• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.134.1-134.1
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• 2011

APT(Asian-Pacific Telecommunity)는 아시아-태평양지역 국가의 공동이익을 도모하기 위하여 결성된 아-태지역 전파협의체 조직으로, WRC(세계전파통신회의)회의에서의 아-태 지역 주관청의 공동이익을 얻기 위해 APG(APT Conference Preparatory Group for WRC)회의를 연간 1회의 비율로 개최하고 있다. 2012년의 WRC-12회의에 대비하여 아태지역 회원국의 최종 공동의견서를 작성하기 위해, APG-12 5차회의가 2011년 8월 29일-9월 3일 부산에서 개최되었으며, 전파천문업무 보호 및 22 GHz 대역 달탐사, 38 GHz 대역 Space-VLBI운용대역과 관련된 WRC-12 의제 1.6, 1.11, 1.12 등에 대한 회의가 있었다. WRC-12 의제 1.6은 수동업무(전파천문업무, 지구탐사위성 및 우주연구업무)를 능동업무의 유해혼신으로부터 보호하기 위하여 제정한 전파규칙 각주 5.565조의 개정 검토와 관련된 의제이다. 따라서 한국천문연구원에서는 275 GHz 이상 대역에서 전파천문업무의 원활한 운용을 위해, APG-12 5차회의에 참석하여 WRC-12회의에 제출하기 위한 아-태지역 국가의 공동의견서 작성에 주도적인 역할을 담당하였다. 본 발표에서는 APG-12 5차 회의에 제안한 우리나라의 기고서 제안 내용 및 동 회의에서 의 최종 아태지역 회원국 공동의견서 결과 및 향후 대응책에 대해서도 알아보고자 한다.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.1
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• pp.72.2-72.2
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• 2011

세계전파통신회의 (WRC; World Radiocommunication Conference)회의는 국제전기통신연합(ITU)에서 발행하는 국제 전파법과 관련된 전파규약을 갱신하거나 새로운 법 제정을 위해, 3-4년 간격으로 개최되는 전파통신 관련 회의라고 할 수 있다. 차기 WRC회의는 2012년 1월23일 - 2월 17일에 개최되며, 따라서 동 회의에서 다룰 의제들의 사전 연구결과에 대한 보고서가 필요하다고 하겠다. 그러므로 WRC 본회의 개최 6개월 전에 상기 기술문서를 의제별로 종합 작성하기 위해 CPM (Conference Preperatory Meeting) 회의를 개최해야 하며, 본 CPM회의에서 작성된 기술보고서의 내용들은 WRC 본회의에서의 여러 가지 국제법의 결정사안에 대한 중요한 정보를 제공하게 된다고 할 수 있다. 2011년 2월 14일-2월 25일에 걸쳐 스위스에서 개최된 CPM-11 2차회의에서는 전파천문업무 보호 및 22 GHz 대역 달탐사, 38 GHz 대역 Space-VLBI운용대역과 관련된 WRC-11 의제 1.6, 1.11, 1.12 등에 대해 활발한 토론이 있었다. 따라서 한국천문연구원에서는 향후 일본과 국제공동관측을 수행하게될 space-VLBI의 운용과 관련하여, 관련 과학업무의 보호를 위한 동 회의의 최종결과 및 향후 WRC-12회의에 대한 대응책에 대해서도 알아보고자 한다.

• Journal of Astronomy and Space Sciences
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• v.20 no.1
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• pp.83-94
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• 2003

Chon-Mun-Ryu-Cho (天文類抄), written (edited) by Lee Sun-Ji (李純之) during the period of King Se-Jong, is a representative astronomy book of Cho-Sun (朝鮮: A.D. 1392-1910) Dynasty. We find and study in the first page of the book; the description of 28 oriental constellations as a Sasin (four mythical oriental animals)-animal sky map which is not widely known yet. The map consists of four groups of constellations, each of which represents the Sasin: Chang-Ryong (蒼龍: dragon), Baek-Ho (白虎: tige.s with Ki-Rin [離隣: Oriental giraffe]), Ju-Jak (朱崔: Chinese phoenix), Hyun-Mu (玄武: a tortoise interwined with a snake). Each group (animals) spans 2 ～ 7 of 28 oriental constellations (宿). As we know from the illustration (論說) of the Chon-Sang-Yol-Cha-Bun-Ya-Ji-Do (天象列次分野之圖), a representative sky map of Cho-Sun Dynasty, astronomy in Cho-Sun Dynasty is closely related to that in Go- Gu-Rye. (高句麗: B.C. 37 -A.D. 668) Dynasty. Since these Sasin-animals appear in most mural paintings of Go-Gu-Rye. (高句麗) tombs, visualization of sky with these animal constellations could have been established as early as in Go-Gu-Ryer Dynasty. We also reconstruct this ”A Sasin-animal Korean sky map” based on the shapes of the Sasin and Ki-Rin from Go-Gu-Ryer paintings and 28 oriental constellations in Chon- S an g- Yol- C h a- B un- Ya- J i- Do.

