• Korean Journal of Medicinal Crop Science
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• v.15 no.6
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• pp.398-404
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• 2007

This study was performed to investigate the enhancement of anticancer activities and immuno modulatary activities from R. coreanus. by ultra high pressure extracts process. The cytotoxicity on human kidney cell (HEK293) was showed below 19.5% in adding 1.0 $mg/m{\ell}$ concentration. The anticancer activity was increased over 10% by high pressure processing in AGS and A549 cells. The immune cell growth using human immune B and T cells was improved by the high pressure extracts of Rubus coreanus in adding 1.0 $mg/m{\ell}$ concentration. The secretion of two kinds of cytokine, the IL-6 and $TNF-{\alpha}$ from human immune B and T cells were also enhanced in adding extracts by high pressure process of R. coreanus. The ultra high pressure extraction technique showed high efficiency in extracting of bioactive compound. The ultra high pressure technique could be used combined with other technique to improve the extracting rate and extracting efficiency.

• Korean Journal of Environmental Agriculture
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• v.22 no.4
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• pp.261-265
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• 2003

In order to examine the difference in processing quality of potato tubers among localities, chemical properties of soils were analyzed and climatic conditions were investigated. Potatoes (Solanum tuberosum L.) were grown at seven localities of Korea during two years from 1994 to 1995. Soil samples and tubers were obtained from 2 to 3 commercial farms per locality with 10 days interval from 70 days before harvesting. As the result of that, higher correlation in processing quality was found with organic material content among soil conditions. On the climatic conditions, minimum temperature and sunshine hours during the period from 30 to 11 days before harvesting exhibited highly significant negative correlations with all quality parameters except reducing sugar content. Additionally, regression equations based on the observed level of these factors showed the relatively high coefficients of determination for dry matter content and chip color. To produce higher quality potatoes for processing, therefore, climatic conditions such as minimum temperature and sunshine hour and soil condition such as organic matter content have to be considered before the selection of areas or fields.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.19 no.1
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• pp.57-65
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• 2007

Shallow water waves are hindcasted from sea wind fields, which include wave transformations such as shoaling, refraction, diffraction, reflection and wave breaking. In case of estimating sea wind field in shallow water, the sea wind revised from free wind obtained by the typhoon model is widely used. However, this method is not able to consider the effect of land topography on the wind field, which will be important factor for shallow water wave forecasting and hindcasting. In this study, therefore, the effect of land topography on sea wind field in shallow water is investigated for shallow water wave forecasting and hindcasting with high accuracy. The 3-D MASCON model is introduced to consider the influence of land topography on the wind field. And, for two areas divided by the topographical characteristics, i.e. shielded and opened coastal areas, sea wind field is examined by comparison between initial wind field by typhoon model and modified wind field by 3-D MASCON model. Finally, applying these sea wind fields to SWAN model, the results of shallow water wave calculated in shielded and opened coastal areas are compared, and, also, the effect of MASCON model on shallow water wave forecasting and hindcasting is discussed.

• Journal of Chest Surgery
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• v.33 no.2
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• pp.117-124
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• 2000

