 95% CI: 1.168~1.528), alcohol drinking (AOR: 1.126, 95% CI: 1.012~1.254), soda drink consumption (AOR: 1.800, 95% CI: 1.565~2.071), sweet drink consumption (AOR: 1.715, 95% CI: 1.431~2.054), and insufficient sleep time a day (AOR: 1.307, 95% CI: 1.197~1.427) were associated with energy drink consumption. Conclusions: In conclusion, energy drink consumption in Korean high school students were associated with such factors as psychological factors (depression) and health related behavioral characteristics (smoking, alcohol, sleep, soda and sweet drink). Thus, intervention programs in schools and communities should focus on these psychological and health related behavioral characteristics.

A Study of Representation of Jong-no and Bon-jung in Modern Boy and Assassination : Focusing on the Post-colonialism (<모던보이>와 <암살>의 본정과 종로 재현 연구 -탈식민주의를 중심으로-)

  • Chin, Su-Mee
    • The Journal of the Korea Contents Association
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    • v.19 no.7
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    • pp.234-245
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    • 2019
  • In this paper, I examined the representation of post-colonialism focusing on the spaces in Modern Boy and Assassination. These movies represented Bon-jung and Jong-no as a mixed-residence quarter, over the dual city theory, the orthodoxy of geography. It can be interpreted as the birth of a hybrid subject in post-colonialism. The representation of Bon-jong in Modern Boy was centered around Mitsukoshi Department Rooftop Garden, Namsan Music Center and Myeongdong Cathedral. The representation of Bon-jung in Assassination was centered around Anemone Cafe and Mitsukoshi Department Store. Set in the history of the new building the Japanese Government General of Korea in Jong-no, Modern Boy used it as a place of struggle. The representation of Jong-no in Assassination was centered around the mansion of Kang In-kuk, a pro-Japanese collaborator. Modern Boy and Assassination showed the post-colonialism that breaks through modern binary oppositions by a 'female' national heroine. describing Bon-jung as both a mixed-residence quarter and the original home of post-colonialism movement, they also showed a different aspect from the existing Kyung-sung representations.

Analysis of Fun Elements and User Preferences in Environment Adaptive Survival Games (환경 적응적 생존 게임의 재미 요소와 사용자 분석)

  • Song, Doo Heon
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.23 no.3
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    • pp.305-310
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    • 2019
  • Survival horror games aim to seek cathartic psychological escapism from the framed fear or hostile environment. However, if the goal of the game playing is only "survival" against hostile environment, the motivation of such environment adaptive games may not be based on the framed fear. We may call such games as "environment adaptive survival games". In this paper, we analyze the contents of six such survival games that have large user groups in Steam platform based on the pilot survey. We extract 13 almost common fun elements that induce the fun of such games. An online user survey was conducted through multiple survival game cafe to investigate who play such games. There was no gender differences in playing time but females prefer constructing tools as a fun element and play puzzle and simulation games more than males. We found that survival games could be welcomed by female users under 30 years old if 'horror' element was minimized.

Assessment for Exposure Levels of Hazardous Substances in Kids Cafes within Some Metropolitan Area (일부 수도권지역에서의 키즈카페 내 유해물질 노출수준 평가)

  • Kim, Ho-Hyun;An, Sun-Min;Lee, Jae-Young;Choi, In-Seak;Lee, Jeong-Hun;Nam, Yi-Hyun;Yoo, Si-Eun;Jung, Da-Young;Lee, Chul-Woo;Park, Choong-Hee
    • Journal of Environmental Health Sciences
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    • v.45 no.1
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    • pp.54-61
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    • 2019
  • Objectives: In this study, we investigated an assessment for exposure levels of hazardous substances to kids cafes that unregulated by law. Methods: Heavy metals, volatile organic compounds, formaldehyde, pesticides and phthalate were measured at 20 kids cafes in Gyeonggi-do and Incheon. Samplings were conducted from April to July in 2018. Results: Heavy metals were detected over the standard mainly around the floor and walls in the 19 kids cafes. Pesticides were detected in 7 locations with chlorpyrifos, diazinon and cypermethrin, and showed the highest detection level of chlorpyrifos. The concentrations of DEHP in all kids cafes were exceeded with standard. The risk assessment results showed that HCHO as carcinogen had a safety level and DEHP as non-carcinogens had a safety level as assessed to be under than 0.1. Conclusions: Considering the exposure investigation results and the importance of child health protection, kids cafe should be included in the legal management list of children's activities zones.

