• Environmental Mutagens and Carcinogens
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• v.8 no.1
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• pp.35-46
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• 1988

출생직후부터 새끼쥐에 유발시킨 납중독이 중추의 특정 신경계에 미치는 신경독성의 선택성 여부를 알아보고자 하였다. 특정 신경계의 한 예로 모노아민성 신경계를 선택하여 납중독의 지표로 모노아민성 신경계의 효소인 MAO (mono-amine oxidase)의활성을 측정하였으며, 비특정 조직의 지표로 Na+K+-ATPase의 활성을 측정하였다. Wistar계의 흰쥐에서 태어난 새끼들에게 출생직후부터 전실험기간을 통해 0.05% 혹은 0.2% 초산납 (PbAc2)용액을 식수로 공급하여 납중독을 유발시켰다. 생후 2, 4, 6 및 8주된 새끼쥐의 MAO 및 Na+K+-ATPase활성을 대뇌, 간뇌, 중뇌, 뇌교-연수 및 다섯부위에서 각기 측정하였다.

• The Korean Journal of Zoology
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• v.17 no.1
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• pp.17-22
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• 1974

The G-6-PD (glucose-6-phosphate dehydrogenase) activity, the first step in the pentose phosphate shunt, of rat livers during prenatal and pstnatal development in different sexes was studied. The enzyme activity is very high (54.2 units) at 16 days of embryo ad then decreases to a low level (17.6 units) at 13days after birth. There are significant increase between 13 and 15 days of age and continuously increases to the level of 53.2 units at 19days of age. The G-6-PD activity in female rat livers was slightly higher than in males.

• Journal of Labour Economics
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• v.42 no.1
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• pp.107-128
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• 2019

When parental experience improves parenting skills, parents are likely to behave in favor of children of higher birth orders. To examine this hypothesis, this study analyzes birth month based on birth order of children in South Korea where parents prefer to have babies in the earlier months of a year. This study finds that while more babies are born in the earlier months, second-born children are more likely to be so than first children. This implies that parental experience makes for better parents.

• 가정의 벗
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• v.37 no.2 s.426
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• pp.12-13
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• 2004

출생아 100명중 1명에게 나타난다고 하는 선천성 심장병, 태아 심장 초음파 검사로 심장병이 있는 태아가 태어나지도 못하는 등 많은 문제를 가지고 있습니다. 그러나 치료 기술이 발전하여 조기 진단과 적절한 치료를 받게 되면 정상 수명까지 살 수 있습니다.

• Journal of Preventive Medicine and Public Health
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• v.19 no.1 s.19
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• pp.123-129
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• 1986

Fetal weight data from 84 litters of Sprague-Dawley rats were statistically analyzed for the effect of position in the uterine horn on fetal weight. The standard score obtained from the mean weight and standard deviation of all fetuses in a uterine horn were studied for position effect. In control group, the heaviest fetus occupied the middle position with a progressive decrease in weights toward the ovarian and cervical ends of the horn. But the effect related to position for the fetal weight was not statistically significant. In contrast, rats acutely or chronically exposed to carbon monoxide showed statistically significant positional differences of fetal weight within the uterine horns. The findings that the intrauterine position effect on fetal weight which is not signicant in control group may act one of confounders at the situation of transplacental toxicological studios.

• Korea journal of population studies
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• v.29 no.1
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• pp.1-23
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• 2006

본 연구는 한국 기혼여성의 차별출산력 분석으로 인구학적 특성으로 연령, 초혼연령, 혼인상태 및 가족유형(가구구성)을 포함하구 사회경제적 특성으로 거주지역, 교육정도, 경제활동상태, 직업 및 주택 점유형태를 포함하였다. 통계청의 인구주택총조사를 원자료로 하여 인구 및 사회경제적 변인들이 출산력에 미친 영향을 파악하기 위하여 다변량 분석기법을 이용하였다. 초혼연령이 높아지면서 출산수준은 현저히 낮아졌으며, 배우자와 동거하는 기혼부인의 출생아수가 가장 많았으며, 이혼한 경우 가장 적었다. 자녀양육을 위한 부모의 도움을 받을 수 있는 3세대 이상 가족이 동거하는 가구의 경우 출산수준이 상대적으로 높았다. 그러나 최근 이혼이 급증하면서 유배우 상태가 빠르게 감소하구 1세대나 독신가구의 증가와 3세대 이상 가구의 감소는 앞으로의 출산수준을 더욱 빠르게 할 것이다. 사회경제적 특성별 차이에서도 유사한 현상을 발견할 수 있었다. 도시규모가 클수록, 학력수준이 높을수록, 전문사무직종에 근무할 경우, 그리고 전월세로 거주할 경우에 출산수준이 낮았다. 사회경제적 특성별 출생아수의 차이는 1980년에 가장 컸으며, 그 후 지속적으로 감소하고 있다. 더욱이 출산수준이 높은 농촌인구의 급감, 교육수준의 향상으로 교육간 차이의 감소 농어업직에 종사하는 기혼여성의 감소 등은 전체적인 출산수준을 빠르게 감소시키는 요인으로 작용하였다. 기혼부인의 특성별 출생아수의 차이는 여전히 뚜렷하였으나 그 차이는 점차 감소하고 있다. 또한, 출생아수가 많은 집단의 구성비가 빠르게 줄어드는 것을 감안하면 전체적인 출산수준의 감소는 더욱 빨라질 수 있다. 앞으로 2005년 인구주택총조사의 결과가 발표될 때 그 간의 특성별 출생아수의 차이와 인구구성비의 변화를 분석하면 대체출산수준에 근접한 1980년 이후 빠른 출산력의 감소원인을 이해하고 출산력의 장래 변화를 효과적으로 예측하는데 도움이 될 것이다.