Background: Nucleoside transport inhibitor(NTI) Keeps AMP, ADP, ATP levels high in myocytes by inhibiting adenosine cataboilsm so that it may preserve the myocardial contractability during ischemia In this study we investigated the effects of cyclic AMP phosphodiesterase inhibor(C-AMP PDSI) and S-P-nitrobenzyl-6 -thioniosine(NBT; a sort of NIT) on myocadial preservation and changes of constituent enzyme. Material and method: Twenty-six isolated rabbit hearts were perfused with Krebs-Henseleit buffer solution for 20 minutes arrested for 20 minutes and ten reperfused for 30 minutes. The following four groups were prepared and hemodynamic changes coronary effluent lactate dehydrogenase (LDH) a-hydroxybutylic accid(a-HBD) levels and myocardial LDH creatine kinase-MB (CK-MB) adenosine deaminase(ADA) a-HBD levels and myocardial LDH creatine kinase-MB (CK-MB) adenosine deaminase(ADA) a-HBD levels were analysed before and after cardiac arest ; Group I(control) ; the heart was only perfused with K-H ; Group II ; the heart was perfused with K-H including C-AMP PDSI(Amrinone 25mg/L); Group III ; the heart was perfused with K-H including NBT(4.19mg/L) ; Group IV ; the heart was perfused with K-H including C-AMP PDSI + NBT. Result : Left venticular developed pressure(LVDP) at 10 minutes of the equilibrium was significantly higher in group III(72.1$\pm$5.3 mmHg p<0.01) and group III(72$\pm$5.6 mmHg P<0.025) as compared with group I (40.8$\pm$4.7mmHg) and LVDP at 20 minutes of the reperfusion was significantly higher in group II(74$\pm$5.3mmHg p<0.01) and group III(72$\pm$5.6mmHg p<0.025) as compared with group I (44.2$\pm$4.6mmHg). Percentage recovery of LVDP at the reperfusion was the highest in group II(123.3%) Percentage recovery of coronary flow at the equilibrium reperfusion were higher in group II(310%, 270%) group III(230%, 290%) group IV(310%, 280%) as compared with group I (100%) respectively. Myocadial LDH level was significant lower in group IV(33495$\pm$1802 IU/gm p<0.04) as compared with group I(48767$\pm$1421 IU/gm) Myocadial CK-MB level was significant higher in group II(74820$\pm$1421 IU/gm) compared with group I (45450$\pm$1737 IU/gm) Myocadial ADA level was significant higher group IV(1215$\pm$8 IU/gm p<0.05) compared with group I(125$\pm$15 IU/gm) but there was no significant difference between group I and group II ,III, IV in changes of coronary effluent LDH, a-HBD levels. Conclusion: C-AMP PDSI solely appears to have a better effect on myocardial preservation after ischemia than NBT but with no synergistic effect and it could keep CK-MB leve high in myocardial tissues.

• Korean Journal of Medicinal Crop Science
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• v.18 no.3
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• pp.143-150
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• 2010

This study showed the increase of antitumor activities of water soluble E. sinica extract by nano-encapsulation process with lecithin. Five groups of lecithin only group (LO), lecithin nano-encapsulated E. sinica group (LE), E. sinica only group (EO), one negative control group (NCO) and positive control group (PCO) were set for several anticancer experiment and fed into Sarcoma-180 injected mice. The cytotoxicity of LE on the human normal kidney cell (HEK293) showed 14.8% lower than 19.2% of EO and 18.4% of LO. Growth of human liver carcinoma cell and human stomach carcinoma cell as representative of digestive system in vitro was inhibited up to about 85.1% and 87.3%, in adding 1.0 mg/$m{\ell}$ of LE, which values 15% higher than that from conventional EO. The survival rates of each mice group were 40%, 63%, 48%, 33% and 100%, respectively after 40 days of injecting Sarcoma-180. The increment of their body weights of the extract feeding groups was suppressed down to 10~15%, compared to the negative control. The nano-particles also reduced the hypertrophy of the internal organs such as spleen and liver down to 15~20%, compared to those as the other groups. Among them, LE effectively reduced the size of tumor form to 20%. From these results, in vitro and in vivo antitumor activities of E. sinica could be enhanced by using nano-encapsulation process with lecithin because of better permeation into the cancer cells by confocal observations.

• Korean Journal of Organic Agriculture
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• v.22 no.3
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• pp.483-490
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• 2014

The study was conducted to the effect of inclusion of chitosan-oligosaccharide in drinking water on the blood component profile, immunity and antioxidative enzyme of broiler chickens. A total of 28,000 broiler chickens (Arbor Acre) at 1 days of age were fed the commercial diet until 35 days of age, the treatment divided into two treatments, normal control group and chitosan-oligosaccharide in drinking water group. In concentration of glucose, treatment was significantly decreased than control (P<0.05), but not statistically different on the Triglyceride, Total cholesterol, HDL-cholesterol and LDL-cholesterol in the Blood component profile of broiler chicks. The concentration of glutamic oxalacetic transaminase (GOT) was statistically different but the concentration of glutamic pyruvate transaminase (GPT) was significantly decreased in treatment fed chitosan-oligosaccharide than control (P<0.05). Immunoglobullins in the blood, concentration of IgG was not significantly different among control and treatment but concentration of IgM was significantly increased in fed chitosan-oligosaccharide than control (P<0.05). Antioxidant and super oxide dismutase (SOD) was not different among control and treatment and concentration of catalase and glutathione peroxidase were significantly increased in fed chitosan-oligosaccharide than control (P<0.05).