The Effects of Cultural Marketing on Customer Satisfaction of Coffee Shops: Focused on Jeju Island Cafe (커피전문점의 문화 마케팅이 고객만족에 미치는 영향 : 제주도 카페를 중심으로)

  • Lee, Jin-Joo;Wang, Chae-Yeon;Hyun, Mi-Hui;Han, Sangho
    • The Korean Journal of Franchise Management
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    • v.10 no.1
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    • pp.33-42
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    • 2019
  • Purpose - Since the number of cafés operated by using cultural marketing in Jeju Special Self-Governing Province is increasing, this study emphasizes the necessity of cultural marketing, which is a different strategy of specialty coffee shops, focusing on Jeju Island. The purpose of this study is to investigate the effect of positive effects of service quality and brand image on customer satisfaction through cultural marketing. Research design, data, and methodology - It emphasizes the necessity of cultural marketing of specialty coffee shops, and how the positive effects of service quality and brand image brought through cultural promotion, culture support, cultural support, cultural enterprise influence customer satisfaction. The results of this study are as follows. In order to verify the research hypothesis of this study, Jeju residents who have experience using cultural marketing conducted in coffee shops in Jeju Island are targeted. The cafe in Jeju area, which runs from April 4 to April 14, 2018. A total of 110 copies of the questionnaire were distributed, and the final 100 copies were used as final empirical analysis data. Result - The results of the study are as follows. First, promotion and culture business activities have positive influence on brand image. Second, production and cultural business activities had positive effects. Third, brand image has a positive effect on customer satisfaction. Fourth, service quality has a positive effect on customer satisfaction. Conclusions - The implications of this study are following as: First, if you want to grow into a cultural enterprise in the province by enhancing your brand image, you need to prioritize cultural direction and business direction for cultural companies among sub-factors of cultural marketing. Second, it is necessary to improve the customer satisfaction through the improvement of the brand image considering the composition of the stores in the city, the facilities and the atmosphere, and the consumer tendency such as product and customer age.

A Truth about 'Deformed' Love in Carson McCullers' The Ballad of the Sad Cafe (카슨 매컬러스의 '불구적' 사랑에 관한 통찰 -『슬픈 카페의 노래』를 중심으로)

  • Park, So Jin
    • Journal of English Language & Literature
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    • v.57 no.2
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    • pp.315-337
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    • 2011
  • This paper aims to examine a truth about love - the close relationship between a person's passionate love and that same person's loneliness and suppressed desires, a relationship that Carson McCullers (1917-1967) portrays in The Ballad of the Sad Cafe. McCullers, one of several brilliant writers from Southern America, managed to overcome her cruel situation and showed deep insight into the human condition, particularly in regard to the relation between love and isolation. The Ballad of the Sad Cafe, like her other works, examines the spiritual isolation and the agony of love that three lovers experience. The love in this story is a triangular relationship among the three main characters, Amelia, Lymon and Marvin Macy. The distinctive characteristics of love described in this story are that each character falls into blind and passionate love for the person he/she loves, no matter how the beloved responds. Love also changes the lover, not the beloved, revealing the completely opposite nature of the lover. The opposite nature and the inner secrets that the love reveals about the lovers reflect their frustrated and suppressed desires, which is femininity and motherhood for Amelia, non-violent masculine power for Macy, and physical attraction and power for the hunchback, Lymon. These suppressed desires are rooted in the deep sense of frustration that they had to experience in their childhood. In short, the seemingly unconditional love of the main characters is not an ideal, altruistic love, but a reflection of their inner desires. This story, however, does not seem to criticize this kind of love but simply tries to give an honest picture of what love might be. It also admits that 'deformed' love is still better than no love (and consequently no stimulus) because what really damages and causes decay in human beings and in a community, is the state of boredom.

Developing Appropriate Inventory Level of Frequently Purchased Items based on Demand Forecasting: Case of Airport Duty Free Shop (수요예측을 통한 다빈도 구매상품의 적정재고 수준 결정 모형개발: 공항면세점 사례)

  • Cha, Daewook;Bak, Sang-A;Gong, InTaek;Shin, KwangSup
    • The Journal of Bigdata
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    • v.5 no.2
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    • pp.1-15
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    • 2020
  • The duty-free industry before COVID-19 has continuously grown since 2000, along with the increase of demand in tourism industry. To cope with the increased demand, the duty free companies have kept the strategies which focused on the sales volume. Therefore, they have developed the ways to increase the volume and capacity, not the efficient operations. In the most of previous research, however, authors have proposed the better strategies for marketing and supporting policies. It is very hard to find the previous research which dealt with the operations like logistics and inventory management. Therefore, in this study, it has been predicted the future demand of frequently purchased items in airport duty free shops based on the estimated number of departing passengers by the linear regression, which concluded with the appropriate inventory level. In addition, it has been analyzed the expected effects by introducing the inventory management policy considering the cost and efficiency of operations. Based on the results of this study, it may be possible to reduce total cost and improve productivity by predicting the excessive inventory problems at duty-free shops and improving cycles of supplying items.