• Korean Chemical Engineering Research
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• v.59 no.1
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• pp.106-111
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• 2021

In this study, an ultrasound-assisted micellar extraction process was developed to efficiently purify the anticancer substance paclitaxel from the plant cell Taxus chinensis. The problem of many extraction steps and long phase separation time in the traditional micellar process could be dramatically improved. The highest paclitaxel yield (~96%, extracted twice) was obtained at 180 W of ultrasonic power and 1.5 h of ultrasonic irradiation time, which was 24.7% higher than that of the traditional method. In addition, the partition coefficient (K) showed a maximum value (24.0) at 180 W of ultrasonic power and 1.5 h of irradiation time. There was no significant difference in the purity of paclitaxel, and the purity of initial paclitaxel (6.81%) increased to 22.0% after purification. Compared to the traditional method, the phase separation time of the back extraction decreased by 40.7-56.2% (ultrasonic power 80 W), 46.3-67.6% (ultrasonic power 180 W), and 51.9-67.6% (ultrasonic power 250 W), respectively. The phase separation time decreased as the ultrasonic power (80-250 W) and irradiation time (0.5-2.5 h) increased.

• The Journal of the Acoustical Society of Korea
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• v.43 no.3
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• pp.335-343
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• 2024

This paper came up with the theoretical modelling of the metrology for the acoustic power using ultrasonic radiation force and showed some theoretical results. In order to do this, a scattering model for a rigid circular cone based upon the Kirchhoff approximation was made, which was followed by the calculation of acoustic power, and then, was converted to the radiation force. From these works, it provided the accuracy and limitation of the conventional method using a circular cone, and the expanded metrology modelling that can be applied to a circular cone with arbitrary apex angle. Using these, this study provided the dependence of the metrology for the acoustic power using ultrasonic radiation force on the frequency and the size of the target. As a result, the correction was yielded in the value of the acoustic power calculated by the suggested International Electrotechnical Commission (IEC) method, which needs to be added when the frequency and the size of the target was considered.

• The Journal of the Acoustical Society of Korea
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• v.9 no.2
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• pp.25-33
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• 1990

An ultrasonic power measurement system in milliwatt range was constructed. The ultrasonic power can be determined by measuring the radiation pressure on a target using self-compensating microbalance. Measurement was performed using a perfect reflector and a perfect absorber. In order to check the feasibility of the system, the ultrasonic power for the two targets was measured. Also, the systematic measurement errors and the reproducibility were examined. The relative error between two targets is proved to be within 2%. Also when the ultrasonic power range is larger than 10mW, the standard deviation for repeated measurement becomes smaller than ${\pm}$2%.

• The Journal of the Acoustical Society of Korea
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• v.24 no.8
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• pp.431-440
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• 2005

The precise measurement of ultrasonic power is important to the qualify assurance and the safety of medical ultrasonic equipments In the Present work, a brier theory was introduced to determine the ultrasonic Power from the time valving balance-indication due to the radiation force acting on an absorbing target and/or other causes such as buoyancy during the repetition of on/off behavior of ultrasonic irradiation. The developed automated system measuring the ultrasonic power was described in detail with the precise mechanical alignment tool , the electric signal generation network, the control and measurement network and the appropriate procedure. The ultrasonic power measured by the developed system was compared to the reference data calibrated by the other national metrology institute at 1 MHz, 5 MHz, 10 MHz, and 15 MHz over the range 10 mW to 10 W. Their relative differences are within $5\%$.

• The Journal of the Acoustical Society of Korea
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• v.29 no.6
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• pp.355-364
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• 2010

Considering biological safety, it is very important to measure acoustic power from ultrasonic array probe for diagnostic ultrasound imaging applications. In this paper, to measure acoustic power from each element on array probe for ultrasonic diagnostic equipment, we reconstruct and automate the acoustic power measurement system. The acoustic power from linear, phased and curved array were measured and analyzed. As a result of measurement, the effects caused by directivity of sound beam from curved array were founded. To remove these effects, we developed and applied the correction model. The proposed system is useful to evaluate characteristics of the acoustical output power of array probe.

• Proceedings of the Acoustical Society of Korea Conference
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• 1993.06a
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• pp.174-178
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• 1993

초음파 변환기의 방사 컨덕턴스를 결정하기 위해서는 변환기로부터 방사된 음향파워와 입력전압의 정밀측정을 요구하게 된다. 음\ulcorner파워는 초음파를 거의 완전 반사시킬 수 있는 표적을 사용하여 변환기로부터 방사된 음압에 의해 표적에 가해진 힘을 수동맞저울과 레이저 간섭계로 측정하여 구하였으며, 입력전압을 열 변환기와 전압계를 한 시스템으로 하여 정밀 측정하였다. 방사 컨덕턴스의 최대 측정오차는 $\pm$4% 이내로 평가되었다.

• Journal of the Korean Society for Precision Engineering
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• v.24 no.9
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• pp.37-43
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• 2007

• Journal of radiological science and technology
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• v.38 no.4
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• pp.443-449
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• 2015

An ultrasound probe has a big impact on Doppler images even though it has very high risk of frequent function-breakdowns occurring in medical ultrasound scanners. This study experimentally analyses the impacts of an ultrasonic probe's defected elements on power & color Doppler images. The results show that, the bigger the size of defected probe elements is, and the closer a group of action elements is to the center, the more the brightness of images and the velocity of Doppler diminish. When elements' defects increase in color & power Doppler images, false images are formed to be mistaken for blood-vessel plaque in neighboring regions. Accordingly, whenever element defects are suspected, we need check-up process in B-mode. From this respective, it is advisable to have primary interest in a probe and carry out continuous probe QA for ultrasonography.

• Korean Chemical Engineering Research
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• v.54 no.2
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• pp.229-233
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• 2016

In this study, an efficient ultrasound-assisted liquid-liquid extraction process was developed for recovering of paclitaxel from plant cell cultures. The optimal ultrasonic power and operating time were 250 W and 15 min at fixed ratio of bottom phase, methylene chloride to top phase, MeOH (25%, v/v). Under the optimal conditions developed in the present method, most of the paclitaxel (~92%) was recovered from crude extract by a single extraction step. Due to the synergistic effect of ultrasound by the addition of inorganic salt, an appropriate inorganic salt concentration and the ultrasonic power were found to be required for the effective recovery of paclitaxel using ultrasound-assisted liquid-liquid extraction.

• The Journal of the Acoustical Society of Korea
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• v.24 no.2
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• pp.78-86
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• 2005

This study considers the magnitude of the harmonic components radiated from the ultrasonic contrast agents (UCA) activated by a typical diagnostic ultrasound. The nonlinear dynamic response of UCA to a 2 MHz diagnostic ultrasound pulse was predicted using Gilmore Model. The elastic property of the shell membrane of the UCA was ignored in the numerical model. Simulation was carried out for the UCA varying from 1 - 9 $\mu$m in its initial radius and the driving diagnostic ultrasound whose mechanical index (MI) ranges from 0.125 to 8. The powers of the sub. ultra and second harmonics of the acoustic signal from the UCA activated were compared with that of the fundamental component. The results show that. if the UCA is bigger than its resonant size (2 $\mu$m in radius for the present case) the sub harmonic power was much bigger than the fundamental. In particular, the 2nd harmonic component currently used as an imaging parameter for the harmonic imaging, was predicted to be lower in power than both the sub and the ultra harmonic component. This study indicates that, for obtaining harmonic imaging with UCA, the sub or ultra harmonics could be taken as imaging parameters better than the 2nd harmonic component.