• Economic and Environmental Geology
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• v.52 no.5
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• pp.381-393
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• 2019

Carbonate breccias occur sporadically in the Middle Cambrian Daegi Formation on the southern limb of the Baegunsan Syncline, Taebaeksan Basin. These carbonate breccias have been largely interpreted either as sedimentary breccias or as tectonic, fault-related breccias. Recent study, however, indicates that the majority of these breccias are a solution-collapse breccia which is causally linked to the paleokarstification. Extensive karstification is attributed to prolonged subaerial exposure of the carbonate platform. The exposed surface is a record of interruption in sedimentation on the carbonate platform. In the stratigraphic record, such karst-related post-depositional features are recognized as meteoric diagenetic features, paleosols, and solution-collapse breccias. Solution-collapse breccias are particularly well preserved and most profound in the carbonate rocks below the major unconformities, which also are evidence of prolonged subaerial exposure. The Middle Cambrian Daegi Formation provides an example of solution-collapse breccias. The formation and preservation of the solution-collapse breccias imply that a stratigraphic discontinuity surface (unconformity) can be designated within the Daegi Formation.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.31 no.5
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• pp.278-293
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• 2019

The joint distribution of wave height and period has been maltreated despite of its great engineering value due to the absence of any analytical model for wave period, and as a result, no consensus has been reached about the effect of nonlinearity on these joint distribution. On the other hand, there was a great deal of efforts to study the effects of non-linearity on the wave height distribution over the last decades, and big strides has been made. However, these achievements has not been extended to the joint distribution of wave height and period. In this rationale, we first express the joint distribution of wave height and period as the product of the marginal distribution of wave heights with the conditional distribution of associated periods, and proceed to derive the joint distribution of wave heights and periods utilizing the models of Longuet-Higgins (1975, 1983), and Cavanie et al. (1976) for conditional distribution of wave periods, and height distribution derived in this study. The verification was carried out using numerically simulated data based on the Wallops spectrum, and the nonlinear wave data obtained via the numerical simulation of random waves approaching toward the uniform beach of 1:15 slope. It turns out that the joint distribution based on the height distribution for finite banded nonlinear waves, and Cavanie et al.'s model (1976) is most promising.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.258-258
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• 2019

