• Tuberculosis and Respiratory Diseases
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• v.40 no.5
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• pp.532-539
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• 1993

Background: Physician's estimates of patient survival often influence clinical decisions, especially those near the end of life. In addition. clinical decisions frequently reflect trade-offs between morbidity and length of survival. As a result, accurate estimates of survival can be extremely useful in clinical decision. When the episode of acute respiratory failure in chronic obstructive lung disease, evaluation of the severity of the condition and short term prognosis is difficulit based on the available clinical or paraclinical data at the time of admission. Method: In this study, we performed a retrospective study in Chung Ang University Hospital, 74 patients (51 males, 23 females), who were hospitalized with chronic obstructive lung disease with acute respiratory failure from 1980 to 1992. We evaluated these patients to determine lung prognostic factors at time of admission in the Intensive Care Unit (ICU) that predict short term survival, and to determine the possible application of the Simplified Acute Phsiology Score (SAPS) to this population, All patients were treated with similar regimen during the hospitalization. Results: The results were as follows: 1) Hospital mortality was 34%(25/74 patients) and surival rate was 66%(49/74 patients) in COPD with acute respiratory failure. The prognosis of the older age was much poorer than those of the young age. 2) There was no difference in mortality according to the results of basal pulmonary test and arterial blood gas analysis. 3) The SAPS at admission was higher in those patients who expired(10.8) than the survived(6.5), and there was positive correlation between SAPS and mortality (r=0.91, p<0.05). 4) Prognostic factors in acute respiratory failure complicating COPD which were identifiable at time of admission to the ICU were as follows: cachexia, encephalopathy, serum creatinine and phosphate. Conclusion: In conclusion, the SAPS might have a good prognostic value for determination of short term survival among chronic obstructive lung disease with acute respiratory failure.

• Journal of the Society of Disaster Information
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• v.13 no.4
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• pp.442-454
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• 2017

Biological weapon is manipulated and produced from microorganisms such as bacteria, virus, rickettsia, fungi etc. It is classified as one of the Weapons of Mass Destruction (WMD) along with chemical weapon and radiological weapon. Biological weapon has a number of operational advantages over the other WMDs including ease of development and production, low cost and possibility of covert dissemination. In this study we analyze the history of biological weapon's development and the existing biological threats. Then, we predict the social impact of biological attack based on the physical properties of biological agent and infection mechanisms. By analyzing the recognition, dispersion pattern of agents, characteristics of the diseases in the biological weapon related historical events such as Sverdlovsk anthrax accident, 2001 anthrax attack, we found out some of the facts that biological attack would not likely to be recognized rapidly, produce large number of the exposed, increase number of paients who suffed from severe respiratory illness. It would lead the public health and medical service providers to be struggled with hugh burden. Base on the facts that we found from this case study, we suggested the main capabilities of public health required to respond to bioterrorism event efficiently. Syndromic surveillance and other reporting system need to be operated effeciently so that any suspicious event should be detected promptly. the pathogen which suspected to be used should be identified through laboratory diagnostic system. It is critical for the public health agency to define potentially exposed population under close cooperation with law enforcement agencies. Lastly, massive prophylaxis should be provided rapidly to the people at need by operating human and material resources effeciently. If those capacities of public health are consistantly fortified we would be able to deal with threat of bioterrorism successfully.

• Journal of fish pathology
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• v.35 no.1
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• pp.1-25
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• 2022

The aquaculture industry has developed rapidly over the last three decades and is an important industry that supplies over 15% of humans' animal protein intake; therefore, there is a need to increase production to meet the continuous demand. The fish cage farms on the southern coast (Kyengsangnam-do and Jeollanam-do) of Korea are critical resources in aquaculture because they account for approximately 90% of the national total fish cage farms by water area ratio. However, the current aquaculture environment is being gradually affected by climate change, which is a global issue, and its effects are expected to intensify in the future. Therefore, it is urgently imperative to accurately evaluate the effects of climate change on South Korean aquaculture industries and to develop social and national strategies to minimize damage to the fishing industry. The damage to fish farmed in cage farms on the southern coast is increasing annually and the leading causes are high and low water temperature and red tides, which are directly or indirectly related to climate change. At present, global warming can provide opportunities for aquaculture industrialization of fish or other novel species, with economic implications. However, despite such opportunities, the influx of new species can also cause problems such as ecological disturbances, increase in the reproduction frequency of microalgae such as red tide, increase in disease incidence, and occurrence and periods of high water temperatures in summer. The scale of farmed fish mortality is increasing due to the complex effects of these factors. Increased damages due to fish mortality not only have severe economic impacts on the aquaculture industry, but the social costs of responding to the damage and follow-up measures also increase. various active responses can reduce the mortality damage in fish farms such as improving the management skills in aquaculture, improved species breeding, efficient food management, disease prevention, proactive responses, and system-wide improvements. This review article analyzes the large-scale mortality cases occurring in fish cage farms on the southern coast of Korea and proposes measures to mitigate mortality and enhance responses to such scenarios.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.27 no.3
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• pp.218-225
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• 2005

