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EFFECT OF ADMINSTRATION METHOD OF FLUMAZENIL ON THE PLASMA CONCENTRATION AND THE REVERSAL OF SEDATION INDUCED BY MIDAZOLAM (Flumazenil의 투여 방법에 따른 혈장내 농도와 midazolam에 의해 유도된 진정 상태의 환원 효과)

  • Park, Seong-Kyu;Lee, Sang-Ho;Lee, Chang-Seop;Lee, Nan-Young;Oh, You-Hyang
    • Journal of the korean academy of Pediatric Dentistry
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    • v.32 no.3
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    • pp.499-508
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    • 2005
  • The purpose of this study were to evaluate the effect on the reversion of sedation induced by midazolam with flumazenil and to determine the plasma concentration of flumazenil according to the method of administration. Intranasal and intravenous flumazenil were administered to sedated health volunteers aged from 23 to 25 years, in doses typical of those used clinically to induce sedation with midazolam and for reversal with flumazenil. Objective assessment for degree of sedation and vital signs, plasma concentration were made for 2 hours period. 1. Systolic and diastolic blood pressure, $SpO_2$ were not changed by adminstration of flumazenil in sedated subject with midazolam, but pulse rate was increased temporarily. 2. Flumazenil showed the reversal of the sedative effect induced by midazolam regardless of administration methods. But intravenous administration showed more effect on the degree and the duration of reversion than intranasal administration with the exception of on set time. 3. Peak plasma concentration of flumazenil administered by intranasal route reached after 2 min and that of flumazenil administered by intravenous route was 4 min. Thus uptake of flumazenil did not showed any difference in accordance with the adminstration route. 4. Administration of flumazenil resulted in the temporary increase of midazolam plasma concentration.

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A Study on Exploring Weak Signals of Technology Innovation using Informetrics (계량정보분석을 활용한 기술혁신의 Weak Signal 탐색에 관한 연구)

  • Yoo, Sun-Hi;Park, Hyun-Woo;Kim, Kyung-Ho
    • Journal of Technology Innovation
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    • v.17 no.2
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    • pp.109-130
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    • 2009
  • As recently the interest in the future industry grows high, the demand for forecasting the future shape of science and technology, especially exploring 'weak signals' of changes in science and technology, increases as well. The 'weak signals' means that currently they are uncertain and abnormal signals, but are preliminary signals which might lead future changes. Accordingly they can provide important clues to the future forecast. The study of 'weak signals' has its significance in providing important clues to the projection of the future technology earlier. As it has not a long history from its concept to exploration methods to utilization, more intensive study is required. Exploring 'weak signals' has been conducted mainly through the information analysis by experts with a high level of intelligence and sense. However, such an analysis is difficult and broad in scope, and furthermore the interpretation of analysis results is very limited, relying primarily on the decision of experts themselves. The purpose of this study is to provide a more objectified way to support these expert-based tasks. It derives quantitative results from non-structured article information and provides a logical basis for detecting the signals based on the results.

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Dementia Patient Wandering Behavior and Anomaly Detection Technique through Biometric Authentication and Location-based in a Private Blockchain Environment (프라이빗 블록체인 환경에서 생체인증과 위치기반을 통한 치매환자 배회행동 및 이상징후 탐지 기법)

  • Han, Young-Ae;Kang, Hyeok;Lee, Keun-Ho
    • Journal of Internet of Things and Convergence
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    • v.8 no.5
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    • pp.119-125
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    • 2022
  • With the recent increase in dementia patients due to aging, measures to prevent their wandering behavior and disappearance are urgently needed. To solve this problem, various authentication methods and location detection techniques have been introduced, but the security problem of personal authentication and a system that can check indoor and outdoor overall was lacking. In order to solve this problem, various authentication methods and location detection techniques have been introduced, but it was difficult to find a system that can check the security problem of personal authentication and indoor/outdoor overall. In this study, we intend to propose a system that can identify personal authentication, basic health status, and overall location indoors and outdoors by using wristband-type wearable devices in a private blockchain environment. In this system, personal authentication uses ECG, which is difficult to forge and highly personally identifiable, Bluetooth beacon that is easy to use with low power, non-contact and automatic transmission and reception indoors, and DGPS that corrects the pseudorange error of GPS satellites outdoors. It is intended to detect wandering behavior and abnormal signs by locating the patient. Through this, it is intended to contribute to the prompt response and prevention of disappearance in case of wandering behavior and abnormal symptoms of dementia patients living at home or in nursing homes.

