• Phonetics and Speech Sciences
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• v.14 no.2
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• pp.87-99
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• 2022

A review regarding indicators used in Korean research is needed to develop a diagnostic marker system for Korean children with speech sound disorders (SSD). This literature review examined the research conducted to reveal the characteristics of children with SSD of unknown origin in Korea. The researchers in Korea used diverse variables as indicators to identify the natures of children with SSD. These included indicators related to external characteristics of speech sound and comorbid features other than external aspects of speech sound. The attention has been focused on specific indicators so far. This result implies that some indicators may still require closer study in various aspects due to their influence, and some may require more attention due to the limited number of research. This article argues that more research is necessary to comprehensively describe the unique characteristics of children with SSD of unknown origin and suggests a direction for future research regarding diagnostic markers and subtype classification of SSD. It also proposes potential diagnostic markers and a set of assessments for the subtype classification of SSD.

• Biomedical Science Letters
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• v.3 no.2
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• pp.131-138
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• 1997

IgG-$^{188}$Re conjugate was prepared for the diagnosis of abscess. The IgG molecules reduced by 2-mercaptoethanol contained 1.5 free sulfhydryl groups per IgG molecule. The reduced IgG molecule was labelled with $^{188}$Re through chelate to 99％ of labelling yield. The radiochemical purity of IgG-$^{188}$Re conjugate was maintained at 90％ in the presence of human serum for 1 hour. The IgG-$^{188}$Re was intravenously administered into staphylococcal abscess-bearing rats and their biodistribution was monitored at 4 and 24 hours post injection. The IgG-$^{188}$Re conjugate was moderately localized in the abscess tissue. This result implies that the IgG-$^{188}$Re conjugate can be a tool for abscess diagnosis. This technique can be applied for the preparation of various monoclonal antibody labelled with $^{188}$Re.

• Korean Journal of Optics and Photonics
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• v.30 no.2
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• pp.59-66
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• 2019

We report highly sensitive detection of myocardial infarction biomarkers, such as myoglobin and cTnI, within several hundred seconds using a rotating-analyzer ellipsometer and a biosensor with biochips fabricated on a $SiO_2$-coated tilted silicon substrate. We choose the running buffer to be pure phosphate-buffered saline (PBS) or 10% mixed human serum. When we choose the running buffer to be pure PBS, we obtain diagnostic densities of pure myocardial infarction biomarkers of up to 1 ng/ml and 5 pg/ml respectively. Meanwhile, when we use PBS with 10% human serum, the measured densities of myoglobin and cTnI were up to 1 ng/mL and 1 pg/mL respectively. The measured diagnostic densities are less than 1/15 and 1/80 (in cases of myoglobin and cTnI respectively) of those referenced by the World Health Organization.

• Journal of Digital Contents Society
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• v.17 no.6
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• pp.509-521
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• 2016

A novel Samples Balanced Genetic Algorithm combined with Extreme Learning Machine (SBGA-ELM) for Parkinson's Disease diagnosis and detecting bio-markers is presented in this paper. Proposed approach uses genes' expression data of 22,283 genes from open source ParkDB data base for accurate PD diagnosis and detecting bio-markers. Proposed SBGA-ELM includes two major steps: feature (genes) selection and classification. Feature selection procedure is based on proposed Samples Balanced Genetic Algorithm designed specifically for genes expression data from ParkDB. Proposed SBGA searches a robust subset of genes among 22,283 genes available in ParkDB for further analysis. In the "classification" step chosen set of genes is used to train an Extreme Learning Machine (ELM) classifier for an accurate PD diagnosis. Discovered robust subset of genes creates ELM classifier with stable generalization performance for PD diagnosis. In this research the robust subset of genes is also used to discover 24 bio-markers probably responsible for Parkinson's Disease. Discovered robust subset of genes was verified by using existing PD diagnosis approaches such as SVM and PBL-McRBFN. Both tested methods caused maximum generalization performance.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2022.11a
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• pp.224-226
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• 2022

다양한 소스로부터 수집되고 연동되는 데이터를 모델링하는 기술로 그래프 데이터베이스를 활용한 분석 기법이 각광받고 있다. 이 연구에서는 항로표지에서 관측되는 상태 및 주변 정보를 모델링하고, 고장진단 및 예측에 적용할 수 있는 기계학습 기법을 소개한다.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2022.06a
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• pp.100-102
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• 2022

데이터의 품질을 파악하고 그 기준을 선정하는 것은 해양 항로 표지와 같은 분석에 있어서 중요한 역할을 한다. 본 연구에서는 해양 분야에서 디지털 항로표지 데이터의 품질 진단을 위해 공정능력지수를 이용하여 데이터의 품질을 정량적으로 산출하고 그 결과에 대한 판정 기준을 명확히 하여 데이터에 대한 품질을 판단할 수 있는 척도를 제시하였다.

