• Journal of Digestive Cancer Research
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• v.1 no.1
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• pp.43-47
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• 2013

There have been very few reports related to pancreatic cancer developing in the remnant pancreas after a resection for pancreatic cancer. We report two cases of repeated pancreatectomy for second primary pancreatic cancer. A 58-year-old man with a 2.3 cm sized low attenuated pancreatic tail mass on abdomen CT scan, received a distal pancreatectomy (adenosquamous carcinoma, stage IIB) and adjuvant chemoradiotherapy. A follow-up abdomen CT scan revealed a 2.0 cm sized pancreatic head mass in the remnant pancreas at 35 months after the distal pancreatectomy. He received a pancreaticoduodenectomy and diagnosed as ductal adenocarcinoma (stage IIA). Another 62-year-old female was declared pancreatic head mass on a regular health examination. An abdomen CT scan revealed a 3.6 cm sized mixed solid and cystic mass. She received a pylorus-preserving pancreaticoduodenectomy (ductal adenocarcinoma, stage IB) and adjuvant chemoradiation therapy. At 20 months after the resection, a 1.8 cm sized ill-defined low attenuated mass developing in the tail of remnant pancreas was detected on a follow-up abdomen CT scan. The patient received a distal pancreatectomy and diagnosed as ductal adenocarcinoma (stage IIA).

• Journal of the korean veterinary medical association
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• v.47 no.12
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• pp.1086-1090
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• 2011

외인성 췌장부전은 췌장에서 분비되는 소화효소의 부족한 합성 및 분비에 기인한다. 대부분의 개체에서 보이는 임상증상은 체중감소, 다량의 연변, 지방변이다. 혈청 고양이 유사트립신 면역활성 농도검사는 외인성 췌장부전 진단에 있어 매우 유용한 검사법이다. 외인성 췌장부전 환자의 치료는 췌장 소화효소의 공급이다. 대부분의 외인성 췌장부전 환자에서 심각한 혈청 코발라민의 감소와 동반되기 때문에 코발라민의 투여는 반드시 필요하다. 마지막으로 개에 비해 흔하게 확인되진 않지만, 만성적인 연변 및 체중감소를 보이는 환자에서는 진단에 있어 외인성 췌장부전에 대한 고려가 필요하다.

• Proceedings of the KAIS Fall Conference
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• 2009.12a
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• pp.759-763
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• 2009

본 연구의 목적은 도심지역 주민들의 건강생활습관과 췌장암과의 연관성을 파악하는데 있다. 이를 위해 2008년 6월 20일부터 7월 20일까지 종합병원에 내원한 췌장암 환자군 51명, 대조군 116명을 대상으로 설문 및 면접조사를 실시하였다. 연구결과 첫째, 음주량이 증가함에 따라 췌장암발생 위험은 유의하게 증가되었다(P<0.05). 둘째, 췌장암 발생위험에 대한 식사속도, 자극성 음식선호여부, 뜨거운 음료선호여부, 채식선호 정도 등은 환자군과 대조군간에 유의한 차이를 보이지 않았으나 교육수준이 낮을수록 수입이 낮을수록 도시보다는 농 어촌에 거주할수록 췌장암 발생위험도가 유의하게 증가함을 보였다(P<0.01). 셋째, 췌장암 발생에 대한 흡연과 음주의 상협효과 결과 흡연과 음주를 동시에 이용하였을 때 췌장암 발생위험도는 흡연 또는 음주만 이용할 때보다 상협적인 증가를 보였으며 통계적으로 유의하였다(P<0.05). 이상에서 볼 때 췌장암 진단을 위한 정기적인 검사가 보편화되지 않고 대상자의 판단에 의해서만 실시되고 있는 국내 상황을 고려할 때 본 연구에서 유의하게 나타난 위험요인들을 기초로 췌장암 위험 사정 도구의 개발이 필요하다.

• The Monthly Diabetes
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• s.289
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• pp.53-56
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• 2013

당뇨병과 췌장암은 어떠한 관계가 있을까? 제2형 당뇨병의 경우 췌장암의 발생 위험은 1.8배 높다. 우리나라 췌장암 환자의 당뇨병 유병률은 28~30%로 일반인의 당뇨병 유병률이 7~9%에 비하여 3배 이상 높다(중앙암등록본부, 2012). 또한 일반인의 췌장암 유병률이 10만명 당 7명(0.007%)인데 비하여 당뇨병 환자의 췌장암 유병률은 1.6%이고, 췌장암 환자에서 당뇨병이 있을 확률은 40.6%라 한다(대한소화기학회지, 2009).

