• Title/Summary/Keyword: 집합체

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Solid Phase Synthesis of Lysine-exposed Peptide-Polymer Hybrids by Atom Transfer Radical Polymerization (ATRP를 이용한 Lysine 말단기를 가진 펩타이드-고분자 하이브리드 합성)

  • Ha, Eun-Ju;Kim, Mijin;Kim, Jinku;An, Seong Soo A.;Paik, Hyun-Jong
    • Polymer(Korea)
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    • v.38 no.4
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    • pp.550-556
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    • 2014
  • Recently, the peptide(or protein)-polymer hybrid materials (PPs) were sought in many research areas as potential building blocks for assembling nanostructures in selective solvents. In PPs, the facile routes of preparing well-defined peptide-polymer bio-conjugates and their specific activities in various applications are important issues. Our strategy to prepare the peptide-polymer hybrid materials was to combine atom transfer radical polymerization (ATRP) method with solid phase peptide synthesis. The standard solid phase peptide synthesis method was employed to prepare the PYGK (proline-tyrosine-glycine-lysine) peptide. PYGK is an analogue peptide, PFGK (proline-phenylalanine-glycine-lysine), which interacted with plasminogen in fibrinolysis. The peptide and the peptide-initiator were characterized with MALDI-TOF mass spectrometry and $^1H$ NMR spectrometer. The peptide-polymer, pSt-PYGK was characterized by GPC, IR, $^1H$ NMR spectrometer and TLC. Spherical micellar aggregates were determined by TEM and SEM. Current synthesis methodology suggested opportunities to create the well-defined peptide-polymer hybrid materials with specific binding activity.

Theoretical Study for the Structures and Binding Energies of HOOO-(H2O)n (n=1~5) Cluster (HOOO-(H2O)n (n=1~5) 클러스터의 구조와 에너지에 대한 이론적 연구)

  • Kim, Jong-Min;Hong, Sung-Yoon;Kim, Seung-Joon
    • Journal of the Korean Chemical Society
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    • v.59 no.5
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    • pp.387-396
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    • 2015
  • The DFT and ab initio calculations have been performed to elucidate hydrogen interaction of HOOO-(H2O)n (n=1~5) clusters. The optimized geometries, harmonic vibrational frequencies, and binding energies are predicted at various levels of theory. The trans conformer of HOOO monomer is predicted to be thermodynamically more stable than cis form at the CCSD(T) level of theory. For HOOO-(H2O)n clusters, the geometries are optimized at B3LYP/aug-cc-pVTZ and CAM-B3LYP/aug-cc-pVTZ levels of theory. The binding energy of HOOO-H2O cluster is predicted to be 6.05 kcal/mol at the MP2//CAM-B3LYP/ aug-cc-pVTZ level of theory after zero-point vibrational energy (ZPVE) and basis set superposition error (BSSE) correction. The average binding energy per H2O is increased according to adding a H2O moiety in HOOO-(H2O)n clusters up to 7.2 kcal/mol for n=5.

Development of BIM-based Construction Document Information Database Structure through the Link to the BIM Model and Construction Document Information (설계모델과 문서정보의 효율적 연계를 위한 BIM기반 데이터베이스 체계 구축방안)

  • Lee, Donggun;Cha, Heesung;Kim, Kyungrai;Shin, Dongwoo
    • Korean Journal of Construction Engineering and Management
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    • v.16 no.5
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    • pp.42-53
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    • 2015
  • Construction industry has the form of industry progressed through mutual cooperation among participants in various fields. Accordingly, it may be referred to as an aggregate of information where various pieces of information are generated and managed according to each construction phase. Most of the information on the construction project is issued in the form of a document. And document management of the site is critical to successful execution of the project. Therefore, in the construction site to use IT technology for efficient information management. But, most of the information on the construction site is managed by the non-structured document. and Information management in the construction site is difficult to lack of information management systems. In this study, proposed construction information database structure and breakdown structure to the information management of the construction site through the BIM technology. Therefore, previous studies were reviewed about the document management and information link management. and Space breakdown structure and information breakdown structure was proposed to structure the information of the construction site and Database for information storage is designed. And, BIM-based construction information database was examined through the application scenario.

