• Progress in Medical Physics
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• v.16 no.4
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• pp.166-175
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• 2005

The purpose of this study is to develop the optimization method for adjusting the film isocenter shift and to suggest the quantitative acceptable criteria for film dosimetry after optimization In the dynamic conformal arc radiation therapy (DCAR). The DCAR planning was peformed In 7 patients with brain metastasis. Both absolute dosimetry with ion chamber and relative film dosimetry were peformed throughout the DCAR using BrainLab's micro-multileaf collimator. An optimization method for obtaining the global minimum was used to adjust for the error in the film isocenter shift, which is the largest pan of systemic errors. The mean of point dose difference between measured value using ion chamber and calculated value acquired from planning system was $0.51{\pm}0.43\%$ and maximum was $1.14\%$ with absolute dosimetry These results were within the AAPM criteria of below $5\%$. The translation values of film isocenter shift with optimization were within ${\pm}$1 mm in all patients. The mean of average dose difference before and after optimization was $1.70{\pm}0.35\%$ and $1.34{\pm}0.20\%$, respectively, and the mean ratios over $5\%$ dose difference was $4.54{\pm}3.94\%$ and $0.11{\pm}0.12\%$, respectively. After optimization, the dose differences decreased dramatically and a ratio over $5\%$ dose difference and average dose difference was less than $2\%$. This optimization method is effective in adjusting the error of the film isocenter shift, which Is the largest part of systemic errors, and the results of this research suggested the quantitative acceptable criteria could be accurate and useful in clinical application of dosimetric verification using film dosimetry as follows; film isocenter shift with optimization should be within ${\pm}$1 mm, and a ratio over $5\%$ dose difference and average dose difference were less than $2\%$.

• 한국전산유체공학회:학술대회논문집
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• 2005.10a
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• pp.163-167
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• 2005

A research to evaluate efficiency of design optimization was performed for aerodynamic design optimization problem in distributed computing environment. The aerodynamic analyses which take most of computational work during design optimization were divided into several jobs and allocated to associated PC clients through network. This is not a parallel process based on domain decomposition rather than a simultaneous distributed-analyses process using network-distributed computers. GBOM(gradient-based optimization method), SAO(Sequential Approximate Optimization) and RSM(Response Surface Method) were implemented to perform design optimization of transonic airfoil and to evaluate their efficiencies. One dimensional minimization followed by direction search involved in the GBOM was found an obstacle against improving efficiency of the design process in distributed computing environment. The SAO was found quite suitable for the distributed computing environment even it has a handicap of local search. The RSM is apparently the fittest for distributed computing environment, but additional trial and error works needed to enhance the reliability of the approximation model are annoying and time-consuming so that they often impair the automatic capability of design optimization and also deteriorate efficiency from the practical point of view.

• Journal of computational fluids engineering
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• v.11 no.2 s.33
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• pp.19-24
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• 2006

A research to evaluate the efficiency of design optimization was carried out for aerodynamic design optimization problem in distributed computing environment. The aerodynamic analyses which take most of computational work during design optimization were divided into several jobs and allocated to associated PC clients through network. This is not a parallel process based on domain decomposition in a single analysis rather than a simultaneous distributed-analyses using network-distributed computers. GBOM(gradient-based optimization method), SAO(Sequential Approximate Optimization) and RSM(Response Surface Method) were implemented to perform design optimization of transonic airfoils and evaluate their efficiencies. dimensional minimization followed by direction search involved in the GBOM was found an obstacle against improving efficiency of the design process in the present distributed computing system. The SAO was found fairly suitable for the distributed computing environment even it has a handicap of local search. The RSM is apparently the most efficient algorithm in the present distributed computing environment, but additional trial and error works needed to enhance the reliability of the approximation model deteriorate its efficiency from the practical point of view.

• Analytical Science and Technology
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• v.17 no.4
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• pp.322-336
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• 2004

The improved derivatization technique of tamoxifen metabolite in human urine is described for the acylation method that they are substituted by derivatization reagent like acyl anhydride for use of gas chromatography/mass spectrometry. The hydroxyl group of tamoxifen metabolite was derivatized by trifluoroacetic anhydride (TFAA), pentafluoroacetic anhydride (PFPA) and heptaflorobutylic anhydride (HFBA). It was investigated to the gas chromatography/mass spectrometry (GC/MS) technique use negative ion chemical ionization (NCI), positive ion chemical ionization (PCI) and electron impact (EI). In acylation of the metabolites of tamoxifen, the effective reaction temperature and time were shown to be at $50^{\circ}C$ for 30 min. The 4-hydroxytamoxifen, which is known to major metabolite of tamoxifen, was not detected in human urine, whileas the hydroxymethoxytamoxifen was detected. We thought that this result was from the single dose of tamoxifen.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.4
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• pp.537-545
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• 2013