본 연구의 목적은 치아 회분말과 연석고 및 알긴산을 혼합하여 이식한 후 초기 골 형성을 알아보는 데 있다. 백서 30마리의 두개골에 8mm 직경의 골결손부를 형성한 후 인간의 치아 회분말과 연석고 및 알긴산을 혼합하여 이식한 후 대조군, 치아 회분말과 연석고 처치군, 그리고 치아 회분말과 연석고 및 알긴산 혼합 처치군에서 각각의 골 결손부 치유과정을 조직병리학적, 조직형태계측학적으로 비교 관찰하였다. 통계학적으로 주간 변화(4주, 8주)는 유의하지 않았고, 각 그룹 간에 있어도 치아 회분말과 연석고 처치군과 치아 회분말과 연석고 및 알긴산 혼합 처치군 간 모두(4주, 8주) 유의한 차이가 없었다. 그러나 이들 치아 회분말과 연석고 처치군과 치아 회분말과 연석고 및 알긴산 혼합 처치군은 대조군에 비해서는 유의하게 우수한 신생골 형성을 보였다. 비록 통계학적으로는 치아 회분말과 연석고 처치군과 치아 회분말과 연석고 및 알긴산 혼합 처치군이 유의한 차이를 보이지 않았지만 치아 회분말과 연석고 및 알긴산 혼합 처치군에서 보다 더 우수한 신생골 형성 경향을 보였다. 뿐만 아니라, 신생골의 내용면에서도 치아 회분말과 연석고 및 알긴산 혼합 처치군에서 좀더 많은 신생 직조골의 융합이나 골 소주형성이 관찰되어 신생골의 형성 및 성숙에 알긴산이 역할을 담당하는 것으로 사료되었다. 결론적으로 골결손부 치료 방법으로 치아 회분말과 연석고 처치군 또는 치아 회분말과 연석고 및 알긴산 혼합 처치로 결손부에 이식하는 것은 신생골 형성의 양적, 질적 개선에 통계학적으로 유의하며, 알긴산을 이식재와 함께 처리한 경우에 신생골 형성의 양적, 질적 개선에 도움을 줄 수 있을 것으로 사료된다.$1^{\circ}C$ 냉수로 세척하고 PETE tray로 포장하여 $4^{\circ}C$로 저장한 경우 깻잎 고유의 초록색과 향을 유지하고 있어 저온냉수 세척과 tray 포장이 세척 청경채의 선도 유지에 효과가 있는 것으로 나타났다.1%,\;pendimethalin\;1.3{\sim}2.9%$ 및 $3.8{\sim}10.8%,\;ethoprophos\;0.6{\sim}2.7%$ 및 $0.1{\sim}0.3%$이었다. 인공강우실험 후 공약의 토심별 분포를 살펴 본 결과 alachlor와 ethopropho는 토심 $10{\sim}15cm$까지 이동하였고, ethalfluralin과 pendimethalin는 대부분 토심 5 cm 이내에 잔류하였다. 경사도 30%의 경우가 10%에 비하여 각 농약의 유실량이 $0.2{\sim}1.9$ 배 증가하였는데 유출수에 의한 농약의 유실량 차이는 유출수 중 농도 차이로 판단되며, 유실토양에 의한 농약 유실량 차이는 토양 유실량과 관계되는 것으로 생각되었다. 농약의 강우에 의한 유실은 복잡하게 작용하는 많은 환경적 요인에 의하여 영향을 받지만 정교하게 구성된 환경 시나리오에 의하여 예측 가능할 것으로 판단되었다.고 도라지는 물에 우려 푹 삶았고, 감자, 송이 등은 잘게 썰어 쌀과 함께 밥을 조리하였다. 4. 약선 음식조리방법 약선음식의 재료는 평상시 식생활에 사용되고 있던 식품들의 기능성분과 약이성을 이용하여 만성적인 질병과 급성적인 복통 설사 등에 재료의 전처리를 통해 죽으로 많이 이용하였다. 특히 곡류 등은

