• The Journal of Internal Korean Medicine
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• v.33 no.4
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• pp.405-417
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• 2012

Objectives : In the present study, anti-metastatic properties of the methanol extract of L. obtusiloba (MLO) were evaluated. Methods : To determine the effect of MLO on cancer metastasis, we checked matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) activities and expressions in B16F10 melanoma cells. In addition, we performed cell migration assay as well as invasion assay using Matrigel. Finally, we used an in vivo lung metastasis model to confirm the anti-metastatic activity of MLO. Results : 1. MLO showed potent inhibitory effects on MMP-2 and MMP-9 activities and expressions via down-regulation of activation of NF-${\kappa}B$ in B16F10 melanoma cells. 2. Melanoma cell migration and invasion were down-regulated by MLO treatment. 3. Not only in vitro model, but MLO also significantly suppressed lung metastasis in vivo. Conclusions : The present results indicate that MLO has strong inhibitory effect on cancer metastasis. Therefore, L. obtusiloba could be a valuable anti-metastatic agent.

• Korean Journal of Medicinal Crop Science
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• v.16 no.5
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• pp.320-325
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• 2008

Machilus thunbergii has been showed relation to antimicrobial activity on minimal inhibitoty concentration (MIC) and colony forming inhibitory activity (CFIA) test, so that can be used to food preservatives for green vegetable. Nanoparticles has been made of edible materials. 80% of the nanoparticles has been characterized by image analyser and electron microscopy, showing in the range under 300 nm diameter. The sprayed nanoparticles remained on the surface of chicon even after washing by dilution water, then activate biological activities for storage of chicon with storing and releasement system of extracts. Chicon treated nanoparticle has been kept fresh condition about 2 months longer than 3 weeks of the non-treated control. It can be tell that treatment with nanoparticle of M. thunbergii extracts extends storage time of chicon possibly by inhibition of ethylene production through efficiency control on cell breathing.

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.9
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• pp.1045-1052
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• 2017

In this study, a battery of genetic-toxicity studies on corn silk extract with high maysin content were performed according to internationally accepted protocols. In a mutation test using Salmonella Typhimurium TA1535, TA1537, TA98, and TA100, the number of mutant colonies did not significantly increase up to a maximum concentration of $5,000{\mu}g/plate$ in the presence or absence of the S9 metabolic activation system. In the chromosome aberration test using Chinese hamster lung fibroblasts, negative results were observed in the concentration up to $1,250{\mu}g/mL$ of corn silk extract. In the micronucleus test using ICR mice, incidence of polymorphonuclear erythrocytes with a maximum concentration of 2,000 mg/kg corn silk extract did not show any significant difference compared to the negative control group. Based on these results, the test substance, con silk extract, did not influence genotoxicity.

• Journal of the Korean Data and Information Science Society
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• v.20 no.6
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• pp.1155-1167
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• 2009

We made a new sample design for life and consciousness survey of Kyungpook people in 2007. We used the 10% sample survey data of 2005 population and housing census as a survey population. After stratification, we allocate proportionally samples within strata after examining various characteristics in previous survey, which includes economic activity state, an income level per year, and housing possession. And we calculated weight in a new sample design and derived estimators and a formula of standard error using the weights.

• Proceedings of The Korean Society of Health Promotion Conference
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• 2010.05a
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• pp.148-148
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• 2010

본 연구는 서울시 지역주민을 대상으로 스트레스, 우울, 문제음주 간의 인과관계를 검증하고자 시도되었다. 본 연구는 서울시 S구이며, 전체 17개동에서 만 19세 이상인 남녀 주민을 층화집락추출법을 통해 표집된 1234명을 대상으로 하는 면접식 단면조사연구를 수행하였다. 구조방정식 모형을 사용하였으며, 측정모형에서 우울, 알코올장애의 내생잠재변수와 외생잠재변수인 스트레스 및 인구학적 변수(성, 연령, 결혼상태)를 이론변수로 설정하여 이들 간의 상관관계를 추정하였다. 또한 문제음주를 최종내생변인으로 우울을 매개변인으로 설정한 상태에서 경로분석을 실시하여 각 변인들의 상대적 중요성에 대한 평가를 시도하였다. 문제음주에 영향을 미치는 변수는 여성보다는 남성이($\beta=-6.64$, p < .001), 연령이 낮을수록($\beta=-.08$, p < .001), 스트레스가 높을수록($\beta=-.08$, p < .001), 미혼이 기혼($\beta=-1.15$, p < .05)의 순으로 경로계수가 유의하였다. 우울에 미치는 영향력은 스트레스($\beta=-.56$, p < .001)와 문제음주정도($\beta=-.15$, p < .001)의 순으로 경로계수가 유의하였다. 이상과 같이 우울이 직접적으로 문제음주에 영향을 주기보다는 스트레스로 인하여 문제음주가 유발될 수 있고 문제음주를 경유하여 우울에 영향을 미치는 것으로 드러났다. 이상의 연구결과를 종합해 볼 때 문제음주는 스트레스와 우울과 관련성이 크므로 우선적으로 스트레스를 적극적으로 관리하는 것이 중요하다. 또한 알코올과 관련한 통제정책으로 절대적인 음주량을 감소시키는 것이 필요하며, 문제음주자를 조기 발견하여 정신건강에 문제로 발전하지 않도록 하는 예방프로그램의 개발이 시급하다 하겠다.

