• Journal of Haehwa Medicine
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• v.21 no.2
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• pp.95-104
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• 2013

스트레스로 인한 인체의 반응은 중추신경계, 시상하부, 변연계 및 기타 표적기관으로부터 시작되는데, 자율신경계 반응, 내분비계 반응, 면역계 반응 등을 통하여 복합적인 신체 증상으로 발현되며, 스트레스 상황에서는 시상하부-뇌하수체-부신 축 (HPA axis)과 교감신경계의 작용으로 여러 신경전달물질 방출에 변화가 생기며 이러한 변화는 면역기전에 중요한 역할을 하고 일부는 면역세포의 활성에 직접적으로 영향을 미쳐 신체 각종 질병의 원인이 될 것으로 추정된다. 한의학에서는 천인상응(天人相應)의 관점에서 육기(六氣)를 생체자극의 외적 요인으로 간주하고, 생체내적 현상인 정신이 외적 자극을 통하여 나타나는 생체반응을 칠정(七情)으로 보았으며, 이러한 관점에서 스트레스는 신체에 오장(五臟)의 허실(虛實), 혈허(血虛), 정손(精損), 기역(氣逆), 기(氣)의 순환장애, 담연(痰涎), 화(火) 등의 병적인 요인을 만들어 준다. 본 연구에서 재료로 사용된 호초 (Piper nigrum Linne)는 후추나무의 과실을 말린 것으로서 세계적으로 널리 사용되는 향신료이며, 한의학에서는 온중제한하기(溫中除寒下氣), 쾌격소담(快膈消痰), 해독(解毒)등의 효능으로 한담식적(寒痰食積) 완복냉통(脘腹冷通) 곽란(癨亂) 토사(吐瀉)등의 치료에 활용되어 왔다. 특히 쾌격소담(快膈消痰)하는 작용은 정신적 스트레스에 유효할 것으로 생각되므로 본 연구에 이용하게 되었다. 실험동물은 ICR계 생쥐를 이용하였으며, 심리적 스트레스는 옆쪽 cage에서 다른 마우스의 신체에 가해지는 전기 충격을 하루 1시간 동안 지켜보게 하는 것으로 유발하였으며, 이 상태에서 약물을 투여한 그룹을 실험군, 그렇지 않은 그룹을 대조군으로 하였다. 정상군은 아무런 자극 없이 하루 1시간 동안 일정 공간에 가두어 두는 것으로 하였다. 실험 결과, 호초(胡椒) 추출물을 100mg/kg/day 용량으로 5일간 투여한 실험군은 아무런 처치를 하지 않은 대조군에 비해 혈장 중 corticosterone 함량이 유의하게 감소되었고, 뇌에서의 noradrenalin 분비량이 유의하게 증가되었으며, plus maze test에서의 머무름 시간이 연장되는 것으로 나타나 호초(胡椒)가 심리적 스트레스를 효과적으로 억제하고 진정작용이 있는 것으로 사료되나 구체적인 작용기전 및 인체에서의 효과에 대해서는 향후의 보다 자세한 연구가 필요할 것으로 생각된다.

• Journal of fish pathology
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• v.6 no.1
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• pp.65-70
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• 1993

The delicate histological structure of gill in teleosts can be easily affected by a variety of biological, chemical or physical detrimental agents because it is directly exposed to the surrounding water. The epithelium of secondary lamella is thin to allow efficient gaseous exchange and this also renders it particularly vulnerable to various pathogens. As well as the main respiratory role, the gill has other various important functions such as acid-base balance, osmoregulation or the excretion of nitrogenous waste products. Thus destruction of epithelial integrity such as epithelial necrosis or thickening can render a fish very vulnerable to respiratory, secretory and excretory difficulties. This article was tried to describe in detail the common processes of pathological responses correlated to the normal histological structures of the gill in teleosts.

• Korean Journal of Psychosomatic Medicine
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• v.8 no.2
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• pp.149-164
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• 2000

Somatization is regarded as a process rather than a diagnostic entity. It should be emphasized to identify psychopathology rather than to make a choice regarding diagnosis in assessing somatizing patients. Psychiatrists should be aware of the psychosocial cues underlying the patients' physical symptoms. Special skills and strategies are required by nonpsychiatric physicians to facilitate the patients' acceptance of psychiatric treatment. The goal of treatment for somatization is management but not cure. The approach should be flexible, depending on the patients' responses and need. The difficulty in diagnosing and treating somatization is likely to be related to abnormal illness behavior such as the patients' denial of their psychosocial problems and resistance to psychiatric approach. In conclusion, biopsychosocial approach is needed to treat these patients effectively. Psychiatrists should also teach other physicians the interview skill that they could identify these patients as early as possible and facilitate their acceptance of psychiatric treatment.

• Journal of Korean Library and Information Science Society
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• v.41 no.1
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• pp.51-76
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• 2010

This study discussed the trends and characteristics of mental health services in the public libraries of North America. To accomplish this, this study collected its data through literature surveys, observations and interviews with librarians within the Vancouver public library system. The results show that there were many cases in which patrons asked public libraries for information on their mental health problems and the public libraries helped the patrons cope with their problems. The public libraries' assistance programs for national tragedies and natural disasters were temporary services. On the other hand, public libraries were continuously advising and guiding patrons dealing with emotional and psychological problems through the readers' advisory and information services. Specifically, public libraries were actively assisting various sensitive issues that are generated in the development of children and youths(for example, adoption, divorce and separation, remarriage, family, friendship, disabilities, death, self-esteem, emotions, bulling, violence, abuse, suicide, illness, addiction, sexual health, youth pregnancy and so on). The key role of librarians under these circumstances was to guide and recommend appropriate books and professional institutions that help solve the problems.

