• 대한불안의학회:학술대회논문집
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• 2004.03a
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• pp.56-63
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• 2004

o 최근 강박장애의 치료가 발전한 것만은 사실이나 아직도 1차 치료에 반응이 없는 환자가 많다. o 치료반응의 평가는 매우 중요하며 현재 Y-BOCS를 이용하여 주로 치료반응을 평가하고 있으나 Y-BOSC 자체도 많은 문제점을 안고 있다. o 약물치료시 특히 치료반응의 여부를 결정짓는 의사결정은 매우 중요하다. o 국내에서도 강박장애 치료알고리듬이 개발되어 강박장애의 치료 및 평가에 있어 기초가 되어야 할 것으로 기대된다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.15 no.2
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• pp.132-142
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• 2004

Most articles of Reactive Attachment Disorder reported Disinhibited Type children adopted from other countries. Reports from only Turkey and Korea focused on Inhibited Type of Reactive Attachment Disorder children whom raised by their own parents and whose symptoms are very similar to Autistic Disorder. Since articles of treatment of Reactive Attachment Disorder, especially for Inhibited Type are very rare, this article informed the author's experiences of treatment for Korean Reactive Attachment Disorder children since 1987. To treat Reactive Attachment Disorder patients and their parents, three important areas must be included : 1) to make a therapeutic environment for a Reactive Attachment Disorder child, 2) to make an attachment between Reactive Attachment Disorder child and his/her mother through individual play therapy, filial therapy, and group therapy with sibling or peer, 3) to catch up developmental delay by speech therapy, cognitive therapy and therapeutic education. This treatment methods can be more easily and more effectively applied to Korean patients than other methods from western countries including USA or England.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1992.05a
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• pp.58-58
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• 1992

연구자들은 제 2상 임상시험의 모델을 검토하기 위하여, 비무작위적 제 2상 임상시험을 진행 위선암환자에서 시행하였다. 병리조직학적으로 확인되고, 객관적으로 계측가능 병변이 있는 위선암 환자를 대상으로 하였으며, 위선암의 조직 진단은 위선암의 모든 유형을 포함하였다. 환자는 (Datelliptinium)율 1일 250 mg/$m^2$씩 3일 연속 30분에 걸쳐 정주하고, 매 3주마다 반복하였다. 반응의 완전평가는 초치료전 실시하여, 14-25명의 환자가 포함될 예정으로 시작하여 총 15명의 환자가 포함되었다. 매 환자마다 매 치료 주기전에 평가를 실시하였다. 최소 1주기 (3일 치료)를 끝낸 환자에서도 반응평가가 가능한 것으로 간주하였으며 치료기간은 반응의 정도와 치료에 대한 내약력으로 결정하였고, 만일 치료에 대해 현저한 독성이 발생되지 않는다면, 치료 반응이 계속되는 동안 약물투여를 계속하였다. 국소진행암의 경우 약물의 반응이 현저하고, 환자의 전신상태가 현저히 개선되어 외과적 절제가 가능하면, 관해로 간주하고 외과적 절제를 실시 후 약물은 4회 투여하고 치료 종료 후 추적 관찰할 계획으로 시행하였다.

• Tuberculosis and Respiratory Diseases
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• v.47 no.1
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• pp.13-25
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• 1999

Background: Ineffective cell-mediated immune response in human tuberculosis is associated with a depressed Thl cytokine response and reduced production of IFN-$\gamma$. Most persons infected with Mycobacterium tuberculosis are healthy tuberculin reactors with protective immunity, but a minority with ineffective immunity develop extensive pulmonary tuberculosis. The cell-mediated immune response is an important aspect of host resistance to mycobacterial infection and is believed to be tightly regulated by a balance between Th1 cytokines including IFN-$\gamma$, IL-12, IL-18, regulated on activation, normal T cell expressed and secreted (RANTES) and Th2 counterparts such as IL-4, monocyte chemoattractant protein-l (MCP-l). Methods: Proliferation and mRNA expression of IFN-$\gamma$, RANTES and MCP-l by RT-PCR in peripheral blood mononuclear cells (PBMCs) in response to in vitro stimulation with mycobacterial antigens were compared in pulmonary tuberculosis patients with cured and treatment failure and in tuberculin-positive and tuberculin-negative healthy subjects. Results: Defective proliferative responsiveness to aqueous TSP antigen was involved with treatment failure tuberculosis patients. Aqueous TSP antigen-induced IFN-$\gamma$ and RANTES mRNA expression was decreased in treatment failure tuberculosis patients compared with healthy tuberculin reactors and cured tuberculosis patients (23.1 % versus 90.0% for IFN-$\gamma$ and 46.2% versus 70.0% versus 46.2% for RANTES). The frequency of MCP-l mRNA expression to aqueous TSP antigen in treatment failure tuberculosis patients was greater than in healthy tuberculin reactors and cured tuberculosis patients (76.9% versus 40.0%). Conclusion: The increasing expression of MCP-1 mRNA in response to aqueous TSP antigen might be predicted to favor Th1 responses and restricted Th1 responses in treatment failure of pulmonary tuberculosis.

