• 감성과학
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• 제9권2호
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• pp.93-100
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• 2006

본 연구에서는 교통사고나 뇌졸중 등에 의해 상지의 장애를 가지는 장애인을 대상으로 하여, 인터넷의 브라우저와 같은 소프트웨어를 사용 할 수 있는 컴퓨터 인터페이스로서 자이로센서를 이용한 무선 자이로 마우스시스템를 개발하고, 임상평가를 통해 그 유용성을 확인하고자 한다. 시스템 개발에 있어서 주안점은, 첫째, 장애인의 경우 휠체어나 침대에 누워서 마우스 조작을 할 수 있도록 시스템의 무선화하는 것, 둘째, 착탈의 용이성과 미관을 위하여 센서를 헤드 밴드에 삽입하는 것, 셋째, 컴퓨터 운영체제에게 클릭신호를 전달하기 위하여, $C5{\sim}C6$ 환자들의 경우에는 클릭 스위치를 사용하고, C4환자의 경우에는 고개의 끄덕임을 검출하도록 하는 것이다. 개발된 시스템을 척수손상으로 인한 상지 장애인을 대상으로 평가실험을 실시하였다. 그 결과 시행횟수가 증가할수록 상하/좌우 이동시의 목표위치에 대한 실제위치의 오차가 감소하고, 1분당 클릭률이 증가하는 경향을 확인하였다. 이로부터, 개발된 무선 자이로마우스 시스템은 환자의 반복사용을 통해 그 유용성이 증가할 것을 알 수 있다.

• 한방재활의학과학회지
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• 제19권2호
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• pp.1-25
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• 2009

Objectives : The purpose of this study was to investigate the effects of Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang, YGKT) and electrical acupuncture treatment in spinal cord injury(SCI)-induced rats. Methods : The subjects were divided into 5 groups ; Normal, Control-no treatment after SCI, Experimental I(Exp. I)-taken with YGKT 500 mg/kg $0.5m{\ell}$ daily after SCI. Experimental II(Exp. II)-taken with electrical acupuncture after SCI and Experimental III(Exp. III)-taken with YGKT 500 mg/kg $0.5m{\ell}$ and electrical acupuncture after SCI. After each operation, the present author observed cytological changes, the motor behavior recovery and nerve regeneration by analysis of the motor behavior tests, EMG, hematological(AST, ALT, WBC), histological and immunological changes. Rats were tested by Motor behavior test at 1st, 3rd, 7th, 14th and 21st day. Results : 1. All the experimental groups were improved compared with control group in the motor behavior tests including Tarlov test, Basso-Beattle-Bresnahan locomotor rating scale, modified inclined plane test, open field test, grid walk test and narrow beam test. Especially Exp. III was significantly improved among other groups. 2. In EMG test, H and M wave were significantly increased in Exp. III. 3. All the experimental groups were significantly decreased compared with control group in AST, ALT and WBC. 4. NGF, BDNF and Trk B of spinal cord gray matter in all the experimental groups were increased compared with control group. Especially, Exp. III was more effective. 5. In histological observations, muscle contraction and denaturation of gastrocnemius muscle of all the experimental groups were inhibited. Especially, those of Exp. III was more effective. On the observations of liver and kidney, cell atrophy and apoptosis of all the experimental groups were decreased compared with control group. Especially, those of Exp. III was more effective. Conclusions : It can be suggested that YGKT and electrical acupuncture may improve motor behavior, EMG, hematological, histological and immunological findings in SCI-induced rats. Especially, combination of these two treatments will be somewhat better in spinal nerve recovery and motor function improvement.

• 한방재활의학과학회지
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• 제19권2호
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• pp.27-49
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• 2009

