• Proceedings of the Korean Nutrition Society Conference
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• 2003.05a
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• pp.161.1-161.1
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• 2003

• Journal of rehabilitation welfare engineering & assistive technology
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• v.7 no.2
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• pp.101-107
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• 2013

In this paper, we were to investigate effect of correction to muscle imbalance in lower limbs according to reduction of weight bearing methods of four point of horizontal shaft using two-belt treadmill. Participants were divided to two group according to each ten peoples who have difference of muscle function in left and right legs over 20%. Experiment progressed forty minutes a day three days a week, total four weeks and we estimated the maximal peak torque and average power for testing joint torque in hip, knee and ankle. The results showed that the correction effect of muscle imbalance to the maximal muscle strength was the most effective in hip joint. Also in knee joint, correction effect of muscular reaction was the most effective too. We thought that reduction of weight bearing methods could be positive effect to correct muscle imbalance in lower limbs.

• Tuberculosis and Respiratory Diseases
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• v.54 no.2
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• pp.199-209
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• 2003

Background : Unexplained weight loss, which commonly occurs in patients with chronic obstructive pulmonary disease(COPD), is important because weight loss is an independent risk factor of mortality and morbidity in these patients. Leptin is known to play an important role in regulating body weight. In addition, the tumor necrosis factor($TNF-{\alpha}$) might also play a potential role in the weight loss experienced in chronic wasting disease. The aim of this study was to determine the influence of plasma leptin and the circulating $TNF-{\alpha}$ system to the difference in the body compositions in patients with COPD. Methods : Spirometry, body composition analysis and the plasma concentrations of leptin, $TNF-{\alpha}$ and a soluble TNF receptor (STNF-R55, -R75) were measured in 31 patients with chronic bronchitis and 10 patients with emphysema. The COPD subtype was classified by the transfer coefficient of carbon monoxide, DLco/VA. Results : The circulating levels of leptin were significantly lower in those patients with emphysema($108.5{\pm}39.37pg/ml$) than those with chronic bronchitis($180.9{\pm}57.7pg/ml$). The circulating levels of sTNF-R55 were significantly higher in the emphysema patients($920.4{\pm}116.4pg/ml$) than in those with chronic bronchitis($803.2{\pm}80.8pg/ml$). There was no relationship between the circulating leptin levels and the activated TNF system in patients with chronic bronchitis and emphysema. However, the circulating leptin levels correlated well with the BMI and fat mass in both patient groups. Conclusion : These results suggest that the weight loss noted in emphysema patients may be associated with the activation of the $TNF-{\alpha}$ system rather than the plasma leptin level.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.319-319
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• 1994

의약품등의 배아(태자) 독성물질에 의해서 유도될 수 있는 태자체중의 감소와 골화지연은 실험동물을 이용한 생식독성 시험에 있어서 자궁내 발육지연 (intrautering growth retardation)으로 평가된다. 태자체중은 측정이 매우 용이한 변수에 속하지만 골화지연의 평가에는 유해인자 (noxa) 의 작용시 기형이 유발되지 않는 골격부위가 가장 적합한데, 어느 골격부위가 발육지연 효과의 평가를 위하여 가장 적합한지를 알아내기 위해서는 태자체중과 골화의 상관성 조사가 필수적이다. 연구결과 골격형성은 골격부위에 따라 큰 차이를 보였는데, 크게는 거의 골화가 종료된 부위 (예: 흉골) 와 골화가 진행증인 부위 (예: 천미추) 로 구분되었고 주요 골격부위의 골화와 태자체중의 관계를 조사한 바, 골격부위에 따라서 상이한 상관관계를 나타내었다. 그런데 본 연구에서 나타난 바로는 ICR 마우스에 있어서 천미추의 골화짐 수가 태자제중과 가장 높은 상관성을 나타내었다. 또한 천미추의 변이계수는 타 골격부위에 비해서 그다지 높지 않았다. 따라서 ICR 마우스를 이용한 생식독성시험에 있어서 천미추의 골화 진행도는 의약품등에 의해 유도될 수 있는 발육지연 효과의 평가를 위한 가장 적합한 지표라고 판단된다.

• Microbiology and Biotechnology Letters
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• v.30 no.4
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• pp.402-409
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• 2002

The effects of protein-bound polysaccharides (A-PBP and L-PBP) that were extracted from the mycelia of two edible mushrooms, namely Agaricus blazai and Lentinus edodes, on serum cholesterol and body weight were investigated in mice and female volunteers. Six groups of Male Balb/c mice were fed six kinds of diet supplement- solutions composed of L-PBP, A-PBP, chitosan, and other fiber constituents, for 30 days under the normal diet. Ninety female volunteers were also supplemented for 8 weeks with six kinds of capsules including control and five test groups as the same manners (two times a day, 4 capsules). From 12 days after feeding of L-PBP (Group I) and A-PBP (Group II), the weight of mice began to reduce as compared with control, whereas that of Group III fed chitosan was decreased 15 days after feeding. Group W and Group V which were fed mixture of L-PBP, A-PBP, chitosan, and other dietary fiber, were more significant in lowering weight. After 4 weeks of the supplementation in women, their serum LDL-cholesterol level and body weights in Group I and II were reduced, but Croup 111 taken with chitosan capsule showed weaker effect than Group I and II. After 8 weeks, LDL-cholesterol content in the sera of Group I (132.5 mg/dL) and II(131.5 mg/dL) was decreased to ideal level (125.4 and 122.8 mg/dL) for healthy blood vessel. In the case of Group W supplemented with mixture of L-PBP, A-PBP, and chitosan, the weight-reduction effect (11.8%) and hypocholesterolemic effect (11.0%) was most significant, indicating their synergistic action. These data suggested that the weight-controlling and hypolipidemic effect of L-PBP and A-PBP was involved, at least in part, in absorption of cholesterol as their role of dietary fiber, as well as cholesterol metabolism.