The elastic recovery of a metal seal is a factor that can be used to assess its sealing performance. In this study, a compliant mechanism topology optimization has been performed to find a structure of a metal O-ring seal that can maintain excellent sealing performance with a maximized elastic recovery over extended operation. An evolutionary structural optimization (ESO) was used as a topology optimization algorithm with two different types of objective functions considering both flexibility and stiffness. In particular, a circular design domain was adopted to consider the outer shape of the metal O-ring seal. The elastic recovery of the optimal topology was calculated and compared to that of a commercial product.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.1
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• pp.95-98
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• 2013

Plate thermometers are used for measuring the radiative heat flux in high-temperature surroundings. The heat flux is calculated from the temperature measured at the back surface of the stainless steel surface of the meter. Heat fluxes from a Schmidt-Boelter gauge are measured as reference heat fluxes. A combined conductive coefficient is introduced to consider the heat loss to insulation, conduction through the stainless plate depth, and conduction from the non-uniform temperature of the plate of the plate thermometer. This coefficient is obtained using the repulsive particle swarm optimization.

• Membrane Journal
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• v.17 no.1
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• pp.67-79
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• 2007

Uniform microcapsules containing ionic model drugs were prepared by controlling various conditions of emulsification procedure using a lab-scale membrane emulsification system with a SPG (Shirasu porous glass) tubular membrane. We observed the effects of various emulsification parameters [concentration and molecular weight of polycaprolatone (PCL) polymer, transmembrane pressure and emulsifier concentration in disperse phase and continuous phase, stirring speed] on the mean size and size ditribution of microcapsules containing lidocaine hydrochloride (cationic drug), sodium salicylate (nonionic drug) and 4-acetaminophen (anionic drug) used as a model drugs. Also, release characteristics of a model drugs from PCL microcapsules were investigated. Controlling membrane emulsification parameters, uniform PCL microcapsules with about $5\;{\mu}m$ of the mean size were finally prepared. The release rate and the burst effect of microcapsules were decreased in condition of the acidic solution, but it was increased in condition of the base solution.

• Journal of Korean Society of Environmental Engineers
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• v.29 no.5
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• pp.515-520
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• 2007

Recently, the treat of sludge is usually progressed by ocean disposal. But it will be totally banned by content of its heavy metal according to London Dumping Convention, gradually. The stable way of treat of sewage sludge should be examined urgently. To solve the problem, recently, there are efficient and environment-oriented method. One of them is to produce absorbent through the activation. This study produces absorbent through steam activation. As basic experiment, optimum activation condition for preparation of good absorbent is researched through study of the fellowing variables : steam flow rate, activated temperature, activation time. As the result of this with standard on iodine adsorptivity, it is chosen, that steam flow rate "30 mL/hr", activation temperature $"500^{\circ}C"$, activation time "60 minutes". At the time, iodine adsorptivity and yield shown that 228.4 mg/g, 77.23%. And also, by using nitrogen adsorption, SEM and EDS are confirmed that pore development, specific surface area, mean pore size, chemical component and content. Pore developed by steam activation is also confirmed that it is micropore.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.4
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• pp.323-329
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• 2013

This study attempts to simulate the structure of a woody leaf netted venation system by using topology optimization techniques. Based on finite element method (FEM) analysis of an incompressible fluid, a topology optimal design is applied to those woody leaf netted venation models. To solve the transverse shear locking problem of a thin plate caused by the Mindlin-Reissner plate model where a leaf netted venation is assumed to be a thin plate, a P1-nonconforming element and selective reduced integration are employed. Topology optimal design is applied to multiple physical domains. Combined with the Darcy-Stokes flow problems and extended to the optimal design of fluid channels, the multiple physical models of the flow system are analyzed and venation patterns of leafs are simulated. The calculated optimal shapes are compared with the natural shapes of woody leaf venation patterns. This interdisciplinary approach may improve our understanding of the leaf venation system.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.20 no.6
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• pp.683-690
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• 2007

Topology optimization techniques have been developed as a very efficient design tool and utilized for design engineering processes in many industrial sections during the past decade. And topology optimization has become the focus into structural optimization design up to now. Recently, thermally actuated compliant mechanisms have a wide range of applications. In this research, the thermo-elastic problem is a coupled problem which has to consider heat transfer analysis and structural analysis. Hence, the thermo-elastic problem has to deal with heat transfer material properties and structural material properties at the same time. The numerical examples are presented. From the results, it was shown that in terms of the displacement after optimization. Moreover, this paper compared thermo-system, elastic-system with thermo-elastic system and was shown a good result of topology optimization while thermo-elastic system was used.