Objectives : The purpose of this study was to investigate the effects of Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang) and Cervi Cornu Parvum pharmaco-acupuncture in Spinal Cord Injury(SCI)-induced rats. Methods : The subjects were divided into 5 groups ; Normal, Control no treatment after SCI, Experimental I taken with Yanghyuljanggeungunbo-tang (Yangxuezhuangjinjianbu-tang) 500 mg/kg $0.5m{\ell}$ daily after inducing SCI. Experimental II taken with Cervi Cornu Parvum pharmaco-acupuncture at Taegye(KI3) and $Yangnungch{\acute{o}}n$(GB34) after inducing SCI and Experimental III taken with Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang) 500 mg/kg $0.5m{\ell}$ and Cervi Cornu Parvum pharmaco-acupuncture at KI3 and GB34 to SCI-induced rats. After each operation, the present author observed the motor behavior recovery and nerve regeneration by analysis of the motor behavior tests, EMG, hematological(AST, ALT, WBC), histological and immunological changes. Rats were tested at modified Tarlov test at the 1st, 2nd, 3rd, 4th day, and Motor behavior test at 1st, 3rd, 7th, 14th, 21st day. Results : Results are as follows. 1. All the experimental groups were improved compared with control group in the motor behavior tests including Tarlov test, Basso-Beattle-Bresnahan locomotor rating scale, modified inclined plane test, open field test, grid walk test and narrow beam test. Especially Experimental III was improved significantly among other groups. 2. In EMG test, H wave appeared weak only in Experimental III. And M wave was increased significantly in Experimental III. 3. All the experimental groups were significantly decreased compared with control group in serum AST, serum ALT and serum WBC tests. 4. significantly decreased in Tumor Necrosis Factor-${\alpha}$ test compared with the first day of SCI. 5. Muscle contraction and denaturation of all the experimental groups were inhibited in histological observations of gastrocnemius muscle. Especially, those of experimental III was more effective. 6. NGF and BDNF of spinal cord gray matter in all the experimental groups were increased compared with control group. Especially, those of experimental III was more effective. Conclusions : As above, it can be suggested that Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang) and Cervi Cornu Parvum pharmaco-acupuncture may improve motor behavior, EMG, hematological, histological and immunological findings in Spinal Cord Injury(SCI)-induced rats. Especially, effects will be somewhat better in combination of these two treatments.

• 대한한의학방제학회지
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• 제7권1호
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• pp.131-141
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• 1999

In order to eludidate the mechanism of oxidative stress in cultured spinal motor neurons damaged by oxygen free radicals, cytoxicity was assesed by MTT assay and NR assay after spinal motor neurons from mouse were cultured in media containing various concentrations of xanthine oxidase(XO) and hypoxanthine(HX) for 3 hours. In addition, neuroprotective effects of several herb extracts on oxidant-induced neurotoxicity were examined in these cultures, compared with nerve growth factors such as basic fibroblast growth factor(bFGF). XO/HX decreased cell viability in dose- and time dependent manners on cultured mouse spinal motor neurons, and MTT50 and NR50 values were measured at 20mU/ml XO and 0.1mM HX for 3 hours in these cultures. bFGF significantlt increased cell viability. In neuroprotective of herb extracts, Epimedium Koreanum Nakai(EK) and Alpinia oxphylla Mig(IJI) was very effective in the prevention of the neurotoxicity induced by XO/HX in cultured mouse spinal motor neurons. From the above results, it is suggested that XO/HX shows toxic effect in cultured mouse spinal motor neurons and selective herb extracts such as Epimedium Koreanum Nakai(EK) and Alpinia oxphylla Mig(IJI) were very effective in the increase of cell viability against the neurotoxicity induced by oxygen radicals in these cultures.

• 한국전문물리치료학회지
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• 제24권2호
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• pp.1-8
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• 2017

Background: Individuals with spinal cord injury (SCI) rely on their upper limbs for body-lifting activity (BLA). While studies have examined the electromyography (EMG) and kinematics of the shoulder joints during BLA, no studies have considered foot position during BLA. Objects: This study compared the effects of different foot positions during BLA on the shoulder muscle activities, peak plantar pressure, knee flexion angle, and rating perceived exertion in individuals with SCI. Methods: The study enrolled 13 mens with motor-complete paraplegic SCI, ASIA (American Spinal Injury Association) A or B. All subjects performed BLA with the feet positioned on the wheelchair footrest and on the floor independently. Surface EMG was used to collect data from the latissimus dorsi, pectoralis major, serratus anterior, and triceps brachii. The peak plantar pressure was measured using pedar-X and the knee flexion angle with Image J. Borg's rating perceived exertion scale was used to measure the physical activity intensity level. The paired t-test was used to compare the shoulder muscle activities, peak plantar pressure, knee flexion angle, and rating perceived exertion between the two feet positions during BLA. Results: The activity of the latissimus dorsi, pectoralis major, serratus anterior, and triceps brachii and rating perceived exertion decreased significantly and the peak plantar pressure and knee flexion angle increased significantly when performing BLA with the feet positioned on the wheelchair footrest compared with on the floor (p<.05). Conclusion: These findings suggest that individuals with SCI may perform BLA with the feet positioned on the wheelchair footrest for weight-relief lifting to decrease the shoulder muscle activities and the rating perceived exertion and to increase the peak plantar pressure and the knee flexion angle.