• Journal of Life Science
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• v.26 no.5
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• pp.509-518
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• 2016

Asparagus cochinchinensis is a medical plant that has long been used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although several studies have been conducted on the anti-neuroinflammatory effects of A. cochinchinensis, the correlation between these effects and nerve growth factor (NGF) has not yet been examined. In this study, we investigated the effects of an aqueous extract of A. cochinchinensis (AEAC) on the secretion and action mechanism of NGF in neuronal cells. The concentration of the NGF protein in the supernatant collected from cultured cells increased significantly in B35 cells treated with AEAC in comparison with the vehicle-treated group without any specific cytotoxicity. Furthermore, the mRNA expression of NGF showed a very similar pattern to its protein concentration. To examine the bioactivity of NGF secreted from B35 cells, undifferentiated PC12 cells were cultured in an AEAC-conditioned medium and neuritic outgrowth was observed. The dendrite length of PC12 cells in the AEAC-treated group was significantly higher than that in the vehicle-treated group. Moreover, the level of the downstream effectors p-TrkA and p-ERK of the high-affinity NGF receptor was significantly higher in the AEAC-treated group, while the expression of the downstream effectors of the low-affinity NGF receptor was significantly lower in the same group. These results suggest that AEAC may contribute to the regulation of NGF expression and secretion in neuronal cells; it is therefore an excellent candidate for further investigation as a therapeutic drug for neurodegenerative diseases.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.135-135
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• 2011

APT(Asian-Pacific Telecommunity)는 아시아-태평양지역 국가의 공동이익을 도모하기 위하여 결성된 아-태지역 전파협의체 조직으로, WRC(세계전파통신회의)회의에서의 아-태지역 주관청의 공동이익을 얻기 위해 APG(APT Conference Preparatory Group for WRC)회의를 연간 1회의 비율로 개최하고 있다. 2012년의 WRC-12회의에 대비하여 아태지역 회원국의 최종 공동의견서를 작성하기 위해, APG-12 5차회의가 2011년 8월 29일-9월 3일 부산에서 개최되었으며, 전파천문업무 보호 및 22 GHz 대역 달탐사, 38 GHz 대역 Space-VLBI운용대역과 관련된 WRC-12 의제 1.6, 1.11, 1.12 등에 대한 회의가 있었다. 따라서 한국천문연구원에서는 38 GHz 대역 Space-VLBI운용대역과 관련된 전파천문업무 및 우주연구업무의 원활한 운용을 위해, APG-12 5차회의에 참석하여 WRC-12회의에 제출하기 위한 아-태지역 국가의 공동의견서 작성에 주도적인 역할을 담당하였다. 본 발표에서는 한국천문연구원과 일본국립천문대간 공동연구를 수행하게될 space-VLBI의 적절한 운용보호를 위하여, APG-12 5차 회의에 제안한 우리나라의 기고서 제안 내용 및 동 회의에서의 최종 아태지역 회원국 공동의견서 결과 및 향후 대응책에 대해서도 알아보고자 한다.

• Microbiology and Biotechnology Letters
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• v.44 no.1
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• pp.107-107
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• 2016

• Journal of Life Science
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• v.30 no.4
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• pp.331-342
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• 2020

The suppression of neuroinflammatory responses in microglial cells can be considered a key target for improving the progression of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Asparagus cochinchinensis has traditionally been used as a medicine to treat fever, cough, kidney disease, breast cancer, inflammatory diseases, and brain diseases. In this study, we investigated the neuroprotective mechanism of an aqueous extract from A. cochinchinensis root (AEAC), particularly its anti-inflammatory effects on lipopolysaccharide (LPS)-activated BV-2 microglial cells. BV-2 cells were treated with four different concentrations of AEAC. No significant toxicity was detected in BV-2 cells treated with AEAC. Nitric oxide (NO), cyclooxygenase-2 (COX-2) mRNA, and inducible nitric oxide synthase (iNOS) mRNA levels were 21% lower in the AEAC+LPS group than in the Vehicle+LPS group. Lower proinflammatory (TNF-α and IL-1β) and anti-inflammatory cytokine (IL-6 and IL-10) levels were also detected in the AEAC+LPS group than in the Vehicle+LPS group, albeit at varying rates. Moreover, the phosphorylation of mitogen-activated protein kinase (MAPK) members after LPS treatment was significantly recovered in the AEAC-pretreated group compared to the Vehicle+LPS group, enhancement of the phosphorylation of mitogen-activated protein kinase (MAPK) members after LPS treatment was significantly recovered in the AEAC-pretreated group, while cell cycle arrest at the G2/M phase caused by LPS treatment was less severe in the AEAC+LPS group. The increase in reactive oxygen species (ROS) generation induced by LPS treatment was also lower in the AEAC-pretreated group than in the Vehicle+LPS group. This is the first study to show that AEAC exerts anti-neuroinflammatory activity against LPS stimulation by regulating the MAPK signaling pathway, the cell cycle, and ROS production.