• Clinical and Experimental Pediatrics
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• v.45 no.4
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• pp.524-528
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• 2002

Citrullinemia is a rare inborn error of metabolism of the urea cycle, and was first reported by McMurray, et al. in 1962. It is inherited as an autosomal recessive trait. The normal synthesis of argininosuccinic acid is blocked in this disease due to a deficiency of argininosuccinic acid synthetase(AS), which has been demonstrated in liver cells and fibroblasts. The clinical symptoms are vomiting, lethargy or irritability, convulsion and mental retardation. The diagnosis is made by the finding of an increased plasma citrulline level. Every effort should be made to reduce the blood ammonia level as rapidly as possible before irreversible brain damage occurs. This report describes a case of citrullinemia that was diagnosed through organic acid analysis and amino acid analysis, and reviews the related literatures.

• The Journal of the Korea Contents Association
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• v.16 no.9
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• pp.628-637
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• 2016

The purpose of this study was to explore factors influencing quality of life among cancer survivors in order to identify strategies for cancer survivors to go back to normal life and carry on stable and high quality life. This study used Korea National Health and Nutrition Examination Survey(2010-2014), conducted by Korea Centers for Disease Control and Prevention(KCDC). The sample of this study was 610 cancer survivors and their average time since diagnosis was about 11 years. The most powerful influencing factors for quality of life among cancer survivors were activity limitation(${\beta}$=.30, p<.001), followed by age(${\beta}$=-.20, p<.001), subjective health status(${\beta}$ =-.19, p<.001), and economic status(${\beta}$=.12, p=.004). According to the result, limitation on daily activities or social activities due to physical or mental debilitation was a strong factor that lowers quality of life among cancer survivors. Hence, there is a need for manpower and infrastructure that facilitates, supports, and manage daily activities of cancer survivors.

• Journal of the Korea Society of Computer and Information
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• v.25 no.7
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• pp.113-123
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• 2020

Obstructive sleep apnea (OSA) among sleep disorders is one of relatively common diseases. Patients can be checked for the disease through sleep polysomnography. However, as far as he diagnosis of OSA using polysomnography (PSG) is concerned, many practical problems such as an increasing number of patients, expensive testing cost, discomfort during examination, and the limited number of people for testing have been pointed out. Accordingly, for the purpose of substituting PSG researchers have been actively conducting studies on OSA diagnosis based on machine learning using bio signals. In this regard, we review a rich body of existing OSA diagnosis studies applying machine learning techniques based on bio-signal data. As a result, this paper presents a novel taxonomy of the reviewed studies and provides their comprehensive comparative analysis results. Also, we reveal various limitations of the studies using the bio signals and suggest several improvements about utilization of the used machine learning methods. Finally, this paper presents future research topics related to the application of machine learning techniques using bio signals.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.10 no.2
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• pp.129-134
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• 2010

Diseases such as cardiovascular illnesses, according to the National Statistical Office opened reveals that 600-800 people were killed, blood pressure, arteriosclerosis, heart disease, stroke, etc. will be a flow of blood disorders that occur in cardiovascular illnesses today are fulfilling the Master / Slave samangryulin disease appears high. Died of cardiovascular disease also told them the correct first aid survival when patients are accounted for approximately 40% of emergency rapid response is required. Therefore, this paper, the weak classifier in the AdaBoost algorithm to generate a strong classifier by combining effects throughout the analysis to measure the ECG, and cardiovascular disease that occurred to you as soon as the emergency management system that can deliver on the proposed Desk was. The electrocardiogram data measured by the ZigBee-based sensors, communication devices and emergency transport for emergency alarms in the determination and monitoring of the management desk by providing health services to enable the delivery was fast.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.6 no.1
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• pp.15-18
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• 2010

Sturge-Weber syndrome is a rare nonhereditary developmental condition that is characterized by a hamartomatous vascular proliferation involving the tissue of brain and face. The clinical features are characterized by port wine nevus following one or more divisions of trigeminal nerve, ocular involvement and neurologic involvement such as epilepsy, mental retardation, and contralateral hemiplegia. Oral manifestations include unilateral blood vessel expansion of the oral mucosa, vascular hyperplasia of gingiva, pyogenic granuloma-like massive hemangiomatous proliferation of oral mucosa, macrodontia, ipsilateral macroglossia, blood vessel anomaly of maxilla or mandible and abnormal tooth eruption sequence. This case report is about 11-year-old Sturge-Weber syndrome patient presented port wine nevus on the face, venous malformation on soft plate and buccal mucosa. In this case we performed simple extraction of several deciduous teeth and periodic oral hygiene management. If a patient with Sturge-Weber syndrome has to undergo dental surgery in affected areas of the mouth, great care must be taken to prevent severe hemorrhage.

• Korean Journal of Biological Psychiatry
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• v.19 no.1
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• pp.29-37
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• 2012

The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as a valid biomarker of central serotoninergic activity in humans. The specificity and sensitivity of the LDAEP to changes in serotonergic neurotransmission have recently been explored in many studies about pharmacology and genetics. The majority of evidence for an association between the LDAEP and serotonin activity has come from animal studies. Genetic association studies with the LDAEP have provided conflicting reports with additional evidence outlining sensitivity to other neurotransmitter systems including the dopamine and glutamatergic systems. The LDAEP has been revealed to reflect the pathophysiology of various psychiatric illnesses. There is supporting evidence that major psychiatric disorders have differential LDAEP activities. Overall, the LDAEP shows strong evidence as a potential predictor of antidepressant treatment response. It need to be explored whether the LDAEP could be a biological marker of various psychiatric diseases and treatment prediction of antidepressants and serotonin related drugs.