• 한방재활의학과학회지
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• 제20권2호
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• pp.1-15
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• 2010

Objectives : This study was performed to evaluate the effects of root of Cibotii rhizoma(CR) ethanol extract on the tissue and neuronal damage of the spinal cord injury(SCI). Methods : SCI was induced by mechanical contusion following laminectomy of 10th thoracic vertebra in Sprague-Dawley rats. CR was orally given once a day for 7 days after SCI. Tissue damage and nerve fiber degeneration were examined with cresyl violet and luxol fast blue(LFS) histochemistry. HSP72(as neuronal damage marker), MAP2(as nerve fiber degeneration marker), c-Fos(immediate early gene), and Bax(pro-apoptotic molecule) expressions were examined using immuno-histochemistry. Individual immuno-positive cells expressing HSP72, MAP2, c-Fos and Bax were observed on the damaged level and the upper thoracic and lower lumbar spinal segments. Results : 1. CR reduced degeneration of nerve fibers and motor neuron shrinkage in the ventral horn of the lower lumbar spinal segment, but generally it did not seem to ameliorate the tissue injury following SCI. 2. CR reduced demyelination in the ventral and lateral funiculus of the lower lumbar spinal segment. 3. CR reduced HSP72 expression on the neurons in the peri-central canal gray matter adjacent to the damaged region. 4. CR strengthened MAP2 expression on the motor neurons in the ventral horn and on nerve fibers in the lateral funiculus of the lower lumbar spinal segment. 5. CR reduced c-Fos positive cells in the peri-lesion and the dorsal horn of the damaged level and in the ventral horn of the lower lumbar spinal segment. 6. CR reduced Bax positive cells in the peri-lesion and the dorsal horn of the damaged level and in the ventral horn of the lower lumbar spinal segment. Conclusions : These results suggest that CR plays an inhibitory role against secondary neuronal damage and nerve fiber degeneration. following SCI.

• 한국전문물리치료학회지
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• 제4권3호
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• pp.17-33
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• 1997

The objective of this study was to identify pulmonary functional variations in relation to postural changes, lapse after changing position, and the use of abdominal band in the cervical cord injured. The subjects of this study were 19 quadriplegic patients who had been admitted to the department of the Rehabilitation Hospital, College of Medicine, Yousei University, from April, 1997 through May 3, 1997. A spiroanalyzer was used to measure pulmonary function in supine, standing, time after changing position, and recording to the position, application method, and tightness of the abdominal band. The data were analyzed by the repeated measure one-way ANOVA, and Wilcoxon signed rank test. The findings were as follows: 1. All phase of the patients' pulmonary function improved significantly in supine posture in contrast to standing (vital capacity by $0.46{\ell}$ and expiratory reserve volume by $0.09{\ell}$). 2. The longer the time lapsed from supine posture to standing, the patient's expiratory reserve volume, maximum ventilation volume, vital capacity, and forced expiratory volume increased. 3. When the patient lay in supine position, the maximum ventilation volume, vital capacity, and the forced vital capacity increased then the center line of the abdominal band was placed along iliac crest; on the other hand, when the patient was standing, placing the bottom line of the abdominal band along iliac crest increased the maximum ventilation volume, vital capacity, and forced expiratory volume. 4. In placing the abdominal band in the patients, leaving space between the top and bottom lines of the band helped increased in maximum ventilation volume, vital capacity, and forced vital capacity for patient in supine as well as in standing. 5. When placing the abdominal band to patients in supine posture, reducing the length of the band by 2.5% along the patient's waist line increased the patients' vital capacity, while reducing the length by 10% to patients in standing increased the maximum ventilation volume. The abdominal band should be placed in such a way that the bottom part of the band should be more tightly fastened while leaving enough room for a hand to be placed in between the body and the band for the top part of the hand. It should also be noted that in a supine position, the bottom line of the band should be placed along the iliac crest, while in standing, the center line should be placed along the iliac crest. The length of the band should also be reduced by 2.5% of the waist line in supine position, and in standing, the length should be reduced by 10%. It should also be noted that the pulmonary function of the patients should be measured at least 10 minutes after one position change.

• The Journal of Korean Physical Therapy
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• 제19권4호
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• pp.15-24
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• 2007

Purpose: This study was designed to investigate the effects of treadmill exercise on functional recovery after rat with experimental SCI. Methods: SCI was induced by the NYU-spinal cord impactor(NYU, USA) dropped a weight of 10 gm after laminectomy. Experimental groups were divided into the Group I (normal), Group II (control) and Group III(treadmill exercise). After 2 days of the operation, 24 rats(group II, III) were trained to walk on treadmill for 21 days twice/day, 15 min/session. After operation, rats were tested at modified Tarlov scale at 1, 2, 3, 4 days with divided into 2 groups, and Motor behavior test(BBB locomotor rating scale, Grid walking test, Narrow beam crossing test, Modified inclined plane test) was examined at 1, 3, 7, 14 and 21 days. Histopathological study were performed at 1. 3, 7, 14 and 21 days by H&E, Luxol Fast Blue staining were same times. Results: After SCI an improvement of motor behavior was shown group II, III. The motor behavior test of group Ill showed considerable improvement until 14 days. Conclusion: These results suggest that treadmill exercise treatment can playa role in facilitating recovery of locomotion following spinal cord injury.

