Two Cases of Repeated Pancreatectomy for Pancreatic Cancer Developing in the Remnant Pancreas after a Resection of Pancreatic Cancer - Repeated Pancreatectomy of Pancreatic Cancer -

췌장암 절제 후 잔여췌장에 발생한 췌장암에 대한 반복절제를 시행한 2례 - 췌장암의 반복절제 -

  • Young-Il Kim (Department of Internal Medicine, Center for Liver Cancer, National Cancer Center) ;
  • Sang Myung Woo (Department of Internal Medicine, Center for Liver Cancer, National Cancer Center) ;
  • Woo Jin Lee (Department of Internal Medicine, Center for Liver Cancer, National Cancer Center)
  • Received : 2012.10.10
  • Accepted : 2012.11.26
  • Published : 2013.03.31

Abstract

There have been very few reports related to pancreatic cancer developing in the remnant pancreas after a resection for pancreatic cancer. We report two cases of repeated pancreatectomy for second primary pancreatic cancer. A 58-year-old man with a 2.3 cm sized low attenuated pancreatic tail mass on abdomen CT scan, received a distal pancreatectomy (adenosquamous carcinoma, stage IIB) and adjuvant chemoradiotherapy. A follow-up abdomen CT scan revealed a 2.0 cm sized pancreatic head mass in the remnant pancreas at 35 months after the distal pancreatectomy. He received a pancreaticoduodenectomy and diagnosed as ductal adenocarcinoma (stage IIA). Another 62-year-old female was declared pancreatic head mass on a regular health examination. An abdomen CT scan revealed a 3.6 cm sized mixed solid and cystic mass. She received a pylorus-preserving pancreaticoduodenectomy (ductal adenocarcinoma, stage IB) and adjuvant chemoradiation therapy. At 20 months after the resection, a 1.8 cm sized ill-defined low attenuated mass developing in the tail of remnant pancreas was detected on a follow-up abdomen CT scan. The patient received a distal pancreatectomy and diagnosed as ductal adenocarcinoma (stage IIA).

췌장암에 대한 근치적 절제술 후에 잔여 췌장에서 발생한 췌장암에 대한 보고는 거의 없는 상태이며, 특히 잔여췌장에 발생한 췌장암에 대하여 반복 췌장절제를 시행한 보고는 더욱 드물다. 저자들은 췌장미부에 발생한 췌장암에 대하여 근치적 절제술을 시행 후 35개월에 잔여 췌장에서 발생한 췌장암으로 췌장십이지장 절제술을 시행한 경우와 췌장두부에 발생한 췌장암에 대하여 췌장십이지장 절제술을 시행 후 20개월 만에 잔여 췌장에 췌장암이 발생하여 췌장미부절제술을 시행한 경우를 경험하였기에 고찰과 함께 보고하는 바이다.

Keywords

References

  1. Li D, Xie K, Wolff R, et al. Pancreatic cancer. Lancet 2004;363:1049-1057.
  2. Yeo CJ, Abrams RA, Grochow LB, et al. Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience. Ann Surg 1997;225:621-633.
  3. Hidalgo M. Pancreatic cancer. N Engl J Med 2010;362:1605-1617.
  4. Koizumi M, Sata N, Kasahara N, et al. Remnant pancreatectomy for recurrent or metachronous pancreatic carcinoma detected by FDG-PET: two case reports. JOP 2010;11:36-40.
  5. Kinoshita H, Yamade N, Nakai H, et al. Successful resection of pancreatic carcinoma recurrence in the remnant pancreas after a pancreaticoduodenectomy. Hepatogastroenterology 2011;58:1406-1408.
  6. Ikematsu Y, Tamura H, Nakata Y, et al. Metachronous multiple adenocarcinomas of the pancreas. Int J Clin Oncol 2011;16:726-731.
  7. Miura F, Takada T, Amano H, et al. Repeated pancreatectomy after pancreatoduodenectomy. J Gastrointest Surg 2007;11:179-86.
  8. Sperti C, Pasquali C, Piccoli A, et al. Recurrence after resection for ductal adenocarcinoma of the pancreas. World J Surg 1997;21:195-200.
  9. Kleeff J, Reiser C, Hinz U, et al. Surgery for recurrent pancreatic ductal adenocarcinoma. Ann Surg 2007;245:566-572.
  10. Wada K, Takada T, Yasuda H, et al. A repeated pancreatectomy in the remnant pancreas 22 months after pylorus-preserving pancreatoduodenectomy for pancreatic adenocarcinoma. J Hepatobiliary Pancreat Surg 2001;8:174-178.
  11. Eriguchi N, Aoyagi S, Imayama H, et al. Resectable carcinoma of the pancreatic head developing 7 years and 4 months after distal pancreatectomy for carcinoma of the pancreatic tail. J Hepatobiliary Pancreat Surg 2000;7:316-320.
  12. Dalla Valle R, Mancini C, Crafa P, et al. Pancreatic carcinoma recurrence in the remnant pancreas after a pancreaticoduodenectomy. JOP 2006;7:473-477.
  13. Takamatsu S, Ban D, Irie T, et al. Resection of a cancer developing in the remnant pancreas after a pancreaticoduodenectomy for pancreas head cancer. J Gastrointest Surg 2005;9:263-269.
  14. Tryka AF, Brooks JR. Histopathology in the evaluation of total pancreatectomy for ductal carcinoma. Ann Surg 1979;190:373-381.
  15. Launois B, Franci J, Bardaxoglou E, et al. Total pancreatectomy for ductal adenocarcinoma of the pancreas with special reference to resection of the portal vein and multicentric cancer. World J Surg 1993;17:122-126.
  16. Andea A, Sarkar F, Adsay VN. Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol 2003;16:996-1006.