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http://dx.doi.org/10.9719/EEG.2015.48.3.187

Standardization Studies for the Oriental Mineral Medicine  

Kim, Seon-Ok (Department of Energy Resources Engineering, Pukyong National University)
Park, Maeng-Eon (Department of Earth Environmental Science, Pukyong National University)
Publication Information
Economic and Environmental Geology / v.48, no.3, 2015 , pp. 187-197 More about this Journal
Abstract
Oriental mineral medicines are single or mixture of more than one mineral species or rock/fossil which are used to treat disease. Mineral medicines remove harmful or useless substances to decrease toxicity and secondary effects, and cause the manufacture of medical compounds with increased efficacy. The extraction test is an accepted in vitro system to predict the bioaccessibility of major and minor elements from mineral medicine. It incorporates gastrointerstinal tract parameters representative of a human body that including stomach and small intestinal pH which are the same as digestion condition. The bioaccessibility of a mineral medicine is the fraction that is soluble in the gastrointestinal environment and is available for absorption. Reaction path modeling in the human body can predict digestion with gastric fluid as well as absorption in the small intestine, existence in body fluids and reaction progress of the exhaust process according to pH conditions in body. Also reaction path modeling can predict bioavailability, which is equal to existence rate in the body and the form and amount of a medicine in the body after intake. The study results from predicating the existence form mineral medicines in the body, and proving the effective ingredient using bioaccessibitily and human risk assessment, suggest these that should be necessary data for new medicine development.
Keywords
oriental mineral medicine; standardization; bioavailability; bioaccessibility; human risk assessment;
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Times Cited By KSCI : 1  (Citation Analysis)
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