• Economic and Environmental Geology
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• v.48 no.3
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• pp.187-197
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• 2015

Oriental mineral medicines are single or mixture of more than one mineral species or rock/fossil which are used to treat disease. Mineral medicines remove harmful or useless substances to decrease toxicity and secondary effects, and cause the manufacture of medical compounds with increased efficacy. The extraction test is an accepted in vitro system to predict the bioaccessibility of major and minor elements from mineral medicine. It incorporates gastrointerstinal tract parameters representative of a human body that including stomach and small intestinal pH which are the same as digestion condition. The bioaccessibility of a mineral medicine is the fraction that is soluble in the gastrointestinal environment and is available for absorption. Reaction path modeling in the human body can predict digestion with gastric fluid as well as absorption in the small intestine, existence in body fluids and reaction progress of the exhaust process according to pH conditions in body. Also reaction path modeling can predict bioavailability, which is equal to existence rate in the body and the form and amount of a medicine in the body after intake. The study results from predicating the existence form mineral medicines in the body, and proving the effective ingredient using bioaccessibitily and human risk assessment, suggest these that should be necessary data for new medicine development.

• Korean Journal of Clinical Laboratory Science
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• v.48 no.4
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• pp.296-303
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• 2016

This study was performed to evaluate the effect of hemoglobin (Hb) on bone mineral density (BMD) in university students by performing a quantitative analysis. The subjects included healthy university students aged 20 to 30 years. Although osteoporosis has traditionally been considered as a disease of aging women, it is becoming an increasingly concerning male health problem. Diagnosis of osteoporosis is calculated with a quantitative assessment of BMD. Laboratory blood and urine tests are mainly used with low BMD or fragility fractures to identify any possible causes of bone metabolism disorders. In this study, there was no difference in BMD according to gender. The average red blood cell (RBC), Hb, and Hematocrit (HCT) were significantly higher in males (p<0.01). The correlation between lumbar spine, skeletal muscle mass (SMM), and basal metabolic rate (BMR) was statistically significant (p<0.01). Hb showed a 51.7% statistical influence on BMD by multiple regression analysis. These findings are useful to understand the relationship between BMD and Hb; lower Hb level is associated with lower BMD. The Hb level was the strongest predictor of abnormal BMD. In conclusion, this study showed that a low Hb value was significantly correlated with low bone mass, suggesting that a low Hb value is a risk factor for changes in bone turnover that leads to a decrease bone density.

• Journal of the Korean Applied Science and Technology
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• v.37 no.4
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• pp.925-935
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• 2020

This study aims to provide guidelines for the activities of workplace health managers by identifying their excellent health promotion activities and motivations. For this, consent for the study was obtained from 21 workplace health managers who had worked at the same company for more than five years, and a semi-structured questionnaire was sent via email to collect and qualitatively analyze the data. As a result, 17 categories and three topics were drawn. The derived topics included a sense of reward and accomplishment as workplace health managers, difficulties encountered as workplace health managers, and how to solve the difficulties. The survey respondents answered that they feel a sense of reward and accomplishment when workers open their mind, change their daily life, express gratitude, and pioneer new fields. On the other hand, they feel difficulties with unpredictable health, changes in the organizational culture, secrecy of disease, and people who think their job is easy. As a way of overcoming such difficulties, the research subjects said that it is necessary to read the minds of workers, let them know by themselves, use existing programs, have the most difficult people on their side, and spread their achievements. The results of this study revealed that it is required for workplace health managers to develop professional skills and emphasize the importance of health management to the policy-makers and employees of their workplace by continuously reporting health management performance. In addition, they need to actively benchmark the success strategies of exemplary workplace health managers.