계산 격자에 기반하여 천수 흐름을 모의할 때, 그 격자에 담긴 물의 양을 정확하게 파악할 필요가 있다. 예를 들어, 초기조건으로 수위가 부여된다면 계산격자의 기하 특성에 맞추어 흐름 변수인 수심이나 흐름 단면적으로 바꾸어야하기 때문이다. 필요에 따라서는 모의 결과를 수위로 보이거나 격자 속 수심을 계산에 사용할 수도 있으므로 그 역변환도 고려되어야 한다. 2차원의 삼각형 계산격자에 대해서는 물의 부피와 수위 관계(volume/free-surface relationship)가 이미 정확(exact)하게 구명되어 있다(Hwang, 2017, J. KWRA). 그런데 1차원 문제의 횡단면에서 흐름 단면적과 수위의 관계(area/free-surface relationship)는 수위로부터 면적 환산에 대해서는 정확하나 그 역변환은 그렇지 않다. 매 시간 단계에서 갱신된 흐름 단면적으로부터 수위를 환산하기 위해 미리 작성된 면적-수위 자료를 이용한 선형 보간이 적용된다(Goodell, 2011, The RAS Solution). 이때, 환산 정확도는 자료의 해상도에 의존된다. 다행히 하천 횡단면 대부분을 채워 흐르는 홍수모의에서는 이 문제가 그리 심각하지는 않다. 심지어 수위가 복단면 저수로 턱에 걸쳐있어 흐름단면적이 급변하는 경우에도 환산 수위의 정확도는 크게 훼손되지 않는다. 그러나 미미한 환산 오차일지라도 그로 인해 수위가 저수로 턱을 넘거나 그보다 작을 수 있다. 이 경우, 홍수터의 잠김여부에 따라 수면폭(top width)이 실제 계산 결과에 비해 크게 달라질 수밖에 없다. 수면폭 오차는 그것을 이용하여 결정되는 수리 수심(hydraulic depth)이나 평균 하상고(mean bed level)의 산정에도 전파된다. 이 연구에서는 하천 횡단면에서 수위와 흐름 단면적 사이의 환산 정확도를 크게 높일 수 있는 기법을 제시하였다. 먼저 하천 횡단면에서 주어진 수위에 대해 흐름 단면적을 산정할 수 있는 알고리듬을 보였다. 또한, 횡단면에서 수위와 흐름 단면적의 관계가 단조 증가 함수(monotonically increasing function)임에 착안하여 그 역변환에 대해 해 찾기(root finding) 방법의 하나인 Brent 기법을 적용하였다. 이 기법은 주어진 구간에서 도함수가 알려져 있지 않은 경우에 대해서도 효과적으로 해를 찾을 수 있는 것으로 알려져 있다(Press et al., 2002, Numerical Recipes in C, 2nd Ed.). 내성천 하류 수계의 333개 단면에서 수면폭에 대한 상대 오차를 살펴보면, 선형 보간에 의한 기존 방법으로는 면적-수위 자료의 수가 1,000개가 되어도 그 최대치가 1% 이내에 들지 않은 반면, 이 연구에서 제시한 기법으로 면적-수위 자료 없이도 1% 이내로 줄어드는 것을 확인하였다. 다만, 반복 계산에 의한 계산 시간의 증대를 피할 수 없다. 미리 작성된 면적-수위 자료를 이용하면 계산 비용을 줄일 수 있으며, 약 35개의 구간으로 나누었을 때 비용 대비오차가 적절하였다. 이 연구는 한국건설기술연구원(주요사업 과제번호: 20190116-001)의 지원에 의한 것이다.

• Journal of the Mineralogical Society of Korea
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• v.32 no.2
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• pp.87-102
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• 2019

Pallancata Ag mine is located at the Ayacucho region 520 km southeast of Lima. The geology of mine area consists of mainly Cenozoic volcanic-intrusive rocks, which are composed of tuff, andesitic lava, andesitic tuff, pyroclastic flow, volcano clasts, rhyolite and quartz monzonite. This mine have about 100 quartz veins in tuff filling regional faults orienting NW, NE and EW directions. The Ag grades in quartz veins are from 40 to 1,000 g/t. Quartz veins vary from 0.1 m to 25 m in thickness and extend to about 3,000 m in strike length. Quartz veins show following textures including zonation, cavity, massive, breccia, crustiform, colloform and comb textures. Wallrock alteration features including silicification, sericitization, pyritization, chloritization and argillitization are obvious. The quartz veins contain calcite, chalcedony, adularia, fluorite, rutile, zircon, apatite, Fe oxide, REE mineral, Cr oxide, Al-Si-O mineral, pyrite, sphalerite, chalcopyrite, galena, electrum, proustite-pyrargyrite, pearceite-polybasite and acanthite. The temperature and sulfur fugacity ($f_{s2}$) of the Ag mineralization estimated from the mineral assemblages and mineral compositions are ranging from 118 to $222^{\circ}C$ and from $10^{-20.8}$ to $10^{-13.2}atm$, respectively. The relatively low temperature and sulfur-oxygen fugacities in the hydrothermal fluids during the Ag mineralization in Pallancata might be due to cooling and/or boiling of Ag-bearing fluids by mixing of meteoric water in the relatively shallow hydrothermal environment. The hydrothermal condition may be corresponding to an intermediate sulfidation epithermal mineralization.