• 한국산학기술학회논문지
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• 제20권7호
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• pp.242-248
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• 2019

본 연구는 Electronic Control Unit (EC)기술이 적용된 스마트 홈이 휠체어를 사용하는 장애인의 일상생활활동 수행도와 만족도에 미치는 영향을 알아보고자 하였다. 본 연구의 참여자는 국립재활원 재활병원에 입원한 환자 중에서 지역 사회 복귀와 집으로 퇴원을 계획하는 대상자 중에서 스마트 홈을 경험하기를 원하는 사람을 연구에 포함하였다. 15명의 참여자 중 척수손상장애인은 10명, 나머지 5명은 뇌병변 장애인이었다. 스마트 홈은 ECU기술이 적용된 것으로 가구 및 기반 제품들의 전동화, 기반 시설들의 자동화 그리고 제품과 시설들을 통합하여 스마트 디바이스와 음성으로 제어할 수 있도록 구성하였다. 휠체어 사용자의 일상생활 수행도와 만족도는 캐나다 작업수행평가에 의해 평가되었다. 스마트 홈에서 거주해본 결과 거실과 현관, 침실, 기타(환경적요소) 부분에서 일상생활의 수행도가 3점 이상의 평균값 차이를 보였다. 공간별 수행도 비교 결과, 현재 주거 공간에 비해 스마트 홈 주거 공간별 수행도가 모두 유의미한 차이(p<0.05)로 향상되었다. 만족도 역시, 거실과 현관, 침실, 주방 영역에서 4점 이상의 차이를 보였고 주거 공간별 만족도 비교 결과 모두 유의미한 차이(p<0.05)로 향상되었다. 본 연구는 하이테크 기반의 스마트 홈 적용 가능성의 기초적인 근거를 제공했다는 점에서 임상적 의의를 가진다. 추후에는 근거 수준의 질 향상을 위해 다수의 연구 참여자를 확보한 연구가 진행되어야 할 것이다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2021년도 학술발표회
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• pp.327-327
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• 2021

하수재이용에서 전처리 막여과 공정은 완벽한 고액분리로 인해 후단 역삼투막 손상을 줄일 수 있는 공정으로 각광을 받고 있다. 일반적으로 막여과 공정은 여과->물리세정->충진->여과 와 같은 제막사에서 제공하는 운전 사이클에 맞춰 적용하고 있으며 유지세정 역시 1회/일 또는 1회/주 단위로 정해진 범위에서 수행되고 있다. 이러한 운전 방식은 시시각각 변화하는 막 유입수질에 적절하게 대응하지 못해 장기적으로 막오염 발생에 따른 생산수량 감소는 물론 막오염 제거를 위한 화학세정 주기가 짧아져 전체적인 생산수량이 감소하는 원인이 되고 있다. Raffine(2012)에 따르면 가역적 막오염의 경우 Flux 증가에 큰 영향이 없으나 비가역적 막오염은 Flux 증가에 따라 급격히 증가한다고 보고하고 있으며 이는 제한된 분리막 면적당 처리수 생산량을 증가시키기 위해 비가역적 막오염의 발생량을 줄이는 것이 필요하며 이를 위해 주기적인 강화역세(Chemical Enhanced Backwashing, CEB)가 도입되고 효율적인 유지세정 방법에 대한 연구가 진행되고 있다. 당사에서는 일산에 있는 I 수질복원센터내에 25 m³/일 규모의 막여과 하수재이용 파일롯 플랜트를 설치하고 막여과 하수재이용 공정의 운영 효율을 높이기 위하여 W사에서 개발한 IntelliFluxControl(IFCr) 소프트웨어를 이용하여 하수재이용 막여과 성능을 확인 하였다. IFCr은 실시간으로 변화하는 수질에 따른 막오염 정도에 따라 역세 강도 및 빈도와 CEB 적용 정도를 변화시켜 분리막 운전의 효율을 높일 수 있는 운영 소프트웨어이다. I 수질복원센터의 하수 방류수를 막여과 유입수로 적용하여 40 LMH를 기준으로 IFCr을 적용하지 않은 경우 23.7일 운전 가능하였으나 IFCr을 적용한 경우 50일 연속 운전이 가능하였다. 또한 역세척수를 운전 기간 동안 약 50 m³을 사용한 반면 IFCr을 적용한 경우 이에 절반 수준인 24.1 m³ 만 사용하여 회수율이 91%에서 95%로 증가한 것을 확인 할 수 있었다. 본 연구의 결과는 기존의 제막사에서 제시하는 막 공정 운영방법을 탈피하여 분리막이 갖고 있는 성능을 최대한 끌어 올릴 수 있는 연구 결과라고 판단되며 향후 스케일 업 연구를 통해 실제 플랜트에 적용 가능성이 확인 될 경우 시설의 설치 막모듈 개수와 유지관리비를 동시에 절감할 수 있는 기술이 될 수 있을 것이다