• Korean journal of food and cookery science
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• v.15 no.1
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• pp.68-72
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• 1999

Dried plantain (Plantago asiatica L.) was evaluated as a natural food preservative. The methanol extract of dried plantain at tie concentration of 2,000$\mu\textrm{g}$/ml completely inhibited the growth of B. subtilis, L. monocytogenes and V. parahaemolyticus. When the extract was added to noodles and rice cakes at the concentration of 1, 3 or 5%, less microbial growth was observed compared with the control group. While the noodles with 1% plautain extract were evaluated favorable in terms of color, chewiness and overall guality, 3% addition of the extract gave the best score for rice cakes.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.5
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• pp.2251-2258
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• 2012

This study compared the unweighted sample design, frequency weighted sample design and complex sample design to using 2009 Korea National Health and Nutrition Examination Survey in an effort to identify whether or not there is any difference in potential risk factors. Pearson chi-square test and Rao-scott chi-square test were applied to the analytic methods. As a result of analyses, all the variables were overestimated as significant risk factors in case of the unweighted sample design to which only the frequency weights were applied. In addition, there were differences in the confidence levels and results from the simple random sampling analysis and complex sample design to which no weight was applied. It is necessary to carry out the complex sample design rather than the analysis to which the frequency weights are applied, in order to ensure the findings to represent the whole population when our national statistics data is used.

• The Journal of the Korea Contents Association
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• v.14 no.9
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• pp.450-462
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• 2014

The main purpose of this study was to explore the causal relationships among transactional leadership, coaches' emotional intelligence, and athlete satisfaction in soccer teams. High school, university, and semi-professional soccer players(N=495) in Korea participated in a survey. Transactional leadership inventory, emotional intelligence test, and athlete satisfaction questionnaire previously developed to investigate was performed to utilize. The data were analyzed by structural equation model of the AMOS 18.0. The results were as follows; transactional leadership have meaningful influence on emotional intelligence and athlete satisfaction, and emotional intelligence have significant influences on athlete satisfaction. The mediating effect of leader's emotional intelligence between transactional leadership and athlete satisfaction was confirmed. Findings of this study can enhance our understanding of the emotional leadership to increase athlete satisfaction in Soccer players.

• Journal of agricultural medicine and community health
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• v.38 no.1
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• pp.25-38
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• 2013

Objectives: The aim of this study is to analyze the utilization behaviour and influencing factors of complementary and alternative medicine (CAM) therapies among elderly people with chronic diseases. Methods: The study population was selected among 9 welfare facilities for the aged in 2 cities among Daegu Metropolitan City & Gyeongsangnam Province by two-stage cluster sampling. 250 senior citizens participated in a face-to-face interview using a structured questionnaire. Logistic regression analysis was performed to examine the association between the utilization of CAM therapies and various characteristics of the elderly. All statistics were analyzed using the PASW (ver 18.0). Results: Among 233 elderly peoples, 70.4% (164 persons) had used various kinds of CAM therapies (including nutritional methods, pharmacologic and biologic treatments, etc.) more than once during the last year. 48.8% (64 persons) ~ 60.7% (88 persons) of the elderly used CAM therapies without health and medical experts' counsel. The elderly with perceptions of CAM therapy used it 2 times more than those without knowledge of CAM therapies. The number of chronic diseases was more likely to increase the usage of nutritional methods (OR=2.92, 95% CI: 1.07-7.97), manipulative and body-based practices (OR=5.85, 95% CI: 1.97-17.34), pharmacologic and biologic treatments (OR=2.92, 95% CI: 1.49-8.17). Elderly with diabetes used nutritional methods 3.76 (95% CI: 1.49-9.47) more than elderly without diabetes. Conclusions: CAM therapies use in the aged with chronic diseases appears common. The findings suggest that the clinical efficacy and safety of CAM therapies on medical management of chronic disease may be investigated and that patient-physician communication need to be strengthened.

• Journal of Life Science
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• v.30 no.3
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• pp.267-277
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• 2020

This study was conducted to assess the effect of highly concentrated onion intake on rodents. The experimental animals were divided two groups as follows; water administered group (CON) and Allium cepa administered group (ACE). The ACE group showed a slightly increases in the number of erythrocytes (RBC), hemoglobin (HGB), hematocrit (Hct) levels compared to the control group (p<0.05). Hemoglobin, monocyte, lymphocyte and neutrophil had no significant change (p>0.05) in ACE group and control group. The analysis of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels showed a significant decrease in ACE group compared to the control group (p<0.05). The blood glucose, total protein, HDL-cholesterol were slightly high in ACE group, while triglyceride, total cholesterol levels were lower in ACE group compared to the control group (p<0.05). The levels of cytokines (interluekin-1α (IL-1α), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), interferon-γ (INF-γ), interleukin-18 (IL-18), interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF)) involved in immunity and inflammation in liver tissue and blood have all been confirmed to be within normal range. These findings could be used as basic data to show that highly concentrated dietary onion extract is not toxic to hematological indicators and immune functions.