Elementary Teachers' Epistemological Beliefs and Practice on Convergent Science Teaching: Survey and Self-Study (융합적 과학수업에 대한 초등교사의 인식론적 신념과 실행 -조사연구 및 자기연구-)

  • Lee, Sooah;Jhun, Youngseok
    • Journal of The Korean Association For Science Education
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    • v.40 no.4
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    • pp.359-374
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    • 2020
  • This study is a complex type consisting of survey study and self-study. The former investigated elementary teachers' epistemological beliefs on convergence knowledge and teaching. As a representative of the result of survey study I, as a teacher as well as a researcher, was the participant of the self-study, which investigated my epistemological belief on convergence knowledge and teaching and my execution of convergent science teaching based on family resemblance of mathematics, science, and physical education. A set of open-ended written questionnaires was administered to 28 elementary teachers. Participating teachers considered convergent teaching as discipline-using or multi-disciplinary teaching. They also have epistemological beliefs in which they conceived convergence knowledge as aggregation of diverse disciplinary knowledge and students could get it through their own problem solving processes. As a teacher and researcher I have similar epistemological belief as the other teachers. During the self-study, I tried to apply convergence knowledge system based on the family resemblance analysis among math, science, and PE to my teaching. Inter-disciplinary approach to convergence teaching was not easy for me to conduct. Mathematical units, ratio and rate were linked to science concept of velocity so that it was effective to converge two disciplines. Moreover PE offered specific context where the concepts of math and science were connected convergently so that PE facilitated inter-disciplinary convergent teaching. The gaps between my epistemological belief and inter-disciplinary convergence knowledge based on family resemblance and the cases of how to bridge the gap by my experience were discussed.

3D Finite Element Simulation of Pellet-Cladding Mechanical Interaction (3차원 유한요소를 이용한 핵연료와 피복관 기계적 거동 해석)

  • Seo, Sang Kyu;Lee, Sung Uk;Lee, Eun Ho;Yang, Dong Yol;Kim, Hyo Chan;Yang, Yong Sik
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.40 no.5
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    • pp.437-447
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    • 2016
  • In a nuclear power plant, the fuel assembly, which is composed of fuel rods, burns, and the high temperature can generate power. The fuel rod consists of pellets and a cladding that covers the pellets. It is important to understand the pellet-cladding mechanical interaction with regard to nuclear safety. This paper proposes simulation of the PCMI. The gap between the pellets and the cladding, and the contact pressure are very important for conducting thermal analysis. Since the gap conductance is not known, it has to be determined by a suitable method. This paper suggests a solution. In this study, finite element (FE) contact analysis is conducted considering thermal expansion of the pellets. As the contact causes plastic deformation, this aspect is considered in the analysis. A 3D FE module is developed to analyze the PCMI using FORTRAN 90. The plastic deformation due to the contact between the pellets and the cladding is the major physical phenomenon. The simple analytical solution of a cylinder is proposed and compared with the fuel rod performance code results.

Ownership of Human Biological Material - Concerning on Dead Body - (인체 유래 생물학적 물질의 소유권 - 사체를 중심으로 -)

  • Jung, Kyu Won
    • The Korean Society of Law and Medicine
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    • v.18 no.1
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    • pp.37-60
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    • 2017
  • Ownership is the bundle of rights that allow a person or institute to use and control an object. As the biomedical science is advanced, we should consider whether human biological material should be recognized as property. Whether separated parts of the human body can be objects of ownership is a different issue. Many thought that separated parts of the human body could not be objects of ownership. This idea is primarily based on this thought: even if a piece of human biological material is separated from a person, it still relates to that person, and if treated as a thing, human dignity may be harmed. However, some commentators have admitted separated parts of the human body into the realm of property. Though a person owns his/her body or body parts, this does not mean that he/she can do anything he/she desires. There are many natural and social limitations to exercise the ownership of human biological material as discussed above. Human dignity is the core consideration whether or not we recognize that ownership of human biological material biomedical research and knowledge.

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A Preliminary Study on Measuring Void Fraction in a Fuel Rod Assembly by using an X-ray Imaging System (X선 영상 장치를 이용한 핵연료 집합체 내 기포율 측정을 위한 선행 연구)

  • Lee, Sun-Young;Oh, Oh-Sung;Lee, Se-Ho;Lee, Seung-Wook
    • Journal of the Korean Society of Radiology
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    • v.11 no.7
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    • pp.571-578
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    • 2017
  • Bubbles are generated by the boiling of the cooling water when an accident occurs in the reactor and then in order to measure the void fraction, the Optical Fiber Probe(OFP) and optical camera are used in thermal hydraulic safety research. However, such an optical method is not suitable for measuring the void fraction in a $17{\times}17$ array of fuel rods due to the geometrical limitations. This study was conducted as a preliminary study using x-ray system and various phantoms before applying to rod bundles. Through radiographic and tomographic experiments, the tube voltage of the x-ray generator was 130 kVp and the tube current was 1 mA. In addition, it is possible to measure the hole of 1mm in size visually through the bubble resolution phantom, and it is confirmed that the contrast is relatively decreased in the inside of the freon in the case of the contrast evaluation using the road phantom. However, we could obtain good image without distortion when reconstructing the image. Bubble generation phantom experiments were used to confirm the flow direction of the bubbles and to acquire tomography images. The image J tool was used to measure the void fraction of 18 % for a single tomography image. This study has carried out previous researches for the measurement of the bubble rate around the nuclear fuel and could be used as a basic research for continuous research.