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.2 no.2
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• pp.194-203
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• 1999

Purpose: Childhood pancreatitis has more various and somewhat different etiology than adult. Until now the analysis of severity in childhood pancreatitis were not well-known, although several studies have been made. Therefore, we studied the etiology and complications in childhood pancreatitis and analyzed whether Ranson and CT criteria could be applicated to evaluate the severity of childhood pancreatitis patients. Methods: The records of 30 patients with pancreatitis under 15 years of ages who were diagnosed in Asan medical center were reviewed. Age, sex, history, etiology, clinical features and treatment was reviewed in all patients but complications, Ranson and CT criteria were available in only 12 patients. Correlation between the number of complications and both Ranson and CT criteria were calculated with Spearman correlation coefficient. Results: 1. Median age at diagnosis was 7.3 years of age. 28 cases were acute pancreatitis and 2 cases were chronic pancreatitis. 2. Etiology: choledochal cyst(8 cases), drug (7 cases), trauma (4 cases), infection (3 cases), biliary stone or bile sludge (3 cases), idiopathic (2 cases) Hemolytic uremic syndrome, pancreatic duct obstruction, iatrogenic (1 case). 3. Local complications were ascites (5 cases), pseudocyts (4 cases) and systemic complications were hyperglycemia (4 cases), hypocalcemia (3 cases), pleural effusion (3 cases), etc. 4. Positive correlation was found between the number of complication and Ranson creteria (r=0.78, P=0.0016) and between the number of complication and CT criteria (r=0.65, P=0.015) in 13 cases. Conclusion: A trial to search the biliary duct anomaly may help to find the causes of childhood idiopathic pancreatitis, and both Ranson and CT criteria can be applicated to pediatric patients to evaluate the severity of childhood pancreatitis.

• Journal of the Korean Society of Radiology
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• v.81 no.6
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• pp.1436-1447
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• 2020

Purpose To investigate the clinical and CT features at admission to predict the progression to necrotizing pancreatitis (NP) in patients initially diagnosed with interstitial edematous pancreatitis (IEP). Materials and Methods Patients with IEP who underwent contrast-enhanced CT at admission and follow-up CT (< 14 days) were included (n = 178). Two radiologists performed a consensus review of follow-up CT scans and diagnosed the type of acute pancreatitis as IEP or NP. Laboratory findings at admission were recorded. Clinical, CT, and laboratory findings were compared between the IEP-IEP group and IEP-NP group using the chi-square test and the t-test. Multivariate analysis was also performed. Results There were 112 and 66 patients in the IEP-IEP and the IEP-NP groups, respectively. The proportion of patients with alcohol etiology was significantly larger in the IEP-NP group. Among the CT findings, the presence of peripancreatic fluid and heterogeneous parenchymal enhancement were more frequently observed in the IEP-NP group. Among the laboratory variables, serum C-reactive protein levels and white blood cell counts were significantly higher in the IEP-NP group. Multivariate analysis revealed that the presence of peripancreatic fluid and heterogeneous parenchymal enhancement were significant findings distinguishing the two groups. Conclusion CT findings, such as the presence of peripancreatic fluid and heterogeneous pancreatic parenchymal enhancement, may be helpful in predicting the progression to NP in patients initially diagnosed with IEP.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.490-492
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• 2016

Pancreatic ultrasound imaging is used to diagnose pancreatic hyperplasia, pancreatic steatosis, pancreatic cancer and the like. If the diagnosis of pancreatic steatosis is pancreatic parenchyma echo shades splashes spleen than in the pancreas ultrasound it determines that the fat is deposited. And research on ultrasound imaging of pancreatic cancer but is actively conducted research studies on pancreatic steatosis is insufficient In addition, pancreatic steatosis is often an error in accordance with the diagnostic criteria are vague and subjective diagnosis of the artisan. This study was a quantitative analysis using the feature value extracting a feature of an image extracted by applying a parameter to the algorithm GLCM image of the normal and pancreatic fat. Setting a region of interest ($5{\times}5pixel$) in the mild 89 case, moderate 89 case, severe 89 case, total image 267 case using GLCM algorithm, and using the Autocorrelation, Sum average, Sum of squares, Sum varience 4 kinds parameter in each image It was analyzed.