• Neonatal Medicine
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• v.15 no.1
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• pp.38-43
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• 2008

Purpose : The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth. Methods : Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72). The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI). Results : The mean cord serum APN was 29.2${\pm}$10.46 $\mu$g/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001). The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26${\pm}$21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI. Conclusion : APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight.

• The Korean Journal of Food And Nutrition
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• v.15 no.4
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• pp.289-294
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• 2002

This study attempted to evaluate the effectiveness of function of Wax Ground for obesity and the related disease of adult people can be developed by the combination of the 17 food materials screened in this study. The experiments using Sprague-Dawley male rats show that seventeen kinds of food material inhibited the increase of body weight gain, energy intake, fat pads weight, liver triglycerides content, atherogenic index, and blood glucose concentration induced by cafeteria diet. Oral administration of wax gourd decreased most body weight gain, energy intake, fat pads weight, and blood glucose concentration. Liver triglycerides content was the lowest in the group administered mulberry stem extract and the group administered pine leaves showed the lowest atherogenic index. The combined administration of wax gourd, mulberry stem extract and pine leaves improved more the obesity and related symptoms than the individual administrations.

• Journal of Preventive Medicine and Public Health
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• v.22 no.2 s.26
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• pp.276-282
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• 1989

The objective of this study was to examine the impact of changes in maternal age and parity distribution on birth weight. The study population included 7,786 single live births in 1977 and 8,671 single live births in 1987 delivered at 9 medical facilities in Pusan. Data were obtained from the delivery record. The proportion of infants born to the mothers of 25-29 years increased from 56.475 in 1977 to 65.1% in 1987 and the proportion to the mothers of 30-34 years increased from 18.8% in 1977 to 21.6% in 1987. In the same period, the proportions of 1st and 2nd birth order were increased from 56.9% and 28.8% to 59.9% and 36.8%, respectively. The proportion of infants born to the age group of ${\leq}24\;and\;35{\leq}$ years were decreased in 1987. The proportion of births of the third or higher birth order was decreased from 14.2% in 1977 to 3.3% in 1987. Low birth weight (<2500gm) incidence rate was 5.3% in 1977 and it was decreased to 4.0% in 1987. It was estimated that changes in maternal age-parity distribution accounted for 10.7% of the decreased in low birth weight incidence rate. Rest of the change (89.3%) was attributed to the reduction of age-parity specific low birth weight incidence rate. Application of the direct adjustment method was considered to be an adequate tool for evaluating the impact of family planning on neonatal health.

• Journal of Yeungnam Medical Science
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• v.4 no.1
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• pp.25-32
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• 1987

The object of this study was to determine the difference of radiation effect in different fractional doses and to establish optimal fractionation schedule on the whole-abdominal X-ray irradiation. Total 160 mice were irradiated with 150 KVP, 15 mA orthovoltage x-ray machine and two different fractionation (100 cGy/Fr. and 200 cGy/Fr.) were used. Body weight, hemoglobin and WBC count with differential count were analyzed according to the same amount of total dose, same field size and two different fractionation schedules. The result of this study were summarized as follows: There was no significant difference in body weight and hemoglobin concentration by sex or fractional dose. Leukopenic change was prominent in the 3,000 cGy irradiation group and the proportion of decrease was remarkable in the 200 cGy/Fr, group than 100 cGy/Fr, group. Progressive decrease of lymphocyte count and reciprocal increase of neutrophil count were noted as dose increment. The effect of the fractional does on WBC count and proportion of lymphocyte were significant. This suggests that judicious selection of fractional dose may be important in clinical radiotherapeutic practice.

• Journal of Aquaculture
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• v.7 no.2
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• pp.89-96
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• 1994

Spawning of matured olive flounder, Paralichthys olivaceus was accelerated by using single injection of human chorionic gonadotropin (HCG 1,000 IU/kg BW) or carp pituitary extract (CPE 10 mg/kg BW). The body weight of HCG or CPE treated group slightly improved with $5.6\pm0.4\%$ at 2 days after injection or $6.4\pm0.5\%$ at 3 days after injection, Number of eggs spawned increased in the fish treated with HCG or CPE. Surface floating rates of eggs spawned increased in the fish treated with HCG or CPE. Hatching rate also increased in experimental groups compared to the control. Especially superior quality of eggs were obtained 2 and 3 days after injection from HCG treated groups and 3 and 4 days after injection from CPE treated groups at $20^{\circ}$, respectively.