• The Korean Journal of Cytopathology
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• v.7 no.1
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• pp.1-11
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• 1996

From the concepts of cellular pathology and of exfoliative cytology, as elucidated by Virchow and Papanicolaou respectively in the late 19th and early 20th century, have evolved the primary methods for the diagnosis of cancer today. From Papanicolaou's concept of exfoliative cytology developed fine needle aspiration biopsy in the early 1960's, this has become a major diagnostic procedure and has contributed to a significant reduction in open biopsies and, therefore, to medical cost-effectiveness immunobiochemical techniques provided us with a supplement to cancer diagnosis in the 1980's. The immunoperoxidase method, using monoclonal antibodies, is applied primarily as an ancillary measure to elucidate the nature of cancers The availability of specific monoclonal antibodies has greatly facilitated the identification of cell products or surface markers. For example, antibodies directed against intermediate filaments have proved to be of value in determining the histogenesis oi poorly differentiated neoplasms. Tumor markers may serve as biochemical indicators of the presence of a neoplasm. They can be detected In plasma and other body fluids. Their concentration can be applied as a diagnostic test, for monitoring the clinical course of known cancer, and as a screening measure to detect certain cancers in a population at risk. Flow cytometry is a useful tool for distinguishing several cell characteristics, such as the immunophenotype of leukemia-lymphoma cells, the DNA content of neoplastic cells, and cell proliferation rate. Molecular biologic techniques provided a giant step for the management of cancer patients encompassing diagnosis, prognostic evaluation, and therapy. Nucleic acid hybridization techniques are utilized as Southern, Northern, and dot blots and in situ hybridization. Molecular biology and its techniques may bring a blight new horizon for understanding cancer biology and in designing therapy on the basis of gene manipulation.

• Proceedings of the Korea Information Processing Society Conference
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• 2006.11a
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• pp.609-612
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• 2006

본 연구는 진단용 DNA 칩의 자동판독 시스템을 제안하는 것을 목적으로 한다. 일반적인 자동판독 시스템의 사양을 정의하고 그 구현방법을 제안하였다. 응용 예로서 자궁경부암 진단용 DNA 칩을 대상으로 GenePix 스캐너 프로그램 환경에 적용하였다. 영상획득은 GenePix 의 라이브러리를 사용하여 HTML 언어로 구현하였고, 영상의 판단과 보고서 생성은 Microsoft Visual C++ 6.0를 사용하여 COM 형태로 구현하였다. 결과 보고서는 한글 2002 문서에 환자 정보와 결과 정보 등에 해당하는 곳에 미리 정의된 표지문자열들을 삽입하여 템플릿을 만들었다. 판독 시스템은 템플릿을 읽어들여 처리 결과의 내용으로 표지문자열들을 치환하여 보고서를 생성하였다. 제안한 시스템을 통해서 스캐닝을 통한 영상획득, 영상읠 판독, 결과 보고서 생성으로 구성된 전체 판독과정이 사용자의 개입 없이 자동으로 처리될 수 있었다. 본 시스템은 기존에 수작업을 자동화여 판독 시간을 단축하고 판독 기준을 정량화하여 진단용 DNA 칩이 대량검사 활용되는 공헌할 것으로 기대된다.

• The Journal of the Korea Contents Association
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• v.9 no.11
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• pp.240-246
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• 2009

Quality control test in this field of study were carried out in 3 categories, radionuclidic purity, chemical purity and radiochemical purity. Also, indication efficiency was tested every 3 hours changed after binding the radiopharmaceutical to see how long the medicine is available for usage after indicating. The result showed that currently used radiopharmaceutical have good radionuclidic purity and chemical purity. However, radiochemical purity indication showed small differences depending on indication method and indication period. Radiopharmaceutical are indicated by treatment providers, so they need to pay more attention to the indication process and quality control to provide more efficient treatment.

• Korean Journal of Head & Neck Oncology
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• v.23 no.2
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• pp.133-137
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• 2007

With the wide use of ultrasonography and fine needle aspiration of the thyroid gland, the incidence of papillary microcarcinoma of the thyroid gland is rapidly increasing nowadays. To improve the diagnostic accuracy of histopathologic findings of papillary thyroid carcinoma, various molecular markers have been used recently. We analysed the expression of galectin-3, cytokeratin 19 and HBME-1, using immunohistochemical technique in 37 cases of papillary microcarcinoma of the thyroid gland to evaluate the diagnostic value of these molecular markers. Immunohistochemically, galectin-3 expression was found in 37 cases of papillary microcarcinoma. Its localization was mostly cytoplasmic. Cytokeratin 19 expression was found in 36 cases. It was mostly localized to the cytoplasm and membrane. HBME-1 expression was found in all cases. Its localization was plasma membrane. The expression of these three molecular markers was negative in the adjacent normal thyroid tissue and accompanying benign lesions, although there are scattered foci of incomplete positive staining in cases of Hashimoto's thyroiditis. Our findings suggest that the immunohistochemical staining using antibodies for galectin-3, cytokeratin 19 and HBME-1 is an useful adjunctive method for the histopathological diagnosis of a papillary microcarcinoma of the thyroid gland.