A Study on the Compression Characteristics of Decomposed Granite Soil Based on Single Particle Crushing Property (단입자파쇄특성에 기초한 화강풍화토의 압축특성에 관한 연구)

  • 함태규;조용성;김유성
    • Journal of the Korean Geotechnical Society
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    • v.20 no.8
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    • pp.103-111
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    • 2004
  • There are some problems in evaluating the bearing capacity of decomposed granite soils by general equations on account of their inherent compressibility and crushability. In order to investigate this kind of the engineering characteristics on decomposed granite soils in detail, it is necessary to how the micro property of the single particle composing the granite soils, and then the relevance to the macro characteristics of the soils has to be cleared. The reason why the single particle properties are not studied is first the difficulty to find out some regulating parameters, and secondly little understanding of its significance. Furthermore, the water in the decomposed granite soils accelerates the particle crushing. Consequently, increasing of compressibility and decreasing of shear strength would occur. Actually, when the ground settlement is a big issue in the embanked ground using the decomposed granite soils, the sensitive change of compressibility due to the change of water content in the ground becomes conspicuous. In this study, the single particle strength characteristics are studied and microscopic particle shape analyses are performed. In addition the compressibility of the decomposed granite soils and water content effect on the compressibility are analysed based on the test results.

Use Strategies of CPTED for the Safety of University Campus (대학 캠퍼스의 안전을 위한 CPTED 운용전략)

  • Park, Dong-Kyun
    • The Journal of the Korea Contents Association
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    • v.10 no.4
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    • pp.340-347
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    • 2010
  • Though there are many crimes on and out university campus in Korea, no one knows anything about the size or the types of campus crime. But, there are many theft crimes and sex assault in the library and one-room village near the university campus. This study suggested the establish ways and means needed to improve the campus security system, with the focus on the CPTED(Crime Prevention Through Environmental Design). Various types of crime prevention methods are being considered instead of conventional crime suppression measures. Among them, CPTED is drawing global attention. Crime prevention through environmental design is a multi-disciplinary approach to deterring criminal behavior through environmental design. CPTED strategies rely upon the ability to influence offender decisions that precede criminal acts. A truly safe campus can be achieved only through the cooperation of all students, faculty, staff and visitors. The cooperation and involvement of the entire campus community in campus crime prevention is absolutely necessary. University should adopt a series of policies and procedures designed to ensure that every possible precaution is taken to protect persons and property on campus.

Food-Networks and Border-Crossing of Transnational Marriage Migrant Households (초국적 결혼이주가정의 음식: 네트워크와 경계 넘기)

  • Choi, Byung-Doo
    • Journal of the Korean association of regional geographers
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    • v.23 no.1
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    • pp.1-22
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    • 2017
  • This paper is to consider conceptually a formation of food-networks and border-crossing of transnational marriage migrant households on the basis of actor-network theory, and to analyze empirical data on the issues collected by interview with marriage migrant women living around Daegu, S.Korea. Some research results can be argued as follows: First, food can be seen, not as a single material object, but as a multiple and hybrid network of human and nonhuman (material and institutional) actors, in which activities of food cooking and eating are regulated by and (re)construct social relations and placeness of households. Secondly, food-networks in marriage migrant households implement relationships of micro-power (and attachment) in the process of its (re)formation, and hence the food-network, it can be argued, is a field of power in which conflicts and compromising around food cooking and eating are intersecting each others. Thirdly, food-networks in marriage migrant households in both their origin country and in the Korean home are not only affected by macro natural and social environments but also by micro placeness of the households, both of which constitute the food-networks and operate in relations with other actors in the netwroks. Finally, food-networks in marriage migrant households reflect multiple and multi-scalar spatial mobility and placeness of transnational food culture, through which they express topologically 'fluid space' and 'absent presence', in which marriage migrant women can (or cannot) conduct social and cultural border-crossing.

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