The Effects of Music Interventions on High-risk Neonates in NICUs: Systematic Review and Meta-analysis (신생아집중치료실 고위험 신생아 대상 음악중재연구에 대한 체계적 문헌고찰 및 메타분석)

  • Kim, Hye Rang;Park, Hye Young
    • Journal of Music and Human Behavior
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    • v.20 no.2
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    • pp.115-142
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    • 2023
  • The purpose of this study was to analyze and evaluate music intervention research conducted with high-risk neonates in NICUs in both domestic and international settings. Seventeen music intervention studies were identified, and their characteristics, including type of music, music provider, and treatment frequency, and outcomes (i.e., neonatal vital signs) were reviewed and analyzed along with meta-analysis. For music interventions targeting high-risk neonates in NICUs, the effect sizes of the neonates' vital signs were classified as either medium or large. In addition, larger effect sizes were associated with a combination of live and recorded music, nonmusical therapists as the music providers, and treatment frequency of one to five sessions per week. These research findings verify the clinical value of music for high-risk neonates and provide insights into the selection of music elements, music delivery methods, and music providers in NICU music interventions.

동행+함께하는 마음 - 건강 체크 리스트 - 갑자기 찾아오는 심근경색, 체크리스트를 통해 꾸준히 점검하자!

  • Choe, Yong-Gyun
    • 건강소식
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    • v.34 no.12
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    • pp.34-35
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    • 2010
  • 매서운 칼바람이 부는 겨울은 날씨가 추워지는 만큼 건강관리에도 신경을 써야 하는 계절이다. 특히 심근경색은 더더욱 그러하다. 최근 런던열 의과대학 크리시난 바스카란교수의 연구결과에 의하면 기온 1도가 떨어지면 1개월간 심근경색이 발생할 위험이 2% 증가하는 것으로 나타났다. 본격적인 겨울에 들어서는 12월, 심근경색 전선에 이상 징후는 없는지 체크리스트를 통해 점검해보자.

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냉각장치의 고장징후에 대한 전문가시스템의 개발-크실렌 산화 공정을 중심으로-

  • 심종칠;김창은;주용준
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 1996.04a
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    • pp.717-722
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    • 1996
  • 본 연구는 위험성이 큰 화학플랜트에서 크실렌 산화공정의 냉각계통에 잠재한 위험성을 HAZOP (Hazard and Operability Studies) 기법을 통하여 잠재한 위험공정부분을 미연에 파악하고 이를 평가하여 안전의 효율성을 높이며, 또한 평가후 이를 전문가시스템을 통하여 취약점을 미연에 파악할 수 있도록 냉각장치의 전문가시스템을 제시하고자 한다.

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이 가을의 시집 서평

  • Im, Tae-U
    • The Korean Publising Journal, Monthly
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    • s.138
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    • pp.12-13
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    • 1993
  • 지난 시대의 고통스런 사회적 상황은 한편으론 우리시를 풍요롭게 했다. 치열한 시정신들이 뿜어댄 언어는 '고통의 축제'라 할만큼 광채로왔다. 그러나 뜨거운 신열이 잦아든 지금, 그 빈자리에 시쓰기의 존재론적인, 매우 본질적인 의문이 자리한다. 올가을에 출간된 시집들에서 우리는 그런 변화의 구체적 조짐과 징후를 읽어낼 수 있다.

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원자력발전소 - 환경방사선 감시온라인 시스템설치와 운영

  • 김남천
    • Nuclear industry
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    • v.15 no.3 s.145
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    • pp.79-81
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    • 1995
  • 원전으로부터 방사성물질의 외부방출로 인한 환경영향을 측정하고, 뜻하지 않은 사고시 환경에서의 이상징후를 조기에 알아보기 위해, 원자력발전소에서는 환경방사선 감시시스템을 설치$\cdot$운영하고 있다. 감시단말기는 $486DX_2$급으로 20인치 터치스크린 컬러 모니터로 하였고 단말기 조작을 쉽게 하기 위해 화면 터치, 마우스 사용, 키보드 사용 등 어느 것을 사용하여도 가능하도록 하여 누구나 쉽게 측정자료를 출력해 볼 수 있도록 하였다.

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모든 길은 발굽관리에

  • 양창근
    • 월간낙농육우
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    • v.19 no.8 s.208
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    • pp.82-87
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    • 1999
  • 젖소는 건강하고 편안한 상태에서는 그 능력을 최대로 발휘한다. 건강한 젖소는 좋은 번식상태를 유지하며 많은 양의 우유를 생산하기 위해 적당한 양의 사료를 먹을 것이다. 그러므로 목장주는 축군의 전반적인 건강상태를 세밀히 관찰하여야 한다. 젖소의 건강을 유지하는데 가장 강조되어야 할 사항은 건강한 다리와 발굽의 사용이다. 발굽이 건강해야 정상적으로 사료를 섭취하고 발정징후도 보이므로 번식과 밀접한 관계가 있는 중요한 사항이다. 그러므로 예방적 발굽관리가

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