• Food Science and Preservation
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• v.19 no.5
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• pp.744-750
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• 2012

In this study, the optimal conditions for phenolic-compound extraction from medicinal plants were found to be 24 h and about 50% ethanol. The electron-donating scavenging activities (DPPH), ABTS radical-cation decolorization (ABTS), antioxidant protection factor (PF), and thiobarbituric acid reaction substance (TBAR) were measured to determine the antioxidant activities of the extracts of Sanguisorba officinalis Linn., Citrus unshiu Markovich, Melia azedarach L., Asparagus cochinchinensis Merr., Citrus unshiu S., Polygonum aviculare L., and Leonurus sibiricus L. The total phenolic contents of the extracts of medical plants were determined to be 0.45-3.00 mg/g in the water extracts and 0.33-3.15 mg/g in the 50% ethanol extracts. The electron-donating abilities (EDA) of the water and ethanol extracts were both above 85% at the $50{\mu}g/ml$ concentration. The ABTS radical-cation decolorization was above 80% at the $100{\mu}g/ml$ concentration in all the extracts of various medicinal plants. The antioxidant protection factor (PF) of the Melia azedarach L. extracts was found to be $1.65{\pm}0.40$ PF in the water extracts at the $100{\mu}g/ml$ concentration, and was higher than those of the other medicinal-plant extracts. The TBAR inhibition rates of all the medicinal-plant extracts, except Asparagus cochinchinensis Merr., were above 85% at the $100{\mu}g/ml$ concentration. These results confirmed that the various oriental medicinal plants (Sanguisorba officinalis Linn., Citrus unshiu Markovich, Melia azedarach L., Asparagus cochinchinensis Merr., Citrus unshiu S., Polygonum aviculare L., and Leonurus sibiricus L.) that were included in this study are useful functional-food sources.

• Journal of Life Science
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• v.32 no.8
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• pp.647-658
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• 2022

Particulate matter (PM) is known to be involved in the onset and progression of various diseases by promoting oxidative and inflammatory reactions as air pollutants containing various small particles that are harmful. In this study, the protective efficacy of herbal medicines was evaluated in human corneal epithelial cells (hCECs) to select natural products that can protect the eye, the primary organ directly exposed to external pollutants from PM. As a result, five candid ate herbal medicines [Cheonmundong, Asparagus Rhizome; Seokchangpo, Aciru Gramineri Rhizoma; Hwangryeon, Coptidis Rhizoma; Gamgug, Chrysanthemi Indici Flos; and Geumjanhwa (Marigold flower petals)] which showed inhibitory efficacy on PM_2.5-induced cytotoxicity, were selected from among 12 candidate herbal medicines. To evaluate the antioxidant activity of these candidate substances, the reactive oxygen species (ROS) scavenging ability was investigated, and it was found that the extracts of Seokchangpo, Cheonmundong and Hwangryeon showed a significant inhibitory effect on PM_2.5-induced ROS production, which was correlated with the preservation of mitochondrial activity. In addition, it was confirmed that they could block DNA damage caused by PM_2.5 through analysis of 8-hydroxy-2'-deoxyguanosine generation and phosphorylated-H2A histone family member X (γ- H2AX) expression. Furthermore, the increase in inflammasome activity and inflammatory response in PM_2.5-treated hCECs was also canceled in the presence of these extracts. Although additional studies are needed, the results of this study will be used as primary data to find novel natural compounds that protect hCECs from PM.

• The Science & Technology
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• v.32 no.7 s.362
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• pp.68-70
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• 1999

고려대 박물관에 보관되어 있는 우리나라 국보 230호인 '혼천시계'를 만든 사람은 17세기 조선 현종때의 천문학자 송이영으로 알려졌다. 이 혼천시계는 1930년께 서울 인사동에서 엿장수의 고물로 나온 것을 당시 동아일보 시장 김성수씨가 집 한채 값을 주고 매입하여 보관하게 된 것인데 가로 118.5cm, 두께 52.5cm, 높이 99cm 크기로 나무상자 속에 기계시계와 혼천의가 장치된 것이다. 국보 '혼천시계' 주인공을 조명해 본다.