• Journal of Veterinary Clinics
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• v.27 no.6
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• pp.686-692
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• 2010

Computed tomography (CT) is considered as gold standard in evaluating pancreatitis in human, but there have been only a few studies in veterinary field. Balthazar CT severity index (CTSI) used to assess the severity of acute necrotizing pancreatitis in human could be applicable to dogs, because the severity of acute pancreatitis depends on the area of pancreatic necrosis in dogs more than in human. In this study, 25 adult, clinically healthy beagle dogs were used. CT examinations was performed in normal pancreas, positive control group and acute necrotizing pancreatitis induced by autologous bile injection. Balthazar CTSI was applied to canine acute necrotizing pancreatitis in contrastenhanced CT image and compared with the result of histopathologic examination. The Hounsfield unit (HU) of normal canine pancreas was $52.44{\pm}4.58$ and the density was significantly decreased in acute necrotizing pancreatitis (P < .05). In contrast-enhanced CT examination, pancreatic density was decreased significantly and this area was compatible to pancreatic necrosis. Balthazar CTSI showed positive correlation with histopathologic evaluation with a sensitivity of 100% and a specificity of 88.89%. Balthazar CTSI can be applied to evaluate the severity of acute necrotizing pancreatitis in dogs.

• The Korean Journal of Physiology
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• v.22 no.1
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• pp.101-109
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• 1988

최근에 마취한 흰쥐에서 중뇌망상체를 전기적으로 자극하면 췌장의 외분비 기능이 증가하며 이러한 결과는 망상체의 자극으로 인하여 교감신경계의 활성도가 상승하기 때문이라는 보고가 있다. 한편 교감신경계의 활성도가 상승할 경우 교감신경계의 전달 물질인 catecholamine이 교감신경 종말 뿐만 아니라 부신수질에서도 유리된다고 알려져 있다. 그러므로 본 연구에서는 중뇌망상체의 자극으로 인하여 췌장의 외분비 기능이 증가함에 있어 교감신경계가 중요한 역할을 담당하는지를 확인하고, 이때 부신수질이 관여하는가를 알아보고자 하였다. 마취한 흰쥐에게 atropine (1mg/kg) 또는 reserpine (5mg/kg)을 투여하거나 또는 부신을 적출한 다음 중뇌망상체를 전기 자극하면서 췌장액을 채취하였다. 사용한 전기자극의 매개변수는 1.3V, 40Hz, 2msec이었다. atropine과 reserpine을 투여하면 마취한 흰쥐의 자발적 췌장액 분비량과 단백질 분비량은 모두 유의하게 감소하였으나 부신을 제거하면 췌장액 분비량에는 이렇다할 변동이 없는 반면에 단백질 분비량은 유의하게 감소하였다. 중뇌망상체를 전기자극하면 췌장액 분비량과 단백질 분비량 모두가 유의하게 증가하였다. 이러한 망상체의 자극효과는 atropine 전처치에 의하여 이렇다할 영향을 받지 않았으나 reserpine 전처치에 의하여 소실되었다. 그러나 부신을 적출하면 망상체 자극에 의한 췌장액 분비량의 증가는 유지되는 반면에 단백질 분비량의 증가는 소실되었다. 한편 미주신경을 절단한 흰쥐에서 중뇌망상체를 자극하는 동안에 경동맥의 수축기 및 이완기 혈압이 상승하였는데 이러한 망상체의 자극효과도 reserpine의 투여에 의하여 유의하게 감소되었다. 본 실험의 결과를 종합하여 보면 마취한 흰쥐에서 중뇌망상체의 자극은 교감신경계를 활성화시켜 췌장액 분비량과 단백질 분비량에 촉진적인 영향을 미치며, 이때 활성화된 교감신경계는 부분적으로 부신을 경유하게 췌장의 단백질 분비에 촉진적인 영향을 미치는 것으로 생각된다.

• Journal of Nutrition and Health
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• v.19 no.6
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• pp.374-381
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• 1986

The effects of the hormonal factor (CCK) a and neural factor(carbachol) on the exocrine function of the pancreas were studied in th is experiment. A superfusion technique was used for in vitro study of stimulus-secreti- o on coupling in isolated pancreatic acinarce 11s frQm the rats fed heated or raw soybean diet. Chymotrypsin secretion was higher in cells from the raw soybean group than in those from the heated soybean group with both kinds of stimulants(CCK and carbachol), whereas, amylase secretion was higher inthe h heated soybean group than in the raw soy­b bean group. This indicated that chymotrvpsin a and amylase secretion from the acinar cells are not parallel with CCK and carbachol st­i imulation.