• Childhood Kidney Diseases
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• v.11 no.2
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• pp.272-279
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• 2007

Purpose : We tried to find out the clinical parameters which predict the outcome of treatment in children with enuresis. Methods : Enuresis patients who visited our hospital during 2003-2007 were included. Parameters such as age, gender, height, weight, minimal voided volume, maximal voided volume, maximum functional bladder capacity, frequency of voiding, urine S,G. before and after sleep were measured and an enuresis diary was also recorded. The reduction in wetting frequencies were classified into three groups; none(<50%), partial(50-90%) and complete(90%) response groups. We also compared the 'initial responders' who showed improvement(${\ge}50%$) during the 2 weeks of evaluation and behavioral therapy to the 'initial non-responders'. Results : Parameters mentioned above showed no significant relation to the treatment out-come. The response rate during the 2 weeks of the evaluation period was 32%(49/151) [complete in 1.3% (2/151), partial in 29.6% (47/151)]. Two-months' treatment responses were complete in 14(40%), partial in 19(54.3%) and none in 2(5.9%) responders(n=35), while they were 10(13.5%), 46(62.2%) and 18(24.3%), respectively in the non-responders(n=73) (P<0.05). Conclusion : We suggest that initial 'responsiveness' can be used as a predictor for good treatment outcome in patients with enuresis.

• Journal of Korean Classical Literature and Education
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• no.39
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• pp.5-39
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• 2018

This paper aims to identify the characteristics of literary therapy in relation to literature education. It also intends to clarify its distinctiveness. Literary therapy is not to teach literature. It does not deliver knowledge on agreed analyses, backgrounds and the nature of genres. Literary therapy encourages participants to fully appreciate one's thought and emotions and express them. The end goal is self-knowledge rather than the understanding of texts. Literary therapy focuses on self-knowledge through literatures as opposed to literature education which aims to encourage understandings of literature texts. In literary therapy, literature is media for personal growth facilitating self-expansion. Literature works enable participants to view oneself objectively by the means of one's responses to literature works. Literary therapy has more permissive viewpoints on recipients' response to literature texts than literature education. In addition, the subject of literary therapy is more unique and individualistic.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.6 no.1
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• pp.35-49
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• 2000

허리 근육손상은 기대치 못한 상황에서 신체의 적절한 반응이 지연될 경우 근육 염좌와 같은 상해나 요통으로 연결된다. 이 연구는 척추 안정 운동 후 척추의 유연성과 척추 근육의 반응 속도를 만성 요통 환자와 정상인을 대상으로 비교 연구 하였다. 만성 요통 환자 군은 척추 안정 운동을 4주간 20회 시행하였으며 이와 비슷한 특성을 가진 대조군을 비교하였다. 신체 유연성은 환자가 앉은 자세에서 척추를 축으로 신체의 회전 정도를 측정하였다. 척추 반응 속도 측정은 환자가 선 자세에서 두 손으로 판을 들고있는 동안 정구공이 1.8 m (6.4 N)에서 낙하시 좌, 우측 척추 근육의 반응 속도를 Wavelet 분석으로 측정하였다. 연구 결과 척추 안정 운동을 행한 만성 요통 환자군의 신체 유연성과 척추 근육 반응 속도가 통계적으로 유의하게 증가하였다. 척추 유연성은 만성 요통 환자 군에서 131.0cm에서 척추안정 운동후 144.1cm으로 증가하였다 (p<0.05). 척추 근육 반응 속도는 척추 안정 운동을 행한 만성 요통 환자 군에서 90.00msec에서 68.55msec로 (p<0.05), 정상 군에서는 86.28msec에서 75.64msec로 (p>0.05) 단축되었다. 척추 안정 운동은 근, 신경 조직의 반응속도를 증가시키며 특히 만성 요통 환자에서 척추의 안정성을 회복시킨다. 특히 척추의 안정성 증가는 기대치 못한 상황에서 선체의 적절한 반응의 속도를 회복시키며 결과적으로 허리 손상을 예방 할 수 있다. 물리치료학에서 근 골격 신경계의 반응 속도측정을 위한 연구로 Wavelet 분석과 같은 첨단장비를 통한 운동 치료의 질에 관한 연구의 도입이 필요하다. 또한 구체적인 치료적 운동결과의 측정을 통해 물리 치료의 효과성과 효율성을 높이기 위한 생체 의학적 연구가 요망된다.