• Journal of dental hygiene science
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• v.12 no.5
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• pp.486-492
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• 2012

Immunostaing intensity of Dynamin II protein in ameloblast during mouse tooth development showed a significant increase of 48% at the postnatal day 3 and a significant increase of 50% at the postnatal day 5 as compared with the postnatal day 1, but showed a significant decrease of 16% at the postnatal day 7 and a significant decrease of 12% at the postnatal day 10 as compared with the postnatal day 1. From the above results, Dynamin II had relevance to secretion of amelogenin, ameloblastin, enamelin and matrix metalloproteinase-20 proteins for enamel formation in ameloblast. Dynamin II may be involved in the transport of vesicles containing proteins for enamel formation through the acceleration of vesicular formation and may be had a good possibility of secretory regulation of proteins for enamel formation in ameloblast. Therefore, Dynamin II have potential for being used in the field of gene theraphy for periodontal disease and in the regeneration for enamel and dentin tissues lost to dental caries.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.2
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• pp.259-264
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• 2017

Birth weight of a new born baby provides very important information in evaluating many clinical issues such as fetal growth restriction. This paper analyzes birth weight data of babies born in Korea from 2011 to 2013, and it shows that there is a biologically implausible distribution of birth weights in the data. This implies that some errors may be generated in the data collection process. In particular, this paper analyzes the relationship between gestational period and birth weight, and it is shown that the birth weight data mostly of gestational periods from 28 to 32 weeks have noticeable errors. Therefore, this paper employs the finite Gaussian mixture model to classify the collected data points into two classes: non-corrupted and corrupted. After the classification the paper removes data points that have been predicted to be corrupted. This adjustment scheme provides more natural and medically plausible percentile values of birth weights for all the gestational periods.

• Clinical and Experimental Pediatrics
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• v.46 no.4
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• pp.370-375
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• 2003

Purpose : It has been suggested that the exposure to aeroallergens during early infancy after birth is important in the subsequent development of sensitization and allergic diseases. In Korea, the level of house dust mites as one of the important aeroallergens is known to be the highest in autumn. The aim of this study was to test whether the distribution of month of birth bears a relationship to the presence of mite sensitization in children with respiratory allergy. Methods : Skin prick tests and methacholine provocation tests were performed on 1,327 patients with chronic respiratory symptoms who visited Seoul National University Children's Hospital from January 1995 to May 2002. An analysis of patients' month of birth distribution according to the presence of mite sensitization was performed. Results : Atopic subjects who had at least one positive skin test numbered 864(65.1%); and non-atopic subjects numbered 463(34.9%). Among atopic subjects, 787(59.3%) had positive skin tests to mites and 77(5.8%) had positive skin test only to minor allergens. A significantly greater than expected number of mite atopic subjects were born in the months between August and November(P=0.03), however, the birth month of non-atopic subjects didn't show a consistent seasonal preference. Asthma patients numbered 543(40.9%). Among these, atopic asthmatics numbered 421(77.5%) and non-atopic asthmatics, 122(22.5%). Dust-mite atopic asthmatics numbered 387(91.9%) out of 421 atopic asthmatics. Dust-mite atopic asthmatics were born significantly higher in the season lasting from August to November in comparison to non-atopic asthmatics(P=0.002). Conclusion : Month of birth seems to be related with sensitization to allergens. Our results show that August to November is the risk period for the development of mite sensitization in Korea.

• Neonatal Medicine
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• v.18 no.1
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• pp.49-58
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• 2011

Purpose: The purpose of this study was to evaluate the relationship between cord blood adiponectin and insulin-like growth factor (IGF)-I and their effect on fetal growth and insulin resistance in mothers with gestational diabetes mellitus (GDM). Methods: Cord blood adiponectin and IGF-I were compared between mothers with GDM (GDM group, N=53) and controls (non-GDM group, N=101). Neonates were classified into three groups of small for gestational age (SGA, N=26), appropriate for gestational age (AGA, N=97), and large for gestational age (LGA, N=31) by birth weight. The association between cord adiponectin and IGF-I levels was evaluated in relation to maternal and neonatal clinical data. Results: Cord adiponectin was lower in the GDM group than in the non-GDM group (P<0.001). There was no significant difference in cord adiponectin among the SGA, AGA, and LGA groups in the GDM group (P=0.228). The cord adiponectin of AGA in the GDM group was significantly lower than that in the non-GDM group (P<0.001). The most powerful predictor affecting cord adiponectin was the result of maternal 75 g oral glucose tolerance test. The cord IGF-I values between the GDM group and the non-GDM group were not different (P=0.834). Neonates with the heavier birth weight had the higher cord IGF-I levels. The most powerful predictor affecting cord IGF-I was birth weight and the next was maternal parity. Conclusion: Both cord blood adiponectin and IGF-I were associated with fetal growth, but IGF-I was a more general and direct factor affecting fetal body size, and adiponectin seemed to have more association with insulin sensitivity than growth.