Journal of Yeungnam Medical Science
- Volume 4 Issue 1
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- Pages.25-32
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- 1987
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- 2799-8010(eISSN)
Radiation Effect on Body Weight and Peripheral Blood Picture Induced by Whole-Abdominal X-ray Irradiation with Different Fractionation in Mice
백색마우스에 대한 전복부 조사에서 상이한 분할조사가 체중과 말초혈액 소견에 미치는 효과
- Lee, Sung-Heon (Department of Therapeutic Radiology, College of Medicine, Yeungnam University) ;
- Shin, Sei-One (Department of Therapeutic Radiology, College of Medicine, Yeungnam University) ;
- Kim, Myung-Se (Department of Therapeutic Radiology, College of Medicine, Yeungnam University)
- Published : 1987.06.30
Abstract
The object of this study was to determine the difference of radiation effect in different fractional doses and to establish optimal fractionation schedule on the whole-abdominal X-ray irradiation. Total 160 mice were irradiated with 150 KVP, 15 mA orthovoltage x-ray machine and two different fractionation (100 cGy/Fr. and 200 cGy/Fr.) were used. Body weight, hemoglobin and WBC count with differential count were analyzed according to the same amount of total dose, same field size and two different fractionation schedules. The result of this study were summarized as follows: There was no significant difference in body weight and hemoglobin concentration by sex or fractional dose. Leukopenic change was prominent in the 3,000 cGy irradiation group and the proportion of decrease was remarkable in the 200 cGy/Fr, group than 100 cGy/Fr, group. Progressive decrease of lymphocyte count and reciprocal increase of neutrophil count were noted as dose increment. The effect of the fractional does on WBC count and proportion of lymphocyte were significant. This suggests that judicious selection of fractional dose may be important in clinical radiotherapeutic practice.
전복부조사에 대한 X-선의 영향을 체중과 말초혈액 변화를 분석하여 적정 분할회수 및 치료기간설정에 응용하기 위하여 도합 160마리의 백색마우스를 두개의 조사군으로 나누어 제1군은 100cGy과, 제2군은 200cGy으로 나누고 일령이
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