• Radiation Oncology Journal
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• v.14 no.2
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• pp.115-122
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• 1996

Purpose : To improve the treatment results of locally advanced nonsmall cell lung cancer (NSCLC) patients we treated those patients with regional hyperthermia combined with radiotherapy. And we conducted a retrospective analysis of the results. Material and Methods Thirty two nonsmall cell lung cancer Patients treated at the Department of Radiation Oncology, St. Mary's hospital, Catholic University Medical College were the base of this analysis. Fourteen patients of above them were treated with hyperthermia and radiotherapy of more than 3000 cGy in radiation dose. Radiofrequency capacitive hyperthermia was administered twice weekly immediately after radiotherapy. Total sessions of hyperthermia ranged from 3 to 13 times (mean 7.8). Eighteen patient received an external radiation therapy alone Median radiation dose was 5580 cGy (range, 3000-7000 cGy) in fraction of 180-300 cGy, 5 fractions per week. Results: The results of themoradiotherapy group (HTRT group) were compared with radiation alone group (RT group). There were no complete response (CR) and 12 Partial responses (PR) (CR rate $0\%$, response rate $85.7\%$) in HTRT group, whereas there were 2 CRs, 8 PRs and 8 no responses (CR rate $11.1\%$, response rate $55.6\%$) in RT group. There was significant differece in local response rate of the tumors between RT group and HTRT group (p < 0.05). Overall 2 rear survival rate and mean survival were $7.1\%$ and 10.5 months for HTRT group, and $0\%$ and 8.1 months for RT group. However, by the number of hyperthermia. in cases with more than or equal to 10 sessions of hyperthermia, there were significant improvement in 2 year year survival rate and mean survival ($40.0\%$ and 18.2 months) compared with those in cases with less than 10 sessions of hyperhtemia ($7.4\%$ and 7.4 months) (p < 0.05). Conclusion : Thermoradiotherapy in locally advanced NSCLC patients increased their response rate but not 2 year survival and mean survival, therefore thermoradiotherpy with enough number of hyperthermia is suggested that may be one of the effective palliative treatments of those patients. And in cases with more than 10 sessions of hyperthermia, there showed improved 2 year survival rate and mean survival But the number of the cases was small further study in this aspect is required.

• Radiation Oncology Journal
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• v.27 no.2
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• pp.55-63
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• 2009

Purpose: This study was performed to objectively evaluate the rate of tumor response to hypofractionated radiotherapy for advanced squamous cell carcinomas of the head and neck. Materials and Methods: Thirty-one patients with advanced squamous cell carcinoma of the head and neck, who were treated by hypofractionated radiotherapy with 3 Gy per fraction for palliative purpose between 1998 and 2008, were reviewed retrospectively. Every tumor-volume was measured and evaluated from CT (computed tomography) images obtained before and 2~3 months after radiotherapy. The radiation toxicity was assessed during and after radiotherapy. A statistical analysis was performed to investigate overall survival, progressionfree survival, and the prognostic factors for survival and response. Results: The median age of the study patients was 70 years. In addition, 85% of the patients were in stage 4 cancer and 66.7% had an ECOG performance status of 1~2. The mean tumor-volume was 128.4 cc. Radiotherapy was administered with a total dose of 24~45 Gy (median: 36 Gy) over 10~25 days. Twenty-nine patients were treated with 30 Gy or more. The observed complete response rate was 12.9% and the partial response rate was 61.3%. Median survival time was 8.9 months and the 1-year progression-free survival rate was 12.9%. The treatment response rate was confirmed as a prognostic factor in the rate of survival. The primary site, stage, tumor-volume, radiotherapy field and overall radiation-dose showed a significant relationship with survival and treatment response. No grade 4 toxicity was observed during and after radiotherapy. Conclusion: There was an objective tumor-regression in about 74% of patients treated by hypofractionated radiotherapy. Further evaluation is needed to select the appropriate fraction-size and patient who may require the additional radiotherapy.

• The Journal of Korean Academy of Sensory Integration
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• v.6 no.1
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• pp.63-69
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• 2008

Introduction : This study presents a case report of a child with sensory integration dysfunction(mixed sensory modulation disorder and dyspraxia), and describes strategy of the sensory integration intervention to encourage child's inner drive and the change of adaptive response. Main Subject : The subject was a boy, age 5 years and 10 months, who participated in short-term intensive sensory integration therapy program which was provided in a 2008 sensory integration treatment course. Based on results of assessment to the child, This study identifies the treatment goals, contents of treatment and analyze adaptive response' change of four therapy sessions. Conclusion : This case report demonstrates improvement of the adaptive response by sensory integration intervention and impotent to encourage the child's inner drive. However, subjective date, which is sensory integration may produce an effect that is evident during treatment sessions and in home environment have suggested.