• Journal of Life Science
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• v.20 no.8
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• pp.1261-1267
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• 2010

The aim of this study was to investigate the combined effects of aerobic training and diacylglycerol ingestion on lipid profiles and resting metabolic rate changes in obese men. The subjects were divided into 3 groups: the Diacylglycerol group (D, n=6), aerobic training group (E, n=6), and diacylglycerol ingestion and aerobic training group (DE, n=6). Diacylglycerol was ingested and aerobic exercise training performed for 12 weeks. The information from the research was calculated through a Windows SPSS/PC+ Ver. 12.0K statistics package to standardize the means and deviations for each group. Then, two-way repeated measures ANOVA was used to evaluate the research hypothesis. Percent body fat, blood lipid profiles and resting metabolic rate changes were tested to evaluate the combined effect of aerobic exercise training and diacylglycerol ingestion. The results of this study were as follows; DG ingestion was shown to have a positive effect on body weight and body fat, while having a negative effect on resting metabolic rate changes. However, aerobic training was shown to have a positive effect on all factors including body weight, body fat, and resting metabolic rate. In conclusion, DG ingestion and exercise training were not shown to have synergistic effects on resting metabolic rate changes, percent body fat and lipid profiles, while aerobic exercise training was shown to have a positive effect on resting metabolic rate changes, percent body fat, and lipid profiles. To investigate the therapeutic effect of DG ingestion and aerobic exercise for obese men, analysis of catecholamine, cAMP, HSL, or insulin sensitivity should be considered.

• Journal of the Korean Society of Food Science and Nutrition
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• v.40 no.7
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• pp.1053-1062
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• 2011

Reactive oxygen species (ROS), including singlet oxygen (${O_2}^1$), superoxide anion radical ($O_2{\cdot}^-$), hydroxyl radical ($HO{\cdot}$), peroxyl radical ($ROO{\cdot}$), hydrogen peroxide ($H_2O_2$), and hypochlorous (HOCl), are generated as byproducts of normal cellular metabolism. ROS induce damage to many biological molecules, such as lipids, proteins, carbohydrates, and DNA. It is widely believed that some degenerative diseases caused by ROS can be prevented by the high intake of fruits and vegetables due to their antioxidant activities. Recently, research on natural antioxidants has become increasingly active in various fields. Several assays have been developed to measure the total antioxidant capacity of antioxidants in fruits and vegetables in vitro. These assays include those for DPPH radical scavenging activity, SOD-like activity, total polyphenol content, oxygen radical absorbance capacity, reducing power, trolox equivalent antioxidant capacity (ABTS assay), single-cell gel electrophoresis (comet assay), and a cellular antioxidant activity assay. Because different antioxidant compounds may act through different mechanisms in vitro, no single assay can fully evaluate the total antioxidant capacity of foods. Due to the complexity of the composition of foods, it is important to be able to measure antioxidant activity using biologically relevant assays. In this review, recently used assays were selected for extended discussion, including a comparison of the advantages and disadvantages of each assay and their application to fruits and vegetables.

• The Journal of the Korea Contents Association
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• v.14 no.10
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• pp.198-209
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• 2014

Diabetes Mellitus (DM) is well known for increasing morbidity and mortality, especially related to their complications. The purpose of this study was to investigate the factors affecting the prevalence rate of DM and provide a fundamental material to develop an intervention strategy to reduce the prevalence rate of DM. The study subjects were adults aged over 19 on the basis of the primitive data of "The Fifth Korean National Health and Nutrition Examination Survey, 2012". Therefore, the data of 5995 participants were analyzed. For data process, the complex sample analysis module of SPSS 18.0 program was employed to add weighting before analysis. According to the analysis, the prevalence rate of DM of the study subjects was 10.5%. Regarding the odds ratio of DM prevalence, the subjects who graduated from middle school had the odds ratio 2.51 times higher than those who graduated from college and more; those in subjective bad health condition 4.77 times higher than those in subjective good health condition; those in obesity 1.44 times higher; those with high blood pressure 2.57 times higher; those with hyperlipidemia 2.63 times higher; those who fail to control their weight 1.31 times higher; those going on a diet 2.75 times higher. This study revealed that a level of education, perceived health status, obesity, high blood pressure, hyperlipidemia, weight control, and dietary therapy were the predictable variables of the prevalence rate of DM, and thereby suggested the nursing direction and research direction to reduce the prevalence rate of DM.